In the last 5 years, the scientific community has witnessed the development of several AI-based tools for groundbreaking advances in protein science. These tools have enabled scientists to predict pr…

Allosteric communication between non-contacting sites in proteins plays a fundamental role in biological regulation and drug action. While allosteric gain-of-function variants are known drivers of onc...

Structurally constrained cyclic β-amino acids are attractive building blocks for peptide drugs because they induce unique and stable conformations. Introduction of (1S,2S)-2-aminocyclopentanecarboxylic acid [(1S,2S)-2-ACPC] into peptides stabilizes helical conformations, so improving proteolytic stability and cell

Translation termination is essential in all living organisms because it ensures that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factor...

Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

Some cyclic peptides can cross membranes, which is highly attractive for drug development, but it remains difficult to accurately predict membrane permeability or to test it experimentally for large ...

Ledig stilling ved Institut for Molekylærbiologi og Genetik - Neurobiologi, Aarhus Universitet

Uechi et al. found that a small-molecule lipoamide dissolves stress granules (SGs) by targeting SFPQ, a redox-sensitive disordered SG protein, alleviating pathological phenotypes caused by amyotrophic...

Author summary Cyclic peptides are circular chains of amino acid residues that are promising candidates for new therapeutic drugs. Current FDA approved cyclic peptide-based drugs are mostly derived fr...

Motivation: In recent years, tremendous advances have been made in predicting protein structures and protein-protein interactions. However, progress in predicting the structure of RNA, either alone or...

Join us at Chemsymposia 2026 to discover groundbreaking research in physics applications. Connect with experts, engage in insightful discussions, and explore our venue, registration details, and speak...

InstaNovo, a transformer-based model, and InstaNovo+, a multinomial diffusion model, enhance de novo peptide sequencing, enabling discovery of novel peptides, improved therapeutics sequencing coverage...

Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer review initiative by evaluating whether we could implement and adhere to a structured timeline for rapid peer review at Biology Open. A 6-month pilot conducted from July to December 2024 evaluated a structured workflow with pre-contracted reviewers under two payment models: a freelance model or a retainer model. All manuscripts assigned to two of the journal's ten academic editors were included in the Fast & Fair peer review initiative experiment. A structured editorial timeline ensured that all manuscripts received reviews and first decisions within 7 business days. The results demonstrated that 100% of Fast & Fair peer review initiative manuscripts met the turnaround target, with a mean of 4.6 business days (n=20 manuscripts). Review quality was maintained, as indicated by assessments by academic editors. The freelancer model outperformed retainers in cost-effectiveness. These findings suggest that the Fast & Fair peer review initiative is feasible and does not compromise review quality. While scalability remains to be tested, the initiative eliminates a major bottleneck in traditional peer review by streamlining reviewer identification and enforcing a strict editorial timeline. ### Competing Interest Statement The authors of this manuscript have the following competing interests: D.A.G. is the Editor-in-Chief of Biology Open and A.C. is the Managing Editor of Biology Open.