Brett Garabedian
@brettgarabedian.bsky.social
PhD w Jim Paulson at Scripps Research | Building immune therapies aimed at cancer’s sweet spot 🍭 #glycotime | Dabbling in protein degraders #TPD 🎯
Pinned
Targeting Sialidase to PD1 Enhances T cell Function and Tumor Control
Immune therapies targeting the PD1 axis have transformed outcomes in cancer treatment by enhancing T cell-mediated immune responses. However, many tumors evade immune clearance through orthogonal esca...
pubs.acs.org
🔥 HOT OFF THE PRESS 🔥
Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime
pubs.acs.org/doi/full/10....
Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime
pubs.acs.org/doi/full/10....
Reposted by Brett Garabedian
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
November 14, 2025 at 3:39 AM
Ms4a7 expression in cDC1s determines cross-presentation and antitumor immunity
www.science.org/doi/10.1126/... @science.org
www.science.org/doi/10.1126/... @science.org
Reposted by Brett Garabedian
In decades to come, we will look back at 2025 - following the most devastating pandemic in a century - as the year we turned back hard-earned progress on combating infectious diseases.
That means the comeback of preventable diseases. And the emergence of new ones.
www.science.org/content/arti...
That means the comeback of preventable diseases. And the emergence of new ones.
www.science.org/content/arti...
The Trump administration is dismantling efforts to fight the next pandemic
A retreat from investments in drugs and vaccines leaves U.S. less prepared for the next viral scourge, experts warn
www.science.org
November 13, 2025 at 10:06 PM
In decades to come, we will look back at 2025 - following the most devastating pandemic in a century - as the year we turned back hard-earned progress on combating infectious diseases.
That means the comeback of preventable diseases. And the emergence of new ones.
www.science.org/content/arti...
That means the comeback of preventable diseases. And the emergence of new ones.
www.science.org/content/arti...
Reposted by Brett Garabedian
This isn’t even the stuff they’re trying to actually stop from getting out.
November 12, 2025 at 10:59 PM
This isn’t even the stuff they’re trying to actually stop from getting out.
Reposted by Brett Garabedian
I recently gave a talk at Cornell and sat down with Dr. Leifer for her "Immune" podcast. I really enjoyed our wide-ranging conversation, from how I got started in science, how immunity shapes evolution, pandemic risk, and, the current state of US science.
🎧👇
podcasts.apple.com/us/podcast/v...
🎧👇
podcasts.apple.com/us/podcast/v...
Virus-immune Tug-of-war with Kristian Andersen
Podcast Episode · Immune · 11/11/2025 · 1h
podcasts.apple.com
November 13, 2025 at 12:23 AM
I recently gave a talk at Cornell and sat down with Dr. Leifer for her "Immune" podcast. I really enjoyed our wide-ranging conversation, from how I got started in science, how immunity shapes evolution, pandemic risk, and, the current state of US science.
🎧👇
podcasts.apple.com/us/podcast/v...
🎧👇
podcasts.apple.com/us/podcast/v...
Reposted by Brett Garabedian
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
An ultrasensitive and modular platform to detect Siglec ligands and control immune cell function
Siglec-liposomes are a multivalent and modular platform for profiling Siglec ligands and modulating immune cell function.
www.science.org
November 12, 2025 at 9:57 PM
Excited to share our laboratory's research tools to study Siglecs along with some interesting discoveries with these tools. Lot of help from many group, but @zeinab-jc.bsky.social was the major driver of this work. Please reach out if you would like to try them out. www.science.org/doi/10.1126/...
“Here, using a CRISPR–Cas9-based genome-wide knockout approach, we identify SIGLEC12 as a key mediator of necroptosis downstream of MLKL at the PMR step.” Non-sialic acid binding #Siglec #glycotime (?)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SIGLEC12 mediates plasma membrane rupture during necroptotic cell death - Nature
CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating its potential as a...
www.nature.com
November 12, 2025 at 7:22 PM
“Here, using a CRISPR–Cas9-based genome-wide knockout approach, we identify SIGLEC12 as a key mediator of necroptosis downstream of MLKL at the PMR step.” Non-sialic acid binding #Siglec #glycotime (?)
www.nature.com/articles/s41...
www.nature.com/articles/s41...
“ #CD33 …(Fig. 2D)… showed low variability in each individual throughout the longitudinal study, suggesting stable, subject-specific concentrations. “
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
A human pan-disease blood atlas of the circulating proteome
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of divers...
www.science.org
November 12, 2025 at 9:27 AM
“ #CD33 …(Fig. 2D)… showed low variability in each individual throughout the longitudinal study, suggesting stable, subject-specific concentrations. “
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Reposted by Brett Garabedian
“For those who believe the health system is controlled by a conspiracy, Holmes is a victim of Big Pharma. For biohacking enthusiasts into wearable devices, she was an early adopter. For mothers who see themselves as protectors, she is a mom who is trying to provide the best care for her family”
MAHA Is Embracing Elizabeth Holmes. Here’s Why.
An alliance is building between the Trump-aligned movement and convicted Theranos founder.
www.politico.com
November 11, 2025 at 9:17 PM
“For those who believe the health system is controlled by a conspiracy, Holmes is a victim of Big Pharma. For biohacking enthusiasts into wearable devices, she was an early adopter. For mothers who see themselves as protectors, she is a mom who is trying to provide the best care for her family”
Reposted by Brett Garabedian
Fun for the day ...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
November 11, 2025 at 1:53 PM
Fun for the day ...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
Increase of Inhibitory Siglec receptors on T cells mitigates severe immune reactions during acute viral infections
Abstract. Expression of inhibitory Siglec receptors has been described on T cells of patients with viral infection and cancer. However, the exact function
academic.oup.com
November 8, 2025 at 4:00 AM
#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
Reposted by Brett Garabedian
Hundreds of thousands of people, dead because of a decision made by the world's richest man
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 7, 2025 at 12:20 PM
Hundreds of thousands of people, dead because of a decision made by the world's richest man
“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
AbstractTumor-associated macrophages (TAM) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitati...
aacrjournals.org
November 6, 2025 at 3:52 AM
“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Reposted by Brett Garabedian
GAGs FTW! Wow #glycotime!! ⤵️🧪 🥳🥳
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 5, 2025 at 8:05 AM
GAGs FTW! Wow #glycotime!! ⤵️🧪 🥳🥳
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
Reposted by Brett Garabedian
My sixth literary child is born today (and already a best seller on Amazon). Get your copy: www.simonandschuster.com/books/Notes-...
November 4, 2025 at 2:16 PM
My sixth literary child is born today (and already a best seller on Amazon). Get your copy: www.simonandschuster.com/books/Notes-...
Amazing #glycotime immune research on display at GIA2025. Come join us at this free hybrid event and watch talk by some of the best in the field. Register here
We’re thrilled to introduce GIA2025 Trainee Invited Speaker Dr. Jim Paulson, Professor Emeritus in the Department of Immunology and Microbiology at The Scripps Research Institute in La Jolla, CA who’ll talk on the roles of inhibitory Siglecs in regulation of immune responses! #GIA2025 #glycotime
October 29, 2025 at 2:41 AM
Reposted by Brett Garabedian
I have a very bad feeling about this...
October 27, 2025 at 4:51 PM
I have a very bad feeling about this...
Reposted by Brett Garabedian
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 28, 2025 at 2:52 PM
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Brett Garabedian
Exercise intensity modulates the human plasma secretome and interorgan communication https://www.biorxiv.org/content/10.1101/2025.10.22.683699v1
October 23, 2025 at 10:02 PM
Exercise intensity modulates the human plasma secretome and interorgan communication https://www.biorxiv.org/content/10.1101/2025.10.22.683699v1
Reposted by Brett Garabedian
@cellcellpress.bsky.social spotlight
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
October 17, 2025 at 4:39 PM
@cellcellpress.bsky.social spotlight
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Reposted by Brett Garabedian
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
October 18, 2025 at 12:05 AM
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Reposted by Brett Garabedian
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Brett Garabedian
Just on time for my intro lecture on #glycotime in 3D ⤵️🎉
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News
UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.
news.ubc.ca
October 15, 2025 at 5:50 AM
Just on time for my intro lecture on #glycotime in 3D ⤵️🎉
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
Reposted by Brett Garabedian
Fake news
Is dark chocolate good for you?
"Sadly for chocoholics, the health claims for dark chocolate come from wishful thinking and sly marketing, not the findings of science."
Sorry
www.economist.com/science-and-...
"Sadly for chocoholics, the health claims for dark chocolate come from wishful thinking and sly marketing, not the findings of science."
Sorry
www.economist.com/science-and-...
Is dark chocolate actually healthy?
We assess whether that tempting idea is too good to be true
www.economist.com
October 9, 2025 at 4:08 PM
Fake news