Rachael Ott
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rachaelott.bsky.social
Rachael Ott
@rachaelott.bsky.social
2.5K followers 2.5K following 170 posts
Neurobiologist @UofSC 🔬 Super-resolution #microscopy, adipocytes, cytoskeleton, and #neurodegeneration 🦠
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rachaelott.bsky.social
Rachael Ott @rachaelott.bsky.social · Jan 17
For #FluorescenceFriday, tau (blue) and long loops of neurofilament proteins are shown in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy
Tau (blue) and neurofilament (fire) are shown in a primary hippocampal neuron.
Reposted by Rachael Ott
minclab.bsky.social
Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development!
@ijmonod.bsky.social

www.biorxiv.org/content/10.6...
January 26, 2026 at 3:45 PM
Reposted by Rachael Ott
amyengevik.bsky.social
So many tuft cells (yellow/orange) for #TuftTuesday. Immune cells are in green.
January 20, 2026 at 10:03 PM
Reposted by Rachael Ott
carter-lab.bsky.social
Beautiful images from @christlet.bsky.social labelling tubulin in neurons #journalclub
www.biorxiv.org/content/10.6...
January 19, 2026 at 9:29 AM
Reposted by Rachael Ott
elife.bsky.social
A protein called Uninflatable acts as a switch between glial cells growing and glial cells wrapping themselves around axons.

🔗 buff.ly/WRdybO3
January 17, 2026 at 11:01 AM
Reposted by Rachael Ott
brugueslab.bsky.social
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
January 7, 2026 at 4:02 PM
Reposted by Rachael Ott
haoyin.bsky.social
Diffusion first, Binding second

Organ-scale uniform immunostaining in 1 DAY🤠, via temporally controlling antibody reaction strength

CuRVE + eFLASH

🐭👤Brain

62 Ab tested

👉deoxycholic acid + pH
👉compatible with transgenic fluorescent proteins

#NatBiotech 2025
www.nature.com/articles/s41...
January 3, 2026 at 1:16 PM
Reposted by Rachael Ott
actin-paris-saclay.bsky.social
New paper out!
We show how mechanosensitive adherens junction proteins link actomyosin contractility to actin assembly using in vitro reconstitution.
Huge congrats to Aurélie Favarin, Rayan Said, & all authors!
In Science Advances: www.science.org/doi/10.1126/...
#actin #myosin #mechanobiology
January 2, 2026 at 4:00 PM
Reposted by Rachael Ott
amyengevik.bsky.social
Hoping everyone's new year fluorescence is clear and bright. Happy #FluorescenceFriday.
January 3, 2026 at 4:52 AM
Reposted by Rachael Ott
benhayden.bsky.social
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵

rdcu.be/eVZ1A
Rethinking the centrality of brain areas in understanding functional organization
Nature Neuroscience - Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas...
rdcu.be
December 23, 2025 at 1:02 PM
Reposted by Rachael Ott
j-today.bsky.social
I don't always get pretty, isolated, AND transfected primary neurons in culture, but when I do I take advantage.... Rat hippocampal neuron overexpressing ThymosinB4-mScarlet and imaged for 16hr on a @zeiss-microscopy.bsky.social LSM880 with Airyscan. #FluorescenceFriday #Microscopy
December 19, 2025 at 2:01 PM
Reposted by Rachael Ott
natclarke.bsky.social
Felt a little festive at the microscope this morning for #FluorescenceFriday 🎄

Here’s the nervous system of a juvenile sea star ⭐️

Green = acetylated tubulin, red = nuclei

Happy holidays!
Confocal microscopy image of a juvenile sea star (Patiria miniata) viewed from the oral side. The animal has a five-armed, star-shaped body with a central nerve ring. The nervous system is labeled in green, forming radial nerve cords extending into each arm, and cell nuclei are labeled in red throughout the animal. The image appears against a black background and has a holiday-ornament-like appearance.
December 19, 2025 at 5:32 PM
Reposted by Rachael Ott
opazo.bsky.social
✨ Blinking #nanobodies that work for single-molecule localization 🔬
Our new preprint shows that the self-blinking dye JF635b restores robust, buffer-free blinking in #nanobodies, enabling reliable #dSTORM, #MINFLUX, and more, without chemical-switching buffers. Opening new possibilities for #ExM!
December 22, 2025 at 10:45 AM
Reposted by Rachael Ott
zebrafishrock.bsky.social
Network of somatosensory axons and immune cells in the adult zebrafish skin. Credit to @errricpeterman.bsky.social. #ZebrafishZunday 🧪
Depth-coded somatosensory axons and a plethora of mpeg1+ immune cells (cyan) in the adult zebrafish skin.
December 7, 2025 at 11:49 AM
Reposted by Rachael Ott
mag2art.bsky.social
I am presenting at the Science and Art Minisymposium at #CellBio2025 today! The line up is great this year. I am hands down the least qualified person presenting. It is a weird feeling but I am excited! Here is my title slide.
Room 122 4pm
December 7, 2025 at 4:49 PM
Reposted by Rachael Ott
davematus.bsky.social
since you made it all the way to then end - we've already made transgenic lines with the mSG from Ando et al - it's amazing! here's a movie from our Cell Observatory project at the Advanced BioImaging Center 7/7
December 5, 2025 at 9:20 PM
Reposted by Rachael Ott
rcollepardo.bsky.social
Our Science paper is out!

Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group

News: bit.ly/4avnkAr and bit.ly/3XBGVHS

Great perspective by @vram142.bsky.social +K Zhang
December 5, 2025 at 9:47 AM
Reposted by Rachael Ott
martinowk.bsky.social
For #FluorescenceFriday - RNAscope marking subfields of the hippocampus in a section of postmortem human 🧠 tissue. Image credit to the Imaging Development team @lieberinstitute.bsky.social 🔬🧪👩‍🔬
December 5, 2025 at 2:01 PM
Reposted by Rachael Ott
mathpreu.bsky.social
This distal gill tip is giving full branchial art vibes for #FluorescenceFriday 🦓🐟
— who knew oxygen exchange could be this pretty.
🔴 kdrl:mCherry highlights the vasculature
⚪ fgf10b:nEOS marks the pillar cells

#Zebrafish #DevBio #SciArt
December 5, 2025 at 1:39 PM
Reposted by Rachael Ott
daniellebeckman.bsky.social
It's #FluorescenceFriday, and this is a reminder that I'm coordinating a collection on the Brain-Immune-Vascular interface in Dementia for @natureportfolio.nature.com, and we have several APC (Article Processing Charge) waivers available! Check out more here:
www.nature.com/collections/...
The microscopy image shows blood vessels (claudin 5 🔴 ) and astrocytes (GFAP 🔵 ) in the brain.
December 5, 2025 at 5:11 PM
Reposted by Rachael Ott
ricardalert.bsky.social
New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social

www.biorxiv.org/content/10.1...
December 2, 2025 at 8:02 PM
Reposted by Rachael Ott
zebrafish007.bsky.social
Exciting new #Zebrafish research from the #WeinsteinLab, led by Jong Park!
“Specialized gas-exchange endothelium of the zebrafish gill” —

www.biorxiv.org/content/10.6...

Amazing to see red blood cells moving through the gills! Don’t forget to check out the supplemental movies ;-)
December 2, 2025 at 10:48 PM
Reposted by Rachael Ott
mahjoublab.bsky.social
New must-read review article for all lovers of #centrioles and #centrosomes 😍👇
November 28, 2025 at 3:01 PM
Reposted by Rachael Ott
zebrafishrock.bsky.social
One-day-old transgenic zebrafish embryo. Credit to Dr. Kazuhide Shaun Okuda. #ZebrafishZunday 🧪
Side view of a transgenic zebrafish embryo that expresses a fluorescent protein that marks the the vasculature and hatching gland (magenta). In green marks the muscle, eye and parts of the brain. For more info, see ($) https://www.nature.com/articles/s41556-021-00784-w
November 30, 2025 at 7:04 PM
Reposted by Rachael Ott
wallaceucsf.bsky.social
Cells can form patterns within themselves just like embryos do. How? Connie Yan's new preprint shows how the anterior-posterior cytoskeleton pattern in Stentor is dictated by regionalized scaffolding proteins

www.biorxiv.org/content/10.1...
August 19, 2025 at 8:42 AM