Dan J. Hayman
@danjhayman.bsky.social
Using Drosophila to investigate the role of RNA splicing in ageing
Vivensa Foundation ECR Fellow at the Unviersity of Sheffield, hosted in the Simons Lab. PhD in ncRNAs in ageing from the Young Lab at Newcastle University with CIMA.
Vivensa Foundation ECR Fellow at the Unviersity of Sheffield, hosted in the Simons Lab. PhD in ncRNAs in ageing from the Young Lab at Newcastle University with CIMA.
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Knockdown of the fly spliceosome component Rbp1(orthologue of SRSF1) extends lifespan
Biological regulation is a highly intricate process and involves many layers of complexity even at the RNA level. Alternative splicing is crucial in the regulation of which components of a protein-cod...
www.biorxiv.org
September 24, 2025 at 12:01 PM
Latest exciting work from me and @mirresimons.bsky.social (and the first bit of data from my @vivensa.bsky.social ECR Fellowship) now out as a preprint, looking at effects of knocking down individual spliceosome components on lifespan in vivo: www.biorxiv.org/content/10.1...
Reposted by Dan J. Hayman
New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 18, 2025 at 6:57 PM
New preprint. ATF4 activation is thought to lead to longer lifespans. However, our study shows that suppression rather than activation extends lifespan in the fly. New Qs: how we can target ATF4 or its downstream targets to gain targeted longevity benefits.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Dan J. Hayman
Latest. Dan tested the importance of Drosophila immune cells by ablating or expanding them using conditional genetics. Turns out no lifespan phenotype, perhaps because there is compensation within the immune cell lineage. More exciting biology to discover.
journals.biologists.com/jeb/article/...
journals.biologists.com/jeb/article/...
Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival after severe infection
Macrophages are responsible for diverse and fundamental functions in vertebrates. Drosophila blood cells (haemocytes) are dominated by cells bearing a striking homology to vertebrate macrophages (plas...
journals.biologists.com
March 24, 2025 at 12:53 PM
Latest. Dan tested the importance of Drosophila immune cells by ablating or expanding them using conditional genetics. Turns out no lifespan phenotype, perhaps because there is compensation within the immune cell lineage. More exciting biology to discover.
journals.biologists.com/jeb/article/...
journals.biologists.com/jeb/article/...
Really excited to say that from January I'll be starting as an ECR Fellow with the Dunhill Medical Trust based at the University of Sheffield, using Drosophila to look at RNA splicing in ageing!
Seems as good a first post on here as I can come up with!
Seems as good a first post on here as I can come up with!
November 22, 2024 at 7:06 AM
Really excited to say that from January I'll be starting as an ECR Fellow with the Dunhill Medical Trust based at the University of Sheffield, using Drosophila to look at RNA splicing in ageing!
Seems as good a first post on here as I can come up with!
Seems as good a first post on here as I can come up with!
Reposted by Dan J. Hayman
PhD available in my lab, please be in touch should you want more information.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield on FindAPhD.com
PhD Project - Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
November 20, 2024 at 10:47 AM
PhD available in my lab, please be in touch should you want more information.
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Dan J. Hayman
Latest preprint. Well done Dan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Expansion of Drosophila haemocytes using a conditional GeneSwitch driver affects larval haemocyte function, but does not modulate adult lifespan or survival from infection
Macrophages are responsible for diverse and fundamental functions in vertebrates. Fruit flies harbour an innate immune system of which the most populous blood cell (haemocyte) type bears striking homo...
www.biorxiv.org
November 15, 2024 at 12:17 PM
Latest preprint. Well done Dan.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...