Fumiaki Obata
@obataf-lab.bsky.social
PI studying nutritional biology at RIKEN Center for Biosystems Dynamics Research & visiting associate professor in Kyoto University. Interested in Drosophila genetics, amino acid, nutrient, microbiota, metabolism, ageing, lifespan, and many others
Pinned
Fumiaki Obata
@obataf-lab.bsky.social
· Dec 24
A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules
Using the power of Drosophila genetics, Oi et al. identified a nonsecretory antimicrobial peptide, Attacin-D, as an essential factor in inflammatory organ damage in the renal tubules. This study highlights a key player in inflammatory organ injury.
www.cell.com
new work out from the lab @cellreports.bsky.social
A brave phd student Ayano revealed the mechanism how immune activation disrupts renal tubules! The key is a nonsecretory antimicrobial peptide!
www.cell.com/cell-reports...
A brave phd student Ayano revealed the mechanism how immune activation disrupts renal tubules! The key is a nonsecretory antimicrobial peptide!
www.cell.com/cell-reports...
Reposted by Fumiaki Obata
Our new study out @BMC Biology. The first Mosquito study from the lab, driven by a great effort of phd student Yusuke Kato with the hard work of Chisako Sakuma. Amino acid economy meets a blood-sucking insect.
link.springer.com/10.1186/s129...
link.springer.com/10.1186/s129...
Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti - BMC Biology
Background Female Aedes aegypti mosquitoes utilize host blood to support egg maturation by digesting, absorbing, and metabolizing its components. Among these, amino acids are essential as both signali...
link.springer.com
November 27, 2025 at 9:10 AM
Our new study out @BMC Biology. The first Mosquito study from the lab, driven by a great effort of phd student Yusuke Kato with the hard work of Chisako Sakuma. Amino acid economy meets a blood-sucking insect.
link.springer.com/10.1186/s129...
link.springer.com/10.1186/s129...
a tiny contribution from my lab to the great work! Amino acid biology in tumour growth. Congrats! A pint ahead in Melbourne!
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
🧠 New research shows the blood–brain barrier helps control #braintumour growth.
Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.
Read more: www.petermac.org/about-us/new...
Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.
Read more: www.petermac.org/about-us/new...
November 24, 2025 at 4:01 AM
a tiny contribution from my lab to the great work! Amino acid biology in tumour growth. Congrats! A pint ahead in Melbourne!
Reposted by Fumiaki Obata
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
🧠 New research shows the blood–brain barrier helps control #braintumour growth.
Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.
Read more: www.petermac.org/about-us/new...
Led by Prof Louise Cheng, the study finds glial “gatekeeper” cells and a protein called Path influence how #cancer respond to low nutrients.
Read more: www.petermac.org/about-us/new...
November 24, 2025 at 3:19 AM
Tagging first author @joannaqd.bsky.social and collaborators @obataf-lab.bsky.social
Reposted by Fumiaki Obata
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
November 19, 2025 at 10:05 AM
How does the #tumor #microenvironment modulate sensitivity to nutrient restriction? @chengflylab.bsky.social &co show that this is regulated by the SCL36 amino acid transporter Pathetic at the #BloodBrainBarrier perineural glial cells in #Drosophila #brain tumors @plosbiology.org 🧪 plos.io/4ibwXWY
Reposted by Fumiaki Obata
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan
Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...
www.biorxiv.org
September 24, 2025 at 12:01 PM
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Reposted by Fumiaki Obata
New study out! We developed the protocol for dietary manipulation of protein and amino acids in marmoset! FGF21 induction and taurine drop observed. Achieved by intra-RIKEN collab and the first author Yuka's effort. Here comes Primate Nutritional Biology!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels - Scientific Reports
Scientific Reports - Manipulating dietary protein and amino acids in the common marmoset Callithrix jacchus impacts circulating metabolites and FGF21 levels
www.nature.com
September 13, 2025 at 12:15 PM
New study out! We developed the protocol for dietary manipulation of protein and amino acids in marmoset! FGF21 induction and taurine drop observed. Achieved by intra-RIKEN collab and the first author Yuka's effort. Here comes Primate Nutritional Biology!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fumiaki Obata
Reposted by Fumiaki Obata
「読み進めるほどに「腹八分目」という漠然とした言葉の奥深さが沁みてくる」
「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」
8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735
お陰さまで売れています！
「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」
8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735
お陰さまで売れています！
August 27, 2025 at 7:39 AM
「読み進めるほどに「腹八分目」という漠然とした言葉の奥深さが沁みてくる」
「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」
8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735
お陰さまで売れています！
「江戸時代に「腹八分目」と言い表したヒト（貝原益軒）の直感にも感心する、楽しい読書だった」
8/24読売新聞で、奈倉有里さんが小幡史明『「腹八分目」の生物学』をご書評くださいました。☞ iwnm.jp/029735
お陰さまで売れています！
Reposted by Fumiaki Obata
！重版決定！
先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！
なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。
近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！
なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。
近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
August 25, 2025 at 7:43 AM
！重版決定！
先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！
なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。
近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
先月刊行された『「腹八分目」の生物学――健康長寿の食とはなにか』（http://iwnm.jp/029735）、早々に2刷が決定しました！
なお現在、一部ネット書店でカート落ちが発生しております。お近くのリアル書店などで、ぜひお探しいただけますと幸いです。
近日中に電子書籍版も配信開始予定ですので、そちらもぜひご利用ください🐭
Reposted by Fumiaki Obata
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
August 14, 2025 at 8:04 PM
Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.
自分でも気に入っている部分がいくつかあるのですが、そのうちの一つがここのカロリーです。ドーナツはカロリーゼロの衝撃！
August 7, 2025 at 12:29 PM
自分でも気に入っている部分がいくつかあるのですが、そのうちの一つがここのカロリーです。ドーナツはカロリーゼロの衝撃！
Reposted by Fumiaki Obata
8/3産経新聞で、小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）が紹介されました：
「気鋭の研究者による「食の科学」の一冊」
「生存戦略とも結びついた食の奥深さに驚かされる」
www.sankei.com/article/2025...
「気鋭の研究者による「食の科学」の一冊」
「生存戦略とも結びついた食の奥深さに驚かされる」
www.sankei.com/article/2025...
＜書評＞長寿のカギは「タンパク質の摂取量」 『「腹八分目」の生物学』小幡史明著
「腹八分目」の戒めは、江戸時代から『養生訓』などで広く知られた健康と長寿のための経験則。20世紀に入り、ラットやミジンコといった動物を使った実験でも、食事制限…
www.sankei.com
August 4, 2025 at 4:04 AM
8/3産経新聞で、小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）が紹介されました：
「気鋭の研究者による「食の科学」の一冊」
「生存戦略とも結びついた食の奥深さに驚かされる」
www.sankei.com/article/2025...
「気鋭の研究者による「食の科学」の一冊」
「生存戦略とも結びついた食の奥深さに驚かされる」
www.sankei.com/article/2025...
Reposted by Fumiaki Obata
『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）著者の小幡史明さんに、岩波書店本社へおいでいただきました！
ご著書と記念撮影です。
ただいま好評発売中。
腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
ご著書と記念撮影です。
ただいま好評発売中。
腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
July 23, 2025 at 7:37 AM
『「腹八分目」の生物学――健康長寿の食とはなにか』（iwnm.jp/029735）著者の小幡史明さんに、岩波書店本社へおいでいただきました！
ご著書と記念撮影です。
ただいま好評発売中。
腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
ご著書と記念撮影です。
ただいま好評発売中。
腹八分目のかたも、つい食べ過ぎちゃうかたも、ぜひどうぞ。
Reposted by Fumiaki Obata
#Throwback 🧪
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
Subcellular quantitative imaging of metabolites at the organelle level - Nature Metabolism
Subcellular quantitative analysis has been a long-standing goal of mass spectrometry imaging, but was originally thought to be unattainable. However, recent advances have made organelle-level absolute quantification through mass spectrometry imaging a reality, thanks to the development of nano secondary ion mass spectrometry.
bit.ly
July 19, 2025 at 3:02 PM
#Throwback 🧪
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
COMMENT | Subcellular quantitative imaging of metabolites at the organelle level
@siuzdak.bsky.social
Reposted by Fumiaki Obata
＼ 本日 ☆ 刊行 ／
小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー）
試し読みなどはこちら！ → iwnm.jp/029735
長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。
※電子書籍は8月配信予定です。
小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー）
試し読みなどはこちら！ → iwnm.jp/029735
長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。
※電子書籍は8月配信予定です。
July 15, 2025 at 2:43 AM
＼ 本日 ☆ 刊行 ／
小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー）
試し読みなどはこちら！ → iwnm.jp/029735
長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。
※電子書籍は8月配信予定です。
小幡史明『「腹八分目」の生物学――健康長寿の食とはなにか』（岩波科学ライブラリー）
試し読みなどはこちら！ → iwnm.jp/029735
長寿の鍵となる栄養素とは。腹八分目で、老化そのものも防げるか。不老長寿の薬は……！？ 飽くなき探究をいきいきと伝える。
※電子書籍は8月配信予定です。
Reposted by Fumiaki Obata
📢 New preprint:
“Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition”
Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social.
We’re proud to share this story.
👉 www.biorxiv.org/content/10.1...
“Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition”
Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social.
We’re proud to share this story.
👉 www.biorxiv.org/content/10.1...
Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition
Dietary protein sufficiency during childhood is essential for healthy growth and tissue development. Chronic protein deficiency leads to stunting, height-for-age more than two standard deviations belo...
www.biorxiv.org
July 12, 2025 at 2:36 PM
📢 New preprint:
“Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition”
Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social.
We’re proud to share this story.
👉 www.biorxiv.org/content/10.1...
“Liver FGF21 mediates sex-specific adaptation to juvenile protein malnutrition”
Led by @ameliejoly.bsky.social, co-supervised with @francoisleulier.bsky.social.
We’re proud to share this story.
👉 www.biorxiv.org/content/10.1...
A new review from the lab is out. A phd student Ayano and me summerises the current view of amino acid signalling, revealed by Drosophila genetics. www.sciencedirect.com/science/arti...
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study
Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by s…
www.sciencedirect.com
June 15, 2025 at 5:59 PM
A new review from the lab is out. A phd student Ayano and me summerises the current view of amino acid signalling, revealed by Drosophila genetics. www.sciencedirect.com/science/arti...
Reposted by Fumiaki Obata
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
May 26, 2025 at 7:29 AM
Why use #CRISPR in #Drosophila when RNAi works so well? Because for some genes well is not good enough.
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
Check out new preprint from the lab demonstrating a role for Vps15 in Wingless trafficking. Something that was missed in several RNAi screens.
www.biorxiv.org/content/10.1...
Reposted by Fumiaki Obata
CRISPR mutagenesis is also not perfect. A common limitation is generation of genetic mosaics, where only some cells carry gene knockouts. But our new generation of tools substatially improves on that. Described in the preprint below with flies on their way to VDRC:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
May 26, 2025 at 7:29 AM
CRISPR mutagenesis is also not perfect. A common limitation is generation of genetic mosaics, where only some cells carry gene knockouts. But our new generation of tools substatially improves on that. Described in the preprint below with flies on their way to VDRC:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Fumiaki Obata
De novo serine biosynthesis is protective in mitochondrial disease: Cell Reports www.cell.com/cell-reports...
De novo serine biosynthesis is protective in mitochondrial disease
Jackson et al. show that serine becomes an essential amino acid in mitochondrial muscle
disease, delaying disease progression. Blocking local biosynthesis of serine challenges
cellular phospholipid ho...
www.cell.com
May 19, 2025 at 4:29 AM
De novo serine biosynthesis is protective in mitochondrial disease: Cell Reports www.cell.com/cell-reports...
Reposted by Fumiaki Obata
www.crick.ac.uk/news/2025-05... by Clare Green @crick.ac.uk
New stem cell model sheds light on human amniotic sac development
Researchers at the Francis Crick Institute have developed a new stem cell model of the mature human amniotic sac, which replicates development of the tissues supporting the embryo from two to four wee...
www.crick.ac.uk
May 18, 2025 at 1:36 PM
www.crick.ac.uk/news/2025-05... by Clare Green @crick.ac.uk
Reposted by Fumiaki Obata
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Taurine from tumour niche drives glycolysis to promote leukaemogenesis - Nature
The taurine–taurine transporter axis is a critical dependency of aggressive myeloid leukaemias.
www.nature.com
May 14, 2025 at 4:50 PM
Taurine from tumour niche drives glycolysis to promote leukaemogenesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fumiaki Obata
Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒
April 23, 2025 at 4:36 PM
Calorie restriction extends lifespan in many animal models, but the effects in humans and the mechanisms of action are not clear. A Review in Nature Reviews Endocrinology summarizes evidence regarding potential adverse effects of calorie restriction. go.nature.com/42XV1Xa 🔒