Mike Murphy
@mitoredox.bsky.social
Our lab is interested in all things mitochondrial.
Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms
January 6, 2026 at 9:55 AM
Congrats to Jan whose new paper on persulfide measurement is is out now in Nature Comms
Christmas in the lab....
December 16, 2025 at 2:35 PM
Christmas in the lab....
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research
Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...
doi.org
December 15, 2025 at 11:07 AM
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.
doi.org/10.1038/s441...
doi.org/10.1038/s441...
Congrats to Emma Yu on her new paper on Tafazzin!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models - Nature Communications
Atherosclerosis is the leading cause of death worldwide. Here, the authors show that defective vascular smooth muscle cell tafazzin promotes mitochondrial dysfunction and atherosclerosis, highlighting...
doi.org
December 5, 2025 at 1:06 PM
Congrats to Emma Yu on her new paper on Tafazzin!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Pleased to be a small part of a recent paper led by Thiru Kanneganti at St Judes
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis
Wang et al. identify a new lytic cell death pathway, mitoxyperilysis, triggered by
the synergy of innate immune activation and metabolic stress. This process is regulated
by mTORC2 and involves persis...
www.cell.com
December 4, 2025 at 10:35 AM
Pleased to be a small part of a recent paper led by Thiru Kanneganti at St Judes
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Congrats to Kath Hammond who was awarded a short talk prize at the recent WT "Mitochondrial medicine: therapeutic development" meeting at Hinxton.
November 17, 2025 at 4:31 PM
Congrats to Kath Hammond who was awarded a short talk prize at the recent WT "Mitochondrial medicine: therapeutic development" meeting at Hinxton.
Reposted by Mike Murphy
Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social
October 20, 2025 at 1:58 PM
Excited to share that at the annual MRC MBU symposium I was awarded best poster prize for my PhD project on Succinate Metabolism in Cardiac Ischemia/ Reperfusion Injury! Thanks to my lab, collaborators, and my PI Mike Murphy. @mitoredox.bsky.social
Drs Cherrie Kong and Stephen Harmer (University of Bristol) are offering a fully funded PhD project, "
For information and to apply: www.findaphd.com/phds/project....
For information including application preparation: cherrie.kong@bristol.ac.uk
Application deadline: 15 December 2025
For information and to apply: www.findaphd.com/phds/project....
For information including application preparation: cherrie.kong@bristol.ac.uk
Application deadline: 15 December 2025
Understanding and slowing transverse tubule loss in heart failure at University of Bristol on FindAPhD.com
PhD Project - Understanding and slowing transverse tubule loss in heart failure at University of Bristol, listed on FindAPhD.com
www.findaphd.com
October 18, 2025 at 10:08 AM
Drs Cherrie Kong and Stephen Harmer (University of Bristol) are offering a fully funded PhD project, "
For information and to apply: www.findaphd.com/phds/project....
For information including application preparation: cherrie.kong@bristol.ac.uk
Application deadline: 15 December 2025
For information and to apply: www.findaphd.com/phds/project....
For information including application preparation: cherrie.kong@bristol.ac.uk
Application deadline: 15 December 2025
Congrats to Nils Burger who is just starting his lab at UTSW in Texas! Any prospective PhD students or post-docs should get in touch with Nils.
www.nils-burger-lab.com
www.nils-burger-lab.com
Burger Lab @ UTSW
The Burger Lab
Defining the metabolite protein regulome
www.nils-burger-lab.com
October 13, 2025 at 8:28 AM
Congrats to Nils Burger who is just starting his lab at UTSW in Texas! Any prospective PhD students or post-docs should get in touch with Nils.
www.nils-burger-lab.com
www.nils-burger-lab.com
In Toronto today giving a seminar at the Sick Kids Research Institute on "Mitochondria in Ischemia-Reperfusion Injury: From Basic Science to Potential Therapies"
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.
September 29, 2025 at 12:16 PM
In Toronto today giving a seminar at the Sick Kids Research Institute on "Mitochondria in Ischemia-Reperfusion Injury: From Basic Science to Potential Therapies"
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.
Great to catch up with previous lab member now in Toronto - Thomas Hurd, Ellen Robb and Anna Dare.
Great to see this paper out - another Krieg/Murphy collaboration - and congratulations to Jordan Lee who did most of the work!
academic.oup.com/cardiovascre...
academic.oup.com/cardiovascre...
Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke
AbstractAims. Ischemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischemic tissue,
academic.oup.com
August 14, 2025 at 6:39 PM
Great to see this paper out - another Krieg/Murphy collaboration - and congratulations to Jordan Lee who did most of the work!
academic.oup.com/cardiovascre...
academic.oup.com/cardiovascre...
Great to see Hiran Prag setting up his lab at the University of Manchester - I'm expecting great things!
personalpages.manchester.ac.uk/staff/hiran....
personalpages.manchester.ac.uk/staff/hiran....
Prag Lab - Coming Soon
personalpages.manchester.ac.uk
August 13, 2025 at 7:58 PM
Great to see Hiran Prag setting up his lab at the University of Manchester - I'm expecting great things!
personalpages.manchester.ac.uk/staff/hiran....
personalpages.manchester.ac.uk/staff/hiran....
It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
Mitochondrial Donation and Preimplantation Genetic Testing for mtDNA Disease | NEJM
Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by pronuc...
www.nejm.org
July 17, 2025 at 7:07 AM
It was wonderful to see the NEJM paper today about healthy babies born free of mtDNA disease following mitochondrial donation. Built on decades of work led by Doug Turnbull and his team in Newcastle.
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
It was a great pleasure to attend last week Professor Dunja Aksentijevic's inaugural Professorial Lecture at Queen Mary, University of London. Dunja, it's just the start!
July 17, 2025 at 7:02 AM
It was a great pleasure to attend last week Professor Dunja Aksentijevic's inaugural Professorial Lecture at Queen Mary, University of London. Dunja, it's just the start!
Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications
Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...
doi.org
June 27, 2025 at 12:32 PM
Congrats to Helena Cocheme @cochemelab.bsky.social on her paper on redox regulation of autophagy in Drosophila.
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Good day yesterday at the William Harvey Research Institute Research Day where I was honoured to receive the Derek Willoughby Medal and give a lecture. Great hospitality from Dunja Aksentijevic and Sir Mark Caulfield.
June 26, 2025 at 4:01 PM
Good day yesterday at the William Harvey Research Institute Research Day where I was honoured to receive the Derek Willoughby Medal and give a lecture. Great hospitality from Dunja Aksentijevic and Sir Mark Caulfield.
Series of interesting papers showing that haematopoietic stem cells can undergo damaging clonal haematopoiesis when they acquire mutations that enhance mitochondrial respiration - opening the way to using metformin - and my beloved MitoQ - to prevent this transition.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis - Nature
Metformin may serve as a non-toxic intervention to inhibit mitochondrial metabolism and slow DNMT3A-R882 clonal haematopoiesis expansion, thus delaying or averting progression to acute myeloid le...
doi.org
June 14, 2025 at 9:50 AM
Series of interesting papers showing that haematopoietic stem cells can undergo damaging clonal haematopoiesis when they acquire mutations that enhance mitochondrial respiration - opening the way to using metformin - and my beloved MitoQ - to prevent this transition.
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Congrats to Dunja Aksienijevic on her latest paper!
June 9, 2025 at 8:55 AM
Congrats to Dunja Aksienijevic on her latest paper!
By the Atlantic in Galway at the SFRRI meeting - catching up with old friends and new.
www.sfrrgalway2025.com
www.sfrrgalway2025.com
22nd SFRRI Biennial Meeting I Galway I June 3-6, 2025
Information, Program, Registration, Abstract Submission for the 22nd SFRRI Biennial Meeting
www.sfrrgalway2025.com
June 4, 2025 at 8:40 AM
By the Atlantic in Galway at the SFRRI meeting - catching up with old friends and new.
www.sfrrgalway2025.com
www.sfrrgalway2025.com
Congrats to Renata Goncalves who led a study in Gokhan Hotamisligil's lab that has just come out in Nature - ably assisted by Jillian Riveros!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CoQ imbalance drives reverse electron transport to disrupt liver metabolism - Nature
Reverse electron transport is the mechanism behind excess mitochondrial reactive oxygen species in the livers of obese mice, which has implications for developing therapeutics for fatty liver dis...
www.nature.com
May 29, 2025 at 8:45 AM
Congrats to Renata Goncalves who led a study in Gokhan Hotamisligil's lab that has just come out in Nature - ably assisted by Jillian Riveros!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan.
Well done Abigail!
Well done Abigail!
May 24, 2025 at 9:28 AM
Congratulations to Abigail Giles who was awarded the "The Richard J. Bing Award for Young Investigators" at the recent World Congress of the International Society For Heart Research in Japan.
Well done Abigail!
Well done Abigail!
Congratulations to @clarebryant.bsky.social on her election to the Academy of Medical Sciences!
May 22, 2025 at 6:20 PM
Congratulations to @clarebryant.bsky.social on her election to the Academy of Medical Sciences!
Reposted by Mike Murphy
Delighted that our work describing a potential novel treatment approach for B-cell Acute Lymphoblastic Leukaemia is published today in @natcomms.nature.com. 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition - Nature Communications
CREBBP mutations in B-cell acute lymphoblastic leukemia (B-ALL) are linked to poor prognosis and chemoresistance. Here, the authors show that genetic or pharmacological inactivation of CREBBP sensitiz...
www.nature.com
May 20, 2025 at 9:34 AM
Delighted that our work describing a potential novel treatment approach for B-cell Acute Lymphoblastic Leukaemia is published today in @natcomms.nature.com. 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...