Ryuji Yanase
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ryanase.bsky.social
Ryuji Yanase
@ryanase.bsky.social
270 followers 420 following 6 posts
Research Associate at Uni of Leicester & Uni of Nottingham.
Interested in protozoan parasites, parasite-vector interactions, and meiosis.
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ryanase.bsky.social
Ryuji Yanase @ryanase.bsky.social · Nov 24
Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast.
www.biorxiv.org/content/10.1...
Reposted by Ryuji Yanase
dudinlab.bsky.social
Another #notTHECover unfortunately.

But this gorgeous, Tron-like vibe, drawn by the amazing @munafomarzia.bsky.social for our recent #ExM work with @gautamdey.bsky.social & @centriolelab.bsky.social will still be printed out in the lab.

Read here: www.cell.com/cell/fulltex...
December 26, 2025 at 11:53 AM
Reposted by Ryuji Yanase
bungoakiyoshi.bsky.social
The discovery of the first kinetochore proteins (CENP-A, CENP-B, CENP-C) was reported by Bill Earnshaw and Naomi Rothfield in 1985 in Chromosoma. Forty years later, Chromosoma/Chromosome Research has published a special issue (most articles are open access)
link.springer.com/collections/...
40 years of CENP-A
In 1985, Earnshaw and Rothfield published in Chromosoma a landmark discovery of the centromere-specific protein CENP-A. Subsequent research has shown that ...
link.springer.com
December 22, 2025 at 10:09 AM
Reposted by Ryuji Yanase
florentwaltz.bsky.social
Final version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social

Huge collaborative effort! So glad to see the community already using it to develop new resources & tools.

Check it out here: shorturl.at/z4i4c
#CryoEM #CryoET
December 19, 2025 at 4:45 PM
Reposted by Ryuji Yanase
gautamdey.bsky.social
Thanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍

W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social

journals.biologists.com/jcs/article/...
Evolutionary cell biology comes of age
Summary: This Perspective discusses how the discipline of evolutionary cell biology, by integrating evolutionary theory, comparative physiology and modern molecular approaches, works to understand how...
journals.biologists.com
December 19, 2025 at 4:13 PM
Reposted by Ryuji Yanase
cellraiser.bsky.social
New in ACS SynBio: led by Dennis Bolshakov, we used the awesome power of yeast to define how expression levels, noise, and sequence program the dynamics of synthetic protein waves, allowing us to genetically encode new cellular timescales stable over generations!

pubs.acs.org/doi/full/10....
December 17, 2025 at 3:24 PM
Reposted by Ryuji Yanase
luisjagago.bsky.social
Are you very busy but still want to learn what Aphelids are and why they are important to understand the evolution of Fungi?
Then check out our “Quick guide” on Aphelids published in collaboration with @deemteam.bsky.social, Sergey and Guifré. #protistsonsky
doi.org/10.1016/j.cu...
December 15, 2025 at 5:41 PM
Reposted by Ryuji Yanase
kinetoplastpapers.bsky.social
Anatomy and mechanics of tsetse fly blood feeding www.biorxiv.org/content/10.64898/2025.12.08.692967v1
December 12, 2025 at 8:15 AM
Reposted by Ryuji Yanase
nucleosomepolice.bsky.social
Confused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
December 9, 2025 at 3:14 PM
Reposted by Ryuji Yanase
plosbiology.org
#Diplonemids are among the most diverse & abundant #protists in the deep #ocean. This study localises >5,000 proteins of #Paradiplonema papillatum, revealing #organelle compartmentalisation, including a membrane coated with carbohydrate-degrading enzymes @plosbiology.org 🧪 plos.io/3XvmpIO
Endogenous tagging of novel proteins confirms supervised cluster predictions. Left: Tagged proteins highlighted (black) among relevant predicted clusters, resolved on neighbor-averaged imputed t-SNE. Right: Individual cell lines were generated via endogenous tagging and imaged through fluorescence microscopy for comparison with the compartment-relevant protein was predicted to. Merged microscopy images showing protein signal (green) merged with nuclear and mitochondrial DNA (blue). All imaged cells are oriented with their apical regions facing right and posterior facing left, cell membrane outlines are traced for all images except for L, showing only trace of the papilla, which lacks signal. Scale bar represents 5 μm.
December 4, 2025 at 5:30 PM
Reposted by Ryuji Yanase
biorxiv-cellbio.bsky.social
Differential contributions of β tubulin isotypes to acentrosomal oocyte meiosis in C. elegans https://www.biorxiv.org/content/10.64898/2025.12.03.692175v1
December 4, 2025 at 8:30 AM
Reposted by Ryuji Yanase
jimenezruizlab.bsky.social
Our new paper is out in Nature Communications! 🎉
We explore how Toxoplasma gondii organizes parasite development, combining cell biology and expansion microscopy to reveal new structural insights.
#Toxoplasma @meissnerlab.bsky.social @natcomms.nature.com
www.nature.com/articles/s41...
November 28, 2025 at 11:41 AM
Reposted by Ryuji Yanase
natrevmcb.nature.com
New Online! Critical constituents and assembly principles of centriole biogenesis in human cells
Critical constituents and assembly principles of centriole biogenesis in human cells
Nature Reviews Molecular Cell Biology, Published online: 27 November 2025; doi:10.1038/s41580-025-00921-5The centriole is crucial for fundamental cellular processes in eukaryotes, including cell polarity, signalling and motility. This Review discusses recent insights into the molecular architecture of centrioles and the principles governing their assembly, with a focus on human cells.
bit.ly
November 27, 2025 at 4:20 PM
Reposted by Ryuji Yanase
gautamdey.bsky.social
Our attempt to give multinucleate cells the spotlight they deserve (seriously, they’re everywhere), led by the fearless @mrosjac.bsky.social and with @Markus Ganter

doi.org/10.32942/X2M...

We’d love your feedback while this goes through the peer review process!

#MicroEvoSky
#ProtistsonSky 🧪🌏
November 26, 2025 at 2:05 PM
Reposted by Ryuji Yanase
helsenjana.bsky.social
How do new centromeres evolve while staying compatible with the division machinery?

Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore.

👉 doi.org/10.1038/s41586-025-09779-1
November 26, 2025 at 4:21 PM
Reposted by Ryuji Yanase
cellraiser.bsky.social
How do cells adapt morphology to function? In a 🔥 preprint by @zjmaggiexu.bsky.social , with @dudinlab.bsky.social and @amyweeks.bsky.social , we identify a self-organizing single-cell morphology circuit that optimizes the feeding trap structure of the suctorian P. collini. 🧵 tinyurl.com/4k8nv926
November 18, 2025 at 4:15 PM
ryanase.bsky.social
Our new preprint describes Plasmodium NEK4 as a key regulator coupling meiotic initiation and morphogenesis—a critical step for malaria transmission. This involves MTOC-driven nuclear movement strikingly analogous to "horsetail" movement in fission yeast.
www.biorxiv.org/content/10.1...
November 24, 2025 at 4:08 PM
Reposted by Ryuji Yanase
healthcare-global.bsky.social
people.com/deadly-kissi...
Deadly ‘Kissing Bug’ Disease Chagas Has Spread in the U.S. — Here’s Which States Are Affected
The Centers for Disease Control and Prevention (CDC) reported that the triatomine insect — called the 'kissing bug' — has been found in 32 states in the U.S. and that there could be more than 300,000 ...
people.com
October 18, 2025 at 7:00 AM
Reposted by Ryuji Yanase
plosbiology.org
The flagellar pocket collar (FPC) is a cytoskeletal structure essential for nutrient uptake & immune evasion in #Trypanosome. @mbonhivers.bsky.social &co use U-ExM to provide novel insights into FPC biogenesis, and reveal 2 unknown cytoskeletal structures @plosbiology.org 🧪 plos.io/4n3bWi6
A Trypanosoma brucei cell visualized by confocal microscopy after ultrastructure expansion. The cell was immunolabelled for the BILBO1 protein (yellow) and stained with fluorescent NHS-ester (grey). The flagellar pocket is highlighted in pink. Credit: Marie Zelená
October 10, 2025 at 4:14 PM
Reposted by Ryuji Yanase
cellarchlab.com
Time for a thread!🧵 How different is the molecular organization of thylakoids in “higher” plants🌱? To find out, we teamed up with @profmattjohnson.bsky.social to dive into spinach chloroplasts with #CryoET ❄️🔬. Curious? ..Read on!

#TeamTomo #PlantScience 🧪 🧶🧬 🌾
elifesciences.org/articles/105...
1/🧵
September 25, 2025 at 6:00 PM
Reposted by Ryuji Yanase
elife.bsky.social
🌱 Using ‘compelling’ methods, including #CryoET, researchers mapped spinach thylakoid membranes at single-molecule precision, revealing how photosynthetic complexes are organised and settling long-standing debates on chloroplast architecture.
buff.ly/j3TSIkn
September 20, 2025 at 1:59 PM
Reposted by Ryuji Yanase
cp-trendsparasitol.bsky.social
Our 2025 Sep issue bit.ly/2N9R8Es reviews species sanitation & structural resilience in malaria control, animal trypanosomosis control, parasite genome organization, Leishmania attachment in sandflies, nonchemotherapeutic nematode control, tick & host microbiotas, parasitic neural manipulation &more
September 4, 2025 at 3:24 PM
Reposted by Ryuji Yanase
bspparasitology.bsky.social
A big welcome to everyone who has joined us for the @bspparasitology.bsky.social trypanosomiasis and leishmaniasis meeting this week in the beautiful city of Ceske Budějovice!
Title slide being projected on a screen for the BSP trypanosomiasis and leishmaniasis seminar View of Ceske Budějovice from above. Beautiful city with coloured houses on a clear sunny day
September 1, 2025 at 8:19 PM
Reposted by Ryuji Yanase
tbharat-lab.bsky.social
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
August 31, 2025 at 6:44 PM
Reposted by Ryuji Yanase
eelcotromer.bsky.social
New work on ARK1 (AURKB?) in Plasmodium (malaria parasite) with @ritatewari.bsky.social and Pushkar Sharma. CPC in Plasmodium is (ofcourse..) different compared to conventional models: two INCENPs, no borealin/survivin - mainly at spindle microtubules/MTOCs. Special thanks to @ryanase.bsky.social!
ryanase.bsky.social Ryuji Yanase @ryanase.bsky.social · Aug 28
Pleased to share our new preprint: "Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex". Many thanks to our collaborators.
@ritatewari.bsky.social @eelcotromer.bsky.social @davidguttery.bsky.social

www.biorxiv.org/content/10.1...
August 31, 2025 at 12:26 PM
ryanase.bsky.social
Pleased to share our new preprint: "Plasmodium ARK1 regulates spindle formation during atypical mitosis and forms a divergent chromosomal passenger complex". Many thanks to our collaborators.
@ritatewari.bsky.social @eelcotromer.bsky.social @davidguttery.bsky.social

www.biorxiv.org/content/10.1...
August 28, 2025 at 1:12 PM