Giorgia Tosoni
@giorgitos.bsky.social
Postdoctoral researcher in the Molecular Neurogenetics Lab, Lund University.
🧗🏽♀️🏃🏽♀️🚴🏽♀️🏊🏽♀️
🧗🏽♀️🏃🏽♀️🚴🏽♀️🏊🏽♀️
Reposted by Giorgia Tosoni
@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Unique transcriptional profiles of adult human immature neurons in healthy aging, Alzheimer’s disease, and cognitive resilience
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain controversial. While rodent studies have high...
www.biorxiv.org
April 2, 2025 at 3:07 PM
@labsalta.bsky.social identified persistent populations of immature neurons that were associated with ‘juvenile’ cellular functions, suggesting that these immature populations may actively contribute to maintaining homeostasis within the aged human hippocampus.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
very interesting!!
March 7, 2025 at 6:44 AM
very interesting!!
12/ Huge thanks to all the co-authors, brain donors, and their families—this work wouldn’t have been possible without you! 🙏 We would be super grateful to hear your thoughts on our findings (don’t hold back, we’re all ears)! #Neurogenesis #Alzheimers #resilience
January 10, 2025 at 9:23 AM
12/ Huge thanks to all the co-authors, brain donors, and their families—this work wouldn’t have been possible without you! 🙏 We would be super grateful to hear your thoughts on our findings (don’t hold back, we’re all ears)! #Neurogenesis #Alzheimers #resilience
11/ Our work suggests immature neurons actively support hippocampal plasticity and resilience. Could targeting these cells help unlock new strategies for combating AD? 🏥💡We hope to provide a resource to help explore the molecular basis of aging, AD, and resilience. 🛠️
January 10, 2025 at 9:23 AM
11/ Our work suggests immature neurons actively support hippocampal plasticity and resilience. Could targeting these cells help unlock new strategies for combating AD? 🏥💡We hope to provide a resource to help explore the molecular basis of aging, AD, and resilience. 🛠️
10/ ImN also showed decreased (in silico) intercellular communication in AD brains. In resilient individuals, they maintained crosstalk with other cells critical for anti-inflammatory and neuroprotective signaling. 🤝
January 10, 2025 at 9:23 AM
10/ ImN also showed decreased (in silico) intercellular communication in AD brains. In resilient individuals, they maintained crosstalk with other cells critical for anti-inflammatory and neuroprotective signaling. 🤝
9/ 🛡️ Resilient individuals—cognitively intact despite AD pathology—harbored ImN enriched for anti-inflammatory, anti-amyloidogenic, and neuroprotective transcriptional programs. These cells may actively buffer against AD progression. 💡
January 10, 2025 at 9:23 AM
9/ 🛡️ Resilient individuals—cognitively intact despite AD pathology—harbored ImN enriched for anti-inflammatory, anti-amyloidogenic, and neuroprotective transcriptional programs. These cells may actively buffer against AD progression. 💡
8/ We took extra steps to validate our findings using RNAScope in adult and fetal human brain & human iPSC-derived 3D cultures. Key marker combinations could detect ImN, and increased with hippocampal neuronal differentiation, indicating a role in human hippocampal neurogenesis. 🔬
January 10, 2025 at 9:23 AM
8/ We took extra steps to validate our findings using RNAScope in adult and fetal human brain & human iPSC-derived 3D cultures. Key marker combinations could detect ImN, and increased with hippocampal neuronal differentiation, indicating a role in human hippocampal neurogenesis. 🔬
7/ Yet, are these cells born in adulthood, passively waiting to mature when they ‘grow up’ or lingering remnants of embryonic neurogenesis? Maybe neither: ImN showed “youthful” transcriptional traits vs mature neurons, suggesting they may actively support hippocampal homeostasis.
January 10, 2025 at 9:23 AM
7/ Yet, are these cells born in adulthood, passively waiting to mature when they ‘grow up’ or lingering remnants of embryonic neurogenesis? Maybe neither: ImN showed “youthful” transcriptional traits vs mature neurons, suggesting they may actively support hippocampal homeostasis.
6/ So, what did we find? Our quality control pipeline revealed the presence of immature neurons in adult GC! 🥳Enriched for immature markers, these populations were validated by trajectory inference and integration with the fetal neurogenic dataset.
January 10, 2025 at 9:23 AM
6/ So, what did we find? Our quality control pipeline revealed the presence of immature neurons in adult GC! 🥳Enriched for immature markers, these populations were validated by trajectory inference and integration with the fetal neurogenic dataset.