Marton Liziczai
@marton-liziczai.bsky.social
Reposted by Marton Liziczai
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
December 16, 2025 at 8:17 AM
It’s out! Using cryo-ET in Dicty cells, we take a fresh in situ look at vaults. Surprisingly, we uncover vaults associated with ER and NE membranes, and find that many vaults enclose ribosomes in defined orientations, opening new avenues to their cellular function! www.biorxiv.org/lookup/conte...
Reposted by Marton Liziczai
Under climate change, back-to-back heat extremes threaten food production in Europe and the US, but most losses can be avoided by limiting global warming to 1.5 °C, according to a new study).
usys.ethz.ch/en/news-even...
usys.ethz.ch/en/news-even...
Sequential heat amplifies food production losses
Under climate change, back-to-back heat extremes threaten food production in Europe and the US, but most losses can be avoided by limiting global warming to 1.5 °C, according to a study led by ETH Zur...
usys.ethz.ch
October 2, 2025 at 1:46 PM
Under climate change, back-to-back heat extremes threaten food production in Europe and the US, but most losses can be avoided by limiting global warming to 1.5 °C, according to a new study).
usys.ethz.ch/en/news-even...
usys.ethz.ch/en/news-even...
Reposted by Marton Liziczai
Part of something that we have been working on for a while-A 3.1 Å map of a flexibly tethered 38 kDa domain. Hopefully preprinted soon along with a few other structures. #CryoEM
September 21, 2025 at 3:02 PM
Part of something that we have been working on for a while-A 3.1 Å map of a flexibly tethered 38 kDa domain. Hopefully preprinted soon along with a few other structures. #CryoEM
Reposted by Marton Liziczai
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
August 30, 2025 at 2:11 PM
Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️
Reposted by Marton Liziczai
David Jones PhD manuscript on how mild heat stress (experienced during fever episodes in most malaria infections)changes the cytoadhesion behavior of parasite infected red blood cells is now online and reviewed in eLife.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Physiological febrile heat stress increases cytoadhesion through increased protein trafficking of Plasmodium falciparum surface proteins into the red blood cell
elifesciences.org
August 30, 2025 at 7:50 AM
David Jones PhD manuscript on how mild heat stress (experienced during fever episodes in most malaria infections)changes the cytoadhesion behavior of parasite infected red blood cells is now online and reviewed in eLife.
elifesciences.org/reviewed-pre...
elifesciences.org/reviewed-pre...
Reposted by Marton Liziczai
🥳
First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...
Leopard-EM: An extensible 2DTM package to accelerate in situ structural biology
The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...
www.biorxiv.org
August 30, 2025 at 6:55 AM
🥳
Reposted by Marton Liziczai
ICYMI: New online: Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting
Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting
Nature Structural & Molecular Biology, Published online: 28 August 2025; doi:10.1038/s41594-025-01662-xYang et al. uncover the molecular details of how mitochondrial proteins cross the outer and inner mitochondrial membranes, with hydrophobicity guiding them into distinct pathways toward specific destinations.
go.nature.com
August 29, 2025 at 11:30 AM
ICYMI: New online: Dynamic TOM–TIM23 supercomplex directs mitochondrial protein translocation and sorting
Reposted by Marton Liziczai
New online: Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters
Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters
Nature Structural & Molecular Biology, Published online: 25 August 2025; doi:10.1038/s41594-025-01652-zReddy et al. used ancestral protein reconstruction, cryo-electron microscopy and functional assays to elucidate how a secondary active transporter evolved to harness the energy of sodium gradients to power the concentrative uptake of its substrate.
go.nature.com
August 25, 2025 at 10:25 AM
New online: Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters
Reposted by Marton Liziczai
New online: A structural window into the evolution of secondary transport mechanisms
A structural window into the evolution of secondary transport mechanisms
Nature Structural & Molecular Biology, Published online: 25 August 2025; doi:10.1038/s41594-025-01625-2Protein sequence signatures suggest that eons ago, a bacterial glutamate transporter lost its sodium coupling to make way for a shift to proton coupling. A study now maps this ancient transition in biochemical and structural detail to better understand how secondary transporters control their energetics.
go.nature.com
August 25, 2025 at 10:25 AM
New online: A structural window into the evolution of secondary transport mechanisms
Reposted by Marton Liziczai
Scientists present an advanced new technique for live-imaging regenerating limbs, shown here on a sand flea.
buff.ly/WsOrSlR
buff.ly/WsOrSlR
August 25, 2025 at 10:44 AM
Scientists present an advanced new technique for live-imaging regenerating limbs, shown here on a sand flea.
buff.ly/WsOrSlR
buff.ly/WsOrSlR
Reposted by Marton Liziczai
Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases
go.nature.com/3HpdTqq
go.nature.com/3HpdTqq
Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases - Nature
Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.
go.nature.com
August 23, 2025 at 3:28 PM
Nature research paper: Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases
go.nature.com/3HpdTqq
go.nature.com/3HpdTqq
Reposted by Marton Liziczai
Native plasmodesmata!! I’m a bit late to the party, but it needs to be said again— this is a GIANT accomplishment both for #PlantScience 🌱🌾 and for #TeamTomo ❄️🔬. Huuuge props to @madic.bsky.social & Matthias Pöge for taking what I thought was an impossible challenge and persevering. You did it!💪
New preprint: In situ Architecture of #Plasmodesmata.
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
Using #cryoET, #AlphaFold & proteomics, we uncover the native organization of plant intercellular nanopores.
🔗 doi.org/10.1101/2025...
🧪🧵1/n
#teamtomo #PlantScience #Physcomitrium #Arabidopsis #cryoEM
August 2, 2025 at 10:06 PM
Native plasmodesmata!! I’m a bit late to the party, but it needs to be said again— this is a GIANT accomplishment both for #PlantScience 🌱🌾 and for #TeamTomo ❄️🔬. Huuuge props to @madic.bsky.social & Matthias Pöge for taking what I thought was an impossible challenge and persevering. You did it!💪
Reposted by Marton Liziczai
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
July 12, 2025 at 12:49 AM
Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
Reposted by Marton Liziczai
Cryo-electron tomography: Challenges and computational strategies for particle picking pubmed.ncbi.nlm.nih.gov/40639056/ #cryoem
July 12, 2025 at 3:52 AM
Cryo-electron tomography: Challenges and computational strategies for particle picking pubmed.ncbi.nlm.nih.gov/40639056/ #cryoem
Reposted by Marton Liziczai
The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial www.nature.com/articles/s41...
rdcu.be/euaoK
rdcu.be/euaoK
Individualized mRNA cancer vaccines make strides - Nature Biotechnology
The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial.
www.nature.com
June 30, 2025 at 6:48 PM
The first cancer vaccines matched to a person’s unique tumor neoantigens are forging ahead, with expectations running high as the field awaits results from the first pivotal trial www.nature.com/articles/s41...
rdcu.be/euaoK
rdcu.be/euaoK
Reposted by Marton Liziczai
The DRC has had only a trickle of vaccine doses to fight the mpox outbreak across a geographically vast territory that is home to 100 million people. A new analysis by researchers at the WHO shows it was also hampered by a scattershot use of that limited vaccine supply. scim.ag/40x78sL
Scattershot vaccination fails to slow mpox spread in Congo
Limited vaccine doses weren’t used strategically, WHO analysis finds
scim.ag
June 30, 2025 at 9:00 PM
The DRC has had only a trickle of vaccine doses to fight the mpox outbreak across a geographically vast territory that is home to 100 million people. A new analysis by researchers at the WHO shows it was also hampered by a scattershot use of that limited vaccine supply. scim.ag/40x78sL
Reposted by Marton Liziczai
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET - Nature Communications
This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-e...
www.nature.com
June 15, 2025 at 2:04 PM
"Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Marton Liziczai
Awesome malaria study out now in Nature Microbiology:
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology
A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.
www.nature.com
June 13, 2025 at 10:31 AM
Awesome malaria study out now in Nature Microbiology:
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...
Reposted by Marton Liziczai
Extremely happy to share the first paper of my postdoc work with @parasitematt.
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
June 12, 2025 at 11:42 AM
Extremely happy to share the first paper of my postdoc work with @parasitematt.
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
It is the product of a great collaboration with Akihito Sakoguchi, Hisashi Arase and Shiroh Iwanaga at Osaka University as well as Marcus Widdess and Mike Dustin here in Oxford.
rdcu.be/eqx2J
🧵 1/6
Reposted by Marton Liziczai
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40455995/ #cryoem
June 3, 2025 at 1:44 PM
Structure and organization of full-length epidermal growth factor receptor in extracellular vesicles by cryo-electron tomography pubmed.ncbi.nlm.nih.gov/40455995/ #cryoem
Reposted by Marton Liziczai
CryoEM structure of the central apparatus of the Trypanosoma brucei flagellum www.biorxiv.org/content/10.1101/2025.05.29.656921v1 #cryoem
May 31, 2025 at 3:48 PM
CryoEM structure of the central apparatus of the Trypanosoma brucei flagellum www.biorxiv.org/content/10.1101/2025.05.29.656921v1 #cryoem
Reposted by Marton Liziczai
Join us at 11am (BST) on Monday 7th April for an #LMBSeminar from Rod MacKinnon of Rockefeller University.
He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
April 4, 2025 at 9:56 AM
Join us at 11am (BST) on Monday 7th April for an #LMBSeminar from Rod MacKinnon of Rockefeller University.
He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
He will be discussing ‘Higher order transient structures and the principles of dynamic connectivity in membrane signaling.’
More details: www2.mrc-lmb.cam.ac.uk/news-and-eve...
Reposted by Marton Liziczai
Check out part 2 of my PhD work out now on bioRxiv, in which we explore an amazing protein machinery from the human gut microbiome, the Ruminococcus bromii amylosome.
A short explainer below (1/5).
www.biorxiv.org/content/10.1...
#microbiology #microbiome #teamtomo
A short explainer below (1/5).
www.biorxiv.org/content/10.1...
#microbiology #microbiome #teamtomo
www.biorxiv.org
April 3, 2025 at 12:41 PM
Check out part 2 of my PhD work out now on bioRxiv, in which we explore an amazing protein machinery from the human gut microbiome, the Ruminococcus bromii amylosome.
A short explainer below (1/5).
www.biorxiv.org/content/10.1...
#microbiology #microbiome #teamtomo
A short explainer below (1/5).
www.biorxiv.org/content/10.1...
#microbiology #microbiome #teamtomo
Reposted by Marton Liziczai
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw
Implantation of engineered adipocytes suppresses tumor progression in cancer models - Nature Biotechnology
Adipose manipulation transplantation can reduce tumor growth and proliferation in vitro and in mouse models.
go.nature.com
February 4, 2025 at 3:48 PM
Implantation of engineered adipocytes suppresses tumor progression in cancer models - @nadavahituv.bsky.social go.nature.com/4gqhxvw