Giorgia Tosoni
@giorgitos.bsky.social
Postdoctoral researcher in the Molecular Neurogenetics Lab, Lund University.
🧗🏽♀️🏃🏽♀️🚴🏽♀️🏊🏽♀️
🧗🏽♀️🏃🏽♀️🚴🏽♀️🏊🏽♀️
Pinned
Giorgia Tosoni
@giorgitos.bsky.social
· Jan 10
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience https://www.biorxiv.org/content/10.1101/2025.01.08.631686v1
🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇
Reposted by Giorgia Tosoni
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
October 20, 2025 at 8:00 PM
For obvious reasons, I've become fascinated with retrotransposons. So we ( @alexwhiteley.bsky.social and I) wrote an article now out in Neuron @cellpress.bsky.social on how we think retrotransposons influence brain function and health! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...
Reposted by Giorgia Tosoni
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson's disease
Parkinson's disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to i...
www.biorxiv.org
September 7, 2025 at 7:59 PM
New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Giorgia Tosoni
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent
stem cells and are dynamically regulated throughout neural differentiation. The study
examines the role of L1s...
www.cell.com
August 23, 2025 at 9:47 AM
New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Funded by @asapresearch.parkinsonsroadmap.org
www.cell.com/cell-genomic...
Reposted by Giorgia Tosoni
Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience
The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...
www.nature.com
July 30, 2025 at 8:51 PM
Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Giorgia Tosoni
Why do some people with Alzheimer’s do not show symptoms of Alzheimer's?
During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons.
Read the full article on our website: nin.nl/news/the-eld...
During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons.
Read the full article on our website: nin.nl/news/the-eld...
The elderly brain is less mature than you think and that could protect you from Alzheimer’s Disease - Netherlands Institute for Neuroscience - Master the Mind
nin.nl
July 18, 2025 at 10:50 AM
Why do some people with Alzheimer’s do not show symptoms of Alzheimer's?
During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons.
Read the full article on our website: nin.nl/news/the-eld...
During her PhD, @giorgitos.bsky.social explored this question. Part of the answer led her to an unexpected group of brain cells: underdeveloped neurons.
Read the full article on our website: nin.nl/news/the-eld...
Important perspective on a fascinating study from the Frisén group, which used machine learning to identify neural progenitors in the adult human brain, a fresh lens on a long-standing debate 💥
Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social
Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social
Single-nuclei RNA sequencing combined with machine learning provides a way to identify neural progenitor cells in the adult hippocampus, a new study suggests.
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neurogenesis...
By @claudia-lopez.bsky.social
#neuroskyence
www.thetransmitter.org/neurogenesis...
Machine learning spots neural progenitors in adult human brains
But the finding has not settled the long-standing debate over the existence and extent of neurogenesis during adulthood, says Yale University neuroscientist Juan Arellano.
www.thetransmitter.org
July 3, 2025 at 9:07 PM
Important perspective on a fascinating study from the Frisén group, which used machine learning to identify neural progenitors in the adult human brain, a fresh lens on a long-standing debate 💥
Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social
Always exciting to see this field evolve, and grateful to be part of it @labsalta.bsky.social
Hora est 🎓
Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!
Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!
June 24, 2025 at 6:46 AM
Hora est 🎓
Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!
Last Thursday, I defended my PhD at the University of Amsterdam, @nin-knaw.bsky.social—graduated cum laude ✨ Huge thanks to my amazing supervisor @labsalta.bsky.social, co-promoters Paul Lucassen, Inge Huitinga & @fitzsimonslab.bsky.social. Thanks to all who made the day unforgettable!
Reposted by Giorgia Tosoni
I'm proud of contributing to @nkrauth.bsky.social @clemmensenc.bsky.social @olekiehn.bsky.social discovery of the role of an hypothalamic-brainstem circuit for prioritization of safety. Really impressive amount of work led by @nkrauth.bsky.social
Honored to share that our paper is out today in Nature Neuroscience:
www.nature.com/articles/s41...
We identify a hypothalamic-brainstem circuit linking internal states to locomotion: These projections drive safety-focused movement over competing behavior.
#Neuroscience #Hypothalamus #Locomotion
www.nature.com/articles/s41...
We identify a hypothalamic-brainstem circuit linking internal states to locomotion: These projections drive safety-focused movement over competing behavior.
#Neuroscience #Hypothalamus #Locomotion
A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs - Nature Neuroscience
Animals need to adapt behavior to balance survival with fulfillment of essential needs. Krauth et al. identify neurons in the lateral hypothalamus that, when activated, prioritize survival over other ...
www.nature.com
May 28, 2025 at 12:47 PM
I'm proud of contributing to @nkrauth.bsky.social @clemmensenc.bsky.social @olekiehn.bsky.social discovery of the role of an hypothalamic-brainstem circuit for prioritization of safety. Really impressive amount of work led by @nkrauth.bsky.social
Reposted by Giorgia Tosoni
@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have high...
www.biorxiv.org
April 2, 2025 at 3:07 PM
@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Giorgia Tosoni
Our paper has sparked a lot of people asking me – so Keri, what’s the tldr – is there, or isn’t there, new neurons in the human hippocampus?
It's a little more complicated than a yes or no IMO.
It's a little more complicated than a yes or no IMO.
Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
April 2, 2025 at 3:07 PM
Our paper has sparked a lot of people asking me – so Keri, what’s the tldr – is there, or isn’t there, new neurons in the human hippocampus?
It's a little more complicated than a yes or no IMO.
It's a little more complicated than a yes or no IMO.
Reposted by Giorgia Tosoni
Excited to share our preprint led by Ain Chung
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...
March 19, 2025 at 3:18 PM
Excited to share our preprint led by Ain Chung
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...
& @jasonalipio.bsky.social showing how immature adult-born DGCs preferentially recruit inhibition of CA2 and CA3 to disproportionately affect hippocampal network properties and social memory. We began by asking 1/n
www.biorxiv.org/content/10.1...
Reposted by Giorgia Tosoni
Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
February 22, 2025 at 2:49 AM
Updated from the preprint, our paper, "Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation" is now published.
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Reposted by Giorgia Tosoni
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...
Comparative molecular landscapes of immature neurons in the mammalian dentate gyrus across species reveal special features in humans
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis contribute to plasticity, learning and memory, but their evolutionary changes across species and specialized features...
www.biorxiv.org
February 19, 2025 at 7:10 AM
Check out our latest preprint, where we cross-compared the molecular landscapes of immature neurons in the hippocampus in different mammalian species👨🐵🐷🐭, revealing specialized features in humans. www.biorxiv.org/content/10.1...
Reposted by Giorgia Tosoni
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Streamlit
mssearch.xyz
February 16, 2025 at 7:02 PM
I've been developing a semantic search tool that covers not just bioRxiv and medRxiv, but the entire PubMed database. This means you can search across a massive collection of biomedical research using keywords, questions, hypotheses, or even full abstracts. Try it out: mssearch.xyz
Reposted by Giorgia Tosoni
The NINclusion team launched the NIN Gym to support mental and physical health within the institute. Over the next 10 weeks, employees can join alternating Yoga and Bootcamp sessions led by personal trainer Ties
(@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪
(@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪
January 28, 2025 at 1:49 PM
The NINclusion team launched the NIN Gym to support mental and physical health within the institute. Over the next 10 weeks, employees can join alternating Yoga and Bootcamp sessions led by personal trainer Ties
(@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪
(@tiesverbeekpt.bsky.social) on Thursdays. The first session took place last week! 💪
Reposted by Giorgia Tosoni
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
January 22, 2025 at 8:46 PM
All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.
🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer's disease, and cognitive resilience https://www.biorxiv.org/content/10.1101/2025.01.08.631686v1
January 10, 2025 at 9:23 AM
🧵 1/ Excited to share our new research on immature neurons (ImN) in the adult human brain and their roles in healthy aging, Alzheimer’s disease (AD), and cognitive resilience. Here’s what we discovered 👇
Big achievement for the green office (and not only!), finally LEAF is implemented in our Institute @nin-knaw.bsky.social 💚
🌱 Exciting news from our green office!
Two labs have joined the certified sustainability programme, LEAF. Congratulations to Evgenia Salta’s lab and the @socialbrainlab.bsky.social for earning the bronze award and making impactful strides toward environmentally friendly research practices. 🎉
Two labs have joined the certified sustainability programme, LEAF. Congratulations to Evgenia Salta’s lab and the @socialbrainlab.bsky.social for earning the bronze award and making impactful strides toward environmentally friendly research practices. 🎉
December 19, 2024 at 7:50 PM
Big achievement for the green office (and not only!), finally LEAF is implemented in our Institute @nin-knaw.bsky.social 💚
Reposted by Giorgia Tosoni
Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n
December 3, 2024 at 5:22 PM
Big day for single cell and neuroscience. Trio of single cell perspective pieces discussing applications, opportunities, challenges, and validation of single cell and spatial genomics in neuroscience are out now in Nature Neuroscience. Links in thread below.👇 1/n
Reposted by Giorgia Tosoni
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction - Acta Neuropathologica
Aberrant activity of the retrotransposable element long interspersed nuclear element-1 (LINE-1) has been hypothesized to contribute to cellular dysfunction in age-related disorders, including late-ons...
link.springer.com
December 1, 2024 at 12:56 AM
Elevated expression of the retrotransposon LINE-1 drives Alzheimer’s disease-associated microglial dysfunction
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Giorgia Tosoni
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
November 17, 2024 at 6:48 PM
⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
🔄Share to help people finding its topic/field
- STRUCTURAL BIOLOGY
Structural Biology 1: bsky.app/starter-pack...
Structural Biology 2: bsky.app/starter-pack...
Crystallography: bsky.app/starter-pack...
Synchrotron&CryoEM: bsky.app/starter-pack...
Hello, (Bluesky 🦋) World! I’m Giorgia, and I’m new here. Wrapping up my PhD in the SaltaLab at the Netherlands Institute for Neuroscience. My research focuses on adult neurogenesis, Alzheimer's, and single-cell approaches. Check out our past work here: tinyurl.com/373x5r9z.
Stay tuned for more!
Stay tuned for more!
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: Reconciling controversy or fueling the debate?
Tosoni et al. probe the challenges related to the design, analysis, and interpretation
of single-cell transcriptomic studies in the adult human hippocampal neurogenic niche
and propose a series of cri...
tinyurl.com
December 3, 2024 at 11:56 AM
Hello, (Bluesky 🦋) World! I’m Giorgia, and I’m new here. Wrapping up my PhD in the SaltaLab at the Netherlands Institute for Neuroscience. My research focuses on adult neurogenesis, Alzheimer's, and single-cell approaches. Check out our past work here: tinyurl.com/373x5r9z.
Stay tuned for more!
Stay tuned for more!
Reposted by Giorgia Tosoni
Anyone working with single nuclei data should read this paper! (single cell too, but for nuclei data it's essential)
If I could only have one QC metric for single nuclei data, it would be spliced pct / intronic fraction (I think it's more useful even than number of UMIs 🤯).
#SingleCell
If I could only have one QC metric for single nuclei data, it would be spliced pct / intronic fraction (I think it's more useful even than number of UMIs 🤯).
#SingleCell
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 9:38 AM
Anyone working with single nuclei data should read this paper! (single cell too, but for nuclei data it's essential)
If I could only have one QC metric for single nuclei data, it would be spliced pct / intronic fraction (I think it's more useful even than number of UMIs 🤯).
#SingleCell
If I could only have one QC metric for single nuclei data, it would be spliced pct / intronic fraction (I think it's more useful even than number of UMIs 🤯).
#SingleCell