RitaTewari
@ritatewari.bsky.social
Professor of Parasite Cell Biology
Interest in Cell Division, cell signalling, chromosome segregation, Flagella, centrosome, mitosis and meiosis
Interest in Cell Division, cell signalling, chromosome segregation, Flagella, centrosome, mitosis and meiosis
Reposted by RitaTewari
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
The forgotten half of scientific thinking | PNAS
The forgotten half of scientific thinking
www.pnas.org
June 26, 2025 at 1:23 PM
“The idea that taking walks, reading things unrelated to your research, and hanging out with strangers in a campus pub should be considered part of the serious process of thinking, but might well meet with skepticism in practice.”
www.pnas.org/doi/10.1073/...
www.pnas.org/doi/10.1073/...
Many congratulations Ryuji. Your first paper on Plasmodium biology. Well done.
Excited to share our publication @lsajournal.org showing that divergent Plasmodium kinases drive MTOC, kinetochore and axoneme organisation during male gamete formation. Many thanks, @ritatewari.bsky.social, @davidguttery.bsky.social, @zeeshanm.bsky.social, Tony and David F.
doi.org/10.26508/lsa...
doi.org/10.26508/lsa...
March 25, 2025 at 7:33 PM
Many congratulations Ryuji. Your first paper on Plasmodium biology. Well done.
Happy Holi from our lab. Festival of colours. This to welcome the spring which I hope is round the corner.
March 16, 2025 at 7:43 PM
Happy Holi from our lab. Festival of colours. This to welcome the spring which I hope is round the corner.
Reposted by RitaTewari
📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
March 1, 2025 at 6:36 PM
📸 No one follows more etiquette rules than the Royal Family—but notice how King Charles didn’t make any smart-ass or demeaning comments about Zelensky’s attire today.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Why? Because respect isn’t about clothes—it’s about character. And that’s something money can’t buy.
Reposted by RitaTewari
The Nikon AX-NSPARC demo is gearing up at the
@ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪
@ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪
February 14, 2025 at 9:58 AM
The Nikon AX-NSPARC demo is gearing up at the
@ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪
@ncis-marseille.bsky.social! Starting for #FluorescenceFriday with a large field-of-view confocal #cellfie of COS cells labeled for actin ⚫ endoplasmic reticulum 🟡 mitochondria 🔴 and nucleus 🔵. Fluorescence microscopy is also nice in inverted colors 🌈🧪
Reposted by RitaTewari
The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella
February 1, 2025 at 9:39 AM
The world is full of crazy and sad news, but here is a protein that localizes to only one of the two flagella
Reposted by RitaTewari
Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance.
journals.plos.org/plospathogen...
Modes and mechanisms for the inheritance of mitochondria and plastids in pathogenic protists
Pathogenic protists are responsible for many diseases that significantly impact human and animal health across the globe. Almost all protists possess mitochondria or mitochondrion-related organelles, ...
journals.plos.org
January 25, 2025 at 10:29 PM
Plastids & mitochondria arose from separate endosymbioses of prokaryotes.Their prokaryotic ancestry makes them susceptible to antibiotics. Antibiotics kill pathogenic protists by targeting their plastids or mitochondria. Here we review the lop sided inheritance.
journals.plos.org/plospathogen...
Reposted by RitaTewari
The next GRC on volume Electron Microscopy is coming soon. Don't miss this opportunity and apply now as the number of seats is limited. #volumeEM
www.grc.org/volume-elect...
As I am new to bsky, please share widely (do we still say retweet?). 🙏
www.grc.org/volume-elect...
As I am new to bsky, please share widely (do we still say retweet?). 🙏
2025 Volume Electron Microscopy Conference GRC
The 2025 Gordon Research Conference on Volume Electron Microscopy will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
www.grc.org
November 12, 2024 at 11:14 AM
The next GRC on volume Electron Microscopy is coming soon. Don't miss this opportunity and apply now as the number of seats is limited. #volumeEM
www.grc.org/volume-elect...
As I am new to bsky, please share widely (do we still say retweet?). 🙏
www.grc.org/volume-elect...
As I am new to bsky, please share widely (do we still say retweet?). 🙏
Many congratulations Richard and team. Great story on DNA replication.
New paper @uofgsii.bsky.social led by @scotomorph.bsky.social @marquescata.bsky.social where we show that T. brucei DNA replication dynamics reflect structural and functional compartmentalisation of the genome, including stability. Well done Marija, and thanks all co-authors!
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications
A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...
doi.org
January 17, 2025 at 8:07 PM
Many congratulations Richard and team. Great story on DNA replication.
Reposted by RitaTewari
A couple of weeks left to apply to join Development's *Pathway to Independence* programme
Support & mentoring for post-docs on the academic job market
Deadline: January 31
journals.biologists.com/dev/pages/pi...
Support & mentoring for post-docs on the academic job market
Deadline: January 31
journals.biologists.com/dev/pages/pi...
Development PI Programme | Development | The Company of Biologists
Development PI Programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our second call for our Pathway to I...
journals.biologists.com
January 17, 2025 at 9:21 AM
A couple of weeks left to apply to join Development's *Pathway to Independence* programme
Support & mentoring for post-docs on the academic job market
Deadline: January 31
journals.biologists.com/dev/pages/pi...
Support & mentoring for post-docs on the academic job market
Deadline: January 31
journals.biologists.com/dev/pages/pi...
Reposted by RitaTewari
What started out as chromosome-counting blossomed into an exciting tale of evolution at the interface between the volatile centromere and the reliable, stable cell division machinery - the latest from the brilliant Jana Helsen, now looking to start her own group!
W/ @gsherloc.bsky.social
🧪🌎
W/ @gsherloc.bsky.social
🧪🌎
Centromere evolution isn't a sudden switch!
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
Our study shows centromere transitions are a step-by-step process driven by a combination of drift and selection. Discover how the kinetochore interface shapes this gradual change in our new preprint 🥳 doi.org/10.1101/2025.01.16.633479 🧵(1/8)
January 17, 2025 at 5:11 PM
What started out as chromosome-counting blossomed into an exciting tale of evolution at the interface between the volatile centromere and the reliable, stable cell division machinery - the latest from the brilliant Jana Helsen, now looking to start her own group!
W/ @gsherloc.bsky.social
🧪🌎
W/ @gsherloc.bsky.social
🧪🌎
Reposted by RitaTewari
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
Phosphatases: from basic research to translation
Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…
meetings.embo.org
January 17, 2025 at 6:58 PM
If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...
Reposted by RitaTewari
New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today:
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!
www.sciencedirect.com/science/arti...
1/
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!
www.sciencedirect.com/science/arti...
1/
January 16, 2025 at 4:11 PM
New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today:
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!
www.sciencedirect.com/science/arti...
1/
SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion!
www.sciencedirect.com/science/arti...
1/
Reposted by RitaTewari
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei - Nature Communications
A full description of trypanosome genome replication has proved elusive. Here, after genome assembly, the authors reveal compartmentalisation of DNA replication activity and stability between transcri...
doi.org
January 17, 2025 at 6:29 AM
DNA replication beyond the cores of megabase chromosomes of T. brucei -- some of my PhD work is FINALLY out! doi.org/10.1038/s414... thank you to @rmc9z.bsky.social @marquescata.bsky.social Emma, Dario, Kathryn, Graham and Craig!
Delighted to share our first manuscript on @bsky.app on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @zeeshanm.bsky.social; @eelcotromer.bsky.social; @ryanase.bsky.social ; Tony; Sarah; David F; Karine; Igor; Cyrille; Declan. Link:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 6, 2024 at 3:26 PM
Delighted to share our first manuscript on @bsky.app on a novel SUN1-ALLAN complex in Plasmodium MTOC and NE organization. Many thanks @zeeshanm.bsky.social; @eelcotromer.bsky.social; @ryanase.bsky.social ; Tony; Sarah; David F; Karine; Igor; Cyrille; Declan. Link:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by RitaTewari
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
November 26, 2024 at 9:12 PM
Here we are! To celebrate our arrival, here is a #trypanosome expanded ~13 times & stained for tubulin, individual cortical #microtubules can be recognised, what was only achievable by EM before. Images: Christine Girard-Blanc & Thierry Blisnick. Many thanks to @centriolelab.bsky.social for training
Reposted by RitaTewari
"Any pleasure I may take in the distinction of [being a Royal Society fellow] is diminished by the fact it is shared with someone who appears to be modelling himself on a Bond villain" www.researchprofessionalnews.com/rr-news-uk-c...
Royal Society fellow resigns over Elon Musk membership - Research Professional News
Dorothy Bishop lambasts world’s oldest scientific academy as she quits in protest
www.researchprofessionalnews.com
November 25, 2024 at 5:30 PM
"Any pleasure I may take in the distinction of [being a Royal Society fellow] is diminished by the fact it is shared with someone who appears to be modelling himself on a Bond villain" www.researchprofessionalnews.com/rr-news-uk-c...
Reposted by RitaTewari
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 23, 2024 at 1:29 PM
Cryptosporidium is an important public health threat, and it deserves better genetic tools to study it! Here we’ve developed a targeted in vivo CRISPR genetic screen to identify parasite genes required for survival and virulence…
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by RitaTewari
I like this plan from EupathDB - No paywall 😀. We can volunteer to pay a fee from lab budgets. And a "mortgage calculator" tool coming up in Jan to guide us estimate that fair price based on several variables like lab size and usage.
youtu.be/aSS6fiGVBG4?...
youtu.be/aSS6fiGVBG4?...
Parasitology Community Meeting
YouTube video by VEuPathDB
youtu.be
November 21, 2024 at 11:00 PM
I like this plan from EupathDB - No paywall 😀. We can volunteer to pay a fee from lab budgets. And a "mortgage calculator" tool coming up in Jan to guide us estimate that fair price based on several variables like lab size and usage.
youtu.be/aSS6fiGVBG4?...
youtu.be/aSS6fiGVBG4?...
Reposted by RitaTewari
"Given the current political reality and the expansion of attacks on science, it is time for scientists to be more effective, forceful, and vociferous as their own political advocates." 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Scientists as political advocates
Science, both teaching and doing, is under attack. The recent US presidential election of a person and platform with anti-science bias exemplifies this. The study of climate processes and patterns and...
www.science.org
November 21, 2024 at 9:49 PM
"Given the current political reality and the expansion of attacks on science, it is time for scientists to be more effective, forceful, and vociferous as their own political advocates." 🧪
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by RitaTewari
Check out our new paper showing that male gametocytes need an active mitochondrion for gametogenesis:
www.nature.com/articles/s42...
Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes.
@lshtm.bsky.social🧵
www.nature.com/articles/s42...
Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes.
@lshtm.bsky.social🧵
Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparum - Communications Biology
Male gametocytes rely on mitochondrial ATP to fuel gametogenesis in Plasmodium falciparum.
www.nature.com
November 18, 2024 at 9:44 AM
Check out our new paper showing that male gametocytes need an active mitochondrion for gametogenesis:
www.nature.com/articles/s42...
Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes.
@lshtm.bsky.social🧵
www.nature.com/articles/s42...
Also, we have a big plug for our excellent new antibody marker specific for male gametocytes and gametes.
@lshtm.bsky.social🧵
Reposted by RitaTewari
New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events
Understanding genome duplication requires characterisation of the locations where DNA replication initiates, termed origins. Genome-wide mapping of DNA replication origins has mainly been derived from...
www.biorxiv.org
November 18, 2024 at 10:00 AM
New preprint from others in the lab - Mapping origins of DNA replication in Leishmania.
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Great work Jeziel, Gabriel, @marquescata.bsky.social, Marija, Craig, Dario and the boss!
www.biorxiv.org/content/10.1...
Reposted by RitaTewari
Only two weeks to go to the UK Vector-Borne Diseases meeting in Liverpool (3-4th December). We are full and there is no further registration for in-person attendance. Therefore, we have opened up online attendance - see here if interested. @baylism.bsky.social payments.liv.ac.uk/conferences-...
UK VBD Conference 2024 | University of Liverpool
The threat to the UK from vector-borne diseases is rising at astonishing pace. Mosquito and tick species have invaded; Usutu virus is present; Lyme disease
payments.liv.ac.uk
November 18, 2024 at 11:48 AM
Only two weeks to go to the UK Vector-Borne Diseases meeting in Liverpool (3-4th December). We are full and there is no further registration for in-person attendance. Therefore, we have opened up online attendance - see here if interested. @baylism.bsky.social payments.liv.ac.uk/conferences-...
Reposted by RitaTewari
New preprint! How do cells rewire chromosome segregation during meiosis? We identify a germline-specific mRNA splice isoform for a critical kinetochore protein. This alternative protein transforms its regulatory control, contributing to proper fertility.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 19, 2024 at 6:37 PM
New preprint! How do cells rewire chromosome segregation during meiosis? We identify a germline-specific mRNA splice isoform for a critical kinetochore protein. This alternative protein transforms its regulatory control, contributing to proper fertility.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by RitaTewari
Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva
meetings.embo.org/event/25-mei...
meetings.embo.org/event/25-mei...
Meiosis: Exploring diversity to discover the fundamentals
Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …
meetings.embo.org
November 14, 2024 at 3:45 AM
Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva
meetings.embo.org/event/25-mei...
meetings.embo.org/event/25-mei...