Glenn Masson
@glennmasson.bsky.social
Scientist at School of Medicine, University of Dundee. Using cryo-EM and my beloved HDX-MS to investigate all things ISR Kinase - GCN2, HRI, PERK (and I guess PKR). https://glennmasson.com
Another day another birthday party. The brief for this one was rainbow marshmallow sprinkles and I think I achieved that. Now for the ensuing hyperglycemic coma...
February 8, 2026 at 5:19 PM
Another day another birthday party. The brief for this one was rainbow marshmallow sprinkles and I think I achieved that. Now for the ensuing hyperglycemic coma...
Reposted by Glenn Masson
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
February 3, 2026 at 1:57 PM
I watched much of Ian Chapman's (Head of @ukri.org) appearance this morning at @ukparliament.parliament.uk Science, Innovation and Technology Committee..
A few points and new information that bioscientists may find interesting...
A 🧵
A few points and new information that bioscientists may find interesting...
A 🧵
I advised two groups at the UoD to wait for the next MRC Capital Equipment grant rather than the BBSRC Capital Equipment grant, as their proposal was perhaps a better fit for the MRC. Turns out the MRC capital equipment grant never materialised!
January 28, 2026 at 9:58 AM
I advised two groups at the UoD to wait for the next MRC Capital Equipment grant rather than the BBSRC Capital Equipment grant, as their proposal was perhaps a better fit for the MRC. Turns out the MRC capital equipment grant never materialised!
Reposted by Glenn Masson
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
January 27, 2026 at 9:40 AM
Exciting opportunity for a #postdoc to join @suyangzhang.bsky.social’s group in the LMB Structural Studies Division to investigate co-transcriptional splicing using cryo-EM and biochemistry.
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Read more: www.nature.com/naturecareer...
Apply by 11 FEB
#PostdocJobs #ScienceJobs
Nothing will make Universities flee from embracing and embedding AI faster than sharing IP % points lol
Lmao the bubble is fit to burst, boys
This is a hysterical and insane choice, I hope they follow through!
This is a hysterical and insane choice, I hope they follow through!
January 23, 2026 at 11:56 AM
Nothing will make Universities flee from embracing and embedding AI faster than sharing IP % points lol
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2127
Closing date: Wednesday 18 February 2026, 23:59
www.dundee.ac.uk
January 21, 2026 at 11:33 AM
Please share! We've an exciting one-year postdoctoral position available in my group - drug discovery using HDX-MS for a Parkinson's disease target. Join us on high-impact, translational research at the cutting edge of structural biology. We're a friendly bunch! www.dundee.ac.uk/work-for-us/...
Reposted by Glenn Masson
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
January 13, 2026 at 9:12 PM
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
love the colour scheme here
January 13, 2026 at 1:16 PM
love the colour scheme here
Reposted by Glenn Masson
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop https://www.biorxiv.org/content/10.64898/2026.01.08.698367v1
January 9, 2026 at 4:45 AM
Structural basis for a phosphoinositide-driven mTORC2-AKT positive feedback loop https://www.biorxiv.org/content/10.64898/2026.01.08.698367v1
Reposted by Glenn Masson
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge) on FindAPhD.com
PhD Project - Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge), listed on FindAPhD.com
www.findaphd.com
December 28, 2025 at 6:18 PM
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Glenn Masson
PXD053875 🚨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
🚨 New dataset alert! 🚨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
🚨 New dataset alert! 🚨
December 23, 2025 at 7:00 PM
PXD053875 🚨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
🚨 New dataset alert! 🚨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
🚨 New dataset alert! 🚨
Yes it's odd. Reputable lab I think as well so I'm surprised by their response.
December 17, 2025 at 8:03 PM
Yes it's odd. Reputable lab I think as well so I'm surprised by their response.
Without giving the game away it's not the ligand I am concerned about some other bits of the structure. The validation report looks fine. I have numerous other concerns with the manuscript and the fact this wasn't supplied after asking also raised alarm bells. Will ask again, thanks for the advice.
December 17, 2025 at 8:01 PM
Without giving the game away it's not the ligand I am concerned about some other bits of the structure. The validation report looks fine. I have numerous other concerns with the manuscript and the fact this wasn't supplied after asking also raised alarm bells. Will ask again, thanks for the advice.
Thanks -structure is held on pdb, no mtz. Will poke the editor a little more forcefully
December 16, 2025 at 6:11 PM
Thanks -structure is held on pdb, no mtz. Will poke the editor a little more forcefully
Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social
December 16, 2025 at 5:37 PM
Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social
Wait wut
PXD064417 🚨
Artificially contaminating Pleistocene Rhinoceros dental enamel with dog saliva
🚨 New dataset alert! 🚨
Artificially contaminating Pleistocene Rhinoceros dental enamel with dog saliva
🚨 New dataset alert! 🚨
December 16, 2025 at 11:00 AM
Wait wut
This is great!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
Sunday Feature - The Great Egyptian Music Mystery - BBC Sounds
Ellie Chan traces the story of a set of unique and puzzling manuscripts
www.bbc.co.uk
December 8, 2025 at 10:57 AM
This is great!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.
December 6, 2025 at 11:16 AM
Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.
A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence
Our next Junior Research Fellowship is open to early career researchers engaged in any aspect of: Applied Mathematics & Theoretical Physics, Biological Sciences, Medical Sciences, Physics or Veterinary Sciences. Find out more and apply by 12 December:
Junior Research Fellowship
The Governing Body of St Catharine’s College invites applications for election to a Junior Research Fellowship tenable from 1 October 2026 for three years. The Fellowship is open to those who are engaged in research in any aspect of: Applied Mathematics and Theoretical Physics, Biological Sciences (Biochemistry, Cell Biology, Genetics, Pathology, Pharmacology, Physiology, Development and Neuroscience, Plant Sciences, Psychology, Zoology), Medical Sciences, Physics, Veterinary Sciences.
www.caths.cam.ac.uk
December 2, 2025 at 12:08 PM
A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence
Reposted by Glenn Masson
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
www.nature.com
November 17, 2025 at 12:12 PM
I’m really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📢New preprint has landed! 📢
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry
Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) is an established tool in drug discovery, used to characterize target engagement and conformational dynamics, frequently used in both biopharmace...
www.biorxiv.org
November 14, 2025 at 9:34 AM
📢New preprint has landed! 📢
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
Wait, what?
eIF2B Selectively Anchors and Activates Mutant KRAS https://www.biorxiv.org/content/10.1101/2025.11.10.686860v1
November 13, 2025 at 8:16 AM
Wait, what?
This is so illuminating. For all its potential faults, pubpeer manages to justify its existence very regularly. Just imagine if the Wakefield/MMR paper had been published in the era of pubpeer and had been so rosolutely picked apart - we would be living in a different world.
This is one of the most remarkable academic debacles I've ever seen.
A large RCT got published in BMJ. There are currently 44 Pubpeer comments, mostly about the data, including...well. Read for yourself.
pubpeer.com/publications...
A large RCT got published in BMJ. There are currently 44 Pubpeer comments, mostly about the data, including...well. Read for yourself.
pubpeer.com/publications...
PubPeer - Prevention of acute myocardial infarction induced heart fail...
There are comments on PubPeer for publication: Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (P...
pubpeer.com
November 11, 2025 at 8:53 PM
This is so illuminating. For all its potential faults, pubpeer manages to justify its existence very regularly. Just imagine if the Wakefield/MMR paper had been published in the era of pubpeer and had been so rosolutely picked apart - we would be living in a different world.