Agingdoc⭐David Barzilai🔔MD PhD, MS, MBA, DipABLM
@agingdoc.bsky.social
Longevity medicine best practices | healthspan | precision medicine | geroscience | bio/acc | consulting @ agingdoc.com
Connect: http://linkedin.com/in/agingdoc
Connect: http://linkedin.com/in/agingdoc
Pinned
I'm honored to join Harvard Medical School as a part-time Lecturer.
If you're a colleague at @harvardmed.bsky.social working on upcoming conferences or educational initiatives across healthspan I’d welcome the opportunity to collaborate.👨⚕️
Please reach out at
🔗https://www.linkedin.com/in/agingdoc/
If you're a colleague at @harvardmed.bsky.social working on upcoming conferences or educational initiatives across healthspan I’d welcome the opportunity to collaborate.👨⚕️
Please reach out at
🔗https://www.linkedin.com/in/agingdoc/
Boston’s Longevity Obsession: What Works and What’s Expensive BS
We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...
We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...
Boston's Longevity Obsession: What Works and What Doesn't
We talked to doctors at Mass General, Brigham and Women's, and more.
www.bostonmagazine.com
February 1, 2026 at 9:20 PM
Boston’s Longevity Obsession: What Works and What’s Expensive BS
We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...
We're becoming more & more obsessed with living forever—but not all the treatments are created equal. What works, what doesn’t and whether optimizing every aspect of your life is really worth it.
www.bostonmagazine.com/news/2026/01...
How to Make Friends as an Adult
A practical guide for expanding your circle, with advice from sociable people.
www.nytimes.com/article/how-... @nytstyle.bsky.social
A practical guide for expanding your circle, with advice from sociable people.
www.nytimes.com/article/how-... @nytstyle.bsky.social
How to Make Friends as an Adult
www.nytimes.com
February 1, 2026 at 7:27 PM
How to Make Friends as an Adult
A practical guide for expanding your circle, with advice from sociable people.
www.nytimes.com/article/how-... @nytstyle.bsky.social
A practical guide for expanding your circle, with advice from sociable people.
www.nytimes.com/article/how-... @nytstyle.bsky.social
Senate advances bills rejecting Trump’s efforts to slash research funding 🧪
The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.
www.highereddive.com/news/senate-...
The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.
www.highereddive.com/news/senate-...
Senate advances bills rejecting Trump’s efforts to slash research funding
The White House sought cuts of 40% or more at some agencies, but lawmakers from both parties are pushing to hold science spending relatively steady.
www.highereddive.com
January 20, 2026 at 10:40 PM
Senate advances bills rejecting Trump’s efforts to slash research funding 🧪
The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.
www.highereddive.com/news/senate-...
The White House requested cuts of 40% or more at some agencies. But lawmakers from both parties are pushing to hold science spending relatively steady.
www.highereddive.com/news/senate-...
Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds
Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards
www.mcgill.ca/newsroom/cha...
Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards
www.mcgill.ca/newsroom/cha...
Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds
Gamma irradiation, an industry-standard sterilization method for medicinal and recreational cannabis, does not fully eliminate toxic fungi or their chemical residues, a McGill University study has fou...
www.mcgill.ca
January 15, 2026 at 7:39 PM
Irradiated cannabis might still harbour toxic fungi and residues, McGill study finds
Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards
www.mcgill.ca/newsroom/cha...
Researchers raise concerns about possible health risks for vulnerable users, point to a need for better methods and safeguards
www.mcgill.ca/newsroom/cha...
Targeted delivery of genome editors in vivo
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
January 13, 2026 at 3:18 PM
Targeted delivery of genome editors in vivo
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
🧬"Targeted delivery promises to considerably expand the therapeutic applicability of genome editing, moving closer to the ideal of a precise ‘magic bullet’ that safely and effectively treats diverse genetic disorders." 🩺
www.nature.com/articles/s41...
👍⚕️
January 13, 2026 at 3:17 PM
👍⚕️
My friend Andrew Steele is building this:
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
December 28, 2025 at 6:07 PM
My friend Andrew Steele is building this:
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
The majority of poor health and deaths globally are caused by diseases that become common with age...
"But public policy has yet to catch up.. & longevity science is underappreciated, and underfunded
We exist to change that" 🧑⚕️⚕️
thelongevityinitiative.org
This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
December 23, 2025 at 2:20 AM
This company is developing gene therapies for muscle growth, erectile dysfunction, and “radical longevity”
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
💉 A small group of volunteers will receive multiple injections of the experimental treatments next month, says Unlimited Bio 👨🏻⚕️
t.co/hMdyfVk58W
Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
December 6, 2025 at 3:22 PM
Interrupting Prolonged Sitting Reduces Postprandial Glucose Concentration in Young Men With Central Obesity
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
👉 Interrupted prolonged sitting [3 min light walking or 1.5 minutes of moderate walking every 30 minutes] reduced postprandial glucose concentrations.
academic.oup.com/jcem/article...
People often ask me the same question:
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
November 28, 2025 at 11:20 PM
People often ask me the same question:
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
“What’s the single most promising anti-aging measure coming in the next decade?”
If you care about where longevity medicine is truly heading, this one’s worth a look.
🔗https://www.instagram.com/reel/DRni2qQgNTS
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM on X: "Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric" / X
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function "...suggests that the loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric
x.com
November 19, 2025 at 12:41 AM
Semaglutide versus caloric restriction-induced weight loss: insights into effects on skeletal muscle mass and function
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
"[suggests] loss of muscle function and mass during treatment is not unique to GLP-1RA pharmacology but rather reflects the biology of caloric restriction…"
x.com/agingdoc1/st...
November 9, 2025 at 10:48 PM
AI Learns to Design the Human Body’s Most Elusive Proteins
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
AI Learns to Design the Human Body’s Most Elusive Proteins - Neuroscience News
A new machine learning method has achieved what even AlphaFold cannot — the design of intrinsically disordered proteins (IDPs), the shape-shifting biomolecules that make up nearly 30% of all human pro...
neurosciencenews.com
October 7, 2025 at 12:07 AM
AI Learns to Design the Human Body’s Most Elusive Proteins
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
🤩 Summary: A new machine learning method has achieved what even AlphaFold cannot… their ever-changing structures have defied traditional AI prediction models.
neurosciencenews.com/ai-protein-d...
This AI tool predicts your risk of 1,000 diseases — by looking at your medical records
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
September 30, 2025 at 11:28 AM
This AI tool predicts your risk of 1,000 diseases — by looking at your medical records
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
Trained on 400,000 medical records, the system can predict risks 20 years in advance — plus, how AIs could make you more likely to cheat
nature.com/articles/d41...
@shamini.bsky.social 🧪
@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov
August 28, 2025 at 10:45 PM
@erictopol.bsky.social is right — we haven’t rigorously validated gerotherapeutics in humans, and even if we did, we’d need to show they also compress morbidity.
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Some source for optimism: for some animal models, better healthspan can track increased longevity.
pmc.ncbi.nlm.nih.gov/articles/PMC...
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
www.nytimes.com
August 5, 2025 at 1:22 PM
Fraudulent Scientific Papers Are Rapidly Increasing, Study Finds
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
A statistical analysis found that the number of fake journal articles being churned out by “paper mills” is doubling every year and a half. 🤯
www.nytimes.com/2025/08/04/s...
See you there!
August 2, 2025 at 4:05 PM
See you there!
👍
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
August 2, 2025 at 11:02 AM
👍
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
You’re not on X anymore right (making sure I didn’t miss you there for cross-posting)?
Keep up the great work Laura!
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
www.nytimes.com
August 2, 2025 at 10:59 AM
Healthy Lifestyle Can Help People at Risk for Dementia, Study Finds
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
The study found that a combination of exercise, healthy diet and other behaviors led to cognitive benefits…
www.nytimes.com/2025/07/28/h...
DNA Methylation Ageing Atlas Across 17 Human Tissues
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
July 28, 2025 at 9:01 PM
DNA Methylation Ageing Atlas Across 17 Human Tissues
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...
👉“Our open-access atlas provides a foundational resource for dissecting the molecular architecture of human aging and identifying testable targets for intervention..”
@nireynon.bsky.social and coauthors
www.biorxiv.org/content/10.1...