Andrew Octavian Sasmita
@aosasmita.bsky.social
Neuro postdoc at UCC 🇮🇪 PhD at MPI-NAT, 🇩🇪 | Alzheimer's x glia x sex differences x gut microbiome 🔬🧠 | (he/they) 🏳️🌈
Pinned
A Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience Bulletin
Amyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...
link.springer.com
Where does Aβ come from in Alzheimer’s disease? 🔍
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage
Inhibition of the colony-stimulating factor 1 receptor (CSF1R) through BLZ945 effectively depletes microglia (MG) in an in vitro model of lysophosphatidylcholine-induced oligodendroglial damage. Desp...
onlinelibrary.wiley.com
February 10, 2026 at 3:31 PM
Dynamics and Impact of Repopulating Microglia Following Oligodendroglial Damage
onlinelibrary.wiley.com/doi/full/10....
onlinelibrary.wiley.com/doi/full/10....
Reposted by Andrew Octavian Sasmita
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 8, 2026 at 7:41 PM
A new preprint introduces aDISCO, a DISCO-based clearing approach that makes whole archival FFPE human tissues transparent and antibody-compatible, enabling true 3D light-sheet histology across brain & multiple organs at cellular resolution. Aguzzi & Helmchen teams.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Andrew Octavian Sasmita
The study shows how intestinal macrophages can modulate synucleinopathy along the gut-brain axis, strengthening the growing view that the gut plays an important role in the earliest stages of Parkinson’s disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
www.nature.com
January 28, 2026 at 4:46 PM
The study shows how intestinal macrophages can modulate synucleinopathy along the gut-brain axis, strengthening the growing view that the gut plays an important role in the earliest stages of Parkinson’s disease.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Where does Aβ come from in Alzheimer’s disease? 🔍
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
A Question of Origins: Non-neuronal Sources of Amyloid-β - Neuroscience Bulletin
Amyloid-β (Aβ) plaques and neurofibrillary tau tangles are hallmarks of Alzheimer’s disease (AD). While the intracellular localization of tau tangles within neurons nominates them as the primary produ...
link.springer.com
January 20, 2026 at 1:25 PM
Where does Aβ come from in Alzheimer’s disease? 🔍
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
In this review, we explore Aβ production and functions of APP processing in non-neuronal cells as well as how targeting non-neuronal Aβ could lead to a more holistic disease prevention/targeting.
link.springer.com/article/10.1...
Reposted by Andrew Octavian Sasmita
Mammals regrowing their brain? 🧠🤯
Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working.
A wild reminder of how flexible brains can be, and why nature still has a lot to teach us.
#Neuroscience #AnimalResearch
Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working.
A wild reminder of how flexible brains can be, and why nature still has a lot to teach us.
#Neuroscience #AnimalResearch
Scientists found that this tiny mammal ‘regrows’ its brain in winter. And it could help cure Alzheimer’s | Discover Wildlife
Researchers discovered that the common shrew can shrink itself during the winter
www.discoverwildlife.com
January 20, 2026 at 9:10 AM
Mammals regrowing their brain? 🧠🤯
Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working.
A wild reminder of how flexible brains can be, and why nature still has a lot to teach us.
#Neuroscience #AnimalResearch
Shrews can shrink their brains by ~20% in winter and grow them back later. No brain cells die, they just lose water and keep working.
A wild reminder of how flexible brains can be, and why nature still has a lot to teach us.
#Neuroscience #AnimalResearch
The Microbiota Shapes Central Nervous System Myelination in Early Life
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com
January 19, 2026 at 10:17 PM
The Microbiota Shapes Central Nervous System Myelination in Early Life
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Andrew Octavian Sasmita
Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1
https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1
January 12, 2026 at 5:02 PM
Neuronal age drives β-sheet accumulation and, together with ApoE4, enhances synaptic Aβ localization in APPNL-F neurons #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1
https://www.biorxiv.org/content/10.64898/2026.01.10.697647v1
Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 11, 2026 at 3:47 PM
Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Andrew Octavian Sasmita
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 7, 2026 at 6:54 PM
Mitochondrial transfer from glia to neurons protects against peripheral neuropathy @nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrew Octavian Sasmita
Spatial transcriptomics reveals effects of maternal immune activation and microbiome depletion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 6, 2026 at 2:32 PM
Spatial transcriptomics reveals effects of maternal immune activation and microbiome depletion
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrew Octavian Sasmita
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry
Dereddi, Djannatian, and colleagues show that oligodendrocytes use mechanical cues
to measure axon size. The stretch-activated channel TMEM63A converts membrane tension
into calcium signals, which cal...
www.cell.com
January 2, 2026 at 3:55 PM
We identified how mechanical forces shape myelin development. The TMEM63A channel in oligodendrocytes converts physical cues into molecular signals that control myelin growth.
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Oligodendrocyte mechanotransduction channel TMEM63A regulates myelin sheath geometry: Neuron www.cell.com/neuron/fullt...
Reposted by Andrew Octavian Sasmita
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration - Nature Neuroscience
Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.
www.nature.com
January 2, 2026 at 3:24 PM
TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration www.nature.com/articles/s41...
Reposted by Andrew Octavian Sasmita
Menopause hormone therapy does not appear to impact dementia risk ucl.ac.uk/news/2025/de... by @ucl.ac.uk
#Alzheimers #dementia #WomensHealth #menopause
#Alzheimers #dementia #WomensHealth #menopause
Menopause hormone therapy does not appear to impact dementia risk
A major review of prior research has found no evidence that menopause hormone therapy either increases or decreases dementia risk in post-menopausal women, in a new study led by UCL researchers.
ucl.ac.uk
December 26, 2025 at 9:24 PM
Menopause hormone therapy does not appear to impact dementia risk ucl.ac.uk/news/2025/de... by @ucl.ac.uk
#Alzheimers #dementia #WomensHealth #menopause
#Alzheimers #dementia #WomensHealth #menopause
Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease - Biology of Sex Differences
Background Sex-dependent differences in prevalence and severity are characteristics of Alzheimer’s disease (AD). Using the 3×Tg-AD mouse model, we previously reported that adult males show early behav...
link.springer.com
December 25, 2025 at 2:14 PM
Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Aducanumab reduces plaques and other pathologies but significantly increases vascular Aβ deposits. Seems that whether you clear plaques or limit plaque deposition (via microglial depletion in vivo pre-plaque deposition), the consequence is vascular Aβ deposits 🤨 www.alzforum.org/news/confere...
Amyloid Immunotherapy Affects Multiple Alzheimer’s Pathologies | ALZFORUM
www.alzforum.org
December 22, 2025 at 7:58 PM
Aducanumab reduces plaques and other pathologies but significantly increases vascular Aβ deposits. Seems that whether you clear plaques or limit plaque deposition (via microglial depletion in vivo pre-plaque deposition), the consequence is vascular Aβ deposits 🤨 www.alzforum.org/news/confere...
Reposted by Andrew Octavian Sasmita
I really liked this paper - data supporting super interesting idea that Alzheimer's disease pathology may have evolved as part of an innate immune defense response to microbial infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons - Nature Neuroscience
The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the innate immune system in the brain an...
www.nature.com
December 22, 2025 at 3:59 PM
I really liked this paper - data supporting super interesting idea that Alzheimer's disease pathology may have evolved as part of an innate immune defense response to microbial infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model - Biology of Sex Differences
Background Women are nearly twice as likely to be diagnosed with Alzheimer’s Disease (AD) over their lifetime. However, historically, preclinical studies utilizing AD rodent models to define new thera...
link.springer.com
December 17, 2025 at 7:52 PM
Consideration of sex as a biological variable over the history of the 5xFAD Alzheimer’s Disease mouse model
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Andrew Octavian Sasmita
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons
www.nature.com/articles/s41... @natneuro.nature.com
www.nature.com/articles/s41... @natneuro.nature.com
December 17, 2025 at 3:43 PM
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons
www.nature.com/articles/s41... @natneuro.nature.com
www.nature.com/articles/s41... @natneuro.nature.com
Lesion-remote astrocytes govern microglia-mediated white matter repair
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Lesion-remote astrocytes govern microglia-mediated white matter repair - Nature
After spinal cord injury, lesion-remote astrocytes acquire heterogeneous, spatially restricted reactivity states that shape neuroinflammation, neural repair and neurological recovery.
www.nature.com
December 17, 2025 at 7:10 PM
Lesion-remote astrocytes govern microglia-mediated white matter repair
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
Circadian disruptions perturb the brain and immune system and increase the risk of developing Alzheimer’s Disease (AD), yet whether this involves dysregulation of brain immunity remains less clear. He...
www.biorxiv.org
December 16, 2025 at 4:05 PM
The circadian clock regulates scavenging of fluid-borne substrates by brain border-associated macrophages
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Reposted by Andrew Octavian Sasmita
Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease @jem.org @jonykipnis.bsky.social @leonsmyth.bsky.social @washumedicine.bsky.social
rupress.org/jem/article-...
rupress.org/jem/article-...
December 2, 2025 at 4:47 PM
Amyloidosis of bridging veins is a pathologic feature of Alzheimer’s disease @jem.org @jonykipnis.bsky.social @leonsmyth.bsky.social @washumedicine.bsky.social
rupress.org/jem/article-...
rupress.org/jem/article-...
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease
Fascinating study from the lab of @lukensjohnr.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Fascinating study from the lab of @lukensjohnr.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease
INTRODUCTION CLEC7A is a surface receptor that is highly upregulated on microglia in many Alzheimer's disease (AD) models. Little is known about the role that microglial CLEC7A signaling plays in AD...
alz-journals.onlinelibrary.wiley.com
November 28, 2025 at 6:06 PM
Microglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease
Fascinating study from the lab of @lukensjohnr.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Fascinating study from the lab of @lukensjohnr.bsky.social
alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Andrew Octavian Sasmita
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease - Nature Neuroscience
Engineering human microglia with a Down-syndrome-linked myeloid gene variant resists tau-induced dysfunction and protects neurons in chimeric brains, offering proof of concept for transformative micro...
www.nature.com
November 24, 2025 at 2:33 PM
A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Andrew Octavian Sasmita
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia - Nature Neuroscience
Lecanemab, a leading therapy for Alzheimer’s disease, induces an Fc-mediated transcriptional program in human microglia, linked to osteopontin and enhanced plaque phagocytosis, suggesting alternative ...
www.nature.com
November 24, 2025 at 2:35 PM
The Alzheimer’s therapeutic Lecanemab attenuates Aβ pathology by inducing an amyloid-clearing program in microglia
www.nature.com/articles/s41...
www.nature.com/articles/s41...