Nellie Kwang
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nelliekwang.bsky.social
Nellie Kwang
@nelliekwang.bsky.social
30 followers 27 following 4 posts
MD-PhD student at UCI, bioinformatician in training, potter, chorister, cat mother
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Reposted by Nellie Kwang
roylab-ucsd.bsky.social
Incredible by @odedrechavi.bsky.social...an AI-thingy that reviews your manuscript with a very high bar and takes no prisoners. But you can do this in your pajamas and no one gets to see it. Takes a while but once you get the results you'll know why: www.qedscience.com
October 24, 2025 at 3:38 PM
Reposted by Nellie Kwang
leadcoalition.bsky.social
New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com

#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence
New landscape of the diagnosis of Alzheimer's disease
Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...
www.thelancet.com
September 23, 2025 at 7:25 PM
Reposted by Nellie Kwang
pluchinolab.bsky.social
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease | Nature Neuroscience

www.nature.com/articles/s41...
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience
The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...
www.nature.com
July 15, 2025 at 9:43 PM
Reposted by Nellie Kwang
jef.works
In this blog post, I use #RStats to analyze ICE detention data. #Datavisualization shows record numbers of detainees without any criminal records. Further more/bigger ICE facilities are popping up far from the border.

Code along and take a look for yourself: jef.works/blog/2025/07...

#CodeTutorial
July 10, 2025 at 7:20 PM
Reposted by Nellie Kwang
jasonsynaptic.bsky.social
While I’m a big fan of new technologies that help us study human biology…there’s still no replacement for animal research! See my article in Gen News. www.genengnews.com/topics/trans...
Why We Still Need Animal Research in a World of AI and Organoids
The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.
www.genengnews.com
July 12, 2025 at 2:56 AM
Reposted by Nellie Kwang
liganlab.bsky.social
🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway
The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…
www.sciencedirect.com
June 24, 2025 at 12:58 PM
Reposted by Nellie Kwang
natneuro.nature.com
At the myelin-axon interface, axon-glial signaling, paranodal architecture, and β-amyloid aggregation are altered in Alzheimer's disease, implicating myelin-axon disruption in disease progression

@jgrutzendler.bsky.social @yifeicai.bsky.social

www.nature.com/articles/s41...
Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience
In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...
www.nature.com
June 20, 2025 at 2:13 PM
Reposted by Nellie Kwang
natneuro.nature.com
Heat shock proteins function as signaling molecules to mediate neuron–glia communication via extracellular vesicles during aging in C. elegans

www.nature.com/articles/s41...
Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging - Nature Neuroscience
Glia–neuron interactions are highly complex. Glial cells can sense and modulate different aspects of neuronal activity. Here in Caenorhabditis elegans, the authors show that early aged sensory neurons...
www.nature.com
June 23, 2025 at 3:33 PM
Reposted by Nellie Kwang
lukensjohnr.bsky.social
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
www.nature.com/articles/s41...
Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity - Nature Immunology
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss is linked to r...
www.nature.com
June 26, 2025 at 2:56 PM
Reposted by Nellie Kwang
aosasmita.bsky.social
Emerging connections between myelin and Alzheimer’s disease

www.nature.com/articles/s41...
Emerging connections between myelin and Alzheimer’s disease - Nature Cell Biology
Recent literature has explored the contributions of oligodendrocytes and myelin dysfunction to Alzheimer’s disease. Here, we discuss emerging evidence that oligodendrocytes may directly contribute to ...
www.nature.com
July 2, 2025 at 4:36 AM
Reposted by Nellie Kwang
lindsayhohsfield.bsky.social
Excited to share our new paper out in @cp-neuron.bsky.social today! We discovered the neuroanatomical route that myeloid cells use to enter the brain parenchyma. Check it out here: authors.elsevier.com/c/1lCYs3BtfH...
June 3, 2025 at 4:00 PM
Reposted by Nellie Kwang
aosasmita.bsky.social
Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions

onlinelibrary.wiley.com/doi/10.1111/...
Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions
(Figure created with Biorender.com. Publication license has been obtained with Biorender).
onlinelibrary.wiley.com
June 8, 2025 at 6:45 AM
Reposted by Nellie Kwang
hadley.nz
Happy 18th birthday ggplot2! #rstats
Balloon wall art inspired by the ggplot2 hex sticker. The display features a hexagonal frame made of black balloons, filled with white balloons inside and surrounded by a background of light and dark blue balloons. A line graph with black balloon segments and round coloured nodes runs across the centre, and the word “ggplot2” is spelled out in black balloon letters below the chart.
June 10, 2025 at 11:56 PM
Reposted by Nellie Kwang
phagocyticpai.bsky.social
We're now appreciating how the immune and nervous systems communicate across body & brain, and there's still more to explore!

Had a fun time co-writing this with some amazing immunologists and neuroscientists @nickmroz.bsky.social @arimolofskylab.bsky.social @annamolofskylab.bsky.social 😎🧠
Cross-regulation between the nervous system and type 2 immunity
The nervous and type 2 immune systems regulate each other via cytokines and neurotransmitters, suggesting previously unidentified therapeutic avenues.
www.science.org
May 23, 2025 at 11:28 PM
Reposted by Nellie Kwang
johnsonlab.bsky.social
What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs
APOE4 reshapes the lipid droplet proteome and modulates microglial inflammatory responses
Excess lipid droplet (LD) accumulation is implicated in various diseases, including Alzheimer's disease (AD), yet the mechanisms underlying this accum…
www.sciencedirect.com
June 3, 2025 at 1:09 AM
Reposted by Nellie Kwang
aosasmita.bsky.social
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis

molecularneurodegeneration.biomedcentral.com/articles/10....
Evidence suggesting that microglia make amyloid from neuronally expressed APP: a hypothesis - Molecular Neurodegeneration
While APP is largely neuonally expressed, Aβ amyloid is largely produced by microglia as the clearance mechanisms for damaged membranes becomes overwhelmed.
molecularneurodegeneration.biomedcentral.com
May 9, 2025 at 10:57 PM
Reposted by Nellie Kwang
alexlish.bsky.social
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.

Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Reposted by Nellie Kwang
raflynn5.bsky.social
Exciting work from @blurtonjoneslab.bsky.social + Spitale labs -- new examples of how iPSC-microglia can be used as a long-term, in vivo platform for a therapeutic protein payload in models of Alzheimer’s disease

@cp-cellstemcell.bsky.social
sciencedirect.com/science/article/pii/S1934590925000992
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…
sciencedirect.com
April 18, 2025 at 3:03 PM
Reposted by Nellie Kwang
natneuro.nature.com
A Review on #microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration

www.nature.com/articles/s41...
Microglia heterogeneity, modeling and cell-state annotation in development and neurodegeneration - Nature Neuroscience
Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.
www.nature.com
April 17, 2025 at 5:23 PM
Reposted by Nellie Kwang
denadubal.bsky.social
"We have far to go and more to do" - thanks Katherine Bourzac @bourzac.bsky.social at @nature.com for including me in this thoughtful piece and highlighting our work on the X chromosome. Why women experience #Alzheimer’s disease differently from men www.nature.com/articles/d41...
Why women experience Alzheimer’s disease differently from men
Sex and gender research could lead to better, more equitable treatments — if it is allowed to continue without political interference.
www.nature.com
April 17, 2025 at 4:18 AM
Reposted by Nellie Kwang
natrevneurol.nature.com
New online! Alzheimer disease seen through the lens of sex and gender
Alzheimer disease seen through the lens of sex and gender
Nature Reviews Neurology, Published online: 14 April 2025; doi:10.1038/s41582-025-01071-0Sex and gender influence the entire healthcare ecosystem of Alzheimer disease (AD). In this Review, Castro-Aldrete et al. present a holistic view of sex and gender in AD, and discuss how these factors affect research and policy efforts to improve AD prevention, diagnosis and treatment.
bit.ly
April 14, 2025 at 10:22 PM
Reposted by Nellie Kwang
rachaelott.bsky.social
For #FluorescenceFriday, tau (cyan) and neurofilament proteins (fire) are shown in these primary hippocampal neurons 🔬 #Neuroscience #Microscopy
Neurofilament proteins (fire) and tau (cyan) are shown in two primary hippocampal neurons.
April 11, 2025 at 8:31 PM
Reposted by Nellie Kwang
adamkinzinger.substack.com
The Trump administration’s war on science is slashing funding, shutting down labs, and driving top researchers overseas. The cost? Medical breakthroughs, technological innovation, and America’s future. My latest

adamkinzinger.substack.com/p/the-scienc...
The Science Brain Drain
How Trump's Cuts Are Crippling American Innovation and Ceding the Future
adamkinzinger.substack.com
March 31, 2025 at 4:11 PM
Reposted by Nellie Kwang
asm.org
Removing the top leadership at NIAID, NIH and other health agencies, including the CDC and FDA, will damage America’s position as a leader in groundbreaking research in disease prevention and treatment. That puts us all at risk. Read our statement: asm.org/Press-Releas...
ASM Statement on Removal of NIH & NIAID Leadership
Removing the top leadership at NIAID, NIH and other health agencies including CDC and FDA will damage America’s position as a leader in groundbreaking research in disease prevention and treatment.
asm.org
April 1, 2025 at 4:53 PM