Peter AF
@doctorpaf.bsky.social
Clinician scientist and consultant neurologist. Interested in neuromuscular diseases, #neuropathy, #ALS, #nerve #regeneration, neuron #glia interactions and #Schwanncells.
Pinned
Peter AF
@doctorpaf.bsky.social
· Dec 16
2025 PNS Call for Abstracts - Submission Deadline Extended - pnsociety.com
pnsociety.com
PNS2025 meeting for the first time will include a consortium dedicated to nerve injury & repair.
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Targeting SARM1: from inhibition for neuroprotection to activation for neuroablation
Sterile alpha and TIR motif-containing protein 1 (SARM1),is a central enzyme that
drives programmed axon degeneration and has gathered significant interest as a therapeutic
target. Despite preclinical...
www.cell.com
October 21, 2025 at 6:16 AM
In this review @Andrea-Loreto.bsky.social and I discuss the breadth of therapeutic potential for the neurodegenerative enzyme SARM1
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
- Challenges for SARM1 therapeutic inhibition
- SARM1 in non-neuronal cells
- SARM1 activation for selective peripheral neuroablation.
www.cell.com/trends/pharm...
Reposted by Peter AF
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...
Sir John Gurdon, 1933-2025 | Wellcome
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 October. He made a discovery that opened up the field of cloning research, and created one of the best environments for res...
wellcome.org
October 9, 2025 at 1:39 PM
A Nobel-winning scientist of great modesty and humour, John Gurdon died on 7 Oct. Not only did he make a discovery that laid the foundations for stem cell research, he also created one of the best environments for research at the Wellcome/CRUK Gurdon Institute wellcome.org/news/sir-joh...
Reposted by Peter AF
It is 22 years ago today that my best friend, Nick Everton, died. He was 17 years old. Not much time to leave a mark on the world you would think.
But those of us who knew him came away irreversibly altered by even the short time we shared together....
🧵
But those of us who knew him came away irreversibly altered by even the short time we shared together....
🧵
June 13, 2025 at 2:07 PM
It is 22 years ago today that my best friend, Nick Everton, died. He was 17 years old. Not much time to leave a mark on the world you would think.
But those of us who knew him came away irreversibly altered by even the short time we shared together....
🧵
But those of us who knew him came away irreversibly altered by even the short time we shared together....
🧵
It’s with a very heavy heart that I share with you the news that Prof Kristjan Jessen has passed away.
Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades.
Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.
Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades.
Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.
June 6, 2025 at 7:42 AM
It’s with a very heavy heart that I share with you the news that Prof Kristjan Jessen has passed away.
Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades.
Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.
Kristjan with his wife Rhona were at the forefront of the #Schwanncell field for over 3 decades.
Kristjan was my first scientific mentor & he taught me a lot. He will be sorely missed.
Reposted by Peter AF
Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience
White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...
www.nature.com
May 22, 2025 at 10:21 AM
Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...
Just finished the Peripheral Nerve Society meeting in Edinburgh #PNS2025. The last few days have been a whirlwind of science and medicine with inspiring talks and great posters in everything to do with peripheral nerve. It’s also been great to catch up with old colleagues.
May 21, 2025 at 9:34 AM
Just finished the Peripheral Nerve Society meeting in Edinburgh #PNS2025. The last few days have been a whirlwind of science and medicine with inspiring talks and great posters in everything to do with peripheral nerve. It’s also been great to catch up with old colleagues.
I had a great experience publishing in @jcellsci.bsky.social - would highly recommend it!
Did you know…
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
It’s free to publish in Journal of Cell Science – there are no submission charges, page charges or colour fees. We also plant a tree for every peer-reviewed article we publish🌳
For details, visit our website:
journals.biologists.com/jcs/pages/re...
April 12, 2025 at 10:14 AM
I had a great experience publishing in @jcellsci.bsky.social - would highly recommend it!
Reposted by Peter AF
THREAD
Things that didn't make the news that will likely change our lives for the better
The news is not an accurate reflection of the world.
Good news doesn't get reported as much.
Here are the wonderful things researchers have achieved recently.
1/24
Things that didn't make the news that will likely change our lives for the better
The news is not an accurate reflection of the world.
Good news doesn't get reported as much.
Here are the wonderful things researchers have achieved recently.
1/24
February 16, 2025 at 4:31 PM
THREAD
Things that didn't make the news that will likely change our lives for the better
The news is not an accurate reflection of the world.
Good news doesn't get reported as much.
Here are the wonderful things researchers have achieved recently.
1/24
Things that didn't make the news that will likely change our lives for the better
The news is not an accurate reflection of the world.
Good news doesn't get reported as much.
Here are the wonderful things researchers have achieved recently.
1/24
This sounds completely shocking. I really hope it’s not as bad as it sounds.
The damage today (actually yesterday) to the intramural program appears to especially bad.
It also appears (although I need more confirmation) that most or all of the tenure track investigators in their first 2 years in several, and perhaps all, institutes were terminated.
7/n
It also appears (although I need more confirmation) that most or all of the tenure track investigators in their first 2 years in several, and perhaps all, institutes were terminated.
7/n
February 16, 2025 at 8:32 PM
This sounds completely shocking. I really hope it’s not as bad as it sounds.
This is very sad news!
January 14, 2025 at 1:58 PM
This is very sad news!
Reposted by Peter AF
Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm
Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm
From weightlifting to woodland walks, Guardian readers and health experts share their tried-and-tested ways to keep burnout at bay
Overwhelm can come from multiple worries going round and round in our heads like a washing machine, which can deplete our…
www.theguardian.com
January 1, 2025 at 11:27 AM
Make a much shorter to-do list! 15 quick, simple ways to avoid overwhelm
It’s amazing how humanity spent hundreds of years trying to eradicate disease from food/beverages and through vaccination to reduce child mortality and increase life expectancy & we are throwing it away in an instant.
Sheer madness.
Sheer madness.
Raw milk, raw water. No benefits, all risk, and we're still doing this going in to 2025. I wrote about it years ago and it's still as dangerous now.
December 31, 2024 at 7:53 PM
It’s amazing how humanity spent hundreds of years trying to eradicate disease from food/beverages and through vaccination to reduce child mortality and increase life expectancy & we are throwing it away in an instant.
Sheer madness.
Sheer madness.
Reposted by Peter AF
The woes of the govt are overdone. Their biggest problem is a consistent tendency to favour tactics over strategy. And failing to change the law to protect British democracy from Musk's money, is the worst example of this yet. My piece for
the i.
inews.co.uk/opinion/dona...
the i.
inews.co.uk/opinion/dona...
Donald Trump and Elon Musk will unite British politics - against them
We are primed for manipulation
inews.co.uk
December 28, 2024 at 10:38 AM
The woes of the govt are overdone. Their biggest problem is a consistent tendency to favour tactics over strategy. And failing to change the law to protect British democracy from Musk's money, is the worst example of this yet. My piece for
the i.
inews.co.uk/opinion/dona...
the i.
inews.co.uk/opinion/dona...
Wishing everyone a very Merry Christmas/Happy holidays!🎄
December 25, 2024 at 10:36 AM
Wishing everyone a very Merry Christmas/Happy holidays!🎄
Reposted by Peter AF
Thou shalt pay Amazon workers fairly, for they are as close as it gets to being Santa’s elves. Without them, Christmas doesn’t happen.
December 23, 2024 at 12:31 AM
Thou shalt pay Amazon workers fairly, for they are as close as it gets to being Santa’s elves. Without them, Christmas doesn’t happen.
Reposted by Peter AF
A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease
washingtonpost.com/wellness/202...
washingtonpost.com/wellness/202...
December 17, 2024 at 3:32 PM
A neurologist with 2 APOE4 copies tells us about his experience with #Alzheimers disease
washingtonpost.com/wellness/202...
washingtonpost.com/wellness/202...
PNS2025 meeting for the first time will include a consortium dedicated to nerve injury & repair.
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
2025 PNS Call for Abstracts - Submission Deadline Extended - pnsociety.com
pnsociety.com
December 16, 2024 at 2:59 PM
PNS2025 meeting for the first time will include a consortium dedicated to nerve injury & repair.
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
Please submit abstracts on all aspects of nerve repair including #axondegeneration #axonregenration #immunecells #repairschwanncells #translation #surgicalrepair
pnsociety.com/2025-pns-cal...
Reposted by Peter AF
I know it's not Friday but I just want to revisit this because look at this beautiful painting I was given by artist @ab-etc.bsky.social - the photo doesn't do it justice but it is called Thalamus Poppies (I would add a heart emoji but they don't seem to be working). Thank you Anne!
December 5, 2024 at 9:35 AM
I know it's not Friday but I just want to revisit this because look at this beautiful painting I was given by artist @ab-etc.bsky.social - the photo doesn't do it justice but it is called Thalamus Poppies (I would add a heart emoji but they don't seem to be working). Thank you Anne!
Finally! We’re still waiting on Monklab to migrate over too!
Welcome to BlueSky @lyons-lab.bsky.social
December 4, 2024 at 6:53 PM
Finally! We’re still waiting on Monklab to migrate over too!
Reposted by Peter AF
What is or is not #Neuroinflammation 🧵? Please share your thoughts & perspectives! This article is an excellent example of a well-considered viewpoint in a broad dialogue that the Journal of Neuroinflammation wishes to have with #neuroscience #neuroskyence #immunosky #neurodegeneration communities
What does neuroinflammation mean? Food for thought to advance the field
👇👇👇👇
journals.sagepub.com/doi/10.1177/...
👇👇👇👇
journals.sagepub.com/doi/10.1177/...
Neuroinflammation: The Abused Concept - Elena Galea, Manuel B. Graeber, 2023
Scientific progress requires the relentless correction of errors and refinement of hypotheses. Clarity of terminology is essential for clarity of thought and pr...
journals.sagepub.com
December 3, 2024 at 5:09 AM
What is or is not #Neuroinflammation 🧵? Please share your thoughts & perspectives! This article is an excellent example of a well-considered viewpoint in a broad dialogue that the Journal of Neuroinflammation wishes to have with #neuroscience #neuroskyence #immunosky #neurodegeneration communities
Reposted by Peter AF
Paradigm shift
December 1, 2024 at 7:21 PM
Paradigm shift
Reposted by Peter AF
👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge - Nature Immunology
Why joints are highly responsive to systemic inflammation is unknown. Hasegawa et al. sought to address this question, developing a whole-mount imaging system of the entire synovium to profile the vas...
www.nature.com
November 26, 2024 at 1:19 PM
👏 to Tetsuo Hasegawa & others of Clatworthy lab
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
& beyond for this amazing analysis of macrophage-nociceptor interactions within the joint: the blood-joint barrier, "equipped to sense circulating stimuli & telegraph their presence via pain" #neuroskyence #PainResearch
www.nature.com/articles/s41...
Reposted by Peter AF
1/ We're experiencing a huge influx of users, and with that, a predictable uptick in harmful content posted to the network.
As a result, for some very high-severity policy areas like child safety, we recently made some short-term moderation choices to prioritize recall over precision.
As a result, for some very high-severity policy areas like child safety, we recently made some short-term moderation choices to prioritize recall over precision.
November 26, 2024 at 12:08 AM
1/ We're experiencing a huge influx of users, and with that, a predictable uptick in harmful content posted to the network.
As a result, for some very high-severity policy areas like child safety, we recently made some short-term moderation choices to prioritize recall over precision.
As a result, for some very high-severity policy areas like child safety, we recently made some short-term moderation choices to prioritize recall over precision.
Reposted by Peter AF
'Skeetorial' of our latest paper: link.springer.com/article/10.1...
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
November 24, 2024 at 12:18 PM
'Skeetorial' of our latest paper: link.springer.com/article/10.1...
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
So proud of first author Christina Antoniou for this, now a postdoc with @melissa-gammons1.bsky.social.
(1) NMNAT2 is a repressor of SARM1 NADase in axons. A few people have NMNAT2 LoF mutations. Many more have low expression.
Reposted by Peter AF
Sign of the times, no more bluebird on the biorxiv engagement tab..
November 24, 2024 at 9:59 AM
Sign of the times, no more bluebird on the biorxiv engagement tab..