Glenn Masson
@glennmasson.bsky.social
Scientist at School of Medicine, University of Dundee. Using cryo-EM and my beloved HDX-MS to investigate all things ISR Kinase - GCN2, HRI, PERK (and I guess PKR). https://glennmasson.com
Reposted by Glenn Masson
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge) on FindAPhD.com
PhD Project - Exploring Resistance to KRAS inhibitors (KRASi) of differentiated Mechanism of Action at Babraham Institute (Cambridge), listed on FindAPhD.com
www.findaphd.com
December 28, 2025 at 6:18 PM
Pssst! I have a PhD position available. Please pass it on
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Reposted by Glenn Masson
PXD053875 π¨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
π¨ New dataset alert! π¨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
π¨ New dataset alert! π¨
December 23, 2025 at 7:00 PM
PXD053875 π¨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
π¨ New dataset alert! π¨
Cyclophilin D (CypD) is a drug-target protein ligand that can be pushed to fHDX-MS in the double-digit mM range. This study proposes a methodological framework for FBDD.
π¨ New dataset alert! π¨
Yes it's odd. Reputable lab I think as well so I'm surprised by their response.
December 17, 2025 at 8:03 PM
Yes it's odd. Reputable lab I think as well so I'm surprised by their response.
Without giving the game away it's not the ligand I am concerned about some other bits of the structure. The validation report looks fine. I have numerous other concerns with the manuscript and the fact this wasn't supplied after asking also raised alarm bells. Will ask again, thanks for the advice.
December 17, 2025 at 8:01 PM
Without giving the game away it's not the ligand I am concerned about some other bits of the structure. The validation report looks fine. I have numerous other concerns with the manuscript and the fact this wasn't supplied after asking also raised alarm bells. Will ask again, thanks for the advice.
Thanks -structure is held on pdb, no mtz. Will poke the editor a little more forcefully
December 16, 2025 at 6:11 PM
Thanks -structure is held on pdb, no mtz. Will poke the editor a little more forcefully
Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social
December 16, 2025 at 5:37 PM
Reviewing a x-ray crystallography paper, I have asked for the .mtz file, as they talk quite a bit about the density supporting their findings. Authors have refused. Am I out of touch w/ x-ray data now or is that kind of insane? #crystallography @markohyvonen.bsky.social @scurry.bsky.social
Wait wut
PXD064417 π¨
Artificially contaminating Pleistocene Rhinoceros dental enamel with dog saliva
π¨ New dataset alert! π¨
Artificially contaminating Pleistocene Rhinoceros dental enamel with dog saliva
π¨ New dataset alert! π¨
December 16, 2025 at 11:00 AM
Wait wut
This is great!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
Sunday Feature - The Great Egyptian Music Mystery - BBC Sounds
Ellie Chan traces the story of a set of unique and puzzling manuscripts
www.bbc.co.uk
December 8, 2025 at 10:57 AM
This is great!
www.bbc.co.uk/sounds/play/...
www.bbc.co.uk/sounds/play/...
Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.
December 6, 2025 at 11:16 AM
Waking up to a morning of awkward looks and disappointment every morning...this Ashes series is like Christmas day on repeat.
A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence
Our next Junior Research Fellowship is open to early career researchers engaged in any aspect of: Applied Mathematics & Theoretical Physics, Biological Sciences, Medical Sciences, Physics or Veterinary Sciences. Find out more and apply by 12 December:
Junior Research Fellowship
The Governing Body of St Catharineβs College invites applications for election to a Junior Research Fellowship tenable from 1 October 2026 for three years. The Fellowship is open to those who are engaged in research in any aspect of: Applied Mathematics and Theoretical Physics, Biological Sciences (Biochemistry, Cell Biology, Genetics, Pathology, Pharmacology, Physiology, Development and Neuroscience, Plant Sciences, Psychology, Zoology), Medical Sciences, Physics, Veterinary Sciences.
www.caths.cam.ac.uk
December 2, 2025 at 12:08 PM
A wonderful opportunity to be part of the friendliest college in Cambridge! A JRF is a wonderful springboard to academic independence
Reposted by Glenn Masson
Iβm really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
RAF inhibitors activate the integrated stress response by direct activation of GCN2 - Nature Communications
Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target ...
www.nature.com
November 17, 2025 at 12:12 PM
Iβm really pleased to share the link to a new Cook Lab paper published today in Nature Communications.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
π’New preprint has landed! π’
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
Spatially Resolved Determination of Small Molecule Protein Affinities by Hydrogen Deuterium Exchange Mass Spectrometry
Hydrogen Deuterium Exchange Mass Spectrometry (HDX-MS) is an established tool in drug discovery, used to characterize target engagement and conformational dynamics, frequently used in both biopharmace...
www.biorxiv.org
November 14, 2025 at 9:34 AM
π’New preprint has landed! π’
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
We show how HDX-MS can derive Kd at AN AMINO ACID RESOLUTION using HDX-MS against drugs.
Comments and criticisms welcome!
Spatially Resolved Determination of Small Molecule Protein Affinities by HDX-MS.
www.biorxiv.org/content/10.1...
Wait, what?
eIF2B Selectively Anchors and Activates Mutant KRAS https://www.biorxiv.org/content/10.1101/2025.11.10.686860v1
November 13, 2025 at 8:16 AM
Wait, what?
This is so illuminating. For all its potential faults, pubpeer manages to justify its existence very regularly. Just imagine if the Wakefield/MMR paper had been published in the era of pubpeer and had been so rosolutely picked apart - we would be living in a different world.
This is one of the most remarkable academic debacles I've ever seen.
A large RCT got published in BMJ. There are currently 44 Pubpeer comments, mostly about the data, including...well. Read for yourself.
pubpeer.com/publications...
A large RCT got published in BMJ. There are currently 44 Pubpeer comments, mostly about the data, including...well. Read for yourself.
pubpeer.com/publications...
PubPeer - Prevention of acute myocardial infarction induced heart fail...
There are comments on PubPeer for publication: Prevention of acute myocardial infarction induced heart failure by intracoronary infusion of mesenchymal stem cells: phase 3 randomised clinical trial (P...
pubpeer.com
November 11, 2025 at 8:53 PM
This is so illuminating. For all its potential faults, pubpeer manages to justify its existence very regularly. Just imagine if the Wakefield/MMR paper had been published in the era of pubpeer and had been so rosolutely picked apart - we would be living in a different world.
HRG is critical to immunity and coagulation, but a beast to work with due to disordered sections and PTMs. We gained some structural insights by working with human HRG, which is made in humans! Great collaboration with chums @ St Andrews Dr Alan Stewart & Steve. portlandpress.com/biochemj/art...
Investigating the conformational landscape of human histidine-rich glycoprotein using amide HDX-MS
Histidine-rich glycoprotein (HRG) is a multi-domain plasma protein involved in immune modulation, angiogenesis, coagulation and fibrinolysis. Despite its broad biological relevance, structural investi...
portlandpress.com
November 6, 2025 at 1:33 PM
HRG is critical to immunity and coagulation, but a beast to work with due to disordered sections and PTMs. We gained some structural insights by working with human HRG, which is made in humans! Great collaboration with chums @ St Andrews Dr Alan Stewart & Steve. portlandpress.com/biochemj/art...
Reposted by Glenn Masson
Our mission is to determine the molecular mechanisms of disease in order to advance human health.
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
November 6, 2025 at 10:40 AM
Our mission is to determine the molecular mechanisms of disease in order to advance human health.
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
Want to join our vibrant and diverse research institute as a funded PhD or taught MPhil student? Apply by the 2nd December 2025.
More information here: www.cimr.cam.ac.uk/postgraduate...
An excellent example of writing on a topic which my students would describe as "obvious" to the audience. The ability to distil these points with such clarity while not fudging the truth still escapes me
November 6, 2025 at 8:50 AM
An excellent example of writing on a topic which my students would describe as "obvious" to the audience. The ability to distil these points with such clarity while not fudging the truth still escapes me
Reposted by Glenn Masson
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
November 3, 2025 at 10:04 AM
Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching
That latter, within reason.
October 23, 2025 at 10:24 AM
That latter, within reason.
Reposted by Glenn Masson
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - MCDB - UOD2016
Closing date: Thursday 6 November 2025, 23:59
www.dundee.ac.uk
October 15, 2025 at 12:53 PM
Attention membrane traffickers! I'm recruiting a post-doc to my lab in Dundee. We're dissecting the functions of intrinsically disordered domains of COPII coat proteins. We think they control timing of coat assembly and morphology of carriers.
www.dundee.ac.uk/work-for-us/...
www.dundee.ac.uk/work-for-us/...
Wonderful that this is out, with data from PhD student Vanesa, now at GSK. Excellent nose-to-tail examination of how WEE1 inhibitors activate GCN2, paradoxically, of course. Congrats to Steve Jackson, Aldo Bader, + Stefan Marciniak and all the other groups and authors. www.nature.com/articles/s41...
WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2 - Nature Communications
Inhibitors of the protein kinase Wee1 are promising drugs for cancer therapy. Here, the authors show that these drugs activate the integrated stress response via GCN2, synergising with mRNA translation defects. They suggest strategies such as PROTACs or ISR inhibitors to improve WEE1 mediated toxicity.
www.nature.com
October 9, 2025 at 12:28 PM
Wonderful that this is out, with data from PhD student Vanesa, now at GSK. Excellent nose-to-tail examination of how WEE1 inhibitors activate GCN2, paradoxically, of course. Congrats to Steve Jackson, Aldo Bader, + Stefan Marciniak and all the other groups and authors. www.nature.com/articles/s41...
At a party, John asked us students if we knew who Max Perutz was. I said "yes, he was a man who named himself after a lecture theatre." With supreme magnanimity he laughed. Met months later and he clocked me and we talked research for ages. Meant so much to a student! www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 6:00 PM
At a party, John asked us students if we knew who Max Perutz was. I said "yes, he was a man who named himself after a lecture theatre." With supreme magnanimity he laughed. Met months later and he clocked me and we talked research for ages. Meant so much to a student! www.cam.ac.uk/research/new...
Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...
GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling
During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...
www.science.org
October 2, 2025 at 11:27 PM
Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...
Wonderful to be part of this study with Stefan et al.!
Our new reviewed preprint now available in @elife.bsky.social
βA GCN1-independent activator of the kinase GCN2β
First authors, PhD student @jessyzhu-jiayi.bsky.social & PDRA @giulia-ema.bsky.social
Pleased to be exploring the new eLife publishing model
#ISRliterature
doi.org/10.7554/eLif...
βA GCN1-independent activator of the kinase GCN2β
First authors, PhD student @jessyzhu-jiayi.bsky.social & PDRA @giulia-ema.bsky.social
Pleased to be exploring the new eLife publishing model
#ISRliterature
doi.org/10.7554/eLif...
A GCN1-independent activator of the kinase GCN2
doi.org
September 28, 2025 at 9:47 AM
Wonderful to be part of this study with Stefan et al.!