Jenny Sachweh
@jennysachweh.bsky.social
Scientist. She/her. I like cryoET, fluorescences microscopy, and cell biology.
Developing cryoCLEM methods in the Mahamid lab at EMBL Heidelberg. Formerly studying NPCs in the Beck Lab at MPIBP Frankfurt. MBL Physiology’23 alumn.
Developing cryoCLEM methods in the Mahamid lab at EMBL Heidelberg. Formerly studying NPCs in the Beck Lab at MPIBP Frankfurt. MBL Physiology’23 alumn.
Happy to see that our paper on NPC (a)symmetry inspired a newspaper article!
Les pores nucléaires sont les portes du noyau de nos cellules. Pour réguler le trafic entre compartiments, ces portes sont orientées et sécurisées comme des postes de contrôle transfrontaliers.
Comment s’organise leur assemblage dissymétrique entre une face et l’autre?
www.lemonde.fr/sciences/art...
Comment s’organise leur assemblage dissymétrique entre une face et l’autre?
www.lemonde.fr/sciences/art...
Dans nos cellules, la valse d’une protéine oriente les pores nucléaires
CARTE BLANCHE. Dans sa Carte blanche au « Monde », Alice Lebreton décortique l’organisation de ces tunnels entre le noyau et le reste de la cellule, à la lumière d’une protéine responsable du transpor...
www.lemonde.fr
November 15, 2025 at 4:48 PM
Happy to see that our paper on NPC (a)symmetry inspired a newspaper article!
Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!
November 7, 2025 at 3:49 PM
Yesterday I finally defended my PhD thesis - time to say thank you to all those who were part of this journey as mentors, collaborators, colleagues and friends!
Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!
Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...
November 6, 2025 at 5:32 AM
Great work of @deglushk.bsky.social from my PhD lab @mpibp.bsky.social on how to get more information out of all the membranes you see in cryoET data!
Reposted by Jenny Sachweh
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Dodonova Group – Organisational principles and 3D architecture of archaeal chromatin
www.embl.org
October 15, 2025 at 10:38 AM
We are looking for motivated #postdocs to join the lab! Biochemistry/microbiology/cryo-EM experience? Excited by #cryo-EM/ET, #chromatin? ❄️🧬🧫
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Interdisciplinary projects, top EMBL facilities!
Email CV + short cover letter → svetlana.dodonova@embl.de
Info about the group: www.embl.org/groups/dodon...
Reposted by Jenny Sachweh
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
October 28, 2025 at 3:07 PM
Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
Reposted by Jenny Sachweh
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Course Offerings | Marine Biological Laboratory
go.mbl.edu
October 28, 2025 at 6:08 PM
🔬 Applications are now open!
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network.
➡️Apply today: go.mbl.edu/courses
Reposted by Jenny Sachweh
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
October 15, 2025 at 6:26 AM
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
www.biorxiv.org/content/10.1...
#teamtomo
Reposted by Jenny Sachweh
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 6, 2025 at 5:52 PM
We present multi-immersion Oblique Plane microscope (miOPM), a light-sheet platform that can be adapted to a wide range of applications, from sensitive live cell imaging to imaging organs and cleared tissues.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jenny Sachweh
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
August 26, 2025 at 8:56 PM
What could be more exciting than watching Euplotes scurry around under the microscope? How about adding some raptorial predation by supergiant cannibal cells?
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
www.biorxiv.org/content/10.1...
Video by Vittorio Boscaro.
1/n
Reposted by Jenny Sachweh
If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...
August 23, 2025 at 11:21 PM
If you are thinking about the future of structural biology, we are too! Our two cents (Jürgen Plitzko and I) just got published online here: authors.elsevier.com/sd/article/S...
Reposted by Jenny Sachweh
How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!
August 19, 2025 at 7:31 PM
How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
The small GTPase Ran defines nuclear pore complex asymmetry
Nuclear pore complexes (NPCs) bridge across the nuclear envelope and mediate nucleocytoplasmic exchange. They consist of hundreds of nucleoporin build…
www.sciencedirect.com
August 18, 2025 at 4:26 PM
My PhD paper is in press @cellpress.bsky.social and now online: www.sciencedirect.com/science/arti...!
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Contents: weird #NPCs in yeast and flies, #CLEM, in situ #cryoET and more!
Made possible by the amazing @becklab.bsky.social team at @mpibp.bsky.social and collaborators! #TeamTomo
Reposted by Jenny Sachweh
At EMBL Grenoble, lead an independent research group using bold, original approaches to integrate complementary structural biology methods with emerging nano X-ray imaging technologies, bridging scales and modalities to unravel molecular mechanisms.
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
August 8, 2025 at 7:17 AM
At EMBL Grenoble, lead an independent research group using bold, original approaches to integrate complementary structural biology methods with emerging nano X-ray imaging technologies, bridging scales and modalities to unravel molecular mechanisms.
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Reposted by Jenny Sachweh
The Molecular Systems Biology Unit is looking for an independent research group leader in one of many different areas from integrative structural biology to synthetic biology, and from AI-driven approaches to engineering biological systems.
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
August 7, 2025 at 8:28 AM
The Molecular Systems Biology Unit is looking for an independent research group leader in one of many different areas from integrative structural biology to synthetic biology, and from AI-driven approaches to engineering biological systems.
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
embl.wd103.myworkdayjobs.com/en-US/EMBL/d...
Reposted by Jenny Sachweh
We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 5, 2025 at 12:41 PM
We are excited to announce the first in-cell structure of a LINC complex within a native nuclear envelope at subnanometer resolution!! #In-cell cryo-ET + #atomistic MD simulations! @tomdendooven.bsky.social et al!!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The MPG is advertising directorships - powerful positions for which recruitment is usually started by them reaching out to potential candidates. Let’s hope this open call will get some great (but maybe overlooked) scientists on the candidate list and doesn’t accidentally select for oversized egos…
Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.
August 3, 2025 at 1:51 AM
The MPG is advertising directorships - powerful positions for which recruitment is usually started by them reaching out to potential candidates. Let’s hope this open call will get some great (but maybe overlooked) scientists on the candidate list and doesn’t accidentally select for oversized egos…
Reposted by Jenny Sachweh
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
June 27, 2025 at 10:58 AM
After 5 amazing years @pilhoferlab.bsky.social I'm starting my lab @embl.org Grenoble this November embl.org/wollweber
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
We'll image Asgard archaea and many other strange microbes ( #archaeasky, #protistsonsky..) to understand eukaryogenesis
First job ad: #teamtomo scientist!🔬❄️ tinyurl.com/2rdu2ze6
Reposted by Jenny Sachweh
You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!
Interested in research infrastructures career?
The #ARISE2 Fellowship Programme might be right for you.
MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪
🗓️ Call opening: 30 June
www.embl.org/training/ari...
The #ARISE2 Fellowship Programme might be right for you.
MSCA funded, the programme supports STEM researchers in becoming leaders in research infrastructures, driving innovation in life sciences 🧪
🗓️ Call opening: 30 June
www.embl.org/training/ari...
May 19, 2025 at 4:08 PM
You are a scientist or an engineer (with a PhD) and you want to upskill to learn about delivering scientific infrastructure for the lifesciences (experimental or computational)? You want to work in Europe, in an internationally excellent service delivery team? ARISE2 is for you!
Beautiful cutting-edge in situ cryoET work (with very pretty figures) from the Grange lab!
Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!
Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!
A generalizable and targeted molecular biopsy approach for in situ cryogenic electron tomography of vitreous brain tissue pubmed.ncbi.nlm.nih.gov/40527314/ #cryoem
June 19, 2025 at 8:53 AM
Beautiful cutting-edge in situ cryoET work (with very pretty figures) from the Grange lab!
Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!
Great to see how the field is getting closer to doing structural work in tissues and how development in FIB technology, lift-out procedures, and correlative light microscopy contribute!
Reposted by Jenny Sachweh
Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?
June 3, 2025 at 12:45 AM
Hey optical tech dev folks: how do you do alignment? Can you outline your alignment procedures for positioning optics and verifying their correct positioning?
Reposted by Jenny Sachweh
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps https://www.biorxiv.org/content/10.1101/2025.05.27.656403v1
May 28, 2025 at 5:17 AM
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps https://www.biorxiv.org/content/10.1101/2025.05.27.656403v1
Reposted by Jenny Sachweh
1. Can you figure out where I was standing when I took this picture?
ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.
ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.
April 29, 2025 at 4:49 AM
1. Can you figure out where I was standing when I took this picture?
ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.
ChatGPT could. Given the photograph (scrubbed of all header information), the new chain of thought model, ChatGPT o.3, was able to pinpoint the location with a few meters.
Reposted by Jenny Sachweh
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...
🔗 www.pnas.org/doi/10.1073/...
Reducing the effects of radiation damage in cryo-EM using liquid helium temperatures | PNAS
The physical limit in determining the atomic structure of biological molecules is
radiation damage. In electron cryomicroscopy, there have been num...
www.pnas.org
April 23, 2025 at 4:23 AM
After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it.
🔗 www.pnas.org/doi/10.1073/...
🔗 www.pnas.org/doi/10.1073/...
Reposted by Jenny Sachweh
Using the 'right tool for the job'. It's not fashionable, but a powerful and often underappreciated approach...
-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!
doi.org/10.1101/2022...
-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!
doi.org/10.1101/2022...
April 14, 2025 at 3:59 PM
Using the 'right tool for the job'. It's not fashionable, but a powerful and often underappreciated approach...
-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!
doi.org/10.1101/2022...
-> Here's the yeast lifespan machine. Just a simple microscope with incubation, but full control over the hardware & software produced an excellent data platform!
doi.org/10.1101/2022...
Reposted by Jenny Sachweh
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
April 9, 2025 at 1:07 PM
Thrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...