Matthew Murphy
@mzchem-murphy.bsky.social
Mass spectrometry, metabolomics, lipidomics. Wannabe cyclist. Views are my own and not my employer’s.
Reposted by Matthew Murphy
New from 404 Media: a small town is fighting a $1.2 billion AI datacenter for America's nuclear weapon scientists. It is fighting the construction of a "high-performance computing facility" that would service a nuclear weapons laboratory 1,500 miles away.
www.404media.co/a-small-town...
www.404media.co/a-small-town...
A Small Town Is Fighting a $1.2 Billion AI Datacenter for America's Nuclear Weapon Scientists
Ypsilanti, Michigan has officially decided to fight against the construction of a 'high-performance computing facility' that would service a nuclear weapons laboratory 1,500 miles away.
www.404media.co
November 10, 2025 at 2:49 PM
New from 404 Media: a small town is fighting a $1.2 billion AI datacenter for America's nuclear weapon scientists. It is fighting the construction of a "high-performance computing facility" that would service a nuclear weapons laboratory 1,500 miles away.
www.404media.co/a-small-town...
www.404media.co/a-small-town...
Reposted by Matthew Murphy
It’s a pretty great day when a project you’ve spent the last 10 years on is featured in NYT!
New Pill From Merck Could Slash Cholesterol Levels, Trials Show www.nytimes.com/2025/11/08/h...
New Pill From Merck Could Slash Cholesterol Levels, Trials Show www.nytimes.com/2025/11/08/h...
New Pill From Merck Could Slash Cholesterol Levels, Trials Show
www.nytimes.com
November 8, 2025 at 8:24 PM
It’s a pretty great day when a project you’ve spent the last 10 years on is featured in NYT!
New Pill From Merck Could Slash Cholesterol Levels, Trials Show www.nytimes.com/2025/11/08/h...
New Pill From Merck Could Slash Cholesterol Levels, Trials Show www.nytimes.com/2025/11/08/h...
Reposted by Matthew Murphy
Wilhelm Röntgen discovered X-rays #OTD in 1895 when he noticed that emanations from a Crookes tube caused a platino-barium screen to fluoresce. The rays exposed photographic plates but were blocked by bone and metal.
This early plate shows his wife's hand. 🧪 ⚛️
Image: Wellcome Trust
This early plate shows his wife's hand. 🧪 ⚛️
Image: Wellcome Trust
November 8, 2025 at 5:07 PM
Wilhelm Röntgen discovered X-rays #OTD in 1895 when he noticed that emanations from a Crookes tube caused a platino-barium screen to fluoresce. The rays exposed photographic plates but were blocked by bone and metal.
This early plate shows his wife's hand. 🧪 ⚛️
Image: Wellcome Trust
This early plate shows his wife's hand. 🧪 ⚛️
Image: Wellcome Trust
Reposted by Matthew Murphy
Women should have jobs, but Ross Douthat shouldn’t.
November 6, 2025 at 3:07 PM
Women should have jobs, but Ross Douthat shouldn’t.
Reposted by Matthew Murphy
I think a lot about the story Carl Reiner told: he’d have been a sewing machine repairman if not for a free WPA drama class. That led to other theater work, to Sid Caesar, to Mel Brooks, and all the rest. All because of one free class paid for by a government that felt the arts were worth teaching.
you ever think about the works progress administration? I sure do. I wish that was a thing now. I would be so glad to contribute my labor to like. A random ass local bridge
November 7, 2025 at 1:28 AM
I think a lot about the story Carl Reiner told: he’d have been a sewing machine repairman if not for a free WPA drama class. That led to other theater work, to Sid Caesar, to Mel Brooks, and all the rest. All because of one free class paid for by a government that felt the arts were worth teaching.
Reposted by Matthew Murphy
Biologist David Sabatini loses again in legal fight against Whitehead Institute | Science | AAAS www.science.org/content/arti...
Biologist David Sabatini loses again in legal fight against Whitehead Institute
Judge dismisses final claim against scientist’s former employer and curtails lawsuit directed at woman who accused him of sexual harassment
www.science.org
November 7, 2025 at 1:13 AM
Biologist David Sabatini loses again in legal fight against Whitehead Institute | Science | AAAS www.science.org/content/arti...
Reposted by Matthew Murphy
November 5, 2025 at 11:09 PM
Reposted by Matthew Murphy
Reposted by Matthew Murphy
It’s hard to believe but there was a cartoon about an immigrant mouse and it was seen as totally fine and not controversial and not woke because it was an aspirational and nice thing about America that people could come here and find a better life
November 5, 2025 at 9:08 PM
It’s hard to believe but there was a cartoon about an immigrant mouse and it was seen as totally fine and not controversial and not woke because it was an aspirational and nice thing about America that people could come here and find a better life
Reposted by Matthew Murphy
Over the weekend, the Director of the NIH accepted an award from a RFK Jr.-allied anti-public health dark money group founded by an accused serial sexual harasser.
Throughout the speech, he repeatedly joked that his current job is “terrible.”
www.importantcontext.news/p/nih-direct...
Throughout the speech, he repeatedly joked that his current job is “terrible.”
www.importantcontext.news/p/nih-direct...
NIH Director Accepts Award From Anti-Vax Dark Money Group Founded By Accused Sexual Harasser
Jay Bhattacharya reunited with his old ally Jeffrey Tucker weeks after the political operative was revealed to have faced a sexual harassment scandal.
www.importantcontext.news
November 5, 2025 at 12:21 PM
Over the weekend, the Director of the NIH accepted an award from a RFK Jr.-allied anti-public health dark money group founded by an accused serial sexual harasser.
Throughout the speech, he repeatedly joked that his current job is “terrible.”
www.importantcontext.news/p/nih-direct...
Throughout the speech, he repeatedly joked that his current job is “terrible.”
www.importantcontext.news/p/nih-direct...
Reposted by Matthew Murphy
Lex did such incredible work under extraordinarily difficult working conditions, and it’s an absolute outrage that this is happening to them and the other good folks who got got today
I was laid off from Teen Vogue today along with multiple other staffers, and today is my last day.
certainly more to come from me when the dust has settled more, but to my knowledge, after today, there will be no politics staffers at Teen Vogue.
certainly more to come from me when the dust has settled more, but to my knowledge, after today, there will be no politics staffers at Teen Vogue.
November 3, 2025 at 8:00 PM
Lex did such incredible work under extraordinarily difficult working conditions, and it’s an absolute outrage that this is happening to them and the other good folks who got got today
Reposted by Matthew Murphy
A device exploded inside the Goldenson Building in Harvard’s Longwood medical campus early Saturday morning, according to a message from the Harvard University Police Department to University affiliates.
Matan H. Josephy and Laurel M. Shugart report.
www.thecrimson.com/article/2025...
Matan H. Josephy and Laurel M. Shugart report.
www.thecrimson.com/article/2025...
Authorities Investigating Explosion on Harvard’s Medical Campus, Believed To Be Intentional | News | The Harvard Crimson
A device exploded inside the Goldenson Building in Harvard’s Longwood medical campus early Saturday morning, according to a message from the Harvard University Police Department to University…
www.thecrimson.com
November 1, 2025 at 6:11 PM
A device exploded inside the Goldenson Building in Harvard’s Longwood medical campus early Saturday morning, according to a message from the Harvard University Police Department to University affiliates.
Matan H. Josephy and Laurel M. Shugart report.
www.thecrimson.com/article/2025...
Matan H. Josephy and Laurel M. Shugart report.
www.thecrimson.com/article/2025...
Reposted by Matthew Murphy
Between this and the Louvre prosecutor describing the suspects’ statements as “minimalist” while bragging that they had worked on the case over a weekend it’s an absolutely incredible week for Frenchness
A French cyclist survived for three days after a horrendous 130-foot fall into a ravine, kept alive by the bottles of red wine he had in his shopping bag, police said.
Cyclist falls down 130-foot ravine in France, survives 3 days by drinking wine he had in shopping bag
A helicopter airlifted him to hospital, with a rescue doctor calling his survival "a miracle."
cbsn.ws
October 31, 2025 at 1:18 PM
Between this and the Louvre prosecutor describing the suspects’ statements as “minimalist” while bragging that they had worked on the case over a weekend it’s an absolutely incredible week for Frenchness
Reposted by Matthew Murphy
q: why did the outfielders raise their arms during this play?
a: according to the ancient scrolls in which the rules of baseball were found, if a ball lands and doesn't bounce that ball is declared god. the players were worshipping god. i doubt there will be a game 7 or any further baseball seasons
a: according to the ancient scrolls in which the rules of baseball were found, if a ball lands and doesn't bounce that ball is declared god. the players were worshipping god. i doubt there will be a game 7 or any further baseball seasons
November 1, 2025 at 3:19 AM
q: why did the outfielders raise their arms during this play?
a: according to the ancient scrolls in which the rules of baseball were found, if a ball lands and doesn't bounce that ball is declared god. the players were worshipping god. i doubt there will be a game 7 or any further baseball seasons
a: according to the ancient scrolls in which the rules of baseball were found, if a ball lands and doesn't bounce that ball is declared god. the players were worshipping god. i doubt there will be a game 7 or any further baseball seasons
Reposted by Matthew Murphy
🤮🤮🤮🤮
I hate this for the world, because how many brilliant Ada Lovelaces have we lost because they were gurlz.
I hate this for the world, because how many brilliant Ada Lovelaces have we lost because they were gurlz.
a woman in overalls is dancing in front of a mirror with the word bravas on the bottom
ALT: a woman in overalls is dancing in front of a mirror with the word bravas on the bottom
media.tenor.com
October 31, 2025 at 11:54 PM
🤮🤮🤮🤮
I hate this for the world, because how many brilliant Ada Lovelaces have we lost because they were gurlz.
I hate this for the world, because how many brilliant Ada Lovelaces have we lost because they were gurlz.
Reposted by Matthew Murphy
My wife has volunteered at a local food bank for years and confirms what many of you have probably heard: in this case, straight cash is a good donation if you can do it.
The food banks have better access and buying power than individuals do, and can try to address item imbalances as they see them.
The food banks have better access and buying power than individuals do, and can try to address item imbalances as they see them.
October 31, 2025 at 3:13 PM
My wife has volunteered at a local food bank for years and confirms what many of you have probably heard: in this case, straight cash is a good donation if you can do it.
The food banks have better access and buying power than individuals do, and can try to address item imbalances as they see them.
The food banks have better access and buying power than individuals do, and can try to address item imbalances as they see them.
Reposted by Matthew Murphy
Reposted by Matthew Murphy
I can’t stress this enough: you cannot understand politics without reading this paragraph about why there’s no such thing as a 1/3rd pound hamburger
October 30, 2025 at 2:26 AM
I can’t stress this enough: you cannot understand politics without reading this paragraph about why there’s no such thing as a 1/3rd pound hamburger
This is what the internet was built for. This and transferring important scientific data across the globe.
I regret to inform everyone that my pedantic brain couldn’t let me live until I knew whether or not dodger blue and blue jays blue are the same blue. They are ONE PANTONE NUMBER APART.
October 30, 2025 at 2:23 AM
This is what the internet was built for. This and transferring important scientific data across the globe.
Reposted by Matthew Murphy
They are also intentionally conflating machine-learning and generative AI slop to confuse and try to make GenAI seem necessary. Google Maps traffic stuff is machine learning, not GenAI, for example. Auto-correct is too. Don't let them make you lose the thread. GenAI slop is slop.
the nyt posts this stuff like avoiding AI for 48 hours is hard and meanwhile i have literally never once intentionally used an AI program for anything ever
October 28, 2025 at 6:44 PM
They are also intentionally conflating machine-learning and generative AI slop to confuse and try to make GenAI seem necessary. Google Maps traffic stuff is machine learning, not GenAI, for example. Auto-correct is too. Don't let them make you lose the thread. GenAI slop is slop.
Reposted by Matthew Murphy
The White House is asking people not to share pictures of the East Wing because it’s even worse today.
October 21, 2025 at 10:54 PM
The White House is asking people not to share pictures of the East Wing because it’s even worse today.
Reposted by Matthew Murphy
Reposted by Matthew Murphy
timsCompare is free, open-source, and available now on GitHub! All feedback, bug reports, and feature ideas are welcome.
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
GitHub - kronigert/timsCompare: A desktop application for mass spectrometry users to load, view, compare timsTOF methods and export isolation schemes and method reports from Bruker's .d method directo...
A desktop application for mass spectrometry users to load, view, compare timsTOF methods and export isolation schemes and method reports from Bruker's .d method directories. - kronigert/timsCom...
github.com
October 15, 2025 at 11:01 AM
timsCompare is free, open-source, and available now on GitHub! All feedback, bug reports, and feature ideas are welcome.
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
github.com/kronigert/ti...
#MassSpec #TeamMassSpec #Proteomics #timsTOF #diaPASEF #diagonalPASEF
(Disclaimer: This is an independent project, not an official Bruker tool.)
Reposted by Matthew Murphy
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine synthesis
Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and
SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as
a key mediator of mitochondrial impo...
www.cell.com
October 11, 2025 at 4:15 PM
Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @cp-cellmetabolism.bsky.social www.cell.com/cell-metabol...
Reposted by Matthew Murphy
Not sure if this is THE first charge detection commercial MS release from a major vendor, but it’s certainly one of the first.
Analyses macromolecules from 100 MDa and beyond. No charge state deconvolution necessary.
www.waters.com/nextgen/au/e...
Analyses macromolecules from 100 MDa and beyond. No charge state deconvolution necessary.
www.waters.com/nextgen/au/e...
Xevo CDMS: A New Era in Mass Spectrometry
YouTube video by Waters Corporation
www.youtube.com
October 13, 2025 at 11:18 AM
Not sure if this is THE first charge detection commercial MS release from a major vendor, but it’s certainly one of the first.
Analyses macromolecules from 100 MDa and beyond. No charge state deconvolution necessary.
www.waters.com/nextgen/au/e...
Analyses macromolecules from 100 MDa and beyond. No charge state deconvolution necessary.
www.waters.com/nextgen/au/e...