Nils Burger
@nilsburger.bsky.social
Assistant Professor at UTSW Medical Center
Postdoc Chouchani Lab at Dana-Farber Cancer Institute and Harvard Medical School | PhD University of Cambridge - Murphy Lab MRC Mitochondrial Biology Unit
Postdoc Chouchani Lab at Dana-Farber Cancer Institute and Harvard Medical School | PhD University of Cambridge - Murphy Lab MRC Mitochondrial Biology Unit
Pinned
Nils Burger
@nilsburger.bsky.social
· Dec 31
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
Research Assistant I, Pharmacology
Click the link provided to see the complete job description.
utsw.taleo.net
October 16, 2025 at 4:25 PM
Excited to share that we are hiring a research assistant for my lab at UTSW in Dallas (www.nils-burger-lab.com). Please share with your mentees.
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
utsw.taleo.net/careersectio...
We are also looking for motivated, curious, and enthusiastic postdoctoral fellows!
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
October 1, 2025 at 1:23 PM
Excited to share that I’ve started my lab as an assistant professor at the University of Texas Southwestern Medical Center in Dallas.
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
Thank you to all the mentors, friends, and colleagues who have supported me throughout the years!
Reposted by Nils Burger
We are seeking a life science research professional/technician (medcareers.stanford.edu/job/stanford...) and a postdoctoral fellow(postdocs.stanford.edu/prospective/...). If you are interested in using mass spec and machine learning to understand protein function and druggability please reach out!
September 18, 2025 at 5:00 AM
We are seeking a life science research professional/technician (medcareers.stanford.edu/job/stanford...) and a postdoctoral fellow(postdocs.stanford.edu/prospective/...). If you are interested in using mass spec and machine learning to understand protein function and druggability please reach out!
Fantastic story by Haopeng Xiao, the Chouchani Lab, and collaborators. Happy I could be a part of it!
We developed a MS and machine learning approach to globally identify protein regulators of metabolism. We found protein LRRC58 controls cellular cysteine catabolism by mediating degradation of CDO1, the rate-limiting enzyme of the catabolic cysteine shunt to taurine. www.nature.com/articles/s41...
Covariation MS uncovers a protein that controls cysteine catabolism - Nature
A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.
www.nature.com
September 18, 2025 at 12:04 PM
Fantastic story by Haopeng Xiao, the Chouchani Lab, and collaborators. Happy I could be a part of it!
Reposted by Nils Burger
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
Postdoctoral Researcher (Ph.D./Dr. rer. nat., m/f/div., E13 TV-L, 100%) - Deutsches Diabetes-Zentrum (DDZ)
Institut für Klinische Biochemie und Pathobiochemie (Direktor: Univ.-Prof. Dr. rer. nat. Hadi Al-Hasani), Nachwuchsforschungsgruppe Crosstalk (Leiterin: Melanie Mittenbühler, Dr.) (25019)
ddz.de
July 30, 2025 at 10:53 AM
‼️ We're looking for a postdoc to join our team starting January 1st, 2026! ‼️
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
Are you curious about how exercise promotes positive changes at the molecular level in obesity and diabetes? If so, consider applying or reach out with any questions.
ddz.de/job/postdoct...
ddz.de/en/research/...
Reposted by Nils Burger
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 11:21 AM
🎉Excited to share our latest paper, published in Nature Communications!🎉
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
"Enhancing autophagy by redox regulation extends lifespan in Drosophila"
#redox #metabolism #ageing #Drosophila
@natcomms.nature.com @mrc-lms.bsky.social
doi.org/10.1038/s414...
Reposted by Nils Burger
Important new paper in Nature from Gero Miesenböck's lab showing that the accumulation of lipid peroxidation products from mitochondrial ROS production leads in sleep.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Sleep pressure accumulates in a voltage-gated lipid peroxidation memory - Nature
Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...
doi.org
April 9, 2025 at 8:11 AM
Important new paper in Nature from Gero Miesenböck's lab showing that the accumulation of lipid peroxidation products from mitochondrial ROS production leads in sleep.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by Nils Burger
Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social
Thanks to everyone involved!
www.cell.com/cell-metabol...
Thanks to everyone involved!
www.cell.com/cell-metabol...
February 17, 2025 at 5:33 PM
Our paper showing that ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST is now published @cp-cellmetabolism.bsky.social
Thanks to everyone involved!
www.cell.com/cell-metabol...
Thanks to everyone involved!
www.cell.com/cell-metabol...
Reposted by Nils Burger
Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf!
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
Doctoral Student (PhD/Dr. rer. nat., m/f/div., E13 TV-L 65%) - Deutsches Diabetes-Zentrum (DDZ)
A job-opening of the German Diabetes-Center (DDZ). (24681)
ddz.de
February 13, 2025 at 9:11 AM
Very happy to share that my research group has launched at the German Diabetes Center (DDZ) in Düsseldorf!
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
We're looking for a PhD student to study the effects of inter-tissue communication on energy balance and metabolic health. Interested? Get in touch!
ddz.de/en/job/docto...
Reposted by Nils Burger
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses[1][1]–[6][2], but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we a...
www.biorxiv.org
January 10, 2025 at 7:45 AM
1/🧵for our latest research now out as a preprint on #biorxiv, led by @EloiseMLMrqs 💫
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
**An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo**
#mitochondria #immunometabolism #macrophages
📄Read here: www.biorxiv.org/content/10.1...
Reposted by Nils Burger
New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ
January 17, 2025 at 11:16 AM
New studies from our lab by Tevis Vitale and Jason Liang in @naturecancer.bsky.social Selective deficiency of complex I subunits causes tumor immunogenicity via T cell surveillance and Immune Checkpoint Blockade responsiveness Collaboration with Widlund, Gygi and Wucherpfennig labs rdcu.be/d6BgJ
Reposted by Nils Burger
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo
Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses, but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this q...
www.biorxiv.org
January 6, 2025 at 9:34 AM
📢Preprint alert! Very excited to share the first preprint from the lab spearheaded by stellar postdoc Eloïse Marques. An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and in vivo. 1/n
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Nils Burger
Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders
New article by @platorremuro.bsky.social published in @naturecellbiology.bsky.social Chaperone-mediated insertion of mitochondrial import receptor TOM70 protects against diet-induced obesity- With Kajimura, Gygi and Eck labs @danafarber.bsky.social @harvardcellbio.bsky.social
rdcu.be/d5ptF
rdcu.be/d5ptF
January 3, 2025 at 3:29 PM
Very excited to start 2025 sharing our latest work @ppuigserverb.bsky.social published in @naturecellbiology.bsky.social! We have shown that the cytosolic chaperone PPID/CYP40 inserts TOM70, connecting chaperones and mitochondrial protein biogenesis to the development of chronic metabolic disorders
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...
The human zinc-binding cysteine proteome
A deep mapping of the human zinc-binding cysteine proteome (ZnCPT) defines thousands of zinc-binding protein cysteines across major domains of biology and discovers glutathione reductase as zinc-targetable cancer vulnerability.
www.cell.com
December 31, 2024 at 4:21 PM
Thrilled to share our new paper @Chouchani Lab in Cell; what a great way to end this year! We establish a deep mapping of the zinc-binding human cysteine proteome (ZnCPT) and discover glutathione reductase as zinc-targetable cancer vulnerability. www.cell.com/cell/fulltex...