Mike Murphy
LightNews LightNews
mitoredox.bsky.social
Mike Murphy
@mitoredox.bsky.social
300 followers 4 following 37 posts
Our lab is interested in all things mitochondrial.
Posts Replies Media Videos
mitoredox.bsky.social
doi.org/10.1038/s414...
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis - Nature Communications
Clonal hematopoiesis is driven by the selective advantage of mutant hematopoietic stem cells. Here, authors discover that elevated mitochondrial activity is a targetable mechanism by which mutant hema...
doi.org
June 14, 2025 at 9:50 AM
mitoredox.bsky.social
doi.org/10.1038/s415...
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs - Nature
Dnmt3a mutations in mouse haematopoietic stem and progenitor cells equivalent to R882 mutations in human cause increased mitochondrial respiration, suggesting that this is a mechanism of clonal h...
doi.org
June 14, 2025 at 9:50 AM
mitoredox.bsky.social
Shows convincingly that that obesity increases mitochondrial ROS by RET in the liver in vivo to drive insulin resistance. This is proposed to be due to defects in CoQ biosynthesis - some fascinating findings here that will take time to explore by the community.
May 29, 2025 at 8:45 AM