Richard Eva Lab
@richardevalab.bsky.social
CNS regeneration lab, King's College London, Wolfson SPaRC. We use neuronal cell biology to study axon regeneration, identifying and testing new therapies for eye disease and spinal cord injury.
Reposted by Richard Eva Lab
Our latest review with @doctorpaf.bsky.social! We discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1.
-Challenges for SARM1 inhibition for neuroprotection
-Roles in non-neuronal cells
-SARM1 activation for selective peripheral neuroablation
dlvr.it/TNnCBh
-Challenges for SARM1 inhibition for neuroprotection
-Roles in non-neuronal cells
-SARM1 activation for selective peripheral neuroablation
dlvr.it/TNnCBh
October 21, 2025 at 5:44 AM
Our latest review with @doctorpaf.bsky.social! We discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1.
-Challenges for SARM1 inhibition for neuroprotection
-Roles in non-neuronal cells
-SARM1 activation for selective peripheral neuroablation
dlvr.it/TNnCBh
-Challenges for SARM1 inhibition for neuroprotection
-Roles in non-neuronal cells
-SARM1 activation for selective peripheral neuroablation
dlvr.it/TNnCBh
Reposted by Richard Eva Lab
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that
drives programmed axon degeneration and has gathered significant interest as a therapeutic
target. Despite preclinical...
www.cell.com
October 21, 2025 at 6:16 AM
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Reposted by Richard Eva Lab
I’m excited to share that my PhD work is out in @jcb.org! Big thanks to my amazing mentor @stephgupton.bsky.social and inspiring collaborator @coronin.bsky.social!!!!
Ho, @stephgupton.bsky.social et al. find that coronin 1A mediates neuronal growth cone & filopodial dynamics, & its interaction with E3 ubiquitin ligase TRIM67 is required for morphological responses to the guidance cue netrin-1 rupress.org/jcb/article/...
#Neuroscience #Cytoskeleton #Development
#Neuroscience #Cytoskeleton #Development
October 15, 2025 at 1:26 PM
I’m excited to share that my PhD work is out in @jcb.org! Big thanks to my amazing mentor @stephgupton.bsky.social and inspiring collaborator @coronin.bsky.social!!!!
Reposted by Richard Eva Lab
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
Single-cell RNA sequencing clarifies dermal fibroblast subset representation in vitro and reveals variable persistence of keloid disease-associated features
In vitro models of scarring and fibrosis are essential to improve our understanding of disease mechanisms and ultimately develop much-needed effective therapeutic strategies. This is particularly true...
www.biorxiv.org
August 20, 2025 at 12:22 PM
Happy to announce our preprint going live on BioRxiv! Interested in what’s happening to your fibroblasts’ transcriptomic phenotype once it’s in culture? Look no further!
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
www.biorxiv.org/content/10.1...
@denklab.bsky.social
#fibroblast #scRNAseq #culture #invitro #keloid #ECM #matrix #mesenchymal
Reposted by Richard Eva Lab
The long and newly updated story of lithium and its potential role for helping to prevent Alzheimer's disease
erictopol.substack.com/p/lithium-an...
erictopol.substack.com/p/lithium-an...
August 9, 2025 at 8:54 PM
The long and newly updated story of lithium and its potential role for helping to prevent Alzheimer's disease
erictopol.substack.com/p/lithium-an...
erictopol.substack.com/p/lithium-an...
A huge thank you to the Eva and Bradbury Lab members, @wolfsonsparc.bsky.social, and all the GRC CNS Injury and Repair attendees. So much fun, so much science and all top quality. A poster prize for Zahra to top it off! New ideas, collaborations, connections. As a great conference should be!
July 11, 2025 at 1:52 PM
A huge thank you to the Eva and Bradbury Lab members, @wolfsonsparc.bsky.social, and all the GRC CNS Injury and Repair attendees. So much fun, so much science and all top quality. A poster prize for Zahra to top it off! New ideas, collaborations, connections. As a great conference should be!
Love this. Who needs sheets!?
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass: Developmental Cell www.cell.com/developmenta...
Tubular ER structures shaped by ER-phagy receptors engage in stress-induced Golgi bypass
Song et al. demonstrate that an ER tubulovesicular structure (ER tubular body [ER-TB]),
shaped by the tubular ER-phagy receptors ATL3 and RTN3L, plays an important role in
stress-induced Golgi bypass ...
www.cell.com
June 12, 2025 at 8:17 AM
Love this. Who needs sheets!?
Reposted by Richard Eva Lab
*New paper alert* - extracellular tau blocks synaptic plasticity in vivo via its microtubule-binding domain, which can be rescued by our Gen2 tau antibodies - all the product of a great collaboration with Michael Rowan and colleagues at @tcddublin.bsky.social link.springer.com/article/10.1...
Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region - Acta Neuropathologica
Immunotherapies targeting extracellular tau share the premise that interrupting cell-to-cell spread of tau pathology in Alzheimer’s disease (AD) will slow dementia pathogenesis. Whether these interven...
link.springer.com
June 5, 2025 at 4:32 PM
*New paper alert* - extracellular tau blocks synaptic plasticity in vivo via its microtubule-binding domain, which can be rescued by our Gen2 tau antibodies - all the product of a great collaboration with Michael Rowan and colleagues at @tcddublin.bsky.social link.springer.com/article/10.1...
What an interesting paper, such a huge amount of work! Great to see it cover the different CNS and PNS axon types.
And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!
And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!
A 🧵 to walk those interested through this paper...
Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
May 17, 2025 at 10:00 AM
What an interesting paper, such a huge amount of work! Great to see it cover the different CNS and PNS axon types.
And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!
And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!
Reposted by Richard Eva Lab
Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social
shorturl.at/qVUKz
shorturl.at/qVUKz
Regenerating Retinal Neurons using AAV Vectors / ISCRM
.
shorturl.at
March 26, 2025 at 8:27 PM
Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social
shorturl.at/qVUKz
shorturl.at/qVUKz
Reposted by Richard Eva Lab
Our paper is finally out!
Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...
Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...
April 30, 2025 at 7:42 AM
Our paper is finally out!
Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...
Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...
A fantastic place to work with brilliant colleagues in a vibrant part of London!
Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.
Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.
The Wolfson SPaRC (Sensory, Pain and Regeneration Centre) is recruiting! Two posts available at Lecturer, Senior Lecturer or Reader position. Take a look! @kingsioppn.bsky.social #TranslationalResearch #SpinalCordandBrainRepair #HearingLoss #ChronicPain #Migraine www.kcl.ac.uk/jobs/111846-...
April 4, 2025 at 3:22 PM
A fantastic place to work with brilliant colleagues in a vibrant part of London!
Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.
Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.
Reposted by Richard Eva Lab
Excellent story from the Woolf lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration - Nature Communications
Therapeutic interventions for motor axon regeneration following peripheral nerve injury are currently unavailable. Here authors show local administration of a non-muscle myosin II inhibitor at the inj...
www.nature.com
March 30, 2025 at 11:16 PM
Excellent story from the Woolf lab!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Richard Eva Lab
Significant functional improvements in walking speed/endurance for people with spinal cord injury with combined 4-aminopyridine and paired associative stimulation.
A great study by Dr. Monica Perez and an All Star group.
#SCIrehab 🧪 #phySKYatry
academic.oup.com/brain/advanc...
A great study by Dr. Monica Perez and an All Star group.
#SCIrehab 🧪 #phySKYatry
academic.oup.com/brain/advanc...
Combinatorial approaches increasing neuronal activity accelerate recovery after spinal cord injury
Chen et al. report that patients with spinal cord injury who received treatment with a combination of Hebbian stimulation to strengthen corticospinal synap
academic.oup.com
March 29, 2025 at 7:59 PM
Significant functional improvements in walking speed/endurance for people with spinal cord injury with combined 4-aminopyridine and paired associative stimulation.
A great study by Dr. Monica Perez and an All Star group.
#SCIrehab 🧪 #phySKYatry
academic.oup.com/brain/advanc...
A great study by Dr. Monica Perez and an All Star group.
#SCIrehab 🧪 #phySKYatry
academic.oup.com/brain/advanc...
Reposted by Richard Eva Lab
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish
Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...
www.biorxiv.org
January 27, 2025 at 7:17 PM
Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...
Some interesting findings for ribosomal populations in mature human neurons...
#proteostasis A subcellular map of translational machinery composition and regulation at the single-molecule level | Science www.science.org/doi/10.1126/...
A subcellular map of translational machinery composition and regulation at the single-molecule level
Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...
www.science.org
March 7, 2025 at 3:20 PM
Some interesting findings for ribosomal populations in mature human neurons...
Reposted by Richard Eva Lab
Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration | PNAS
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2
in Caenorhabditis elegans, increases the growth of spontaneous...
www.pnas.org
February 28, 2025 at 2:16 PM
Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.
www.pnas.org/doi/10.1073/...
Ooh, that's very interesting...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease - Nature
Disruption of mucin-domain glycoprotein expression and function in the endothelial glycocalyx are associated with ageing and Alzheimer’s disease, leading to dysregulated blood–brain barrier function.
www.nature.com
February 26, 2025 at 7:42 PM
Ooh, that's very interesting...
An exciting paper demonstrating a complex integrin trafficking mechanism with potential implications for the machinery regulating axon growth and regeneration. Intriguing!
I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday
February 23, 2025 at 1:48 PM
An exciting paper demonstrating a complex integrin trafficking mechanism with potential implications for the machinery regulating axon growth and regeneration. Intriguing!
Reposted by Richard Eva Lab
Masalmeh, RHA, et al. FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. bioRxiv posted 20 February 2025 doi:10.1101/2024.12.11.627900. www.biorxiv.org/content/10.1...
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation
Glycolysis and the TCA cycle are reprogrammed in cancer cells to meet bioenergetic and biosynthetic demands, including by engagement with the extracellular matrix (ECM). We show that focal adhesion ki...
www.biorxiv.org
February 21, 2025 at 8:02 AM
Masalmeh, RHA, et al. FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. bioRxiv posted 20 February 2025 doi:10.1101/2024.12.11.627900. www.biorxiv.org/content/10.1...
Reposted by Richard Eva Lab
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods
A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...
www.nature.com
February 20, 2025 at 1:10 PM
I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Richard Eva Lab
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
December 2, 2024 at 5:52 PM
Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...
doi.org/10.1016/j.cu...
Reposted by Richard Eva Lab
ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...
February 5, 2025 at 11:12 PM
ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...
Reposted by Richard Eva Lab
Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.
February 2, 2025 at 8:47 AM
Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.
Reposted by Richard Eva Lab
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation
Ribosomes cooperate through transient collisions to ensure efficient translation.
www.cell.com
February 1, 2025 at 7:30 AM
Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...