Dvir Schirman
@dvirschirman.bsky.social
@EMBOFellows postdoc in @johan_elf_ lab, @UU_University.
Chromosome organization in bacteria. Combining microscopy and large synthetic libraries to study genotype-to-phenotype.
alumnus of @TPilpel lab
Chromosome organization in bacteria. Combining microscopy and large synthetic libraries to study genotype-to-phenotype.
alumnus of @TPilpel lab
Reposted by Dvir Schirman
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Massively parallel interrogation of the fitness of natural variants in ancient signaling pathways reveals pervasive local adaptation
The nature of standing genetic variation remains a central debate in population genetics, with differing perspectives on whether common variants are almost always neutral as suggested by neutral and n...
www.biorxiv.org
October 22, 2025 at 5:46 PM
One of the most exciting works of my career, years in the making. We used high-throughput precision genome editing to test the fitness effects of thousands of natural variants. Our findings challenge the long-held assumption that common variants are inconsequential.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
I tried the previous version on my preprint, and the feedback was pretty impressive and useful 🧐🔬
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 11:08 PM
I tried the previous version on my preprint, and the feedback was pretty impressive and useful 🧐🔬
Reposted by Dvir Schirman
The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Bioinformatician - Uppsala University
Bioinformatician, Department of Organismal Biology, Uppsala University
www.uu.se
August 12, 2025 at 7:10 AM
The @scilifelab.se ancient DNA unit is looking for an bioinformatician placed at Uppsala University. This is a great way to be part of diverse #aDNA research projects as a staff scientist with permanent (!!) employment:
www.uu.se/en/about-uu/...
www.uu.se/en/about-uu/...
Reposted by Dvir Schirman
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
July 30, 2025 at 10:20 AM
📢 Dear lovers of prokaryotic chromosomes:
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Registration for the Biology & Physics of Chromosomes meeting has been extended until 7 August ⏳.
Join us!
@biophychrom.bsky.social
@danielabarilla.bsky.social
@damelab.bsky.social
@graingerlab.bsky.social
@biochemsoc.bsky.social
#microsky
Reposted by Dvir Schirman
Just few days left to register for this chromosome biology fête! 🧬🧬🧬
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
July 14, 2025 at 12:47 PM
Just few days left to register for this chromosome biology fête! 🧬🧬🧬
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
⏳📆 16 July
www.eventsforce.net/biochemsoc/f...
@vslioy.bsky.social @damelab.bsky.social @graingerlab.bsky.social @biochemsoc.bsky.social @biophychrom.bsky.social
"A missile attack is not going to hold back science, science is held back by itself" 🤣
youtube.com/shorts/FMOi-...
youtube.com/shorts/FMOi-...
couldn't complete the assignment, my lab was destroyed | אין מעבדה, תרקדו עכשיו עם כתוביות
YouTube video by Shahar Halevi | שחר הלוי
youtube.com
June 19, 2025 at 1:55 PM
"A missile attack is not going to hold back science, science is held back by itself" 🤣
youtube.com/shorts/FMOi-...
youtube.com/shorts/FMOi-...
This is how you revolutionize science 🕺
#TCTeAC
#TCTeAC
@odedrechavi.bsky.social says he wants to change science for the better.
How? I’m still not quite sure. But 1.5 days into #TCTeAC, the plan seems to involve, among other things, walk-up songs, jumping, dancing, and a hefty serving of joy.
How? I’m still not quite sure. But 1.5 days into #TCTeAC, the plan seems to involve, among other things, walk-up songs, jumping, dancing, and a hefty serving of joy.
June 11, 2025 at 1:46 PM
This is how you revolutionize science 🕺
#TCTeAC
#TCTeAC
🔬
#TCTeAC brought more stickers for day2, find the girl with the lipstick 💄 to get yours! 😉
June 11, 2025 at 8:07 AM
🔬
Reposted by Dvir Schirman
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 7:45 AM
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Reposted by Dvir Schirman
There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do.
woodstock.img.cas.cz Only 40 spots left!
woodstock.img.cas.cz Only 40 spots left!
April 10, 2025 at 1:20 AM
There's a lot of joy in doing science and Woodstock Night Science (June 10-13 in Prague) will be a celebration of the science that we know and love. Many exciting talks & innovations that will push the boundaries of what a scientific conference can really do.
woodstock.img.cas.cz Only 40 spots left!
woodstock.img.cas.cz Only 40 spots left!
Reposted by Dvir Schirman
Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy!
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Live Cell Imaging of Bacillus subtilis and Streptococcus pneumoniae using Automated Time-lapse Microscopy
42.1K Views. University of Groningen. This protocol provides a step-by-step procedure to monitor single cell behavior of different bacteria in time using automated fluorescence time-lapse microscopy....
www.jove.com
April 8, 2025 at 1:26 PM
Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy!
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Thermo are planning to discontinue these in September but have indicated they will look into this further.
If I make list of labs using them Thermo might not kill the product
Please RT🔬🦠
Reposted by Dvir Schirman
We are looking for a postdoc with microbiology background for #superresolution #singlemolecule #ERC tracking project. Apply by 27.4.2025. 🦠🔬🧫
Pls share!
www.aalto.fi/en/open-posi...
Pls share!
www.aalto.fi/en/open-posi...
April 1, 2025 at 7:30 AM
We are looking for a postdoc with microbiology background for #superresolution #singlemolecule #ERC tracking project. Apply by 27.4.2025. 🦠🔬🧫
Pls share!
www.aalto.fi/en/open-posi...
Pls share!
www.aalto.fi/en/open-posi...
Reposted by Dvir Schirman
New on #biorXiv: 'Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics'. A theory-experiment collaboration, led by @mariandm.bsky.social + Ran Tahan w/the Lindell group at Technion (and yes, I am excited).
a 🧵
www.biorxiv.org/contenat/10....
a 🧵
www.biorxiv.org/contenat/10....
March 26, 2025 at 2:29 PM
New on #biorXiv: 'Inferring single-cell heterogeneity of bacteriophage life-history traits from population-scale dynamics'. A theory-experiment collaboration, led by @mariandm.bsky.social + Ran Tahan w/the Lindell group at Technion (and yes, I am excited).
a 🧵
www.biorxiv.org/contenat/10....
a 🧵
www.biorxiv.org/contenat/10....
Reposted by Dvir Schirman
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Genome duplication in a long-term multicellularity evolution experiment - Nature
In the Multicellularity Long Term Evolution Experiment, diploid yeast evolve to be tetraploid under selection for larger multicellular size, revealing how whole-genome duplication can arise due to its...
www.nature.com
March 5, 2025 at 11:00 PM
1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dvir Schirman
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
February 8, 2025 at 9:21 PM
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.
Reposted by Dvir Schirman
Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
January 30, 2025 at 8:42 PM
Hi folks, I'm excited to share a whale of a tale (sorry, bad pun), where we engineer snowflake yeast to express sperm whale myoglobin, and explore how oxygen-binding proteins may have helped overcome anatomical limitations to early multicellularity. 🧪 #MEvoSky
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Reposted by Dvir Schirman
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria
Single-cell decisions made in complex environments underlie many bacterial phenomena. Image-based transcriptomics approaches offer an avenue to study such behaviors, yet these approaches have been hin...
www.science.org
January 24, 2025 at 4:30 AM
This week @science.org Sarfatis, Moffitt et al. from @bostonchildrens.bsky.social @harvardmed.bsky.social @broadinstitute.org
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Highly multiplexed spatial transcriptomics in bacteria | Science www.science.org/doi/10.1126/...
#microsky #microbial #microbiology #genomics
#transcriptomic 🦠🧫
Reposted by Dvir Schirman
If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
January 21, 2025 at 7:49 PM
If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
Reposted by Dvir Schirman
We are excited to announce that the call for the new SciLifeLab PULSE postdoctoral program is now open!
This unique program invites talented researchers to propose individually designed projects see : www.scilifelab.se/research/pul.... The deadline for applications is March 31, 2025.
PULSE
SciLifeLab PULSE: Program for Future Leaders in Life Science SciLifeLab PULSE is a comprehensive postdoctoral program, that will train 48 future leaders in life sciences. PULSE focuses on innovative, ...
www.scilifelab.se
January 7, 2025 at 2:46 PM
We are excited to announce that the call for the new SciLifeLab PULSE postdoctoral program is now open!
This unique program invites talented researchers to propose individually designed projects see : www.scilifelab.se/research/pul.... The deadline for applications is March 31, 2025.
Reposted by Dvir Schirman
We are seeking a motivated postdoc to join our lab! Our research focuses on live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions.
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Interested? Please DM me!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Interested? Please DM me!
November 30, 2024 at 12:32 PM
We are seeking a motivated postdoc to join our lab! Our research focuses on live-cell imaging/analysis to reveal how chromatin behaves in living cells and how its behavior contributes to cellular functions.
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Interested? Please DM me!
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Interested? Please DM me!
Reposted by Dvir Schirman
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues - Nature Biotechnology
Chromatin organization is measured in single cells using droplet microfluidics.
www.nature.com
November 19, 2024 at 1:24 PM
Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Dvir Schirman
New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL
November 14, 2024 at 8:43 AM
New conference that will explore gene regulation mechanisms at molecular resolution. We bring bring together a fine crowd that uses microscopy, genomics and theory to chart the future of the booming fields of #singlemoleculegenomics and #singlemoleculemicroscopy. Join us July 15-18th 2025 at EMBL
I’m excited to share the first preprint from my postdoc at
@johan_elf_
lab together with Konrad Gras. 🧬🦠
biorxiv.org/content/10.1...
(1/14)
@johan_elf_
lab together with Konrad Gras. 🧬🦠
biorxiv.org/content/10.1...
(1/14)
A dynamic 3D polymer model of the Escherichia coli chromosome driven by data from optical pooled screening
The DNA of bacterial cells is organized in a highly dynamic chromosome structure. To guarantee its propagation, the chromosome must replicate, segregate, and accommodate other biological processes lik...
biorxiv.org
November 12, 2024 at 1:34 PM
I’m excited to share the first preprint from my postdoc at
@johan_elf_
lab together with Konrad Gras. 🧬🦠
biorxiv.org/content/10.1...
(1/14)
@johan_elf_
lab together with Konrad Gras. 🧬🦠
biorxiv.org/content/10.1...
(1/14)
Reposted by Dvir Schirman
Thinking about moving (now more than ever?): Here’s a great postdoc funding opportunity if you’d like to join the academic community in Sweden. Happy to act as your host lab, if you’re interested in evolution and genomics in yeast
www.scilifelab.se/research/pul...
www.scilifelab.se/research/pul...
About the PULSE program
About the PULSE program PULSE builds upon and further leverages the unique SciLifeLab community, fostering excellence in biology-, technology-, and data-driven research. The program emphasises key res...
www.scilifelab.se
November 6, 2024 at 2:20 PM
Thinking about moving (now more than ever?): Here’s a great postdoc funding opportunity if you’d like to join the academic community in Sweden. Happy to act as your host lab, if you’re interested in evolution and genomics in yeast
www.scilifelab.se/research/pul...
www.scilifelab.se/research/pul...