The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions https://www.biorxiv.org/content/10.1101/2025.06.10.658867v1

Siglec-9 is an inhibitory receptor that tones down immune responses, in this case, blocking antigen presentation by the cells of the immune system. If this mutation is reverted to the pre-Omicron version antibody responses to Omicron increased by about 10-fold. Furthermore, when the mutation was...

The unique molecular recognition features of Siglec-10: structural insights into sialoglycan and antibody interactions https://www.biorxiv.org/content/10.1101/2025.06.10.658867v1

Bu şeker kaplı stromal hücrelere maruz kalan makrofajlar ve NK hücreleri, bağışıklık aktivitesini baskılayan bir reseptör olan Siglec-10'u daha fazla üretti ve tümörü saldırmak yerine inaktif veya "tolerant" hale geldi.

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer https://www.biorxiv.org/content/10.1101/2025.05.06.652455v1

Upon engagement with Siglec-9, antigen-presenting cells like macrophages have reduced function, and in mice, introducing this mutation into the delta spike protein (S375F) resulted in a ~10-fold drop in antibody titers. And reverting it with Omicron resulted in an ~10-fold increase in titers.

Stromal cell sialylation suppresses NK cell function through Siglec-10 engagement #glycotime www.biorxiv.org/content/10.1...

New research from our lab has been published! Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells: www.frontiersin.org/articles/10....

New work on the structure of Siglec-10. Great collaboration that was solidified with a visit to Spain last year with fantastic discussions with June Ereno-Orbea and Jesus Jimenez-Barbero. Nice contributions on modeling by @elisafadda.bsky.social.
www.biorxiv.org/content/10.1...

New fabulous #glycotime fresh off the bioRxiv press!⬇️ 🎉 In this brilliant team effort led by Klaudia Sobczak, Jesús Jimenez-Barbero, and June Ereño Orbea 🤩 with many contributions 🌍, we characterised the 3D structure + binding mechanism of sialosides by Siglec-10 🧵 1/3

doi.org/10.1101/2025...

When glycan recognition is linked to immune response, you need fine tuning! 😎

Here ⬇️ we show how human Siglecs act as molecular precision tools, recognising the glycan and also the biological environment (or context) these glycans are found in. A 1/5 #glycotime🧵 ⬇️

doi.org/10.1101/2025...

“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime

aacrjournals.org/cancerres/ar...

In our contribution, @silviadandrea.bsky.social and I looked at the binding of GT1b (Siglec-10 fav buddy), which is polysialylated and has a very fancy structure 😍 MD simulations show how *multiple Arg* contribute to the recognition and binding, providing an atomistic perspective to experiment ⬇️ 2/3

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer https://www.biorxiv.org/content/10.1101/2025.05.06.652455v1

Elbette, sonuçların laboratuvar ve hayvan modellerinden insanlara aktarılması gerekiyor, ancak sonuçlar çok umut verici.

Araştırmalar ayrıca ST6GALNAC6 ve Siglec-10'un umut verici yeni ilaç hedefleri olduğunu gösterdi.

#Siglec #SialicAcid #Glycotime

www.tandfonline.com/doi/full/10....