Adrian Saurin
@adesaurin.bsky.social
Professor of Genome Stability at University of Dundee. #kinase #phosphatase #cellcycle #senescence #cancer #mitosis #aneuploidy.
Looking for simple ways to explain complexity.
www.saurinlab.com
Looking for simple ways to explain complexity.
www.saurinlab.com
Pinned
Adrian Saurin
@adesaurin.bsky.social
· Apr 1
A chemical-genetic system to rapidly inhibit the PP2A-B56 phosphatase reveals a role at metaphase kinetochores - Nature Communications
Phosphatase enzymes are challenging to study due to a lack of specific inhibitors. Here, authors develop a chemical-genetic system to inhibit and characterize a major Ser/Thr phosphatase complex, and ...
www.nature.com
Delighted to share a chemical-genetic system we developed to rapidly inhibit a serine/threonine phosphatase complex (within secs). This will make it much easier to study #phosphatases. The system is also applicable to other “undruggable” enzymes.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Adrian Saurin
Last days to apply this position in our group! Do join us in this great Institute @crg.eu, with great colleagues, and help shaping the science and culture of our lab!
📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere.
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
February 9, 2026 at 2:24 PM
Last days to apply this position in our group! Do join us in this great Institute @crg.eu, with great colleagues, and help shaping the science and culture of our lab!
Reposted by Adrian Saurin
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
February 3, 2026 at 1:57 PM
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
Reposted by Adrian Saurin
Two new papers from the lab published in The EMBO Journal!
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
February 2, 2026 at 4:18 PM
Two new papers from the lab published in The EMBO Journal!
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
link.springer.com/article/10.1...
By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading
link.springer.com/article/10.1...
By Arianna Esposito Verza and others – On mechanism of activation of PLK1
@ukri.org Could you please make a statement about whether this will impact on grants already in review from autumn 2025? It's hard to accept grant opportunities closing, but even harder to accept the rug being pulled after review. Rumours of a 1-5% acceptance rate would be incredibly hard to take
Today, we're sharing an open letter from our Chief Executive, Professor Sir Ian Chapman, outlining changes to UKRI investment approach, and addressing concerns about research funding and the financial position of STFC. Read his letter here: www.ukri.org/news/open-le...
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
www.ukri.org
February 2, 2026 at 10:26 AM
@ukri.org Could you please make a statement about whether this will impact on grants already in review from autumn 2025? It's hard to accept grant opportunities closing, but even harder to accept the rug being pulled after review. Rumours of a 1-5% acceptance rate would be incredibly hard to take
Reposted by Adrian Saurin
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate).
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
Listen, I get that UKRI wants to pivot. But killing both at once is devastating.
Let's hope at least one opens by summer... #AcademicSky
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
www.researchprofessionalnews.com
February 1, 2026 at 2:07 PM
At a time when the UK should be capitalising on its global reputation as a great place to do science, this is an enormous own goal. I am so sorry for all those who jobs are going to be impacted.
Reposted by Adrian Saurin
PhD position in my lab!
January 28, 2026 at 5:25 PM
PhD position in my lab!
Wholeheartedly agree with this. Well said
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Brooklyn Beckham and Prince Harry are the canaries in the coalmine. The children of Instagram will be next | Rhiannon Lucy Cosslett
A generation of overexposed children are being used by their parents for social media clout. What happens when they start to speak out, asks Guardian columnist Rhiannon Lucy Cosslett
www.theguardian.com
January 25, 2026 at 12:47 PM
Wholeheartedly agree with this. Well said
www.theguardian.com/commentisfre...
www.theguardian.com/commentisfre...
Reposted by Adrian Saurin
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2127
Closing date: Wednesday 18 February 2026, 23:59
www.dundee.ac.uk
January 21, 2026 at 11:33 AM
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
Reposted by Adrian Saurin
We are also recruiting a Postdoc in cell/molecular biology!
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
January 23, 2026 at 4:23 PM
We are also recruiting a Postdoc in cell/molecular biology!
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
3yr, fully funded by @cancerresearchuk.org more details here: news.cancerresearchuk.org/2025/11/27/s...
Apply here: www.imperial.ac.uk/jobs/search-...
Reposted by Adrian Saurin
Group-based Prediction System (GPS) 6.0
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
January 11, 2026 at 12:30 PM
Group-based Prediction System (GPS) 6.0
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
gps.biocuckoo.cn
Online server for protein Post-Translational Modifications
Kinase-specific phosphosite prediction across 185 species!
>10 other PTMs
#NucAcidRes 2023
academic.oup.com/nar/article/...
Reposted by Adrian Saurin
We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci.
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
January 7, 2026 at 11:44 AM
We are back on Jan 19 at 3pm CET! Our first seminar for 2026 will feature Prof. Benjamin Turk (@benturklab.bsky.social) and Dr. Giorgia Massacci.
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
Register to attend: tinyurl.com/PMCseminar2
Previous seminars: www.youtube.com/@PMCModularity
The best thing I’ve listened to all year. A brilliantly articulated vision about the dangers of AI which stresses the importance of societal pressure in demanding a safe future. Please consider listening and deciding for yourself if and how you can help
open.spotify.com/episode/1S8F...
open.spotify.com/episode/1S8F...
AI Expert: We Have 2 Years Before Everything Changes! We Need To Start Protesting! - Tristan Harris
Podcast Episode · The Diary Of A CEO with Steven Bartlett · 27/11/2025 · 2h 23m
podcasts.apple.com
December 14, 2025 at 3:56 PM
The best thing I’ve listened to all year. A brilliantly articulated vision about the dangers of AI which stresses the importance of societal pressure in demanding a safe future. Please consider listening and deciding for yourself if and how you can help
open.spotify.com/episode/1S8F...
open.spotify.com/episode/1S8F...
2 recent preprints show the mitotic stopwatch monitors more than just mitotic delays - it protects against WGD, cell enlargement and other stresses that mildly activate p53. It may act to amplify p53 signals to suppress tumourigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.6...
The mitotic stopwatch limits the proliferation of whole genome doubled cells
Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...
www.biorxiv.org
December 8, 2025 at 10:21 AM
2 recent preprints show the mitotic stopwatch monitors more than just mitotic delays - it protects against WGD, cell enlargement and other stresses that mildly activate p53. It may act to amplify p53 signals to suppress tumourigenesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.6...
Reposted by Adrian Saurin
We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging.
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: www.oist.jp/careers/post...
Website: www.oist.jp/research/res...
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: www.oist.jp/careers/post...
Website: www.oist.jp/research/res...
Cell Proliferation and Gene Editing Unit
Every day, millions of cells divide to sustain essential tissue functions. Errors in this process can lead to developmental disorders or cancer. Our research focuses on the molecular mechanisms of cel...
www.oist.jp
December 7, 2025 at 1:00 AM
We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging.
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: www.oist.jp/careers/post...
Website: www.oist.jp/research/res...
If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you.
More info: www.oist.jp/careers/post...
Website: www.oist.jp/research/res...
Reposted by Adrian Saurin
Last 3 days to apply for this post. Deadline 27/10/25
We are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share.
www.jobs.ac.uk/job/DOW912/s...
www.jobs.ac.uk/job/DOW912/s...
Senior Research Technician at University of Birmingham
Explore an exciting academic career as a Senior Research Technician. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
October 24, 2025 at 8:21 AM
Last 3 days to apply for this post. Deadline 27/10/25
Reposted by Adrian Saurin
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
PhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.
The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR
candidate.hr-manager.net
October 23, 2025 at 4:18 PM
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
A simple idea for how paclitaxel achieves tumour selectivity: It is better retained inside dense tissue, allowing tumour levels to stay high even after it has cleared the healthy cells. A model that requires testing, but could be used to improve treatments if correct
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
A perfusion-based model to explain how paclitaxel achieves tumour-selective killing
Paclitaxel (taxol) is a commonly used chemotherapeutic that stabilizes microtubules to inhibit chromosome segregation during mitosis. Although it is used effectively to treat a wide variety of solid t...
www.biorxiv.org
October 6, 2025 at 9:15 PM
A simple idea for how paclitaxel achieves tumour selectivity: It is better retained inside dense tissue, allowing tumour levels to stay high even after it has cleared the healthy cells. A model that requires testing, but could be used to improve treatments if correct
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
“We have economies that need to grow, whether or not they make us thrive; what we need are economies that make us thrive, whether or not they grow.”
www.nature.com/articles/d41...
www.nature.com/articles/d41...
End GDP mania: how the world should really measure prosperity
The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.
www.nature.com
October 2, 2025 at 8:21 PM
“We have economies that need to grow, whether or not they make us thrive; what we need are economies that make us thrive, whether or not they grow.”
www.nature.com/articles/d41...
www.nature.com/articles/d41...
Reposted by Adrian Saurin
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
September 18, 2025 at 8:02 PM
@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer.
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Deadline 15th October. Get in touch if you have any questions.
Please repost!
More details:
www.imperial.ac.uk/jobs/search-...
Reposted by Adrian Saurin
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
September 20, 2025 at 7:43 AM
The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.
Start mining data now: dataminer.depmap.sanger.ac.uk
Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
The mitotic stopwatch limits the proliferation of whole genome doubled cells
Whole genome doubling (WGD) is a frequent event in tumourigenesis that promotes chromosomal instability and tumour evolution. WGD is sensed indirectly due to the presence of extra centrosomes, which a...
www.biorxiv.org
September 19, 2025 at 10:23 AM
Very excited to post our latest work showing the mitotic stopwatch monitors more than just mitotic delays - it protects against whole genome doubling and cell enlargement.
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Great work by fantastic postdocs Lindsey and Reece (& student Maria)
#PostdocAppreciationWeek
www.biorxiv.org/content/10.1...
Reposted by Adrian Saurin
I've written to Keir Starmer, Kemi Badenoch and Nigel Farage, urging them to join me in condemning Elon Musk's dangerous remarks inciting violence yesterday.
As leaders, we must stand together and make clear Musk will face serious consequences for these actions.
As leaders, we must stand together and make clear Musk will face serious consequences for these actions.
September 14, 2025 at 6:30 PM
I've written to Keir Starmer, Kemi Badenoch and Nigel Farage, urging them to join me in condemning Elon Musk's dangerous remarks inciting violence yesterday.
As leaders, we must stand together and make clear Musk will face serious consequences for these actions.
As leaders, we must stand together and make clear Musk will face serious consequences for these actions.
Reposted by Adrian Saurin
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis
DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segre...
www.biorxiv.org
September 10, 2025 at 3:18 PM
Excited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
Reposted by Adrian Saurin
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.
📅 Deadline: 29th September 2025.
🙏 Please share with anyone who might be interested.
📅 Deadline: 29th September 2025.
🙏 Please share with anyone who might be interested.
Research Technician – Protein Biochemistry at University of Sussex
Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
September 9, 2025 at 8:35 AM
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.
📅 Deadline: 29th September 2025.
🙏 Please share with anyone who might be interested.
📅 Deadline: 29th September 2025.
🙏 Please share with anyone who might be interested.
Reposted by Adrian Saurin
New work from the lab! 🔬
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
Mitotic single-stranded DNA suppression by DDIAS
Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet unde...
www.biorxiv.org
September 10, 2025 at 4:50 PM
New work from the lab! 🔬
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...
We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. 1/n
www.biorxiv.org/content/10.1...