Beverly Piggott
@beverly-piggott.bsky.social
Asst. Prof. at the U of Montana. Previously Jan Lab @ UCSF, U-Michigan. Fly neurobiologist. ❤️ ion channels, brain development, the great outdoors. #newPI opinions are my own.
Reposted by Beverly Piggott
Our paper is now part of the newest Cellular Neurobiology collection @jcb.org, check it out if you haven't yet. 🔬📖
@biljanaermanoska.bsky.social, Baets, and @rodallab.bsky.social show that nonmuscle myosin II regulates presynaptic actin and neuronal mechanobiology in #Drosophila. rupress.org/jcb/article/...
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
📕 In Cellular Neurobiology collection: rupress.org/jcb/collecti...
#SfN25
November 17, 2025 at 8:09 PM
Our paper is now part of the newest Cellular Neurobiology collection @jcb.org, check it out if you haven't yet. 🔬📖
Reposted by Beverly Piggott
I served last year on this committee and have the privilege of chairing it this year. We have amazing students in our field from around the globe--nominate one of them! Make our job difficult 😆 #Drosophila
RT
RT
Calling thesis advisors, department chairs, and supervisory committee members! 📣 Nominate an outstanding PhD/PhD candidate working with Drosophila for the Larry Sandler Award. They'll present at #Dros26. Learn more and submit a nomination: buff.ly/mtfDbBD
@peiferlabunc.bsky.social
@peiferlabunc.bsky.social
November 14, 2025 at 8:28 PM
I served last year on this committee and have the privilege of chairing it this year. We have amazing students in our field from around the globe--nominate one of them! Make our job difficult 😆 #Drosophila
RT
RT
Reposted by Beverly Piggott
First-ever atlas of brain development shows how stem cells turn into neurons
There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!
There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!
November 11, 2025 at 12:13 AM
First-ever atlas of brain development shows how stem cells turn into neurons
There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!
There are 6 excellent human brain development papers in Nature - www.nature.com/articles/d41... Check them out!
Reposted by Beverly Piggott
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution — a Review by Jeffrey J. Colgren & Pawel Burkhardt
@jeffcolgren.bsky.social @pawelburkhardt.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@jeffcolgren.bsky.social @pawelburkhardt.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution - Nature Reviews Neuroscience
Recent studies have shed further light on the evolutionary origins of chemical synapses, In this Review, Colgren and Burkhardt explore how ancient proteins were co-opted into functional assemblies and...
www.nature.com
November 6, 2025 at 4:21 PM
The evolutionary origins of synaptic proteins and their changing roles in different organisms across evolution — a Review by Jeffrey J. Colgren & Pawel Burkhardt
@jeffcolgren.bsky.social @pawelburkhardt.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
@jeffcolgren.bsky.social @pawelburkhardt.bsky.social
#neuroscience #neuroskyence
www.nature.com/articles/s41...
Reposted by Beverly Piggott
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
October 12, 2025 at 2:20 PM
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
unc.peopleadmin.com/postings/307...
Reposted by Beverly Piggott
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
September 30, 2025 at 2:43 PM
Identification of optimal fluorophores for use in the Drosophila embryo by Timothy E Saunders and team: www.biorxiv.org/content/10.1...
Reposted by Beverly Piggott
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
September 29, 2025 at 4:45 PM
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Reposted by Beverly Piggott
Our latest published paper on developmental consequences of a human DVL1 variant in a Drosophila model of Robinow Syndrome.
September 25, 2025 at 12:19 AM
Our latest published paper on developmental consequences of a human DVL1 variant in a Drosophila model of Robinow Syndrome.
Reposted by Beverly Piggott
How is developmental speed regulated ? 🪰
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
September 22, 2025 at 7:07 PM
How is developmental speed regulated ? 🪰
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.
www.biorxiv.org/content/10.1...
A big thanks to everyone involved!
Reposted by Beverly Piggott
We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud!
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
Mitochondrial Complex I and ROS control neuromuscular function through opposing pre- and postsynaptic mechanisms
How do neurons adapt to mitochondrial dysfunction in different tissues? This study shows that Mitochondrial Complex I depletion triggers ROS-driven compensatory signaling in motor neurons that preserv...
journals.plos.org
September 22, 2025 at 10:53 PM
We have an uncorrected proof published for Bhagaban Mallik's study on Mitochondrial Complex I and how it regulates synapse function. You can find it in @plosbiology.org. I am so proud!
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
H/T collaborators: Drs. Sajad Bhat and Xinnan Wang @xinnanwanglab.bsky.social
journals.plos.org/plosbiology/...
Reposted by Beverly Piggott
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
September 22, 2025 at 9:37 AM
🧵1/14 Preprint thread! Can we predict a cell’s fate based on its dynamics? 🔮 Our new study unveils a framework for watching development unfold in real-time, revealing how a cell's shape and movement encode info about its future fate. 🔬📄 Preprint: tinyurl.com/4shf8v4x
Reposted by Beverly Piggott
We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...
www.cell.com/developmenta...
Signaling-dependent refinement of cell fate choice during tissue remodeling in Drosophila pupal wings
Herszterg et al. show that during morphogenesis of the Drosophila pupal wing, a wave
of Notch signaling activity updates cell fates to ensure robust and precise patterning
of wing veins.
www.cell.com
September 19, 2025 at 8:35 AM
We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...
www.cell.com/developmenta...
Reposted by Beverly Piggott
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
September 17, 2025 at 5:38 PM
Wonderful to see our paper on the #organelle signatures of #neurons and #astrocytes out in final form - congratulations, Shannon Rhoads and team!🎉 t.co/BPxKlbU6Ou
Reposted by Beverly Piggott
www.thecrimson.com/article/2025...
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research | News | The Harvard Crimson
FlyBase lost a multimillion dollar grant when the Trump administration cut off Harvard’s federal funding in May. Now the repository is laying off staff — and researchers worldwide are worried.
www.thecrimson.com
September 9, 2025 at 10:44 AM
www.thecrimson.com/article/2025...
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
Harvard Funding Cuts Endanger the Massive Fruit Fly Database That Powers Genetic Research
Reposted by Beverly Piggott
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
MCDB Opens Search for Faculty | U-M LSA Molecular, Cellular, and Developmental Biology (MCDB)
MCDB welcomes applications at the Assistant Professor level from outstanding biological scientists in all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal le...
lsa.umich.edu
August 26, 2025 at 1:29 PM
My MCDB dept is accepting applications for a faculty position at the Assistant Professor level!
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Applications Due by October 15, 2025
We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels.
lsa.umich.edu/mcdb/news-ev...
Reposted by Beverly Piggott
The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Apply - Interfolio
{{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
apply.interfolio.com
September 3, 2025 at 5:26 PM
The University of Notre Dame is hiring 5 tenure or tenure-track professors in Neuroscience, including Computational Neuroscience, across 4 departments.
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Come join me at ND! Feel free to reach out with any questions.
And please share!
apply.interfolio.com/173031
Reposted by Beverly Piggott
Come be my colleague! We are hiring for two tenure-track positions. www.reed.edu/dean_of_facu...
Tenure-Track Positions in Functional Genomics/Genetics and Systems Biology - Office of the Dean of the Faculty - Reed College
www.reed.edu
August 27, 2025 at 6:43 PM
Come be my colleague! We are hiring for two tenure-track positions. www.reed.edu/dean_of_facu...
Reposted by Beverly Piggott
Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!
FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 23, 2025 at 3:07 AM
Please please please, if you are able, consider supporting Flybase fiscally. They need our help! I donated this evening. They are in danger of closing and any amount will help. We cannot allow this critical pillar of science to collapse!
Reposted by Beverly Piggott
Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
April 11, 2025 at 10:57 AM
Embryonic induction of fate is a core concept in developmental biology. But, cells can also modify the physical state of surrounding tissues a process we call 'actuation'.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
I reviewed with
@mayorlab.bsky.social 3 excellent papers that show how actuation and feedback can drive changes in the embryo.
Reposted by Beverly Piggott
Fly folk:
The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource.
Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation:
wiki.flybase.org/wiki/FlyBase...
The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource.
Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation:
wiki.flybase.org/wiki/FlyBase...
FlyBase:Contribute to FlyBase - FlyBase Wiki
wiki.flybase.org
August 22, 2025 at 7:22 PM
Fly folk:
The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource.
Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation:
wiki.flybase.org/wiki/FlyBase...
The Amazing and essential @flybase.bsky.social is in existential need due to Trump termination of the grant that supports this vital resource.
Please donate to help keep Flybase alive. I just did. Info here on how to make a tax deductible donation:
wiki.flybase.org/wiki/FlyBase...
Reposted by Beverly Piggott
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 18, 2025 at 4:26 PM
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Reposted by Beverly Piggott
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Reposted by Beverly Piggott
What happens to the mitotic apparatus during the prolonged spindle assembly checkpoint–induced mitotic arrest?
Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC
Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC
August 5, 2025 at 6:01 PM
What happens to the mitotic apparatus during the prolonged spindle assembly checkpoint–induced mitotic arrest?
Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC
Read the latest #GENETICS study that uses mutational analysis of #Drosophila CMG helicase to answer this question. buff.ly/OoriIaC
Reposted by Beverly Piggott
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial
gap junctions, enabling coordinated dilation of the arterial network during neurovascular
coupling.
www.cell.com
July 25, 2025 at 7:17 AM
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Reposted by Beverly Piggott
I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.
July 28, 2025 at 5:37 PM
I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.