Francesco Scavone
@fscavone.bsky.social
Biology @Stanford | Kopito lab | ubiquitin & UBLs, UFM1, ribosome, protein quality control, autophagy, endoplasmic reticulum | Foodbank volunteer | 🐘:@scavone@mas.to
📷: Sicilian landscape
📷: Sicilian landscape
Reposted by Francesco Scavone
Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
September 22, 2025 at 2:36 PM
Out in @febsj.bsky.social, comment written with @tonyavril.bsky.social from @csignaling.bsky.social.
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
https://doi:10.1111/febs.70259
The SARS-CoV-2 spike protein interacts with HAX1 to modulate cellular stress responses through activation of the UPR
Reposted by Francesco Scavone
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
www.nature.com
September 19, 2025 at 1:52 PM
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Francesco Scavone
From MBoC... Dr. Francesco Scavone (Stanford) shows ATG9A has an unexpected role in trafficking K63-polyubiquitin–modified membrane proteins. Blocking the signal traps cargos in vesicle clusters; once released, they rapidly reach lysosomes. 🔗 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
September 10, 2025 at 1:40 PM
From MBoC... Dr. Francesco Scavone (Stanford) shows ATG9A has an unexpected role in trafficking K63-polyubiquitin–modified membrane proteins. Blocking the signal traps cargos in vesicle clusters; once released, they rapidly reach lysosomes. 🔗 www.molbiolcell.org/doi/10.1091/... #ASCB #CellBiology
Reposted by Francesco Scavone
Absolutely honoured to see our work featured on this month’s cover! 🎉🧬
Artwork by the incredibly talented @doroteaartscience.bsky.social 👇
Artwork by the incredibly talented @doroteaartscience.bsky.social 👇
🏖️Our August issue's out!
Cover: Flexibility of #autophagy initiation
👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...
Cover: Flexibility of #autophagy initiation
👉🏼Review on #metabolism in #embryogenesis #devbio
👉🏼Review on #DNArepair
🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more!
www.nature.com/ncb/volumes/...
August 13, 2025 at 5:04 AM
Absolutely honoured to see our work featured on this month’s cover! 🎉🧬
Artwork by the incredibly talented @doroteaartscience.bsky.social 👇
Artwork by the incredibly talented @doroteaartscience.bsky.social 👇
Reposted by Francesco Scavone
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
July 18, 2025 at 10:55 AM
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
👇 for @zaffagg3 's detailed explanation
www.embopress.org/doi/full/10....
Reposted by Francesco Scavone
#cryoEM confluence in Munich #womeninSTEM
July 17, 2025 at 9:44 PM
#cryoEM confluence in Munich #womeninSTEM
Reposted by Francesco Scavone
new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
June 27, 2025 at 4:01 PM
new preprint alert from the lab: bringing some order into the wide and wild diversity of archaeal histones. Who has acidic histones? who has multiple histones? what histone combinations do archaea employ and why? find all of this and more here
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Francesco Scavone
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
The expanding repertoire of ESCRT functions in cell biology and disease - Nature
This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.
tinyurl.com
June 25, 2025 at 6:24 PM
The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem
Reposted by Francesco Scavone
Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...
June 16, 2025 at 2:42 PM
Check out our latest preprint with the Qi lab on the structure and disease physiology of the human ERAD complex. Outstanding work by Leo, a cell physiologist whom we successfully tempted into structural biology! Preprint: www.biorxiv.org/content/10.1...
Highlight on our recent work on UFMylation by @dimitristypas.bsky.social on @NatureSMB: www.nature.com/articles/s41...
UFMylation-dependent quality control of ER-stalled ribosomes - Nature Structural & Molecular Biology
Nature Structural & Molecular Biology - UFMylation-dependent quality control of ER-stalled ribosomes
www.nature.com
June 15, 2025 at 7:06 PM
Highlight on our recent work on UFMylation by @dimitristypas.bsky.social on @NatureSMB: www.nature.com/articles/s41...
Reposted by Francesco Scavone
Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social
June 12, 2025 at 6:42 PM
Huge thanks to @gthibault.bsky.social and Julie Hollien for organizing a warm, welcoming FASEB ER meeting filled with incredible science! Excited that I will carry the torch as a co-organizer for the 2027 meeting….can’t wait! @faseborg.bsky.social
Reposted by Francesco Scavone
We are excited to get on this project and learn more about chromatin organization! Great to share this good news with Ina and Matilde, congrats everyone!
Congratulations to group leaders Matilde Galli, Ina Sonnen, and Francesca Mattiroli on receiving M-grants from the Dutch Research Council (NWO)! 🎉
With this funding, they’ll explore cell division, gut cell communication and DNA packaging.
Read more here 👉 www.hubrecht.eu/nwo-m-grants...
With this funding, they’ll explore cell division, gut cell communication and DNA packaging.
Read more here 👉 www.hubrecht.eu/nwo-m-grants...
June 12, 2025 at 8:53 PM
We are excited to get on this project and learn more about chromatin organization! Great to share this good news with Ina and Matilde, congrats everyone!
Reposted by Francesco Scavone
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS
FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced
forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...
www.pnas.org
May 29, 2025 at 6:02 PM
Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9
Brief Skytorial!
1/9
Reposted by Francesco Scavone
Excited to present first publication from the Joshi lab, now in @jcb.org
Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.
rupress.org/jcb/article/...
Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.
rupress.org/jcb/article/...
Phosphatidic acid drives spatiotemporal distribution of Pex30 at ER-LD contact sites | Journal of Cell Biology | Rockefeller University Press
In this study, we show that Pex30 dysferlin domain binds PA through its two hydrophobic regions adjacent to beta sheets. We propose that, PA, a precursor f
rupress.org
May 23, 2025 at 2:41 PM
Excited to present first publication from the Joshi lab, now in @jcb.org
Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.
rupress.org/jcb/article/...
Here, we show that phosphatidic acid regulates Pex30 distribution at ER subdomains for lipid droplet biogenesis by binding to dysferlin domain.
rupress.org/jcb/article/...
Reposted by Francesco Scavone
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
N-glycan-dependent protein maturation and quality control in the ER - Nature Reviews Molecular Cell Biology
N-glycosylation of secretory pathway proteins in the ER is crucial for their maturation and quality control. Recent insights into the enzymes and chaperones that facilitate N-glycosylation have expand...
www.nature.com
May 22, 2025 at 4:45 PM
Dan, a friend for many of us, passed at the end of last year. Before leaving, with his students and colleagues, he prepared this gift. Amazing.
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
N-glycan-dependent protein maturation and quality control in the ER | Nature Reviews Molecular Cell Biology
www.nature.com/articles/s41...
New paper from our lab! 🥳🎉 "UFMylation orchestrates spatiotemporal coordination of RQC at the ER"
@Science Advances
www.science.org/doi/10.1126/...
@Science Advances
www.science.org/doi/10.1126/...
UFMylation orchestrates spatiotemporal coordination of RQC at the ER
Structures of stalled ER-bound 60S ribosomal subunits identify cooperative interaction between UFMylation and RQC machineries.
www.science.org
May 2, 2025 at 6:52 PM
New paper from our lab! 🥳🎉 "UFMylation orchestrates spatiotemporal coordination of RQC at the ER"
@Science Advances
www.science.org/doi/10.1126/...
@Science Advances
www.science.org/doi/10.1126/...
Reposted by Francesco Scavone
Happy to have contributed in a small way to this exciting study from Daniel Nomura identifying a new covalent degrader handle that acts through the dcaf16 E3 ligase! 🤩
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...
www.biorxiv.org
April 26, 2025 at 6:09 PM
Happy to have contributed in a small way to this exciting study from Daniel Nomura identifying a new covalent degrader handle that acts through the dcaf16 E3 ligase! 🤩
Reposted by Francesco Scavone
We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin
April 23, 2025 at 9:56 PM
We are looking for a PhD student with interest in protein biochemistry on a really cool project “Cooperation of deubiquitinating enzymes and VCP/p97 in cellular stress responses”. Build your own reactions! fully funded. apply with code 193-25. #ubiquitin
Reposted by Francesco Scavone
Our PKA-autophagy story by outstanding graduate student Ashley Segura (co-led with Rose Citron) published in @embojournal.org, dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with @manciaslab.bsky.social!
AKAP11 recruits PKA holoenzymes to #autophagosomes in a bidirectional functional association, both promoting downstream PKA signaling and increasing AKAP11-PKA complex degradation
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....
@robzonculab.bsky.social @ucberkeleyofficial.bsky.social
www.embopress.org/doi/full/10....
April 23, 2025 at 3:03 PM
Our PKA-autophagy story by outstanding graduate student Ashley Segura (co-led with Rose Citron) published in @embojournal.org, dissects a deep connection between autophagy and PKA in neuronal signaling, with implications for neurological disease. Great collaboration with @manciaslab.bsky.social!
Reposted by Francesco Scavone
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage
Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...
rdcu.be
April 10, 2025 at 2:17 PM
"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL
rdcu.be/ehbaL
Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | PNAS
The integrated stress response (ISR) is a central signaling network that enables eukaryotic
cells to respond to a variety of different environmenta...
www.pnas.org
April 13, 2025 at 2:12 AM
Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits
Abstract. The assembly of ribosomal subunits, primarily occurring in the nucleolar and nuclear compartments, is a highly complex process crucial for cellul
academic.oup.com
April 13, 2025 at 2:11 AM
Highly conserved ribosome biogenesis pathways between human and yeast revealed by the MDN1-NLE1 interaction and NLE1 containing pre-60S subunits
academic.oup.com/nar/article/...
academic.oup.com/nar/article/...
Reposted by Francesco Scavone
Check out our new preprint, in which brilliant @alessandrick.bsky.social revealed a novel function of the RNA-binding protein IGF2BP3 in regulating the unfolded protein response. Please see the wonderful thread by @alessandrick.bsky.social for more detail! www.biorxiv.org/content/10.1...
April 7, 2025 at 5:01 PM
Check out our new preprint, in which brilliant @alessandrick.bsky.social revealed a novel function of the RNA-binding protein IGF2BP3 in regulating the unfolded protein response. Please see the wonderful thread by @alessandrick.bsky.social for more detail! www.biorxiv.org/content/10.1...
Reposted by Francesco Scavone
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 7, 2025 at 3:10 PM
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Francesco Scavone
doi.org/10.1515/hsz-...
I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!
I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!
The nascent polypeptide-associated complex (NAC) as regulatory hub on ribosomes
The correct synthesis of new proteins is essential for maintaining a functional proteome and cell viability. This process is tightly regulated, with ribosomes and associated protein biogenesis factors...
doi.org
April 1, 2025 at 2:57 PM
doi.org/10.1515/hsz-...
I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!
I am super happy to share this review as my first post on Bluesky. After submitting my PhD thesis at the start of the year, my PI Elke Deuerling suggested to write this review with her, covering many of the findings of my thesis. I am excited to see it published today!