High-content protein arrays were used to identify cysteine dioxygenase (CDO1) as a small-molecule glue target for the von Hippel–Lindau (VHL) E3 ubiquitin ligase and induces VHL-dependent proteasomal ...

Synthetic peptide fixes biomolecular condensates, revealing how these enigmatic cell structures actually work.

Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

Nature Reviews Genetics, Published online: 28 May 2025; doi:10.1038/s41576-025-00860-zIn this Tools of the Trade article, Jun Kim and Zhe Liu describe cycleHCR, a method that enables researchers to simultaneously detect several different RNA and protein molecules at high-resolution across tissues.

Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress responses, and by unexpectedly depleting coenzyme A, leading to metabolic inefficiency.

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Quality assurance of segmentation results - Bio-image Analysis with Napari

Nature Reviews Genetics, Published online: 20 May 2025; doi:10.1038/s41576-025-00850-1Synonymous mutations, once deemed neutral, have been shown to influence gene expression and organismal fitness by affecting transcription, mRNA processing, translation and protein folding. In this Perspective, the authors highlight evidence for fitness effects of synonymous mutations and discuss resulting implications for evolutionary and disease genetics.

Background Enhanced glycolysis plays a pivotal role in fueling the aberrant proliferation, survival and therapy resistance of acute myeloid leukemia (AML) cells. Here, we aimed to elucidate the extent...

Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

Acceptable image-editing practices are partly a matter of common sense. But researchers say journals and funders could help scientists by standardizing policies.

La administración colonial francesa puso en marcha en 1855 un centro educativo que tenía el objetivo de formar a los hijos de los reyes locales mediante el borrado de su cultura.

Nature Metabolism, Published online: 15 April 2025; doi:10.1038/s42255-025-01264-3Anxiety-like behaviour in mice, as a result of psychological stress, is shown to be mediated by GDF15 release in response to adipose tissue lipolysis.

Light sheet microscopy with curved light sheets enables tiling-free imaging of an entire intact cleared mouse brain with lateral and axial spatial resolutions of 1.0 μm and 2.5 μm, respectively, in le...

In recent decades, Spain has often been painted as the only European country without a far right. But even in the 1990s, violent street movements were building their forces — and now they’re entering ...

A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments in the mouse brain.