Ana Janeva
@anajaneva.bsky.social
PhD in Eva Hörmanseder's Lab at IES, Helmholtz Munich.
Epigenetic memory and Reprogramming.
CRC 1064 Chromatin Dynamics PhD rep.
UniHeidelberg, EMBL & DAAD alumna. 🇲🇰🇩🇪
Epigenetic memory and Reprogramming.
CRC 1064 Chromatin Dynamics PhD rep.
UniHeidelberg, EMBL & DAAD alumna. 🇲🇰🇩🇪
Pinned
Ana Janeva
@anajaneva.bsky.social
· Jan 26
Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the eff...
www.biorxiv.org
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
Reposted by Ana Janeva
October 15, 2025 at 1:04 PM
Reposted by Ana Janeva
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Ana Janeva
AI has so much potential for interpreting biological images, and yet, annotated biological datasets needed to train AI tools remain scarce.
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
October 13, 2025 at 11:24 AM
AI has so much potential for interpreting biological images, and yet, annotated biological datasets needed to train AI tools remain scarce.
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
Reposted by Ana Janeva
What do you know about version control?🔁 It’s how researchers keep their projects organized, track every change, and never lose work again.
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Introduction to version Control with git and GitHub within RStudio
lmu-osc.github.io
October 9, 2025 at 10:02 AM
What do you know about version control?🔁 It’s how researchers keep their projects organized, track every change, and never lose work again.
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Reposted by Ana Janeva
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 5:49 PM
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Reposted by Ana Janeva
A good day to remember John Gurdon’s school report from his biology master at Eton
October 7, 2025 at 8:45 PM
A good day to remember John Gurdon’s school report from his biology master at Eton
Reposted by Ana Janeva
Dr. John Gurdon, a British biologist and Nobel laureate who in the early 1960s introduced a paradigm-shifting method of cell manipulation that led to the world’s first cloning of a large mammal, a sheep named Dolly, died on Tuesday at 92.
John B. Gurdon, 92, Dies; Nobelist Paved Way for Cloning of Animals
His work in the manipulation of cells laid the foundation for stem cell biology and regenerative medicine and led to the first cloned large mammal, a sheep named Dolly.
nyti.ms
October 8, 2025 at 8:55 AM
Dr. John Gurdon, a British biologist and Nobel laureate who in the early 1960s introduced a paradigm-shifting method of cell manipulation that led to the world’s first cloning of a large mammal, a sheep named Dolly, died on Tuesday at 92.
Reposted by Ana Janeva
🚀 #NAKO Launches the Pilot Phase of Its Trusted Research Environment
📝 Health-focused companies can now apply for secure, GDPR-compliant access to Germany’s largest long-term population health data.
👉 Read more: t1p.de/q0i64
@nako.de
#HelmholtzMunich #DataProtection #HealthResearch
📝 Health-focused companies can now apply for secure, GDPR-compliant access to Germany’s largest long-term population health data.
👉 Read more: t1p.de/q0i64
@nako.de
#HelmholtzMunich #DataProtection #HealthResearch
September 23, 2025 at 7:25 AM
🚀 #NAKO Launches the Pilot Phase of Its Trusted Research Environment
📝 Health-focused companies can now apply for secure, GDPR-compliant access to Germany’s largest long-term population health data.
👉 Read more: t1p.de/q0i64
@nako.de
#HelmholtzMunich #DataProtection #HealthResearch
📝 Health-focused companies can now apply for secure, GDPR-compliant access to Germany’s largest long-term population health data.
👉 Read more: t1p.de/q0i64
@nako.de
#HelmholtzMunich #DataProtection #HealthResearch
Reposted by Ana Janeva
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Epigenetic relay: Polycomb-directed DNA methylation in mammalian development
In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of prom...
journals.plos.org
September 15, 2025 at 7:04 PM
Very excited to share an excellent review from @teresa-urli.bsky.social, published one week before her PhD defense! We did a deep dive into the fascinating biology of the variant Polycomb complex, PRC1.6 (1/5) journals.plos.org/plosgenetics...
Reposted by Ana Janeva
Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...
FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics
The FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics will take place 19–22 October 2026 in Budapest, Hungary. Here we give a taste of the scientific content, flag some of the speaker...
network.febs.org
September 10, 2025 at 2:24 PM
Do not forget to apply to the FEBS Advanced Lecture Course: 6th Danube Conference on Epigenetics (19–22 October 2026, Budapest, Hungary. Will be a great meeting as always. Check out the site: network.febs.org/posts/febs-a...
Reposted by Ana Janeva
🎊 Congratulations to Juliane Glaser (@julianeg.bsky.social) and Valentin Flury (@flurylab.bsky.social) on being awarded each an @erc.europa.eu Starting Grant! – #ERCStG
www.ie-freiburg.mpg.de/6057908/2025...
www.ie-freiburg.mpg.de/6057908/2025...
Two ERC Starting Grants for Max Planck in Freiburg
Two young scientists from the Max Planck Institute in Freiburg, Juliane Glaser and Valentin Flury, have each received €1.5 million in ERC Starting Grants to conduct research into epigenetic mechanisms...
www.ie-freiburg.mpg.de
September 4, 2025 at 10:34 AM
🎊 Congratulations to Juliane Glaser (@julianeg.bsky.social) and Valentin Flury (@flurylab.bsky.social) on being awarded each an @erc.europa.eu Starting Grant! – #ERCStG
www.ie-freiburg.mpg.de/6057908/2025...
www.ie-freiburg.mpg.de/6057908/2025...
Reposted by Ana Janeva
Post doc: "this is the worst rejection I ever got"
PI:
PI:
August 31, 2025 at 5:04 PM
Post doc: "this is the worst rejection I ever got"
PI:
PI:
Reposted by Ana Janeva
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Notes from Beethoven’s genome
Wesseldijk et al. compare the genomic information collected from Ludwig van Beethoven
with population-based datasets used to quantify musical achievement.
www.cell.com
August 7, 2025 at 11:10 AM
If someone you know buys into claims about "genetic optimization" of embryos using polygenic scores of cognition, just send them our 2024 paper on Beethoven & musicality. We wrote it to help communicate limits of individual-level genetic predictions & complexity of links between DNA & behaviour. 🧪👇
Reposted by Ana Janeva
An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses CRISPR to correct a specific mutation
go.nature.com/3Jmdbuy
go.nature.com/3Jmdbuy
A baby benefits from personalized gene editing in the clinic
An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses the gene-editing tool CRISPR to correct a specific mutation.
go.nature.com
August 19, 2025 at 3:08 PM
An infant with an inherited life-threatening metabolic condition has responded to a tailored therapy that uses CRISPR to correct a specific mutation
go.nature.com/3Jmdbuy
go.nature.com/3Jmdbuy
Reposted by Ana Janeva
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
H3K4me3 amplifies transcription at intergenic active regulatory elements
A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields
genesdev.cshlp.org
August 20, 2025 at 1:29 AM
New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...
Reposted by Ana Janeva
We are excited to announce the Otto Meyerhof Prize, awarded by #Boehringer Ingelheim and the #GBM for e𝐚𝐫𝐥𝐲-𝐜𝐚𝐫𝐞𝐞𝐫 scientists conducting research in Germany:
- PhD no more than 8 years ago
- Nominations and self-applications
💶 €5000 prize money
📅 Deadline 30.11.25
📩 Submit to: awards@gbm-online.de
- PhD no more than 8 years ago
- Nominations and self-applications
💶 €5000 prize money
📅 Deadline 30.11.25
📩 Submit to: awards@gbm-online.de
August 20, 2025 at 7:32 AM
We are excited to announce the Otto Meyerhof Prize, awarded by #Boehringer Ingelheim and the #GBM for e𝐚𝐫𝐥𝐲-𝐜𝐚𝐫𝐞𝐞𝐫 scientists conducting research in Germany:
- PhD no more than 8 years ago
- Nominations and self-applications
💶 €5000 prize money
📅 Deadline 30.11.25
📩 Submit to: awards@gbm-online.de
- PhD no more than 8 years ago
- Nominations and self-applications
💶 €5000 prize money
📅 Deadline 30.11.25
📩 Submit to: awards@gbm-online.de
Reposted by Ana Janeva
A great thing about working in a lab is being involved in lab meetings and witnessing everyone's projects take shape. A single project may seem to go slow but all projects together is impressive. Caroline Bartman discussed this on the podcast:
podcasts.apple.com/us/podcast/2... @cbartman.bsky.social
podcasts.apple.com/us/podcast/2... @cbartman.bsky.social
28 | Caroline Bartman and the flash(cards) of inspiration
Podcast Episode · Night Science · 02/13/2023 · 28m
podcasts.apple.com
August 19, 2025 at 3:00 AM
A great thing about working in a lab is being involved in lab meetings and witnessing everyone's projects take shape. A single project may seem to go slow but all projects together is impressive. Caroline Bartman discussed this on the podcast:
podcasts.apple.com/us/podcast/2... @cbartman.bsky.social
podcasts.apple.com/us/podcast/2... @cbartman.bsky.social
Reposted by Ana Janeva
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
August 18, 2025 at 1:00 PM
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
Reposted by Ana Janeva
Nature research paper: Establishment of chromatin architecture interplays with embryo hypertranscription
go.nature.com/3UumSJJ
go.nature.com/3UumSJJ
Establishment of chromatin architecture interplays with embryo hypertranscription - Nature
A study reveals progressive cohesin loading and a hypertranscription state responsible for the formation of genic cohesin islands at active regulatory genes in mouse embryos, highlighting an interplay between chromatin architecture and transcription as they are established for the first time.
go.nature.com
August 18, 2025 at 7:27 AM
Nature research paper: Establishment of chromatin architecture interplays with embryo hypertranscription
go.nature.com/3UumSJJ
go.nature.com/3UumSJJ
Reposted by Ana Janeva
🍹Kefalopoulou, Rullens et al. develop Dam&ChIC to assay #chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division and X chromosome inactivation.
bit.ly/4fGJFMi
bit.ly/4fGJFMi
Retrospective and multifactorial single-cell profiling reveals sequential chromatin reorganization during X inactivation - Nature Cell Biology
Kefalopoulou, Rullens et al. develop Dam&ChIC to assay chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division a...
bit.ly
August 13, 2025 at 7:59 PM
🍹Kefalopoulou, Rullens et al. develop Dam&ChIC to assay #chromatin state at two different time points in the same cell. The method was used to study the reorganization of LADs during cell division and X chromosome inactivation.
bit.ly/4fGJFMi
bit.ly/4fGJFMi
Reposted by Ana Janeva
1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs
Hanna and colleagues show that signaling pathway modulation amplifies the inherent
flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell
fate potential. This endows them...
www.cell.com
August 7, 2025 at 3:29 PM
1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...
Reposted by Ana Janeva
With constantly changing norms around work-life balance I no longer know if "Working 9 to 5" is a song about a difficult situation or an ideal situation
August 6, 2025 at 11:11 AM
With constantly changing norms around work-life balance I no longer know if "Working 9 to 5" is a song about a difficult situation or an ideal situation
Reposted by Ana Janeva
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
Reposted by Ana Janeva
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
www.biorxiv.org
August 4, 2025 at 12:50 PM
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.
www.biorxiv.org/cgi/content/...
Reposted by Ana Janeva
🔬 Stephan Hamperl uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Revealing cellular conflict role in disease and development
Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...
europa.eu
July 29, 2025 at 8:01 AM
🔬 Stephan Hamperl uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Read more 👉 europa.eu/!H7RtjQ
#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de