Milo Imbeni
@pyramidalmilo.bsky.social
PhD in Maastricht, microglia and microscopes
Reposted by Milo Imbeni
Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
February 16, 2026 at 5:48 PM
Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social
Reposted by Milo Imbeni
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
February 16, 2026 at 2:15 PM
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
Reposted by Milo Imbeni
iconic shot of Lucas Pinheiro Braathen on the podium
February 14, 2026 at 4:15 PM
iconic shot of Lucas Pinheiro Braathen on the podium
Reposted by Milo Imbeni
no, it simply isnt.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.
The predominent anti-AI position on bsky is that AI is useless, fake, shit and basically the same as NFTs, destined to collapse in months once everyone sees how poor it is. So anyone who suggests that it could improve or be useful to any boss in any situation in the future must be evil.
February 12, 2026 at 1:19 PM
no, it simply isnt.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.
People are talking about capital using gAI as an excuse to conduct mass lay-offs, about students losing learning because theyre being lied to about gAI in education, about the mass theft of the work of artists and authors to train LLMs, about CSAM and nonconsensual sexual images.
Reposted by Milo Imbeni
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
February 13, 2026 at 10:20 AM
How did life arise from simple chemical building blocks?
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
New #LMBResearch led by @edogia.bsky.social in @philholliger.bsky.social group has identified a small self-replicating ribozyme that could be the answer.
Read more: mrclmb.ac.uk/news-events/...
Reposted by Milo Imbeni
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
www.science.org
February 13, 2026 at 2:19 AM
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Milo Imbeni
finally found this tumblr post expounding on how stupid owls are piraticoctopus.tumblr.com/post/6741867...
February 11, 2026 at 2:01 PM
finally found this tumblr post expounding on how stupid owls are piraticoctopus.tumblr.com/post/6741867...
Reposted by Milo Imbeni
🔬 In this new Open Access paper, the authors propose a new method that does not require a lot of computing power and works even for small datasets that are more typically seen in life sciences. To maintain competitive performance with respect to state-of-the-art methods, their denoising...
February 10, 2026 at 1:36 PM
🔬 In this new Open Access paper, the authors propose a new method that does not require a lot of computing power and works even for small datasets that are more typically seen in life sciences. To maintain competitive performance with respect to state-of-the-art methods, their denoising...
Reposted by Milo Imbeni
This looks phenomenal. I want to read every paper.
Why did consciousness evolve at all? A superb special issue of @royalsocietypublishing.org brings together experts across disciplines to explore the functions of consciousness and why it emerged in some species but not others. @tecumsehfitch.bsky.social royalsocietypublishing.org/rstb/issue/3...
February 8, 2026 at 8:56 PM
This looks phenomenal. I want to read every paper.
Reposted by Milo Imbeni
I have yet to see any evidence that there is a market for AI-generated books outside of people being tricked into thinking they are not AI-generated books. AKA, it is a project of scamming and deceiving people, and really should be treated as fraud
February 8, 2026 at 6:55 PM
I have yet to see any evidence that there is a market for AI-generated books outside of people being tricked into thinking they are not AI-generated books. AKA, it is a project of scamming and deceiving people, and really should be treated as fraud
Reposted by Milo Imbeni
Prediction: In 10 years, “hardest problem” articles like this will shift from the challenge of ”C and perception“ to “C and emotions/mood“. The first is fascinating. The second is required to understand psychiatric functions & conditions.
www.scientificamerican.com/article/what...
www.scientificamerican.com/article/what...
Inside the incredible, infuriating quest to explain consciousness
Will brain science deliver answers about consciousness or hit another wall?
www.scientificamerican.com
February 7, 2026 at 1:44 PM
Prediction: In 10 years, “hardest problem” articles like this will shift from the challenge of ”C and perception“ to “C and emotions/mood“. The first is fascinating. The second is required to understand psychiatric functions & conditions.
www.scientificamerican.com/article/what...
www.scientificamerican.com/article/what...
Reposted by Milo Imbeni
Many people think that eating insects could be a good solution to climate change.
Nope. Not really.
Read more here, and see why Project Drawdown says this is "Not Recommended" as a climate solution.
drawdown.org/explorer/dep...
Nope. Not really.
Read more here, and see why Project Drawdown says this is "Not Recommended" as a climate solution.
drawdown.org/explorer/dep...
Deploy Insect Farming for Food and Feed
This solution involves industrially farming insects, such as crickets, mealworms, and black soldier fly larvae, to produce protein for human consumption, livestock feed, or pet food that is less resou...
drawdown.org
February 6, 2026 at 8:33 PM
Many people think that eating insects could be a good solution to climate change.
Nope. Not really.
Read more here, and see why Project Drawdown says this is "Not Recommended" as a climate solution.
drawdown.org/explorer/dep...
Nope. Not really.
Read more here, and see why Project Drawdown says this is "Not Recommended" as a climate solution.
drawdown.org/explorer/dep...
Reposted by Milo Imbeni
Expansion microscopy may be the hi-res hero that many biologists have been craving.
Expansion Microscopy Has Transformed How We See the Cellular World | Quanta Magazine
How physically magnifying objects using a key ingredient in diapers has opened an unprecedented view of the microbial world.
www.quantamagazine.org
February 5, 2026 at 9:04 PM
Expansion microscopy may be the hi-res hero that many biologists have been craving.
Reposted by Milo Imbeni
"Nested spatiotemporal theta–gamma waves organize hierarchical processing across the mouse visual cortex" www.nature.com/articles/s41...
traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it 🙂
#VisualizationInspo
traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it 🙂
#VisualizationInspo
February 4, 2026 at 10:31 AM
"Nested spatiotemporal theta–gamma waves organize hierarchical processing across the mouse visual cortex" www.nature.com/articles/s41...
traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it 🙂
#VisualizationInspo
traveling waves-related, supershiny looking figures, apparently made in Julia: github.com/brendanjohnh... makes me want to learn it 🙂
#VisualizationInspo
Reposted by Milo Imbeni
Draghi: “L’Europa diventi una vera federazione se vuole avere potere”
Draghi: “L’Europa diventi una vera federazione se vuole avere potere”
Il discorso dell’ex premier e presidente Bce a Lovanio: ”Nel nuovo ordine mondiale l’Europa rischia di diventare subordinata, divisa e deindustrializzata allo …
www.repubblica.it
February 2, 2026 at 12:47 PM
Draghi: “L’Europa diventi una vera federazione se vuole avere potere”
Reposted by Milo Imbeni
You nerds will appreciate this.
I got married on Saturday! It was wonderful.
It was at a rare and historic book library, and we leaned into the theme.
Table centerpieces were books checked out of our library based on our interests, themed to that tables’ guests.
And Eileen made paper roses.
I got married on Saturday! It was wonderful.
It was at a rare and historic book library, and we leaned into the theme.
Table centerpieces were books checked out of our library based on our interests, themed to that tables’ guests.
And Eileen made paper roses.
February 2, 2026 at 6:50 PM
You nerds will appreciate this.
I got married on Saturday! It was wonderful.
It was at a rare and historic book library, and we leaned into the theme.
Table centerpieces were books checked out of our library based on our interests, themed to that tables’ guests.
And Eileen made paper roses.
I got married on Saturday! It was wonderful.
It was at a rare and historic book library, and we leaned into the theme.
Table centerpieces were books checked out of our library based on our interests, themed to that tables’ guests.
And Eileen made paper roses.
Reposted by Milo Imbeni
There is a part of me that’s kinda like, yes queen go off
The ‘Doomsday Glacier’ Could Flood the Earth. Can a 50-Mile Wall Stop It?
Scientists have long opposed polar geoengineering. Some now believe it will be necessary.
www.theatlantic.com
January 31, 2026 at 2:55 PM
There is a part of me that’s kinda like, yes queen go off
Reposted by Milo Imbeni
We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime
www.epfl.ch/labs/dangelo...
www.epfl.ch/labs/dangelo...
Master Projects
DANGELOLAB
www.epfl.ch
January 23, 2026 at 7:13 AM
We have several Master’s thesis projects available in the D’Angelo lab, spanning different areas of lipid biology/biochemistry. If you know someone who might be interested, we’d really appreciate you sharing this. #lipidtime
www.epfl.ch/labs/dangelo...
www.epfl.ch/labs/dangelo...
Reposted by Milo Imbeni
… due to the fact that they cause faulty proteins to be made, but actually most of the dysfunction seems to occur in regulation.) So gene regulation is central to the way we work. But it is immensely complicated. /11
January 30, 2026 at 9:53 AM
… due to the fact that they cause faulty proteins to be made, but actually most of the dysfunction seems to occur in regulation.) So gene regulation is central to the way we work. But it is immensely complicated. /11
Reposted by Milo Imbeni
Norway’s oil fund yielded NOK 2362 billions in 2025, enough to DOUBLE the current budget of Norwegian Research Council for the next 214 years. 🤷♂️
www.nbim.no/no/nyheter-o...
www.nbim.no/no/nyheter-o...
Sterk avkastning i 2025 | Norges Bank Investment Management
www.nbim.no
January 29, 2026 at 7:36 AM
Norway’s oil fund yielded NOK 2362 billions in 2025, enough to DOUBLE the current budget of Norwegian Research Council for the next 214 years. 🤷♂️
www.nbim.no/no/nyheter-o...
www.nbim.no/no/nyheter-o...
Reposted by Milo Imbeni
🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!
January 28, 2026 at 4:20 PM
🧪 We are excited to share this novel open access paper on Phasor Mixing Coefficient to analyze colocalization, developed by folks @i2janelia.bsky.social and @aicjanelia.bsky.social. This is also the first technical paper jointly published with our sister imaging center @malacridalab.bsky.social!
Reposted by Milo Imbeni
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
January 27, 2026 at 10:29 PM
We have two funded postdoctoral positions available. Topics encompass:
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
-Next gen light-sheet fluorescence microscopy instrumentation
-Structured illumination microscopy and other approaches to extend the resolution limit.
-Nonlinear microscopy combined with adaptive optics / phase conjugation
Reposted by Milo Imbeni
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Photonics West 2026 impressions
The Photonics West conference includes a gigantic tradeshow spanning 2 halls of the Moscone Center and some of the space in between. I visited on two consecutive afternoon, trying to at least walk by ...
nicost.github.io
January 26, 2026 at 6:55 PM
One of the perks of living in San Francisco is free visits to the Photonics West trade show. Sharing my notes for those missing out: nicost.github.io/microscope-t...
Beautiful work once again with FIRE mice. Reprogramming microglia for the win!
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
January 26, 2026 at 6:16 PM
Beautiful work once again with FIRE mice. Reprogramming microglia for the win!
Reposted by Milo Imbeni
9. We’ve become so used to all this that we hardly notice it. But isn’t it extraordinary? Almost everyone wants one thing, and almost everyone who represents us – whether in politics or the media – wants the opposite. Yet we tell ourselves we live in a democracy.
January 23, 2026 at 11:37 AM
9. We’ve become so used to all this that we hardly notice it. But isn’t it extraordinary? Almost everyone wants one thing, and almost everyone who represents us – whether in politics or the media – wants the opposite. Yet we tell ourselves we live in a democracy.