Ana Janeva
@anajaneva.bsky.social
Genomics nerd, lover of fiction books & cookbooks.
Epigenetic memory and Reprogramming.
Formerly PhD in Eva Hörmanseder's Lab at Helmholtz Munich.
Epigenetic memory and Reprogramming.
Formerly PhD in Eva Hörmanseder's Lab at Helmholtz Munich.
Pinned
Ana Janeva
@anajaneva.bsky.social
· Jan 26
Digital Reprogramming Decodes Epigenetic Barriers of Cell Fate Changes
Fates of differentiated cells in our body can be induced to change by nuclear reprogramming. In this way, cells valuable for therapeutic purposes and disease modeling can be produced. However, the eff...
www.biorxiv.org
I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here:
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
www.biorxiv.org/content/10.1...
Highlights and key findings from our study in the thread below 👇
Reposted by Ana Janeva
Today i learned about Caroline Herschel! the first woman to receive a salary as a scientist!
en.wikipedia.org/wiki/Carolin...
en.wikipedia.org/wiki/Carolin...
Caroline Herschel - Wikipedia
en.wikipedia.org
January 14, 2026 at 12:27 AM
Today i learned about Caroline Herschel! the first woman to receive a salary as a scientist!
en.wikipedia.org/wiki/Carolin...
en.wikipedia.org/wiki/Carolin...
Reposted by Ana Janeva
"It is crucial for us, young scientists, to come together from different countries and build a network," says Marlies Oomen, EMBO Postdoctoral Fellow at Helmholtz Munich. 🧪
https://www.embo.org/people/global-mobility-sparks-scientific-creativity/
#networking #LifeSciences #research #funding
https://www.embo.org/people/global-mobility-sparks-scientific-creativity/
#networking #LifeSciences #research #funding
January 7, 2026 at 3:05 PM
"It is crucial for us, young scientists, to come together from different countries and build a network," says Marlies Oomen, EMBO Postdoctoral Fellow at Helmholtz Munich. 🧪
https://www.embo.org/people/global-mobility-sparks-scientific-creativity/
#networking #LifeSciences #research #funding
https://www.embo.org/people/global-mobility-sparks-scientific-creativity/
#networking #LifeSciences #research #funding
Reposted by Ana Janeva
Our new preprint is out: www.biorxiv.org/content/10.6...
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!
Hidden sampling biases inflate performance in gene regulatory network inference
Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...
www.biorxiv.org
December 23, 2025 at 7:55 PM
Our new preprint is out: www.biorxiv.org/content/10.6...
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!
Reposted by Ana Janeva
It’s a story of marks written early, carried through a long silence, and then suddenly speaking again. A bit like memory itself.
December 22, 2025 at 2:43 PM
It’s a story of marks written early, carried through a long silence, and then suddenly speaking again. A bit like memory itself.
Reposted by Ana Janeva
After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it:
Our work is now out in Nature Communications:
🔗 nature.com/articles/s41467-025-67692-7
Our work is now out in Nature Communications:
🔗 nature.com/articles/s41467-025-67692-7
nature.com
December 22, 2025 at 4:01 PM
After a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!
Congrats on this exciting story @sandrani.bsky.social and team!!
Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations
Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …
www.sciencedirect.com
December 22, 2025 at 10:56 AM
Congrats on this exciting story @sandrani.bsky.social and team!!
Reposted by Ana Janeva
absolutely losing it at my 14yo's biology homework
December 15, 2025 at 2:02 AM
absolutely losing it at my 14yo's biology homework
Reposted by Ana Janeva
Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development
Pioneer transcription factors are crucial for regulating zygotic genome activation and cell differentiation during mouse pre-implantation development. However, how pioneer factors function collectivel...
journals.biologists.com
December 8, 2025 at 5:57 PM
Excited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback.
journals.biologists.com/dev/article/...
journals.biologists.com/dev/article/...
Reposted by Ana Janeva
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon - Nature Communications
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
www.nature.com
December 5, 2025 at 8:05 AM
We have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists.
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
The piece is available open access in Nature Communications:
www.nature.com/articles/s41...
Reposted by Ana Janeva
We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon.
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
Nature Communications - Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
rdcu.be
December 4, 2025 at 12:47 PM
We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon.
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
Reposted by Ana Janeva
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
Reposted by Ana Janeva
Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
December 3, 2025 at 12:43 PM
Pls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
Reposted by Ana Janeva
No offense but I think we underestimate how many of our current problems, both cultural and political, are downstream of the decline in reading, the decline in learning and the loss of interest in the humanities.
December 1, 2025 at 8:59 PM
No offense but I think we underestimate how many of our current problems, both cultural and political, are downstream of the decline in reading, the decline in learning and the loss of interest in the humanities.
Been there, done that!
1/ One of the biggest hidden killer in bioinformatics?
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
Not a bug. Not a crash.
It’s the 0-based vs 1-based coordinate trap.
A thread 🧵
November 27, 2025 at 2:57 PM
Been there, done that!
Reposted by Ana Janeva
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
November 27, 2025 at 1:02 PM
Anthony A. Hyman will become EMBL’s next Director General.
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999.
www.embl.org/news/people-...
Reposted by Ana Janeva
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Application to speak in the Fragile Nucleosome series
Thank you for your interest in our seminar series!
We use a variety of different session formats but, in general, trainees can plan for a ~15 min talk + 5min Q/A and PIs can plan for a ~25min talk +...
forms.gle
November 24, 2025 at 1:50 PM
Do you have an exciting new chromatin/transcription story that you'd like to share with the #FN community?
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB...
Please repost and share!
Reposted by Ana Janeva
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Enhancer-promoter interactions
Genome Biology is calling for submissions to our Collection on enhancer-promoter interactions.
Enhancer–promoter interactions are central to the regulation ...
link.springer.com
November 25, 2025 at 10:55 AM
I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories!
link.springer.com/collections/...
link.springer.com/collections/...
Reposted by Ana Janeva
October 15, 2025 at 1:04 PM
Reposted by Ana Janeva
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Ana Janeva
AI has so much potential for interpreting biological images, and yet, annotated biological datasets needed to train AI tools remain scarce.
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
October 13, 2025 at 11:24 AM
AI has so much potential for interpreting biological images, and yet, annotated biological datasets needed to train AI tools remain scarce.
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
If you generate microscopy data or develop AI tools to interpret it, check it these new guidelines:
www.ebi.ac.uk/about/news/t...
#bioimaging #microscopy
🧬🔬
Reposted by Ana Janeva
What do you know about version control?🔁 It’s how researchers keep their projects organized, track every change, and never lose work again.
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Introduction to version Control with git and GitHub within RStudio
lmu-osc.github.io
October 9, 2025 at 10:02 AM
What do you know about version control?🔁 It’s how researchers keep their projects organized, track every change, and never lose work again.
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Self-Paced Tutorial of the Day: Introduction to Version Control within RStudio ⚙️ lmu-osc.github.io/Introduction...
Reposted by Ana Janeva
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
October 7, 2025 at 5:49 PM
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the @gurdoninstitute.bsky.social
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Read our tribute to the visionary Nobel Laureate and watch an interview from 2012, just after he won: https://bit.ly/4mM8o3r
Reposted by Ana Janeva
A good day to remember John Gurdon’s school report from his biology master at Eton
October 7, 2025 at 8:45 PM
A good day to remember John Gurdon’s school report from his biology master at Eton
Reposted by Ana Janeva
Dr. John Gurdon, a British biologist and Nobel laureate who in the early 1960s introduced a paradigm-shifting method of cell manipulation that led to the world’s first cloning of a large mammal, a sheep named Dolly, died on Tuesday at 92.
John B. Gurdon, 92, Dies; Nobelist Paved Way for Cloning of Animals
His work in the manipulation of cells laid the foundation for stem cell biology and regenerative medicine and led to the first cloned large mammal, a sheep named Dolly.
nyti.ms
October 8, 2025 at 8:55 AM
Dr. John Gurdon, a British biologist and Nobel laureate who in the early 1960s introduced a paradigm-shifting method of cell manipulation that led to the world’s first cloning of a large mammal, a sheep named Dolly, died on Tuesday at 92.