Zhang and colleagues identify the transcription factor GABPA as a regulator of zygotic genome activation, epiblast formation and naive pluripotency establishment.

Three distinguished scientists on leaving academia to advance biomedical research

In a new, large-scale study of sleep behavior, Stanford Medicine scientists found that night owls don’t really thrive late at night.

npj Metabolic Health and Disease - Too old for healthy aging? Exploring age limits of longevity treatments

Cancer cells rely on macropinocytosis to survive in a nutrient-deprived environment. Here, Lambies et al. identified various members of the cell polarity protein network as essential regulators of mac...

Cellular senescence is a key hallmark of aging. It has now emerged as a key mediator in normal tissue turnover and is associated with a variety of age-related diseases, including organ-specific fibrosis and systemic sclerosis (SSc). This review discusses the recent evidence of the role of senescence in tissue fibrosis, with an emphasis on SSc, a systemic autoimmune rheumatic disease. We discuss the physiological role of these cells, their role in fibrosis, and that targeting these cells specifically could be a new therapeutic avenue in fibrotic disease. We argue that targeting senescent cells, with senolytics or senomorphs, is a viable therapeutic target in fibrotic diseases which remain largely intractable.

Professor discusses weekly news in the stem cell and regenerative space including on embryo models and suggests a stem cell book.

Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2.

Ammothumkandy et al. provide a functional role for adult neurogenesis in human cognition. They show that immature neuron levels benefit verbal learning in mesial temporal lobe epilepsy (MTLE) patients. The decline and eventual loss of immature neurons in MTLE hippocampus occurs during a critical period of disease progression.

Intracellular DNA assembly for mRNA vaccine compartmentalization facilitates antigen expression and enhances adjuvant efficacy.

This year’s competition has a special category on artificial intelligence research or quantum science—no Ph.D. needed

Survey of scientists who study ageing finds no consensus on the fundamentals.

Aging is associated with a progressive loss of muscle function. Here the authors characterize mitochondrial capacity and muscle function in young and older adults with similar habitual physical activi...