Takashi Akera Lab
@takashiakeralab.bsky.social
Tenure-Track PI @nih_nhlbi. Cell biology🔬of non-Mendelian segregation 🧬(meiotic drive) and species barrier in 🐭
https://www.nhlbi.nih.gov/science/chromosome-dynamics-and-evolution
https://www.nhlbi.nih.gov/science/chromosome-dynamics-and-evolution
Pinned
Our (@jeffsekelsky.bsky.social, Corbin Jones, & me) #Meiosis, Recombination & Evolution of Sex class @uncchapelhill.bsky.social loved talking w/ @takashiakeralab.bsky.social about his lab's @biorxivpreprint.bsky.social on meiotic cohesin errors & sterility in hybrid mice. doi.org/10.1101/2025...
Thank you so much for having me today! It was great to get feedback on our recent preprint!
Reposted by Takashi Akera Lab
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
November 10, 2025 at 1:26 PM
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: www.imp.ac.at/career/open-...
Reposted by Takashi Akera Lab
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
November 11, 2025 at 9:26 AM
Interested in pursuing a PhD by working on a long-neglected marine organism and making a lot of discoveries? Darwin Trust offers a PhD studentship for international students (anyone non-UK) www.findaphd.com/phds/project...
Reposted by Takashi Akera Lab
Very exciting news: My first first-author paper is now out (open access!) in Chromosoma! link.springer.com/article/10.1...
The synaptonemal complex component corolla regulates meiotic crossover formation in Drosophila melanogaster - Chromosoma
In Drosophila melanogaster females, as in most organisms, the segregation of homologous chromosomes in meiosis depends on the formation of crossovers between them. In most cases, crossovers require th...
link.springer.com
November 10, 2025 at 9:18 PM
Very exciting news: My first first-author paper is now out (open access!) in Chromosoma! link.springer.com/article/10.1...
Reposted by Takashi Akera Lab
Don’t look away.
What some people call ‘suicidal empathy’ other (medical professionals) might call ‘psychopathy’
What some people call ‘suicidal empathy’ other (medical professionals) might call ‘psychopathy’
One analytical model shows that, as of November 5th, the dismantling of U.S.A.I.D. has already caused the deaths of 600,000 people, two-thirds of them children. https://newyorkermag.visitlink.me/jUzNSc
The Shutdown of U.S.A.I.D. Has Already Killed Hundreds of Thousands
The short documentary “Rovina’s Choice” tells the story of what goes when aid goes.
newyorkermag.visitlink.me
November 7, 2025 at 5:18 PM
Don’t look away.
What some people call ‘suicidal empathy’ other (medical professionals) might call ‘psychopathy’
What some people call ‘suicidal empathy’ other (medical professionals) might call ‘psychopathy’
Reposted by Takashi Akera Lab
Wow. Neat. Congratulations!!!
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org
October 30, 2025 at 11:55 PM
Wow. Neat. Congratulations!!!
Reposted by Takashi Akera Lab
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
October 30, 2025 at 8:41 PM
Among the anti-recombinases, FIGNL1 rules them all. So much that inactivating it brings BRCA2-deficient cells to life. Who is responsible for RAD51 loading without BRCA2/FIGNL1, check out the paper to find out! Great collaboration with @raychaudhurilab.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Takashi Akera Lab
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Brandeis University honors Fred Hutch molecular biologist
Dr. Steven Henikoff, a molecular biologist at Fred Hutch Cancer Center, has won the prestigious Rosenstiel Award for Distinguished Work in Basic Medical Research from Brandeis University recognizing h...
www.fredhutch.org
October 31, 2025 at 12:48 AM
Dr. Steven Henikoff receives the 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research.
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
www.brandeis.edu/rosenstiel/r...
(Personal note: I continue to be inspired and astonished by my postdoctoral mentor & current colleague)
Reposted by Takashi Akera Lab
🧪hey all, a friend and colleague, @maddoxfornc.bsky.social, is running for Congress in North Carolina. He is a scientist, professor, and parent, perspectives that are especially important right now. I hope you will support his run for Congress. Find out more here: www.maddoxforcongress.com/about/
Meet Paul Maddox
Paul Maddox is a world-renowned cancer researcher, two-time entrepreneur, and native son of Western North Carolina–and now, a candidate for U.S. Congress. ....
www.maddoxforcongress.com
October 30, 2025 at 7:26 PM
🧪hey all, a friend and colleague, @maddoxfornc.bsky.social, is running for Congress in North Carolina. He is a scientist, professor, and parent, perspectives that are especially important right now. I hope you will support his run for Congress. Find out more here: www.maddoxforcongress.com/about/
Reposted by Takashi Akera Lab
"There’s a cancer running through Washington, D.C., and I’m running to cure it." #NC11
www.maddoxforcongress.com/2025/10/24/l...
www.maddoxforcongress.com/2025/10/24/l...
PAUL MADDOX ANNOUNCES FOR NORTH CAROLINA’S 11TH CONGRESSIONAL DISTRICT | Paul Maddox for Congress
www.maddoxforcongress.com
October 24, 2025 at 2:56 PM
"There’s a cancer running through Washington, D.C., and I’m running to cure it." #NC11
www.maddoxforcongress.com/2025/10/24/l...
www.maddoxforcongress.com/2025/10/24/l...
Reposted by Takashi Akera Lab
When all your PCRs fail, except for the negative control 😱
October 30, 2025 at 7:43 PM
When all your PCRs fail, except for the negative control 😱
Reposted by Takashi Akera Lab
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
October 26, 2025 at 2:01 AM
Domesticated animals have pulled our heavy carts and turned our large mills for centuries. But what about the opposite end of the spectrum—what if the wheel you want to turn is so small you can’t see it?
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Turns out we can harness the power of bacteria to power the world’s smallest machines.
1/7 ⚛️🧪
Reposted by Takashi Akera Lab
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Enhancer-promoter compatibility is mediated by the promoter-proximal region
Gene promoters induce transcription in response to distal enhancers. How enhancers specifically activate their target promoter while bypassing other promoters remains unclear. Here, we find that the p...
www.biorxiv.org
October 16, 2025 at 3:06 PM
What is a promoter? And how does it work?
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
We very happy to share our latest work trying to understand enhancer-promoter compatibility.
I am very excited about the results of @blanka-majchrzycka.bsky.social, which changed the way I think about promoters
www.biorxiv.org/content/10.1...
Reposted by Takashi Akera Lab
Happy Sunday ovo-lovers! A new issue of #cebooc is here!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
October 26, 2025 at 8:04 AM
Happy Sunday ovo-lovers! A new issue of #cebooc is here!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
biomed.news/bims-cebooc/...
This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/
Thanks @biomednews.bsky.social for preselecting!
Reposted by Takashi Akera Lab
非天然アミノ酸の効率的導入
タンパク質設計における非天然アミノ酸の導入のボトルネックに、細胞内取り込み効率の低さがある。今回細菌のトランスポーターを利用/改変して同時に最大2つの非天然アミノ酸を高効率に導入する手法を確立。基礎から応用まで発展に期待
www.nature.com/articles/s41...
タンパク質設計における非天然アミノ酸の導入のボトルネックに、細胞内取り込み効率の低さがある。今回細菌のトランスポーターを利用/改変して同時に最大2つの非天然アミノ酸を高効率に導入する手法を確立。基礎から応用まで発展に期待
www.nature.com/articles/s41...
Hijacking a bacterial ABC transporter for genetic code expansion - Nature
Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins with novel…
www.nature.com
October 22, 2025 at 10:01 AM
非天然アミノ酸の効率的導入
タンパク質設計における非天然アミノ酸の導入のボトルネックに、細胞内取り込み効率の低さがある。今回細菌のトランスポーターを利用/改変して同時に最大2つの非天然アミノ酸を高効率に導入する手法を確立。基礎から応用まで発展に期待
www.nature.com/articles/s41...
タンパク質設計における非天然アミノ酸の導入のボトルネックに、細胞内取り込み効率の低さがある。今回細菌のトランスポーターを利用/改変して同時に最大2つの非天然アミノ酸を高効率に導入する手法を確立。基礎から応用まで発展に期待
www.nature.com/articles/s41...
Reposted by Takashi Akera Lab
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
October 15, 2025 at 12:22 PM
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)
Reposted by Takashi Akera Lab
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1
October 21, 2025 at 9:30 PM
Scm3 interacts with the N-terminal tail of Cse4 to regulate kinetochore assembly in budding yeast https://www.biorxiv.org/content/10.1101/2025.10.20.683541v1
Reposted by Takashi Akera Lab
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
October 11, 2025 at 2:10 AM
BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:
Reposted by Takashi Akera Lab
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
www.crick.ac.uk
October 10, 2025 at 8:20 AM
The @crick.ac.uk is recruiting Early Career Group Leaders
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
- Lab set-up, research costs, salaries for up to 5 researchers
- Support for up to 12 years
- Access to our core facilities
- Competitive salary
- Fantastic colleagues
- All areas of biology
Deadline 27 Nov
www.crick.ac.uk/careers-stud...
Reposted by Takashi Akera Lab
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
October 9, 2025 at 2:43 PM
How do SMC complexes load onto DNA to get ready for loop extrusion?
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
@roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸♂️🤸♂️🤸♂️.
Check out the new paper: www.cell.com/molecular-ce...
Reposted by Takashi Akera Lab
Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
October 6, 2025 at 6:09 PM
Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...
Reposted by Takashi Akera Lab
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 7, 2025 at 8:51 AM
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Reposted by Takashi Akera Lab
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
October 6, 2025 at 9:51 AM
The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
Reposted by Takashi Akera Lab
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi were honored for research into how the body helps the immune system avoid attacking your own tissues instead of foreign invaders.
The medicine Nobel Prize goes to 3 scientists for work on peripheral immune tolerance
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi were honored for research into how the body helps the immune system avoid attacking your own tissues instead of foreign invaders.
n.pr
October 6, 2025 at 2:15 PM
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi were honored for research into how the body helps the immune system avoid attacking your own tissues instead of foreign invaders.
Reposted by Takashi Akera Lab
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
October 5, 2025 at 5:29 PM
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Congrats Mia and Mike🎉 Great paper for journal club!
Check out this new Levine-Lampson collaboration, led by the talented Hyuk-Joon Jeon.
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
We explored the consequences of inheriting long telomeres from dad and short telomeres from mom. Or the reciprocal. Turns out, parent-of-origin matters (in mice, at least).
authors.elsevier.com/c/1loW-3QW8S...
authors.elsevier.com
October 5, 2025 at 3:25 AM
Congrats Mia and Mike🎉 Great paper for journal club!