Lightnews — Scholar-powered news

Nicola Lorè @nicolaivan.bsky.social · Oct 7

Super interesting paper on Novel #Genetic Loci for Nontuberculous #Mycobacterial Pulmonary Disease. I'm glad to see that part of the validation was performed using our previous published data. Enjoy the paper! atsjournals.org/doi/10.1164/...

Novel Genetic Loci for Nontuberculous Mycobacterial Pulmonary Disease and Potential Protective Effect of Body Mass Index | American Journal of Respiratory and Critical Care Medicine | Articles in Pres...

atsjournals.org

Reposted by Nicola Lorè

Cystic Fibrosis Trust @cysticfibrosis.org.uk · Sep 23

Do you have a story about how antibiotics have made a difference in your lives or the lives of your loved ones?

Your story and photo could be up in lights at #PiccadillyCircus in London during #WAAW25.

Visit the Fleming Initiative to find out more.

➡️ www.fleminginitiative.org/thank-you-an...

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Reposted by Nicola Lorè

Waggoner Lab @labwaggoner.bsky.social · Sep 14

@biorxivpreprint.bsky.social Requirements for development of T-helper1 and T-follicular helper cells from a common precursor @unileiden.bsky.social
www.biorxiv.org/content/10.1...

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Nicola Lorè @nicolaivan.bsky.social · Sep 4

Rejected…..rejected….

Reposted by Nicola Lorè

Ivan Zanoni @lozanzi.bsky.social · Sep 3

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Interferons in health and disease

The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...

www.cell.com

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Reposted by Nicola Lorè

Science Magazine @science.org · Aug 18

"For half an hour, I vented everything I had been holding in for months … my supervisor … then calmly offered a line I’ll never forget: 'You are here to learn to ride a bicycle, not to invent a bicycle.' That one sentence landed softly, but it cracked something open." https://scim.ag/4lt1Ru0

An illustration of a man riding a bike surrounded by wheels and other bike parts, with text: How a Ph.D. is like riding a bike

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Reposted by Nicola Lorè

Bryan Yipp @bryanyipp.bsky.social · May 30

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis

Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

www.cell.com

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Nicola Lorè @nicolaivan.bsky.social · Jul 31

Super interesting. Does it work for NTM?

Nature @nature.com · Jul 31

Nature research paper: SuFEx-based antitubercular compound irreversibly inhibits Pks13

go.nature.com/40JdOnN

SuFEx-based antitubercular compound irreversibly inhibits Pks13 - Nature

A preclinical covalent compound, CMX410, contains a aryl fluorosulfate warhead that targets the acyltransferase domain of Mtb Pks13, an essential enzyme in cell-wall biosynthesis, making it a promising candidate for tuberculosis treatment regimens.

go.nature.com

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Reposted by Nicola Lorè

Jose M. Adrover @adrover.bsky.social · Jul 17

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Nicola Lorè @nicolaivan.bsky.social · Jun 6

Super happy to have attended “The Nontuberculous #Mycobacteria Conference 2025” in Fort Collins! Great talks, outstanding science, and a really cool location. Huge thanks to the organizers. Always a pleasure to reconnect with friends and colleagues! #ntm

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Reposted by Nicola Lorè

Elisabeth Bik - Perpetrator 5, a fraudulent microbiologist @elisabethbik.bsky.social · May 16

What a great day to be at @childrensphila.bsky.social and @pennmedicine.bsky.social

Published today:

www.nejm.org/doi/full/10....

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Reposted by Nicola Lorè

Nature @nature.com · May 10

A strain of bacterium that often causes infections in hospital can break down plastic

https://go.nature.com/3SvsiTC

Microbe that infests hospitals can digest medical-grade plastic ― a first

Nature - The bacterium Pseudomonas aeruginosa produces an enzyme that breaks down biodegradable plastics.

go.nature.com

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Reposted by Nicola Lorè

Ivan Zanoni @lozanzi.bsky.social · May 3

#WeekendRead #NoTimeToDie! Matt, Better &co show @ Science Immunology that efferocytosis of apoptotic neutrophils (not epithelial cells) by alveolar macrophages reprograms their metabolism, boosting glutaminolysis & decreasing ROS, thus favoring repair but facilitating secondary bacterial infections

Cell type–specific efferocytosis determines functional plasticity of alveolar macrophages

MPO activates an immunometabolic rheostat to restrict the functional plasticity of macrophages in favor of proresolving properties.

www.science.org

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Nicola Lorè @nicolaivan.bsky.social · Apr 29

Totally agree! “The term antibiotic—literally "opposing life", from the Greek roots ἀντι anti, "against" and βίος bios, "life"…..”
I hope to work in this field in the future!

Thiago Carvalho @cyrilpedia.bsky.social · Dec 8

The set up:

"This extensive use of antibiotics is based on the assumption that, other than toxicity issues when used in large doses, antibiotics disrupt biological processes in microbes and not the host."

www.science.org/doi/10.1126/...

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

Antibiotics inhibit production of the protective mucus in the colon, thus predisposing to gut inflammation.

www.science.org

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Reposted by Nicola Lorè

Journal of Experimental Medicine @jem.org · Apr 11

Fahd Al Qureshah, @casanovalab.bsky.social, Qian Zhang et al. show that a common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity. rupress.org/jem/article/...

📘In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025

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Nicola Lorè @nicolaivan.bsky.social · Apr 8

New cell cell communication…….mitochondrial exchanges!

www.nature.com/articles/d41...

Cells are swapping their mitochondria. What does this mean for our health?

Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.

www.nature.com

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Nicola Lorè @nicolaivan.bsky.social · Mar 17

Ready for the #telethon 2025 scientific convention! #Rimini #italy

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Reposted by Nicola Lorè

Olivier Neyrolles @oneyrolles.bsky.social · Mar 13

Excited to share our last study. Huge congrats to Sarah Monard, Arnaud Métais, @gclugo.bsky.social, @chrisverollet.bsky.social and all colleagues!
We have found a mysterious cell type inside TB lung lesions that seems neuron-like but isn't quite a nerve cell.
Let's dive in👇

shorturl.at/x4Sb5

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Reposted by Nicola Lorè

Achille Broggi🧪👨🏼‍🔬🔬 @achillebro.bsky.social · Mar 5

#interferon history is immunology history! the original cytokine :)

1980/1985 News @40yearsago.bsky.social · Mar 5

[January 16th, 1980] Scientists at Biogen have successfully produced human interferon, a natural virus fighter, in a laboratory using gene-splicing techniques, potentially making it a more affordable treatment for various viral infections and cancers.

#history #1980s

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Reposted by Nicola Lorè

1980/1985 News @40yearsago.bsky.social · Mar 5

[January 16th, 1980] Scientists at Biogen have successfully produced human interferon, a natural virus fighter, in a laboratory using gene-splicing techniques, potentially making it a more affordable treatment for various viral infections and cancers.

#history #1980s

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Reposted by Nicola Lorè

Seth Thomas Scanlon @immunoeditor.bsky.social · Feb 26

"If I had to name a person who has done more for the benefit of human health, with less recognition than anyone else, it would be Maurice Hilleman."—Richard Gallo

The man who developed 40 vaccines

Microbiologist Maurice Hilleman, PhD’44, and his feathered friends.

mag.uchicago.edu

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Reposted by Nicola Lorè

European Society of Mycobacteriology @esmyco.bsky.social · Jan 29

Hello @bsky.app 🦋! We’re the European Society of Mycobacteriology (ESM) on a mission to decode the mysteries of mycobacteria 🦠🔬. Stay tuned for exciting research, TB updates, and more. Let’s shape the future of global health together!

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Nicola Lorè @nicolaivan.bsky.social · Jan 29

edition.cnn.com/2025/01/29/s...

Unprecedented asteroid samples contain organic compounds and minerals crucial to life, scientists say | CNN

Scientists have detected organic compounds and minerals necessary for life in the samples collected by the OSIRIS-REx mission from a near-Earth asteroid named Bennu.

edition.cnn.com

Nicola Lorè @nicolaivan.bsky.social · Jan 27

Super cool work! Congrats to the authors.
Spatial bacterial transcriptomics is coming up!

“Highly multiplexed #spatial transcriptomics in #bacteria”

www.science.org/doi/10.1126/...

Highly multiplexed spatial transcriptomics in bacteria

Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...

www.science.org

Reposted by Nicola Lorè

ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · Jan 20

Great recent work from Sanika Vaidya and Knut Drescher Lab

Mammalian innate immunity recognizes bacterial cell wall peptidoglycan (PG) via TLR2

Turns out multiple bacteria also sense PG from their lysed compatriots as a danger signal to trigger biofilm formation!

www.nature.com/articles/s41...

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