Nicola Lorè
@nicolaivan.bsky.social
Biomedical researcher interested in host-pathogen interaction, microbes and lung Immunity.
Pinned
Nicola Lorè
@nicolaivan.bsky.social
· Dec 22
Dual spatial host-bacterial gene expression in Mycobacterium abscessus respiratory infections
Communications Biology - Dual spatial gene expression assay in tissues with chronic lung infection by Mycobacterium abscessus paves the way for the simultaneous detection of host and bacterial...
rdcu.be
Repost in Bluesky. Our paper on #Dual spatial gene expression approach to dissect #host-#bacteria interaction in respiratory infections.
rdcu.be/dWuBQ
rdcu.be/dWuBQ
Super interesting paper on Novel #Genetic Loci for Nontuberculous #Mycobacterial Pulmonary Disease. I'm glad to see that part of the validation was performed using our previous published data. Enjoy the paper! atsjournals.org/doi/10.1164/...
Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index | American Journal of Respiratory and Critical Care Medicine | Articles in Pres...
atsjournals.org
October 7, 2025 at 7:55 AM
Super interesting paper on Novel #Genetic Loci for Nontuberculous #Mycobacterial Pulmonary Disease. I'm glad to see that part of the validation was performed using our previous published data. Enjoy the paper! atsjournals.org/doi/10.1164/...
Reposted by Nicola Lorè
Do you have a story about how antibiotics have made a difference in your lives or the lives of your loved ones?
Your story and photo could be up in lights at #PiccadillyCircus in London during #WAAW25.
Visit the Fleming Initiative to find out more.
➡️ www.fleminginitiative.org/thank-you-an...
Your story and photo could be up in lights at #PiccadillyCircus in London during #WAAW25.
Visit the Fleming Initiative to find out more.
➡️ www.fleminginitiative.org/thank-you-an...
September 23, 2025 at 12:10 PM
Do you have a story about how antibiotics have made a difference in your lives or the lives of your loved ones?
Your story and photo could be up in lights at #PiccadillyCircus in London during #WAAW25.
Visit the Fleming Initiative to find out more.
➡️ www.fleminginitiative.org/thank-you-an...
Your story and photo could be up in lights at #PiccadillyCircus in London during #WAAW25.
Visit the Fleming Initiative to find out more.
➡️ www.fleminginitiative.org/thank-you-an...
Reposted by Nicola Lorè
@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 14, 2025 at 5:20 PM
@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rejected…..rejected….
September 4, 2025 at 4:00 PM
Rejected…..rejected….
Reposted by Nicola Lorè
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune
responses against infections, but they are also involved in inflammatory and autoimmune
diseases. This review maps...
www.cell.com
September 3, 2025 at 4:55 PM
Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...
Reposted by Nicola Lorè
"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0
August 18, 2025 at 1:08 PM
"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0
Reposted by Nicola Lorè
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary
fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors
leads to worsening of inflamm...
www.cell.com
May 30, 2025 at 3:41 PM
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social
www.cell.com/immunity/abs...
www.cell.com/immunity/abs...
Super interesting. Does it work for NTM?
Nature research paper: SuFEx-based antitubercular compound irreversibly inhibits Pks13
go.nature.com/40JdOnN
go.nature.com/40JdOnN
SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature
A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.
go.nature.com
July 31, 2025 at 8:17 AM
Super interesting. Does it work for NTM?
Reposted by Nicola Lorè
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 11:28 AM
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Super happy to have attended “The Nontuberculous #Mycobacteria Conference 2025” in Fort Collins! Great talks, outstanding science, and a really cool location. Huge thanks to the organizers. Always a pleasure to reconnect with friends and colleagues! #ntm
June 6, 2025 at 7:14 AM
Super happy to have attended “The Nontuberculous #Mycobacteria Conference 2025” in Fort Collins! Great talks, outstanding science, and a really cool location. Huge thanks to the organizers. Always a pleasure to reconnect with friends and colleagues! #ntm
Reposted by Nicola Lorè
What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social
Published today:
www.nejm.org/doi/full/10....
Published today:
www.nejm.org/doi/full/10....
May 16, 2025 at 4:25 AM
What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social
Published today:
www.nejm.org/doi/full/10....
Published today:
www.nejm.org/doi/full/10....
Reposted by Nicola Lorè
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/3SvsiTC
https://go.nature.com/3SvsiTC
Microbe that infests hospitals can digest medical-grade plastic ― a first
Nature - The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.
go.nature.com
May 10, 2025 at 10:47 AM
A strain of bacterium that often causes infections in hospital can break down plastic
https://go.nature.com/3SvsiTC
https://go.nature.com/3SvsiTC
Reposted by Nicola Lorè
#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections
Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages
MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.
www.science.org
May 3, 2025 at 2:49 PM
#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections
Totally agree! “The term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"…..”
I hope to work in this field in the future!
I hope to work in this field in the future!
The set up:
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."
www.science.org/doi/10.1126/...
Antibiotics damage the colonic mucus barrier in a microbiota-independent manner
Antibiotics inhibit production of the protective mucus in the colon, thus predisposing to gut inflammation.
www.science.org
April 29, 2025 at 7:48 PM
Totally agree! “The term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"…..”
I hope to work in this field in the future!
I hope to work in this field in the future!
Reposted by Nicola Lorè
Fahd Al Qureshah, @casanovalab.bsky.social, Qian Zhang et al. show that a common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity. rupress.org/jem/article/...
📘In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 11, 2025 at 7:15 AM
Fahd Al Qureshah, @casanovalab.bsky.social, Qian Zhang et al. show that a common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity. rupress.org/jem/article/...
📘In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
📘In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
March 17, 2025 at 1:02 PM
Reposted by Nicola Lorè
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
March 13, 2025 at 6:43 AM
Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇
shorturl.at/x4Sb5
Reposted by Nicola Lorè
#interferon history is immunology history! the original cytokine :)
March 5, 2025 at 9:41 AM
#interferon history is immunology history! the original cytokine :)
Reposted by Nicola Lorè
Reposted by Nicola Lorè
"If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman."—Richard Gallo
The man who developed 40 vaccines
Microbiologist Maurice Hilleman, PhD’44, and his feathered friends.
mag.uchicago.edu
February 26, 2025 at 8:19 PM
"If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman."—Richard Gallo
Reposted by Nicola Lorè
Hello @bsky.app 🦋! We’re the European Society of Mycobacteriology (ESM) on a mission to decode the mysteries of mycobacteria 🦠🔬. Stay tuned for exciting research, TB updates, and more. Let’s shape the future of global health together!
January 29, 2025 at 7:39 PM
Hello @bsky.app 🦋! We’re the European Society of Mycobacteriology (ESM) on a mission to decode the mysteries of mycobacteria 🦠🔬. Stay tuned for exciting research, TB updates, and more. Let’s shape the future of global health together!
Super cool work! Congrats to the authors.
Spatial bacterial transcriptomics is coming up!
“Highly multiplexed #spatial transcriptomics in #bacteria”
www.science.org/doi/10.1126/...
Spatial bacterial transcriptomics is coming up!
“Highly multiplexed #spatial transcriptomics in #bacteria”
www.science.org/doi/10.1126/...
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 27, 2025 at 3:40 PM
Super cool work! Congrats to the authors.
Spatial bacterial transcriptomics is coming up!
“Highly multiplexed #spatial transcriptomics in #bacteria”
www.science.org/doi/10.1126/...
Spatial bacterial transcriptomics is coming up!
“Highly multiplexed #spatial transcriptomics in #bacteria”
www.science.org/doi/10.1126/...
Reposted by Nicola Lorè
Great recent work from Sanika Vaidya and Knut Drescher Lab
Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2
Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!
www.nature.com/articles/s41...
Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2
Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!
www.nature.com/articles/s41...
January 20, 2025 at 2:42 PM
Great recent work from Sanika Vaidya and Knut Drescher Lab
Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2
Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!
www.nature.com/articles/s41...
Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2
Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!
www.nature.com/articles/s41...