Jose M. Adrover
@adrover.bsky.social
Studying the cancer-cardiovascular disease interplay, with a focus on how cancer reprograms the hematopoietic and immune systems, at the Francis Crick Institute in London
http://www.adroverlab.com
http://www.adroverlab.com
Reposted by Jose M. Adrover
🏆 MRS Sue Eccles Early Career Investigator Award: Jose M. Adrover
November 4, 2025 at 2:05 PM
🏆 MRS Sue Eccles Early Career Investigator Award: Jose M. Adrover
Reposted by Jose M. Adrover
🚀 Two weeks to go!
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
2nd MRS Early Career Research Virtual Meeting | Metastasis Research
The 2025 MRS Early Career Research Virtual Meeting is a two day meeting aimed at engaging trainees and early career researchers from around the world and highlighting recent advances in metastasis research through keynote presentations, invited talks, panel discussions, and selected talks from abstracts. The meeting is organized and hosted by the Early Career Leadership Council (ECLC) of the MRS. Abstracts are being accepted for consideration for oral presentations. Abstract submission is open to graduate students, postdoctoral fellows, medical students, residents, clinical fellows, and researchers within 3 years of starting their own independent research group. Registration for this meeting is free for MRS Members!
metastasis-research.org
November 3, 2025 at 4:02 PM
🚀 Two weeks to go!
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
The ECR Meeting brings together early-career scientists driving the next wave of metastasis research.
⚡ Don’t miss:
💡 Inspiring talks from rising leaders
💬 Community-led discussions
🌍 A global metastasis community
🗓️ Register by Nov 18 ➜ bit.ly/4qyxE0o
Program ➜ bit.ly/4qtpVR9
Reposted by Jose M. Adrover
This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
📘 In #Cytokines collection: rupress.org/jem/collecti...
#Cytokines2025
📘 In #Cytokines collection: rupress.org/jem/collecti...
#Cytokines2025
November 1, 2025 at 3:15 PM
This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
📘 In #Cytokines collection: rupress.org/jem/collecti...
#Cytokines2025
📘 In #Cytokines collection: rupress.org/jem/collecti...
#Cytokines2025
My lab will be recruiting a PhD student this year. Have a look and apply if it sounds interesting!
adroverlab.com/open-call-fo...
adroverlab.com/open-call-fo...
Open call for a PhD student - Cancer Macroenvironment Lab
Investigating the role of neutrophils in tumour progression, microenvironment dynamics and metastatic spread Application deadline: 5th of November, 2025 Project background and description Our laborato...
adroverlab.com
October 16, 2025 at 8:05 AM
My lab will be recruiting a PhD student this year. Have a look and apply if it sounds interesting!
adroverlab.com/open-call-fo...
adroverlab.com/open-call-fo...
Reposted by Jose M. Adrover
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 2:06 PM
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Reposted by Jose M. Adrover
🔥Trio Fatale: Neutrophils, NETs and Necrosis
👉 authors.elsevier.com/a/1lk-k3qNrU...
We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau
Congrats!
👉 authors.elsevier.com/a/1lk-k3qNrU...
We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau
Congrats!
September 9, 2025 at 3:20 PM
🔥Trio Fatale: Neutrophils, NETs and Necrosis
👉 authors.elsevier.com/a/1lk-k3qNrU...
We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau
Congrats!
👉 authors.elsevier.com/a/1lk-k3qNrU...
We summarized for @cp-immunity.bsky.social
"Neutrophils drive vascular occlusion, tumour necrosis and metastasis" published in @nature.com by @megeblad.bsky.social @adrover.bsky.social rdcu.be/eFdau
Congrats!
Reposted by Jose M. Adrover
A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
September 7, 2025 at 7:12 PM
A new model of #TumorNecrosis👹
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Tumor CXCL1➡️myeloid skewing➡️
Ly6C-low Neutrophil forms intravascular #NeutrophilExtracellularTrap➡️
Intratumoral vascular occlusion➡️
Pleomorphic Necrosis-to-Metastasis
a role of TGFβ
@adrover.bsky.social @megeblad.bsky.social Nature 2025
www.nature.com/articles/s41...
Reposted by Jose M. Adrover
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
August 18, 2025 at 1:45 PM
Heart of the matter: #Neutrophils, #cancer, and #CardiovascularDisease. New review from Saira Ambreen, Afshan McCarthy, Andrés Hidalgo, and Jose Adrover @adrover.bsky.social @crick.ac.uk: rupress.org/jem/article/...
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
#TumorImmunology #CardiovascularBiology #InnateImmunity #inflammation
Reposted by Jose M. Adrover
#Cancer patients display an elevated burden of #CardiovascularDisease. This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
August 11, 2025 at 4:15 PM
#Cancer patients display an elevated burden of #CardiovascularDisease. This review from Ambreen, @adrover.bsky.social et al. explores cancer-elicited changes to #neutrophil behaviour and proposes ways in which these may contribute to cardiovascular pathology. rupress.org/jem/article/...
Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
Heart of the matter: Neutrophils, cancer, and cardiovascular disease | Journal of Experimental Medicine | Rockefeller University Press
Cancer and cardiovascular disease are the leading causes of death worldwide. Cancer patients display an abnormally elevated burden of cardiovascular diseas
rupress.org
August 12, 2025 at 12:47 PM
Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social
rupress.org/jem/article/...
rupress.org/jem/article/...
Thanks to Cancer Discovery for highlighting our manuscript with such a nice summary!
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis
Major Finding: A Ly6GhighLy6Clow subset of neutrophils drives pleomorphic necrosis by forming intravascular neutrophil extracellular traps (NET).Concept: Tumor cells adjacent to neutrophil-induced nec...
aacrjournals.org
August 4, 2025 at 11:37 AM
Thanks to Cancer Discovery for highlighting our manuscript with such a nice summary!
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
Intravascular Neutrophil-Derived NETs Drive Tumor Necrosis and Metastasis aacrjournals.org/cdnews/news/...
Reposted by Jose M. Adrover
@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening
Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...
Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature
Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...
www.nature.com
August 4, 2025 at 10:40 AM
@cdi-einstein.bsky.social Director @jaguirreghisolab.bsky.social co-leads a study showing how viral infections can trigger via IL6 signaling awakening of dormant breast cancer cells in lungs. CDI's research focuses in part on host variations controlling the timing of residual cancer awakening
Reposted by Jose M. Adrover
Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis
go.nature.com/4lzilSb
go.nature.com/4lzilSb
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
go.nature.com
July 23, 2025 at 7:54 AM
Nature research paper: Neutrophils drive vascular occlusion, tumour necrosis and metastasis
go.nature.com/4lzilSb
go.nature.com/4lzilSb
Reposted by Jose M. Adrover
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma
Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...
www.biorxiv.org
July 27, 2025 at 12:28 PM
Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value
Reposted by Jose M. Adrover
A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 23, 2025 at 2:14 PM
A fascinating study reports that neutrophils and NETs actively induce tumor necrosis. Congratulations, BDP @megeblad.bsky.social and @adrover.bsky.social on your latest publication in @nature.com.
Reposted by Jose M. Adrover
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 7:26 PM
As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature
Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.
www.nature.com
July 17, 2025 at 11:28 AM
I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here: adroverlab.com/open-positio...
Open call for a Postdoctoral Fellow - Cancer Macroenvironment Lab
Open postdoctoral position at the Cancer Macroenvironment Lab led by Dr. Adrover at the Francis Crick Institute in London
adroverlab.com
June 27, 2025 at 8:44 AM
Are you curious about how cancer impacts immune cell progenitors and how that changes mature cell function? My lab will soon be recruiting a Postdoctoral Fellow. If you are interested, please find more information here: adroverlab.com/open-positio...
Reposted by Jose M. Adrover
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Understanding and reversing mammary tumor-driven reprogramming of myelopoiesis to reduce metastatic spread
Tumor-induced systemic accumulation and polarization of neutrophils to an immunosuppressive phenotype is a potent driver of metastasis formation. Yet,…
www.sciencedirect.com
May 8, 2025 at 4:44 PM
💥 Really excited to say that our paper with Karin de Visser and @dewitlab.bsky.social is now online! A beautiful story to culminate years of great collaboration and teamwork at the @nkinl.bsky.social. A 🧵
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!
April 29, 2025 at 2:49 AM
I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!
Reposted by Jose M. Adrover
William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer.
#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk
#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk
April 27, 2025 at 3:33 PM
William Hill is presenting his work on air pollutants in lung adenocarcinoma in a fascinating session exploring ageing and environmental factors in the development and spread of lung cancer.
#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk
#AACR25 | @drwilliamhill.bsky.social | @crick.ac.uk
Reposted by Jose M. Adrover
If you’re attending #AACR25 stop by and say "Hi!" to our colleagues in @cancergrand.bsky.social at stand 2327, and Cancer Tools at stand 2424 in the exhibition hall.
April 26, 2025 at 3:01 PM
If you’re attending #AACR25 stop by and say "Hi!" to our colleagues in @cancergrand.bsky.social at stand 2327, and Cancer Tools at stand 2424 in the exhibition hall.
Reposted by Jose M. Adrover
OBS #Immunology Seminar
Neutrophils and regulation of skin physiology
📆 Thu, 10th April, 12 pm EDT/5 pm CET
🎙️ Speaker
@alazozcan.bsky.social @yalesph.bsky.social
@drusqui.bsky.social @cnic @nature.com
📣 Moderator
@eugecc.bsky.social
us02web.zoom.us/meeting/regi...
Neutrophils and regulation of skin physiology
📆 Thu, 10th April, 12 pm EDT/5 pm CET
🎙️ Speaker
@alazozcan.bsky.social @yalesph.bsky.social
@drusqui.bsky.social @cnic @nature.com
📣 Moderator
@eugecc.bsky.social
us02web.zoom.us/meeting/regi...
April 3, 2025 at 4:20 PM
OBS #Immunology Seminar
Neutrophils and regulation of skin physiology
📆 Thu, 10th April, 12 pm EDT/5 pm CET
🎙️ Speaker
@alazozcan.bsky.social @yalesph.bsky.social
@drusqui.bsky.social @cnic @nature.com
📣 Moderator
@eugecc.bsky.social
us02web.zoom.us/meeting/regi...
Neutrophils and regulation of skin physiology
📆 Thu, 10th April, 12 pm EDT/5 pm CET
🎙️ Speaker
@alazozcan.bsky.social @yalesph.bsky.social
@drusqui.bsky.social @cnic @nature.com
📣 Moderator
@eugecc.bsky.social
us02web.zoom.us/meeting/regi...
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025
March 30, 2025 at 10:48 AM
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!