Brett Garabedian
@brettgarabedian.bsky.social
PhD w Jim Paulson at Scripps Research | Building immune therapies aimed at cancer’s sweet spot 🍭 #glycotime | Dabbling in protein degraders #TPD 🎯
Pinned
Targeting Sialidase to PD1 Enhances T cell Function and Tumor Control
Immune therapies targeting the PD1 axis have transformed outcomes in cancer treatment by enhancing T cell-mediated immune responses. However, many tumors evade immune clearance through orthogonal esca...
pubs.acs.org
🔥 HOT OFF THE PRESS 🔥
Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime
pubs.acs.org/doi/full/10....
Today in ACS Central Science @pubs.acs.org , we report an anti-PD1 #sialidase conjugate that degrades #SialicAcid on PD1+ T cells, inflaming tumors and controlling their growth beyond SOC PD1 blockade in melanoma models #Glycotime
pubs.acs.org/doi/full/10....
“ #CD33 …(Fig. 2D)… showed low variability in each individual throughout the longitudinal study, suggesting stable, subject-specific concentrations. “
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
A human pan-disease blood atlas of the circulating proteome
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. Here, we present a pan-disease resource to enable the study of divers...
www.science.org
November 12, 2025 at 9:27 AM
“ #CD33 …(Fig. 2D)… showed low variability in each individual throughout the longitudinal study, suggesting stable, subject-specific concentrations. “
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Therapeutically useful to know one’s #Siglec-3 abundance changes little over time
www.science.org/doi/10.1126/...
Reposted by Brett Garabedian
“For those who believe the health system is controlled by a conspiracy, Holmes is a victim of Big Pharma. For biohacking enthusiasts into wearable devices, she was an early adopter. For mothers who see themselves as protectors, she is a mom who is trying to provide the best care for her family”
MAHA Is Embracing Elizabeth Holmes. Here’s Why.
An alliance is building between the Trump-aligned movement and convicted Theranos founder.
www.politico.com
November 11, 2025 at 9:17 PM
“For those who believe the health system is controlled by a conspiracy, Holmes is a victim of Big Pharma. For biohacking enthusiasts into wearable devices, she was an early adopter. For mothers who see themselves as protectors, she is a mom who is trying to provide the best care for her family”
Reposted by Brett Garabedian
Fun for the day ...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
November 11, 2025 at 1:53 PM
Fun for the day ...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
Cocktail lecture in my chemistry of cooking class.
Things I'll talk about
Daiquiris (real ones) & riffs on
Liquid Intelligence (Dave Arnold) & entropy
Mindful Mixology (Derek Brown)
Ratatouille
www.nature.com/articles/s41...
www.science.org/doi/10.1126/...
#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
Increase of Inhibitory Siglec receptors on T cells mitigates severe immune reactions during acute viral infections
Abstract. Expression of inhibitory Siglec receptors has been described on T cells of patients with viral infection and cancer. However, the exact function
academic.oup.com
November 8, 2025 at 4:00 AM
#Siglec -9 levels increase on T cells in patients with acute severe acute respiratory syndrome coronavirus 2 (and LCMV) infection relative to levels on healthy controls
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
#SialicAcid #Glycotime
academic.oup.com/pnasnexus/ar...
Reposted by Brett Garabedian
Hundreds of thousands of people, dead because of a decision made by the world's richest man
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 7, 2025 at 12:20 PM
Hundreds of thousands of people, dead because of a decision made by the world's richest man
“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Targeting Interactions Between Siglec-10 and α3β1 Integrin Enhances Macrophage-Mediated Phagocytosis of Pancreatic Cancer
AbstractTumor-associated macrophages (TAM) in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) exhibit immunosuppressive phenotypes and impaired phagocytic activity, facilitati...
aacrjournals.org
November 6, 2025 at 3:52 AM
“In this study, we identified integrin α3β1, composed of ITGA3 and ITGB1 subunits, as a sialylated glycoprotein ligand for #Siglec-10, an inhibitory glyco-immune checkpoint receptor highly expressed on TAMs in PDAC” #SialicAcid #Glycotime
aacrjournals.org/cancerres/ar...
aacrjournals.org/cancerres/ar...
Reposted by Brett Garabedian
GAGs FTW! Wow #glycotime!! ⤵️🧪 🥳🥳
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
www.science.org/doi/10.1126/... @megtriesscience.bsky.social @douglaspdyer.bsky.social
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during psoriasis-like skin inflammation
Leukocytes accumulate in the skin during psoriatic-like inflammation upon cleavage of surface heparan sulfate.
www.science.org
November 5, 2025 at 8:05 AM
GAGs FTW! Wow #glycotime!! ⤵️🧪 🥳🥳
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
"Leukocyte recruitment is a key driver of inflammatory diseases, including psoriasis. Here, we found that leukocytes had the glycocalyx component heparan sulfate on their cell surface and that it was lost in response to psoriasis-like skin inflammation"
Reposted by Brett Garabedian
My sixth literary child is born today (and already a best seller on Amazon). Get your copy: www.simonandschuster.com/books/Notes-...
November 4, 2025 at 2:16 PM
My sixth literary child is born today (and already a best seller on Amazon). Get your copy: www.simonandschuster.com/books/Notes-...
Amazing #glycotime immune research on display at GIA2025. Come join us at this free hybrid event and watch talk by some of the best in the field. Register here
We’re thrilled to introduce GIA2025 Trainee Invited Speaker Dr. Jim Paulson, Professor Emeritus in the Department of Immunology and Microbiology at The Scripps Research Institute in La Jolla, CA who’ll talk on the roles of inhibitory Siglecs in regulation of immune responses! #GIA2025 #glycotime
October 29, 2025 at 2:41 AM
Reposted by Brett Garabedian
I have a very bad feeling about this...
October 27, 2025 at 4:51 PM
I have a very bad feeling about this...
Reposted by Brett Garabedian
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
October 28, 2025 at 2:52 PM
Fully-automated spectral unmixing pipeline that reduces error up to 9000-fold @biorxiv-immuno.bsky.social
doi.org/10.1101/2025...
doi.org/10.1101/2025...
Reposted by Brett Garabedian
Exercise intensity modulates the human plasma secretome and interorgan communication https://www.biorxiv.org/content/10.1101/2025.10.22.683699v1
October 23, 2025 at 10:02 PM
Exercise intensity modulates the human plasma secretome and interorgan communication https://www.biorxiv.org/content/10.1101/2025.10.22.683699v1
Reposted by Brett Garabedian
@cellcellpress.bsky.social spotlight
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
October 17, 2025 at 4:39 PM
@cellcellpress.bsky.social spotlight
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Sugar coats shield immunogenic RNA modification:A new function for RNA glycosylation
www.cell.com/molecular-ce...
on @nature.com
www.nature.com/articles/s41... @vijayrathinam.bsky.social
Reposted by Brett Garabedian
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
October 18, 2025 at 12:05 AM
A university that signs the “compact” is one that acknowledges its own inability to compete and succeed based talent and merit. It would signal insecurity and mediocrity to current and future students and faculty. Say no. Recruit the best people, protect their freedom and support their hard work.
Reposted by Brett Garabedian
q.e.d Science
Critical Thinking AI for constructive criticism and science evaluation
qedscience.com
October 15, 2025 at 12:22 PM
Reposted by Brett Garabedian
Just on time for my intro lecture on #glycotime in 3D ⤵️🎉
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
UBC enzyme technology clears first human test toward universal donor organs for transplantation - UBC News
UBC-developed enzymes successfully converted a kidney to universal type O for transplant, marking a major step toward faster, more compatible organ donations.
news.ubc.ca
October 15, 2025 at 5:50 AM
Just on time for my intro lecture on #glycotime in 3D ⤵️🎉
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
The first successful human transplant of a kidney converted from blood type A to universal type O used special enzymes developed by the team led by Prof Stephen Withers and Prof Jayachandran Kizhakkedathu at UBC
news.ubc.ca/2025/10/univ...
Reposted by Brett Garabedian
Fake news
Is dark chocolate good for you?
"Sadly for chocoholics, the health claims for dark chocolate come from wishful thinking and sly marketing, not the findings of science."
Sorry
www.economist.com/science-and-...
"Sadly for chocoholics, the health claims for dark chocolate come from wishful thinking and sly marketing, not the findings of science."
Sorry
www.economist.com/science-and-...
Is dark chocolate actually healthy?
We assess whether that tempting idea is too good to be true
www.economist.com
October 9, 2025 at 4:08 PM
Fake news
Reposted by Brett Garabedian
Get your Zoster vaccine! @naturemedicine.bsky.social
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
October 6, 2025 at 8:27 PM
Get your Zoster vaccine! @naturemedicine.bsky.social
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
A consistent relationship of VZV reactivation with dementia in 100M US adults after controlling for nearly 400 measured characteristics, with zoster vaccines reducing risk of dementia in dose-dependent manner
www.nature.com/articles/s41...
Reposted by Brett Garabedian
NEW: ICE is planning to hire a team of nearly 30 people to surveil social media 24/7, build dossiers on people, and flag them for arrest and deportation. @dell.bsky.social has the scoop: www.wired.com/story/ice-so...
ICE Wants to Build Out a 24/7 Social Media Surveillance Team
Documents show ICE plans to hire dozens of contractors to scan X, Facebook, TikTok, and other platforms to target people for deportation.
www.wired.com
October 3, 2025 at 1:22 PM
NEW: ICE is planning to hire a team of nearly 30 people to surveil social media 24/7, build dossiers on people, and flag them for arrest and deportation. @dell.bsky.social has the scoop: www.wired.com/story/ice-so...
Reposted by Brett Garabedian
A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
This first of its kind procedure could improve access to donor organs because the donor blood type would no longer matter
go.nature.com/3IToaM3
go.nature.com/3IToaM3
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
go.nature.com
October 3, 2025 at 1:43 PM
A real triumph for #glycotime and basic research, thanks to the work of Steve Withers and others.🧪
Reposted by Brett Garabedian
We have people in power making broad claims around certain drugs and autism that have been continuously disproven.
September 25, 2025 at 2:02 PM
We have people in power making broad claims around certain drugs and autism that have been continuously disproven.
“Until we address Trump's corruption as the absolute, primary threat it represents right now, every other national security discussion is pointless, akin to rearranging deck chairs on the Titanic.”
Read the Dekleptocracy substack: "When a phantom foundation with no address, no registration and a founder who might not exist, wires $100 million to the president's crypto company, America has a problem"
dekleptocracy.substack.com/p/trumps-she...
dekleptocracy.substack.com/p/trumps-she...
Trump's Shell Game Threatens American Security
We're pushing to make anti-corruption a top priority on the political agenda to fight authoritarianism, strengthen the rule of law and protect democracy.
dekleptocracy.substack.com
September 23, 2025 at 9:41 PM
“Until we address Trump's corruption as the absolute, primary threat it represents right now, every other national security discussion is pointless, akin to rearranging deck chairs on the Titanic.”