Pavel Kielkowski
@pavelkielkowski.bsky.social
Chemical biology of protein post-translational modifications. https://www.cup.lmu.de/oc/kielkowski/
Reposted by Pavel Kielkowski
One gene can code for proteoforms with:
◼️ different functions
◼️ different sequences
◼️ different regulation
◼️ different cell type expression
Such examples should inform the interpretation of gene deletion experiments seeking to infer "gene functions".
◼️ different functions
◼️ different sequences
◼️ different regulation
◼️ different cell type expression
Such examples should inform the interpretation of gene deletion experiments seeking to infer "gene functions".
November 1, 2025 at 1:51 PM
One gene can code for proteoforms with:
◼️ different functions
◼️ different sequences
◼️ different regulation
◼️ different cell type expression
Such examples should inform the interpretation of gene deletion experiments seeking to infer "gene functions".
◼️ different functions
◼️ different sequences
◼️ different regulation
◼️ different cell type expression
Such examples should inform the interpretation of gene deletion experiments seeking to infer "gene functions".
Reposted by Pavel Kielkowski
For those who like this work: There are still 2 weeks left to apply for the PhD position in my group!
www.chemzymes.com
www.chemzymes.com
Today @chemrxiv.org we write about two major innovations that facilitate in vitro prenoid and terpenoid analogue biosynthesis.
doi.org/10.26434/che...
Thread below 👇
doi.org/10.26434/che...
Thread below 👇
October 27, 2025 at 11:51 AM
For those who like this work: There are still 2 weeks left to apply for the PhD position in my group!
www.chemzymes.com
www.chemzymes.com
Reposted by Pavel Kielkowski
October 15, 2025 at 9:12 AM
Reposted by Pavel Kielkowski
What can HaloTag do for you?
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
October 1, 2025 at 2:11 PM
What can HaloTag do for you?
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
Triggered fluorogenic labelling?
Molecular recording?
Photo-Chemically Induced Dimerisation?
Philipp Mauker's CHalo motif lets reagents do all three, and more.
Read the preprint here -
doi.org/10.1101/2025...
#chembio #fluorescence #cellbio #SLP
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
September 23, 2025 at 7:11 AM
The final version of our article about PLD3 AMPylation is now out shorturl.at/iTxWx. One protein, many proteoforms. Congratulations to Laura and thanks to @marleenberouti.bsky.social @v-hornung.bsky.social @jaelab.bsky.social @hellmichgroup.bsky.social
Reposted by Pavel Kielkowski
New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social
September 9, 2025 at 2:50 PM
New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social
Reposted by Pavel Kielkowski
LMU remains the best German university www.lmu.de/en/newsroom/...
LMU remains the best German university
In the latest Academic Ranking of World Universities, LMU ranks among the world’s top 50 research-intensive universities.
www.lmu.de
August 27, 2025 at 1:10 PM
LMU remains the best German university www.lmu.de/en/newsroom/...
Reposted by Pavel Kielkowski
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Open positions
GR-SCHUHMACHER
www.epfl.ch
August 12, 2025 at 9:32 AM
We are hiring!
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
If you are looking for a postdoc position and you are interested in signaling lipids and proteomics, come join us in beautiful Switzerland!
More information on www.epfl.ch/labs/gr-schu...
Reposted by Pavel Kielkowski
Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀
July 14, 2025 at 12:02 PM
Great talk by Ronald Micura about Challenges in biological RNA chemistry @lmumuenchen.bsky.social 😀
Reposted by Pavel Kielkowski
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Pseudouridine RNA avoids immune detection through impaired endolysosomal processing and TLR engagement
Toll-like receptors (TLRs) 7 and 8 detect RNA degradation products to sense infection.
However, modified nucleosides common in self-RNA—most notably pseudouridine—evade
recognition. This study finds t...
www.cell.com
June 30, 2025 at 5:01 PM
I am very excited to share the second paper of my PhD published in @cp-cell.bsky.social.
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Many thanks to all co-authors, especially from Thomas Carell's group, and my supervisor @v-hornung.bsky.social for their great support and collaboration!
www.cell.com/cell/fulltex...
Reposted by Pavel Kielkowski
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
Research Position (PhD) in organic chemistry and b...
<div style="text-align: justify;">The research group „Organic Chemistry and&nb...
uni-bielefeld.hr4you.org
June 27, 2025 at 9:13 PM
Join us! We are looking for a new team member (PhD student) with strong background in organic chemistry.
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
🙏 RETWEET (We want to recruit internationally)
Organic chemistry meets #DirectedEvolution
Highly interdisciplinary & passionate research group
uni-bielefeld.hr4you.org/job/view/433...
Reposted by Pavel Kielkowski
🎉 Nadace Experientia zná stipendisty pro rok 2025!
👨🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.
👨🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.
Gratulujeme!
👨🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.
👨🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.
Gratulujeme!
June 18, 2025 at 6:59 AM
🎉 Nadace Experientia zná stipendisty pro rok 2025!
👨🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.
👨🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.
Gratulujeme!
👨🔬 Jakub Copko z @iocbprague.bsky.social díky stipendiu ve výši 1 060 000 Kč vycestuje na University of Göttingen.
👨🔬 Lukáš Janecký z @iocbprague.bsky.social získal stipendium ve výši 1 215 000 Kč a zamíří na Stockholm University.
Gratulujeme!
Reposted by Pavel Kielkowski
🚀 PhD position at the intersection of medicinal chemistry and chemical biology.
You'll develop ferroptosis inhibitors to combat bacterial lung infections
🧪 Research (50%) /🎓 Teaching (50%)
Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines
You'll develop ferroptosis inhibitors to combat bacterial lung infections
🧪 Research (50%) /🎓 Teaching (50%)
Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines
Graduate teaching & research assistant medicinal chemistry and/or chemical biology | University of Antwerp
YUFE vacancies
www.uantwerpen.be
June 14, 2025 at 7:20 AM
🚀 PhD position at the intersection of medicinal chemistry and chemical biology.
You'll develop ferroptosis inhibitors to combat bacterial lung infections
🧪 Research (50%) /🎓 Teaching (50%)
Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines
You'll develop ferroptosis inhibitors to combat bacterial lung infections
🧪 Research (50%) /🎓 Teaching (50%)
Looking for someone with:
➡️ Strong background in organic synthesis
➡️ Passion for working across disciplines
Reposted by Pavel Kielkowski
One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
Unifying the analysis of bottom-up proteomics data with CHIMERYS - Nature Methods
CHIMERYS is a spectrum-centric and data acquisition method-agnostic algorithm for the analysis of MS2 spectra. It is capable of deconvoluting any MS2 spectrum, regardless of whether it was acquired by...
doi.org
April 22, 2025 at 11:44 AM
One algorithm to rule them all? CHIMERYS bridges the gap — DDA,DIA and PRM — together at last!
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
With #CHIMERYS, we can now directly compare DDA and DIA data — 🍎 to 🍎 finally made possible.
doi.org/10.1038/s41592-025-02663-w
#KusterLab #WilhelmLab #MSAID #Proteomics
Reposted by Pavel Kielkowski
Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.
Research associate (Ratsstelle) for the duration of 5 years with the option to be tenured (m/f/x)
job-portal.lmu.de
April 15, 2025 at 2:02 PM
Come join our team! We have an opening for a research associate ("Ratsstelle"). Expertise in nucleotide chemistry and LC-MS is required. 👉 job-portal.lmu.de/jobposting/b... Deadline for application is June 01, 2025.
Reposted by Pavel Kielkowski
Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25
April 11, 2025 at 11:34 AM
Back in July 2023 we organized a small bioML symposium at @iocbprague.bsky.social, and it turned out to be a very pleasant and successful event. This summer we are following up with a great line-up of speakers. Please register for free, deadline May 30. tinyurl.com/bioMLPrague25
Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio
Self-assembled PROTACs enable glycoproteins degradation in the living cells
We report here a two-component proteolysis targeting chimeras (PROTACs) strategy selectively targeting O-GalNAcylated and O-GlcNAcylated proteins for proteasomal degradation, which leads to severe tox...
pubs.rsc.org
April 10, 2025 at 4:34 AM
Great to see the new concept of protein PTMs functionalization published in @chemicalscience.rsc.org! The GlyTACs enable selective degradation of glycoproteins in living cells. Congratulation to Haoyu and Liu. Have a look on the full story here: pubs.rsc.org/en/Content/A... #chembio
Reposted by Pavel Kielkowski
We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky
April 2, 2025 at 2:01 PM
We are happy to announce the new team that will organize the Virtual ChemBioTalks from this edition onwards
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky
Marina Rubini
@mlakemeyer.bsky.social
@michellefrei17.bsky.social
Hana Macíčková Cahová
@drglycoben.bsky.social
@borisvauzeilles.bsky.social
@stephanhacker2.bsky.social
(1/4)
#ChemBio #ChemSky
Reposted by Pavel Kielkowski
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio
#ABPP #ChemSky #ChemBio
March 31, 2025 at 5:33 AM
The flash talk session and the posters were a highlight of #ABPP2025. We heard a lot of exciting research into #covalent #fragment screening, #antibiotic development, #microbiome activities, posttranslational modifications #PTMs and lysine-directed #kinase inhibitors.
#ABPP #ChemSky #ChemBio
#ABPP #ChemSky #ChemBio
Reposted by Pavel Kielkowski
The first chemistry.unwrapped video in the ENERGY series is out 💥🔥
Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...
@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky
Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...
@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky
March 19, 2025 at 11:55 AM
The first chemistry.unwrapped video in the ENERGY series is out 💥🔥
Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...
@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky
Watch on YouTube in full quality:
www.youtube.com/watch?v=OdPT...
@chemistryunwrapped.bsky.social @juriceklab.bsky.social #ChemSky #PiSky
Reposted by Pavel Kielkowski
#research #chirality
Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...
@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social
Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...
@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social
March 13, 2025 at 11:26 AM
#research #chirality
Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...
@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social
Stereoanalysis of the Antiparasitic Natural Product Callunene and Its Synthetic Intermediates (Ferenczei, Perlíková) - JNP @acs.org: pubs.acs.org/doi/10.1021/...
@iocbprague.bsky.social #UCTPrague @czechacademy.bsky.social
Reposted by Pavel Kielkowski
Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...
March 10, 2025 at 10:09 AM
Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...
Reposted by Pavel Kielkowski
We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social
March 10, 2025 at 4:48 PM
We are looking for PhD candidates to work in Paris at @sorbonne-universite.fr on synthesis & (photo)catalysis inside cyclodextrins with bimetallic complexes in collaboration with @metallacycle.bsky.social
Reposted by Pavel Kielkowski
