Larry Hunter
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proflhunter.bsky.social
Larry Hunter
@proflhunter.bsky.social

Knowledge based biomedical data science, artificial intelligence for discovery in molecular biomedicine, computational bioethics, theory of mattering. University of Chicago / Big Island HI

Business 36%
Biology 15%

I petition to be included!

@bruces.bsky.social says whatever happens to musicians eventually hits everyone.

Maybe similarly true of Romance authors 🧵👇
So I am going to say something about romance as a genre.

A lot of people think that romance is ignorable because <insert thing they think about romance> and romance authors don't count because <insert thing they think about romance>.

This thread is not about whether you have to like romance.
So I am going to say something about romance as a genre.

A lot of people think that romance is ignorable because <insert thing they think about romance> and romance authors don't count because <insert thing they think about romance>.

This thread is not about whether you have to like romance.

Reposted by Larry W. Hunter

I've been thinking about the "virtual cell" concept and wanted to write up a few thoughts. Specifically on how I think the prior experience in GWAS informs the most likely way these models will be useful.

andrewcarroll.github.io/2025/12/23/t...
The Virtual Cell Will Be More Like Gwas Than Alphafold
There has been significant discussion recently on the concept of the “virtual cell.” I want to summarize the key concepts regarding what the field wants from a virtual cell and the challenges we face....
andrewcarroll.github.io
my festive spirit amidst our grimly stupid reality (2025)

Reposted by Larry W. Hunter

His advice is to look beyond the now:
"If you have political will that is designed to destroy and they have the power to destroy, it is almost futile to try to push against the destruction. Instead, you have to get through the dark age by sort of deciding what the Renaissance is going to look like"

@moorejh pleiotropy-pilled is the new orange.
I guess the preprint came out in 2024 but it was published this year so I'll say this paper from @jeffspence.github.io and @hakha.bsky.social which is probably the paper that pleiotropy-pilled me the most. Really got me to think about what GWAS means www.nature.com/articles/s41...

Reposted by Larry W. Hunter

I guess the preprint came out in 2024 but it was published this year so I'll say this paper from @jeffspence.github.io and @hakha.bsky.social which is probably the paper that pleiotropy-pilled me the most. Really got me to think about what GWAS means www.nature.com/articles/s41...

Tacos!

"In a pan-cancer AI fairness analysis... we identify significant performance disparities in 29.3% of diagnostic tasks across demographic groups defined by self-reported race, gender, and age. FAIR-Path effectively mitigates 88.5% of these disparities" www.sciencedirect.com/science/arti...
Contrastive learning enhances fairness in pathology artificial intelligence systems
AI-enhanced pathology evaluation systems hold significant potential to improve cancer diagnosis but frequently exhibit biases against underrepresented…
www.sciencedirect.com

If the genre of high-priced restaurant take-downs appeals to you, this one is a gem. From @lizcookkc.bsky.social
"The drink tasted like a Cosmo someone had strained through a French Vanilla Yankee Candle."

"Wealth has always been about signifiers, but no one said they had to be this lazy."

defector.com/two-nights-p...
Two Nights Playing With Fire At Patrick Mahomes And Travis Kelce's Steakhouse | Defector
KANSAS CITY, Mo. — As celebrity restaurant mascots, athletes offer a tidy sense of vertical integration: Why not supply the very calories they need to expend on the field? I’m surprised there are so f...
defector.com

There’s no shortage of industry hype, but it’s more than that. Opinion leaders, influencers, social and legacy media, the whole infrastructure of culture.
I’ve spent the past two days as pediatric ward attending and frankly we need both more and even better vaccines not fewer

Cook’s Illustrated skillet spanakopita is a clever update.

Enjoy this complimentary ATK recipe—no login required—for the next 30 days. www.americastestkitchen.com/recipes/1316...

"More people becoming convinced that A.I. is conscious, Bengio said, will have 'bad consequences for society.'”

Our problem isn't what chatbots can or can't do. Our problem is how people think about them.

Addressing this requires more than a technical fix.

www.nytimes.com/2025/12/19/t...
Why Do A.I. Chatbots Use ‘I’?
www.nytimes.com

Important to note that the vast majority of this use is Abridge for "scribing" (producing a transcript of an encounter).

Loss of federal grant funds. "permanent closure following the loss of their Title VI funding." The NC State government is also cutting UNC dramatically, so no substitute or even bridge funding. This is on Trump, and it's intentional.

That's a serious problem, for sure. Best wishes for riding it out!

The dysfunction at the top of NIH is heartbreaking and devastating.
"(Memoli's) actions look like those of a leader who has been given broad discretion to shrink down the agencys infectious-disease work—an area where he may have a few personal grievances. “People are afraid of him,” one official said, pausing. “I’m afraid of him.”
www.theatlantic.com/health/2025/...
The Most Feared Person at the NIH Is a Vaccine Researcher Plucked From Obscurity
While NIH director Jay Bhattacharya focuses on podcasting, his second in command is dramatically remaking the agency.
www.theatlantic.com

You can boil water on top of the wood burning stove to make coffee....

The Smitten Kitchen Pizza Beans recipe took the internet by storm a few years ago, and I have to admit it's good. Beans (with various optional and substitutable vegetables) in tomato sauce with parmesan and mozzarella melted over the top... smittenkitchen.com/2017/09/pizz...
pizza beans
It is always the right season to bake giant white beans as if they were ziti — vegetables, a robust sauce, and a finish with bronzed, melty cheese.
smittenkitchen.com

Another big study showing actual *benefits* of cheese / full fat dairy consumption.

"Higher intake of high-fat cheese and high-fat cream was associated with a lower risk of all-cause dementia"

www.neurology.org/doi/10.1212/...

The next step in RFKJr's mass murder of children. Abominable
SCOOP: American Academy of Pediatrics loses HHS funding after criticizing RFK Jr. Research included reducing sudden infant deaths and identifying autism early. Me and @Paigecunningham.Bsky.Social
www.washingtonpost.com/health/2025/...
American Academy of Pediatrics loses HHS funding after criticizing RFK Jr.
HHS cuts key AAP grants, citing concerns about “identity-based language” and insufficient focus on agency priorities. The organization said the cuts could harm child health.
www.washingtonpost.com
Everyone else go home — this is the year we secure ABOLISH ICE on a Chicago Snowplow

chicagoshovels.org

RFKJr in a nutshell: Reprehensibly unethical study, not peer reviewed, paid for with your tax dollars, which will kill children.