Bryan Yipp
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bryanyipp.bsky.social
Bryan Yipp
@bryanyipp.bsky.social
120 followers 270 following 23 posts
MD trained scientist. Intensivist. Immunologist. Neutrophil biologist.
www.yipplab.com
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bryanyipp.bsky.social
Bryan Yipp @bryanyipp.bsky.social · May 30
Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis
Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...
www.cell.com
Reposted by Bryan Yipp
jci.org
ICYMI: Protection against the fungus among us after mold spore inhalation…

@fungalspore.bsky.social investigate Aspergillus fumigatus infection in mice, revealing communication between plasmacytoid DCs and neutrophils in the lung is necessary for antifungal activity.

www.jci.org/articles/vie...
November 2, 2025 at 2:01 PM
Reposted by Bryan Yipp
drusqui.bsky.social
Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.
October 28, 2025 at 4:41 PM
bryanyipp.bsky.social
www.nature.com/articles/d41...
Google Scholar tool gives extra credit to first and last authors
Researchers welcome the initiative, but say it doesn’t go far enough to capture the nuance of researcher productivity and impact.
www.nature.com
October 26, 2025 at 12:57 AM
bryanyipp.bsky.social
Less is more: Academic publishing needs ‘radical change,’ Cambridge press report concludes  – Retraction Watch share.google/uh38CzCZHGwW...
Less is more: Academic publishing needs ‘radical change,’ Cambridge press report concludes
Academic publishing needs “renewed focus and collective action” to embrace new approaches and ensure the future of the industry, concludes a report from Cambridge University Press, released last we…
share.google
October 23, 2025 at 12:19 AM
Reposted by Bryan Yipp
theonlylabever.bsky.social
Happy to share new work from #theonlylabever, lead by the phenomenal @sltai.bsky.social - who developed a tool to study the biology of ILC3s, identifying their role in controlling CSF2-dependent myeloid cells. 🤗
@mucosalimmunol.bsky.social @societymucosalimm.bsky.social
OA: doi.org/10.1016/j.mu...
October 15, 2025 at 5:11 AM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.
dlvr.it
October 15, 2025 at 7:55 PM
Reposted by Bryan Yipp
labwaggoner.bsky.social
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells
www.nature.com/articles/s41... @natimmunol.nature.com @idoyagalab.bsky.social
October 14, 2025 at 5:53 PM
bryanyipp.bsky.social
www.nature.com/articles/s41...
Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology
Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...
www.nature.com
October 14, 2025 at 7:46 PM
bryanyipp.bsky.social
Mast cells regulate the brain-dura interface and CSF dynamics: Cell www.cell.com/cell/fulltex...
Mast cells regulate the brain-dura interface and CSF dynamics
Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...
www.cell.com
October 2, 2025 at 3:04 PM
Reposted by Bryan Yipp
rupress.org
Paul Kubes & Daniel Mucida are @jem.org Academic Editors! Paul studies how myeloid cells integrate into healthy tissues & maintain homeostasis at Queen's University. Daniel studies how gut immune system balances response & tolerance at @rockefelleruniv.bsky.social - bios: rupress.org/jem/pages/ed...
September 25, 2025 at 3:01 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Trio fatale: Neutrophils, NETs, and necrosis
In a recent issue of Nature, Adrover et al. report a neutrophil subset that induces pleomorphic tumor necrosis through NET-mediated vascular occlusion. This process drives epithelial-to-mesenchymal transition and metastasis of perinecrotic cancer cells, reframing necrosis as an active process and uncovering targetable mechanisms to combat cancer dissemination.
dlvr.it
September 13, 2025 at 12:52 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Born to be wild: Wildings stay the course
The immune system of wildlings—mice with a wild-derived microbiota—has features similar to that in adult humans. In this issue of Immunity, Oh et al. demonstrate the long-term stability of wildling microbiota and immune traits, establishing these mice as an accessible, transferable model for immunology research.
dlvr.it
September 13, 2025 at 2:48 PM
Reposted by Bryan Yipp
labwaggoner.bsky.social
Perspective @cp-immunity.bsky.social A roadmap for defining “extrafollicular” B cell responses
www.cell.com/immunity/ful... @stephanieeisen.bsky.social @vinuesalab.bsky.social et al
September 22, 2025 at 4:40 PM
Reposted by Bryan Yipp
cp-immunity.bsky.social
Online now: A roadmap for defining “extrafollicular” B cell responses
A roadmap for defining “extrafollicular” B cell responses
The term “extrafollicular” is now being used expansively to describe a variety of B cell processes beyond the original use of the term, potentially obscuring important distinct immunological processes. We discuss current uses of the term extrafollicular and propose a framework to help classify these evolving concepts in B cell biology.
dlvr.it
September 22, 2025 at 2:49 PM
Reposted by Bryan Yipp
maxkrummel.bsky.social
How will our increasingly deep understanding of diverse immune archetypes in cancers guide our search for cures?

This perspective describes a future in which we discover drugs based on transitions of tissue/immunobiology through intermediate states, to health. authors.elsevier.com/a/1llig5TA51...
Conceptualization of drugs, akin to chemical catalysts that promote sequential transitions in tissues https://authors.elsevier.com/a/1llig5TA51lD9X
September 17, 2025 at 12:53 PM
Reposted by Bryan Yipp
sciencex.bsky.social
Pain-sensing nerve cells in the lungs play a key role in controlling inflammation linked to pulmonary fibrosis, suggesting new avenues for managing lung scarring through neurological therapies. doi.org/g93vst
Pain-detecting nerve cells could yield new way to manage lung scarring
Researchers at the University of Calgary studying a lethal lung disease called pulmonary fibrosis have found that neurons known to help detect pain are also critical for reducing harmful lung inflammation that leads to the disease.
medicalxpress.com
September 16, 2025 at 8:04 PM
Reposted by Bryan Yipp
nizet.bsky.social
Pleased to share and briefly highlight our new manuscript just published 𝘑𝘊𝘐 𝘐𝘯𝘴𝘪𝘨𝘩𝘵 (a short🧵)

"A STING-adjuvanted outer membrane vesicle nanoparticle vaccine protects against lethal 𝘗𝘴𝘦𝘶𝘥𝘰𝘮𝘰𝘯𝘢𝘴 𝘢𝘦𝘳𝘶𝘨𝘪𝘯𝘰𝘴𝘢 pneumonia"

🔗 doi.org/10.1172/jci....
September 11, 2025 at 2:37 AM
Reposted by Bryan Yipp
payalyokota.bsky.social
Check out this cool new work from Deep's lab at Yale about how nerve associated macs play critical role in controlling homeostasis and reducing inflammation in adipose tissue across lifespan. #Freshoffthepress

www.nature.com/articles/s43...
Nerve-associated macrophages control adipose homeostasis across lifespan and restrain age-related inflammation - Nature Aging
Gonzalez-Hurtado, Leveau and colleagues characterize adipose resident tissue macrophages across lifespan in mice, finding that nerve-associated macrophages, which mitigate inflammation and control lip...
www.nature.com
September 2, 2025 at 10:08 PM
bryanyipp.bsky.social
Interferons in health and disease: Cell www.cell.com/cell/fulltex...
Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...
www.cell.com
August 21, 2025 at 3:24 PM
bryanyipp.bsky.social
www.themodernpeer.com/purr-fect-ci...
Purr-fect Citations: How a Cat Became the World’s Most Cited Academic
Meet Larry, the Scientific Cat Larry — a fluffy, slightly overweight cat — has achieved what many postdocs or even professors only dream of: becoming the most cited “author” in his field. Obviously, ...
www.themodernpeer.com
August 19, 2025 at 1:19 PM
Reposted by Bryan Yipp
immunofever.bsky.social
Fantastic review of #SexxAndImmunity! @soniasharma.bsky.social www.science.org/doi/10.1126/...
Sex differences in tissue-specific immunity and immunology
Biological sex exerts a substantial influence on the immune system and immune-related diseases. Males are more susceptible to the acute effects of viral disease and certain cancers, whereas females ex...
www.science.org
August 17, 2025 at 9:49 PM
Reposted by Bryan Yipp
l-cmurphy.bsky.social
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽

📖 Read our paper here: doi.org/10.1126/sci...

🎬 Watch a summary: youtu.be/MttCA3GGWEM

🧵 Or keep reading for the key points! 🔑 1/19
August 14, 2025 at 6:35 PM
Reposted by Bryan Yipp
jazib.bsky.social
Very excited to share the latest work from the Artis lab! Now out in @natimmunol.nature.com

Your gut’s neurons aren’t just for digestion; they help heal it too!

nature.com/articles/s41...
August 15, 2025 at 1:43 PM
Reposted by Bryan Yipp
sarahhross.bsky.social
Such a beautiful and intricate image! I was fascinated by the creative process for the cover, and loved getting a behind-the-scenes look at the work of artist Rioka Hayama and the Science Visuals team. Have you guessed all the features yet?
science.org Science Magazine @science.org · Aug 12
Can you can identify these 10 components featured on our Evolving Immunity special issue cover? 🔎

Drop your guesses in the comments. We’ll reveal the answers next week, so stay tuned!

Discover more about the special issue here: https://scim.ag/3JdpWYj
A black and white illustration depicting the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. There are blank labels 1–10 throughout the illustration. An illustration depicting the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age.
August 16, 2025 at 12:42 PM
Reposted by Bryan Yipp
nizet.bsky.social
Congratulations to our laboratory affiliate Alice Chen, MD, UCSD Asst. Prof. of Emergency Medicine, on her cool AJEM paper on sepsis in the ER

CVD, hypertension, CKD, cancer increase the risk of admission

High heart rate and temperature predict 7-day return, while hyperlipidemia seems protective.
August 15, 2025 at 3:23 AM