Sam Joseph
@mucinophile.bsky.social
Chemical biology PhD student in the Wright lab @BaylorUniversity. Synthesizing and applying activity-based probes to study mucin-microbiome interactions.
#chemicalbiology #ABPP #mucin #microbiome #proteomics #glycotime
#chemicalbiology #ABPP #mucin #microbiome #proteomics #glycotime
Had a fantastic time at the New Horizons in Drug Discovery conference put on by @thewelchfoundation.bsky.social - also loved this slide from @dschweppe.bsky.social, sums me up pretty well
October 29, 2025 at 5:26 PM
Had a fantastic time at the New Horizons in Drug Discovery conference put on by @thewelchfoundation.bsky.social - also loved this slide from @dschweppe.bsky.social, sums me up pretty well
Reposted by Sam Joseph
You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social
September 23, 2025 at 11:39 PM
You’ve heard of #Lymedisease, but have you ever seen the bacteria that causes it? 🦠 Borrelia burgdorferi, the spiral-shaped culprit transmitted by ticks, swims with a creepy wriggling motion and uses #chemotaxis to navigate. Both fascinating... and disgusting #Microsky 🧪 #IDsky @shawlab.bsky.social
Reposted by Sam Joseph
Next week, Scripps Research scientists Amy Lightner, Michael Bollong & Arnab Chatterjee will speak at #IBDCuttingEdge2025, sharing insights on regenerative medicine, clinical trials, and drug discovery in IBD.
Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L
Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L
September 8, 2025 at 7:22 PM
Next week, Scripps Research scientists Amy Lightner, Michael Bollong & Arnab Chatterjee will speak at #IBDCuttingEdge2025, sharing insights on regenerative medicine, clinical trials, and drug discovery in IBD.
Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L
Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L
Reposted by Sam Joseph
Ruin any book by adding "Tom Clancy's" to the title.
Tom Clancy's Protective Groups in Organic Synthesis
Tom Clancy's Protective Groups in Organic Synthesis
Ruin any book by adding "Tom Clancy's" to the title.
Tom Clancy's Grapes of Wrath
Tom Clancy's Grapes of Wrath
Ruin any book by adding "Tom Clancy's" to the title.
Tom Clancy's Sense and Sensibility
Tom Clancy's Sense and Sensibility
August 27, 2025 at 6:21 PM
Ruin any book by adding "Tom Clancy's" to the title.
Tom Clancy's Protective Groups in Organic Synthesis
Tom Clancy's Protective Groups in Organic Synthesis
Reposted by Sam Joseph
An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....
Gas Phase Separation of Modified Peptides for Activity-Based Protein Profiling
Profiling the reactivity of the proteome with amino-acid level resolution requires the identification and quantification of reacted peptides in the presence of abundant unmodified peptides. Affinity-b...
pubs.acs.org
July 24, 2025 at 12:04 PM
An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....
Reposted by Sam Joseph
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
July 19, 2025 at 9:40 AM
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases www.nature.com/artic...
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#proteomics #prot-paper
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#proteomics #prot-paper
Reposted by Sam Joseph
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. A feature in Nature Biotechnology explores whether it can deliver a new generation of drug targets. 🧪
Probing the proteome
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. Can it deliver a new generation of drug targets?
go.nature.com
July 9, 2025 at 4:15 PM
Chemical proteomics has brought rigor to covalent drug discovery and drugs to the clinic. A feature in Nature Biotechnology explores whether it can deliver a new generation of drug targets. 🧪
Reposted by Sam Joseph
Very pleased to present the next pre-print from our lab #glycotime We showcase PNGaseL from Flavobacterium akiainvivens that we hope will be a useful tool for the glyco community 🍬🧪👩🔬 Special shout out to @cassiebakshani.bsky.social and Paulina (Ludger)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
PNGaseL from Flavobacterium akiainvivens targets a diverse range of N-glycan structures
PNGases are used by a wide range of organisms to remove N-glycan structures from proteins for use as either nutrients or in glycoprotein processing. PNGaseF is the most well-characterised enzyme of th...
www.biorxiv.org
June 5, 2025 at 11:09 AM
Very pleased to present the next pre-print from our lab #glycotime We showcase PNGaseL from Flavobacterium akiainvivens that we hope will be a useful tool for the glyco community 🍬🧪👩🔬 Special shout out to @cassiebakshani.bsky.social and Paulina (Ludger)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Sam Joseph
Biblically accurate nitrogen
Fear not! For I bring you glad tidings of great hypervalency
June 2, 2025 at 3:10 AM
Biblically accurate nitrogen
Reposted by Sam Joseph
May 28, 2025 at 2:20 PM
Reposted by Sam Joseph
Are you really a synthetic chemist if you aren't watching USCSB videos?
May 24, 2025 at 6:49 PM
Are you really a synthetic chemist if you aren't watching USCSB videos?
Reposted by Sam Joseph
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
May 23, 2025 at 8:53 PM
Senator Durbin noted that some (I believe Republican Senators) had indicated the US had been doing more than its share of biomedical research and it was time for other countries take a turn.
I felt I had to interrupt to respond...
I felt I had to interrupt to respond...
Reposted by Sam Joseph
Yikes
Northwestern has not received any NIH funds since March. No written communication about why or what can be done. Thank you Ben Singer for raising awareness at #ATS2025
May 19, 2025 at 2:06 PM
Yikes
Reposted by Sam Joseph
Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!
May 5, 2025 at 4:06 AM
Exciting news: We have released #FragPipe 23, and it's one of our biggest updates ever. Windows installer, support for TMT on Astral and timsTOF, TMT35, PTM site reports for DIA, improved Astral data handling in #MSFragger, improved diaTracer for diaPASEF data, better Skyline integration, and more!
Excited to announce that I passed my 2nd year qualifying exam! This is where the fun begins…
May 3, 2025 at 1:52 PM
Excited to announce that I passed my 2nd year qualifying exam! This is where the fun begins…
Reposted by Sam Joseph
If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.
May 3, 2025 at 12:40 PM
If u ever had to depict proteins as schematics in papers, u know the dilemma: how to create a pretty “blob”?
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.
If structure ends up big & central, u’ll render it with PyMol et al, but for a truly schematic depiction u want a biorender-style icon, but for YOUR protein.
Think I’ve finally found a way.
Reposted by Sam Joseph
The 15th International ABPP Meeting will be happening in Leiden in 2027. While it is still a long way to go, if you enjoyed this year's edition or were sad that you missed out, make sure to already follow @abpp2027.bsky.social to receive all the information in the future!
We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.
April 23, 2025 at 8:01 AM
The 15th International ABPP Meeting will be happening in Leiden in 2027. While it is still a long way to go, if you enjoyed this year's edition or were sad that you missed out, make sure to already follow @abpp2027.bsky.social to receive all the information in the future!
Reposted by Sam Joseph
Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio
Self-assembled PROTACs enable glycoproteins degradation in the living cells
We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...
pubs.rsc.org
April 10, 2025 at 4:34 AM
Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio
Reposted by Sam Joseph
is.... that a capybara for scale
April 7, 2025 at 5:39 PM
is.... that a capybara for scale
Had a fantastic time at #ABPP2025, my first ABPP meeting. Saw outstanding talks, shared what I’ve been working on, and was proud to see my undergrad, Abbey Pitts, win best poster award. Keep an eye out for her, she’ll be applying to PhD programs this Fall. Can’t wait for ABPP 2027!
April 4, 2025 at 5:21 PM
Had a fantastic time at #ABPP2025, my first ABPP meeting. Saw outstanding talks, shared what I’ve been working on, and was proud to see my undergrad, Abbey Pitts, win best poster award. Keep an eye out for her, she’ll be applying to PhD programs this Fall. Can’t wait for ABPP 2027!
Reposted by Sam Joseph
Did you enjoy the amazing #ABPP2025 meeting? Or were you sad that you could not attend?
If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)
If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)
April 3, 2025 at 6:00 AM
Did you enjoy the amazing #ABPP2025 meeting? Or were you sad that you could not attend?
If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)
If so, we are happy to announce that the next iteration of the meeting will happen in beautiful Leiden in The Netherlands in 2027. Keep an eye on this space, to be the first one to learn more. (1/2)
Reposted by Sam Joseph
Chemists aren't just in labs; they're building the future of biology. In an introduction to a special issue of Chemical Reviews, Prof Bryan Dickinson describes how chemists are engineering everything from drug-producing microbes to virus-fighting phages. chemistry.uchicago.edu/news/enginee...
Engineering Life's Future with Synthetic Biology
Bryan Dickinson highlights the impact of chemists in synthetic biology in special issue of Chemical Reviews
chemistry.uchicago.edu
April 1, 2025 at 4:25 PM
Chemists aren't just in labs; they're building the future of biology. In an introduction to a special issue of Chemical Reviews, Prof Bryan Dickinson describes how chemists are engineering everything from drug-producing microbes to virus-fighting phages. chemistry.uchicago.edu/news/enginee...
Reposted by Sam Joseph
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
a cartoon of homer simpson holding a card
ALT: a cartoon of homer simpson holding a card
media.tenor.com
March 2, 2025 at 1:57 PM
I am not going to call this a Bluetorial, because I do not want to sully that term (which, at least I, find joyful).
Let’s call it a Orwellial.
Let’s call it a Orwellial.
Reposted by Sam Joseph
Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social
🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩🔬
February 19, 2025 at 9:43 PM
Bad news — the effective freeze at the NIH’s Center for Scientific Review hits a major chemical biology study section. Not good. @jeremymberg.bsky.social
Reposted by Sam Joseph
