Daniel Fisch
@danielhfisch.bsky.social
Postdoc in the Kagan lab at Boston Children's Hospital, Innate Immunology, Macrophages & Toll-Like Receptors 🔬👨🔬
Reposted by Daniel Fisch
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
November 10, 2025 at 9:17 PM
Truncating RELA variants drive autoinflammation and autoimmunity by impairing the negative feedback control of NF-kB https://www.biorxiv.org/content/10.1101/2025.11.09.687461v1
Reposted by Daniel Fisch
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation | The EMBO Journal
imageimageDNGR-1 (CLEC9A) is a C-type lectin receptor of type-1 conventional dendritic cells (cDC1s) with an important role in cross-presentation of dead cell antigens. This study explores how it equips cDC1s with the ability to cross-present such ...
www.embopress.org
November 3, 2025 at 5:23 PM
Delighted that this study is finally out @embojournal.org. A detailed analysis of how DNGR-1/CLEC9A signals to promote cross-presentation of dead cell-associated antigens yet does not activate dendritic cells.
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Reposted by Daniel Fisch
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Applications for MCSA are up 64%! 50% now come from outside the EU. Trump effect?
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
The European Research market just got a hell of a lot more crowded.
EU should turn on the tap
marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
MSCA Postdoctoral Fellowships 2025 receives record number of 17,058 proposals
This year’s annual MSCA Postdoctoral Fellowships call has attracted considerable interest from the research community with 17,058 proposals submitted.
marie-sklodowska-curie-actions.ec.europa.eu
November 3, 2025 at 8:24 AM
Europe's MSCA postdoctoral fellowships are now attracting many researchers who would have gone to the US. So the payline has dropped below 10% (~1,600 fellowships to 17k applicants). Super tough situation. One more reason to double the next Horizon budget, as proposed by the EU Commission.
Reposted by Daniel Fisch
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
November 1, 2025 at 12:41 PM
🥳 Today marks the start of the lab of former postdoc @florianwollweber.bsky.social at @embl.org Grenoble!
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
www.embl.org/groups/wollw...
Florian-- we will miss you dearly and wish you much success!
With us, Florian applied multiscale imaging 🔬to Asgard archaea ...👇
Reposted by Daniel Fisch
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3.
Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, know...
www.biorxiv.org
October 31, 2025 at 3:49 PM
#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇
Reposted by Daniel Fisch
Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
Research Assistant I, Pharmacology
Click the link provided to see the complete job description.
utsw.taleo.net
October 16, 2025 at 4:25 PM
Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
Reposted by Daniel Fisch
What's in yer basement?
October 15, 2025 at 7:21 PM
What's in yer basement?
Reposted by Daniel Fisch
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
September 28, 2025 at 10:36 AM
📢A new effector-triggered immunity role for GBP1! No place for pathogens to hide now that GBP1 can detect extracellular pathogens that hijack the actin cytoskeleton. Surprise*suprise* GBP1 does this independently of LPS! 🧵
biorxiv.org/content/10.1...
biorxiv.org/content/10.1...
Reposted by Daniel Fisch
meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
www.biorxiv.org
September 26, 2025 at 2:02 PM
meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Daniel Fisch
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
Wall teichoic acid is required for DNA-triggered innate immune receptor activation by Staphylococcus aureus
Receptors that stimulate inflammation are commonly activated by ligands that are buried within microbial cells. The mechanisms that facilitate immunostimulatory ligand release from microbes during inf...
www.biorxiv.org
September 26, 2025 at 11:31 AM
Thrilled to share my work from the @jkagan1.bsky.social lab!
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
TLDR: O-acetylation and wall teichoic acid compete for space on S. aureus peptidoglycan. This competition regulates DNA release, and thus immune receptor activation, during infection!
www.biorxiv.org/content/10.1...
#microsky #immunosky
Reposted by Daniel Fisch
Tools:
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...
Real-time visualization of STAT activation in live cells using genetically encoded biosensors - Nature Chemical Biology
The signal transducer and activator of transcription (STAT) family proteins are attractive drug targets but tools to monitor their activation are lacking. Now, STAT biosensors have been developed for ...
www.nature.com
September 7, 2025 at 11:27 AM
Tools:
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...
"Here, we developed a class of highly sensitive genetically encoded STAT biosensors, termed STATeLights, which allowed direct and continuous detection of STAT activity in live cells with high spatiotemporal resolution."
www.nature.com/articles/s41...
Reposted by Daniel Fisch
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/...
#Inflammasome
#Inflammasome
September 2, 2025 at 4:22 PM
So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.
Reposted by Daniel Fisch
Guilty as charged.
August 20, 2025 at 7:03 PM
Guilty as charged.
Reposted by Daniel Fisch
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
August 21, 2025 at 3:20 PM
#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...
Reposted by Daniel Fisch
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
July 3, 2025 at 3:39 PM
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
Reposted by Daniel Fisch
Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
August 12, 2025 at 7:10 PM
Divergent TIR signaling domains in TLR7 and TLR9 control opposing effects on systemic autoimmunity @jclinical-invest.bsky.social
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Reposted by Daniel Fisch
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Oxidized phospholipid damage signals as modulators of immunity | Open Biology
Damage-associated molecular patterns (DAMPs) are self-derived molecules released during
tissue damage that influence immune responses. Phospholipids, essential to cell membranes
and lung surfactants, ...
royalsocietypublishing.org
July 30, 2025 at 1:28 PM
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Kudos to Joon Choi for his exceptional work.
royalsocietypublishing.org/doi/10.1098/...
Reposted by Daniel Fisch
Zotero has changed my life for the better. What a marvelous piece of software.
July 27, 2025 at 7:12 PM
Zotero has changed my life for the better. What a marvelous piece of software.
Reposted by Daniel Fisch
MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
MyD88 polymerization and association to cellular membranes in a yeast heterologous model - Cellular and Molecular Life Sciences
MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs). Structurally, MyD88 consists...
link.springer.com
July 26, 2025 at 1:27 PM
MyD88 cell biology explored in yeast. The fantastic @VictorJCid
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast.
Kudos to all authors on this exciting finding.
link.springer.com/article/10.1...
Fantastic three days of science at #HFSPmtg25! Thank you @hfspo.bsky.social for hosting us in Melbourne!
July 11, 2025 at 11:26 AM
Fantastic three days of science at #HFSPmtg25! Thank you @hfspo.bsky.social for hosting us in Melbourne!
Reposted by Daniel Fisch
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
July 10, 2025 at 8:34 AM
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!
July 7, 2025 at 10:13 PM
Thank you @inflammasomelab.bsky.social and @s-burgener.bsky.social for the invitation to visit the IMB@UQ in Brisbane! I had a fantastic time presenting my postdoc work in the Kagan lab (@jkagan1.bsky.social) and talking science!
Thank you @embo.org for a fantastic Fellows’ Meeting 2025. So much amazing science and brilliant young scientists gathered in one place really gives back hope for the future of biomedical research! 🔬🧪
June 30, 2025 at 1:34 PM
Thank you @embo.org for a fantastic Fellows’ Meeting 2025. So much amazing science and brilliant young scientists gathered in one place really gives back hope for the future of biomedical research! 🔬🧪
A huge thank you to @cibss.bsky.social and @uni-freiburg.de for hosting me today on my visit back to where my science journey started! What a fun day filled with great scientific discussions 😁
Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k
June 24, 2025 at 4:00 PM
A huge thank you to @cibss.bsky.social and @uni-freiburg.de for hosting me today on my visit back to where my science journey started! What a fun day filled with great scientific discussions 😁
Reposted by Daniel Fisch
Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k
June 18, 2025 at 7:51 AM
Save the date for next week's #CIBSS seminar with Dr. Daniel Fisch (@danielhfisch.bsky.social) from the @bostonchildrens.bsky.social on "Microbial Sensing in Innate Immunity"!
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k
📅 Tue, June 24, 2025 · 12:00–13:00
📍 Inst. of Biology I, Hauptstr. 1 + livestream
More info: kurzlinks.de/y41k