Milo Imbeni
@pyramidalmilo.bsky.social
PhD in Maastricht, microglia and microscopes
Reposted by Milo Imbeni
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
November 13, 2025 at 8:49 PM
I won't talk about NMeth @natmethods.nature.com forever (probably), but I do want to brag a bit about the November focus issue on cell segmentation and tracking, which is many ways is my last hurrah (and final editorial) for the journal. I am so proud of these papers!! www.nature.com/nmeth/volume...
Reposted by Milo Imbeni
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
November 13, 2025 at 2:32 PM
Just 4 days until the start of I2K and its 33 totally free image analysis tutorials and events! Please share with your "home networks", especially early career researchers - the videos will be amazing and high-impact no matter how many people attend live, BUT (1/x)
Reposted by Milo Imbeni
Mycophenolate mofetil reduces the branching of microglial processes https://www.biorxiv.org/content/10.1101/2025.11.12.687812v1
November 13, 2025 at 6:15 PM
Mycophenolate mofetil reduces the branching of microglial processes https://www.biorxiv.org/content/10.1101/2025.11.12.687812v1
Reposted by Milo Imbeni
Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
October 22, 2025 at 1:24 PM
Disease-associated #microglia are a distinct state associated with #AlzheimersDisease, #ALS & #aging. This Essay explores the dynamics, origins & therapeutic potential of these microglia in #neurodegeneration, alongside evidence supporting a protective role @plosbiology.org 🧪 plos.io/49mmzcm
Reposted by Milo Imbeni
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
November 5, 2025 at 11:51 PM
NEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
Reposted by Milo Imbeni
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
November 11, 2025 at 9:48 AM
Local #mRNAtranslation in polarized cells is well studied in neurons but what about #microglia? This study shows that #inflammation enhances microglial #RNA localization & translation via RNA-binding protein IMP1/ZBP1, regulating morphology, motility & phagocytosis @plosbiology.org 🧪 plos.io/486ZLMS
Reposted by Milo Imbeni
Diving into the literature… I think it's the first time I see correlative live-cell/EM data after photobleaching - it shows how intense light can actually destroy microtubules rather than just bleach fluorescent tubulin along a neurite (from onlinelibrary.wiley.com/doi/10.1002/...)
November 10, 2025 at 10:26 AM
Diving into the literature… I think it's the first time I see correlative live-cell/EM data after photobleaching - it shows how intense light can actually destroy microtubules rather than just bleach fluorescent tubulin along a neurite (from onlinelibrary.wiley.com/doi/10.1002/...)
Reposted by Milo Imbeni
Nightmare #423:
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
Stinking, Spongy, Dark, Huge: A Spider Web Unlike Any Seen Before
www.nytimes.com
November 8, 2025 at 7:44 PM
Nightmare #423:
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
-- 1,140 sq ft spider web
-- populated by a metropolis of 111,000 spiders
-- in a cave
😱
www.nytimes.com/2025/11/08/s...
Reposted by Milo Imbeni
Look out for this later #histSTM
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
November 8, 2025 at 6:53 AM
Look out for this later #histSTM
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
(And on Franklin, about whom lots of myths are circulating today, read this: www.nature.com/articles/d41...)
Reposted by Milo Imbeni
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
November 7, 2025 at 12:12 PM
This week, we published in @science.org an article outlining the current ethical and societal implications of research involving human neural #organoids and #assembloids, their transplantation, and highlighted potential next steps.
Reposted by Milo Imbeni
Using #LLMs for science👨💻💬? We have a fun tool for you: introducing #folder2md4llms. It converts an entire folder of docs/code/pdfs/pptx into a single markdown file that you can upload to your chatbot of choice. We use it to talk with our publications database or code repos
github.com/HenriquesLab...
github.com/HenriquesLab...
October 28, 2025 at 5:22 PM
Using #LLMs for science👨💻💬? We have a fun tool for you: introducing #folder2md4llms. It converts an entire folder of docs/code/pdfs/pptx into a single markdown file that you can upload to your chatbot of choice. We use it to talk with our publications database or code repos
github.com/HenriquesLab...
github.com/HenriquesLab...
Reposted by Milo Imbeni
💥 DeepInverse is now part of the official PyTorch Landscape💥
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
DeepInverse Joins the PyTorch Ecosystem: the library for solving imaging inverse problems with deep learning – PyTorch
pytorch.org
November 5, 2025 at 5:31 PM
💥 DeepInverse is now part of the official PyTorch Landscape💥
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
We are excited to join an ecosystem of great open-source AI libraries, including @hf.co diffusers, MONAI, einops, etc.
pytorch.org/blog/deepinv...
Reposted by Milo Imbeni
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
www.thetransmitter.org/computationa...
'Such a map could form the basis for a model in which every input-output function that can measured will act as a piece of the simulation'. Wonderful essay about 'completing' a C. Elegans model, by Boyden and Körding
'Such a map could form the basis for a model in which every input-output function that can measured will act as a piece of the simulation'. Wonderful essay about 'completing' a C. Elegans model, by Boyden and Körding
Whole-brain, bottom-up neuroscience: The time for it is now
Applying new tools to entire brains, starting with C. elegans, offers the opportunity to uncover how molecules work together to generate neural physiology and how neurons work together to generate…
www.thetransmitter.org
November 2, 2025 at 9:03 AM
www.thetransmitter.org/computationa...
'Such a map could form the basis for a model in which every input-output function that can measured will act as a piece of the simulation'. Wonderful essay about 'completing' a C. Elegans model, by Boyden and Körding
'Such a map could form the basis for a model in which every input-output function that can measured will act as a piece of the simulation'. Wonderful essay about 'completing' a C. Elegans model, by Boyden and Körding
Reposted by Milo Imbeni
I always get drawn back to Al Gore telling voters that he’d only raise taxes on the top 1% and then after the election a poll showed that something like 20% of voters thought they were in the top 1% and another 20% thought they would be in the next five years. Just a total tragic disconnect.
Maaaaan, this. So much this. Every time there's any kind of actual in-depth survey we find that the American people are *abysmally* ignorant about even the most basic political facts, but the pundit class just immediately forgets & proceeds with political analysis based on subtle policy differences.
Feels like so many of our convos are revolving about how voters respond to what politicians are doing, or what parties’ positions on issues are, without much actual empirical sense of what they actually know about those topics.
October 29, 2025 at 11:13 PM
I always get drawn back to Al Gore telling voters that he’d only raise taxes on the top 1% and then after the election a poll showed that something like 20% of voters thought they were in the top 1% and another 20% thought they would be in the next five years. Just a total tragic disconnect.
Reposted by Milo Imbeni
Microglia are the brain’s most dynamic cells, constantly extending and retracting their processes to monitor the parenchyma and respond to potential danger with inflammatory signaling.
Our new study in @ScienceAdvances @science.org explores how these functions are regulated.
Our new study in @ScienceAdvances @science.org explores how these functions are regulated.
October 25, 2025 at 3:24 PM
Microglia are the brain’s most dynamic cells, constantly extending and retracting their processes to monitor the parenchyma and respond to potential danger with inflammatory signaling.
Our new study in @ScienceAdvances @science.org explores how these functions are regulated.
Our new study in @ScienceAdvances @science.org explores how these functions are regulated.
Reposted by Milo Imbeni
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
September 15, 2025 at 8:42 AM
We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:
Reposted by Milo Imbeni
That's a hell of a figure. www.alzforum.org/news/researc...
October 28, 2025 at 7:24 PM
That's a hell of a figure. www.alzforum.org/news/researc...
Reposted by Milo Imbeni
🚨Preprint: Semantic Tuning of Single Neurons in the Human Medial Temporal Lobe
1/8: How do human neurons encode meaning?
In this work, led by Katharina Karkowski, we recorded hundreds of human MTL neurons to study semantic coding in the human brain:
doi.org/10.1101/2025...
1/8: How do human neurons encode meaning?
In this work, led by Katharina Karkowski, we recorded hundreds of human MTL neurons to study semantic coding in the human brain:
doi.org/10.1101/2025...
Semantic Tuning of Single Neurons in the Human Medial Temporal Lobe
The Medial Temporal Lobe (MTL) is key to human cognition, supporting memory, emotional processing, navigation, and semantic coding. Rare direct human MTL recordings revealed concept cells, which were ...
doi.org
October 27, 2025 at 3:32 PM
🚨Preprint: Semantic Tuning of Single Neurons in the Human Medial Temporal Lobe
1/8: How do human neurons encode meaning?
In this work, led by Katharina Karkowski, we recorded hundreds of human MTL neurons to study semantic coding in the human brain:
doi.org/10.1101/2025...
1/8: How do human neurons encode meaning?
In this work, led by Katharina Karkowski, we recorded hundreds of human MTL neurons to study semantic coding in the human brain:
doi.org/10.1101/2025...
Reposted by Milo Imbeni
What a time to be alive
The songbird basal ganglia connectome https://www.biorxiv.org/content/10.1101/2025.10.25.684569v1
October 27, 2025 at 5:02 PM
What a time to be alive
Reposted by Milo Imbeni
You might have noticed lots of activity in the napari project recently! 🚀 We're grateful for a grant from CZI that's keeping us going, but grants don't last forever: we're trying to figure out sustainable long term funding. Read our blog post to find out how you can help:
napari.org/island-dispa...
napari.org/island-dispa...
October 21, 2025 at 2:32 PM
You might have noticed lots of activity in the napari project recently! 🚀 We're grateful for a grant from CZI that's keeping us going, but grants don't last forever: we're trying to figure out sustainable long term funding. Read our blog post to find out how you can help:
napari.org/island-dispa...
napari.org/island-dispa...
Reposted by Milo Imbeni
this entire week has been one single PSA: "the cloud" just means "someone else's computer" and that "someone else" is one of three companies and they don't give a s**t about you
October 21, 2025 at 1:36 AM
this entire week has been one single PSA: "the cloud" just means "someone else's computer" and that "someone else" is one of three companies and they don't give a s**t about you
Reposted by Milo Imbeni
𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻??
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
The astrocytic ensemble acts as a multiday trace to stabilize memory - Nature
Emotional experience evokes signalling in astrocytes, which form an ensemble that is reinforced by secondary astrocytic state changes resulting from repeated experience, leading to memory stabilizatio...
www.nature.com
October 21, 2025 at 5:57 PM
𝗘𝗻𝗱 𝗼𝗳 𝘁𝗵𝗲 𝗲𝗺𝗽𝗶𝗿𝗲 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻??
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Astrocytes in the regulation of fear memories!
www.nature.com/articles/s41...
#neuroskyence
h/t @claeneuro.bsky.social
Reposted by Milo Imbeni
Hi. I wrote an essay about AI slop: How it feels like an invasive species for the internet. How its boosters describe building a future that’s devoid of craft. How frictionlessness can be nihilistic & how this stuff seems to leach part of our shared humanity out of the world. I hope you'll read it.
AI’s Invasive Species
The slop is winning.
www.theatlantic.com
October 20, 2025 at 10:47 PM
Hi. I wrote an essay about AI slop: How it feels like an invasive species for the internet. How its boosters describe building a future that’s devoid of craft. How frictionlessness can be nihilistic & how this stuff seems to leach part of our shared humanity out of the world. I hope you'll read it.
Reposted by Milo Imbeni
Why do rustbelts vote radical right? Studying the German Ruhr area, @nilsblossey.bsky.social, @lstoetze.bsky.social and I show: it’s not just about deindustrialization, but also about the original industrialization. Where coal is buried deeper and mining started later, the AfD is stronger today 1/12
October 17, 2025 at 2:29 PM
Why do rustbelts vote radical right? Studying the German Ruhr area, @nilsblossey.bsky.social, @lstoetze.bsky.social and I show: it’s not just about deindustrialization, but also about the original industrialization. Where coal is buried deeper and mining started later, the AfD is stronger today 1/12