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pluchinolab.bsky.social
Pluchino lab - Regenerative Neuroimmunology
@pluchinolab.bsky.social
77 followers 17 following 360 posts
University of Cambridge Team developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇨🇦🇫🇷🇮🇩🇿🇦🇦🇺🇭🇰🇪🇸🇺🇦

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Pluchino lab - Regenerative Neuroimmunology @pluchinolab.bsky.social · Dec 18
pluchinolab.bsky.social
Neuronal synapses are stabilised by activity-dependent vesicular release from oligodendrocyte precursor cells

www.biorxiv.org/content/10.6...
www.biorxiv.org
February 5, 2026 at 5:36 PM
pluchinolab.bsky.social
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis

www.cell.com/cell-metabol...
Mitochondrial transfer from immune to tumor cells enables lymph node metastasis
How cancer cells subvert immunity to colonize the lymph node remains unclear. Terasaki et al. uncover that lymph node metastasis may be driven by an immune-to-cancer mitochondria transfer axis that im...
www.cell.com
February 5, 2026 at 5:25 PM
pluchinolab.bsky.social
Generation and characterization of iPSC-derived microglia for in vitro modeling of stimuli-specific neuroimmune responses

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses
INTRODUCTION Microglia are macrophage-like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derive...
alz-journals.onlinelibrary.wiley.com
February 5, 2026 at 5:23 PM
pluchinolab.bsky.social
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

academic.oup.com/nar/article/...
Loss of SETDB1-mediated H3K9me3 in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons
Abstract. Heterochromatin is characterized by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However,
academic.oup.com
February 5, 2026 at 5:19 PM
pluchinolab.bsky.social
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis

www.nature.com/articles/s41...
Antigen specificity of clonally enriched CD8+ T cells in multiple sclerosis - Nature Immunology
Sabatino and colleagues examine expanded CD8+ T cell clonotypes from a small cohort of multiple sclerosis patients. They identified several cognate peptide epitopes that derive from Epstein–Barr virus...
www.nature.com
February 5, 2026 at 12:42 PM
pluchinolab.bsky.social
Systematic identification of single transcription factor perturbations that drive cellular and tissue rejuvenation

www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
February 4, 2026 at 4:11 PM
pluchinolab.bsky.social
Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance

www.jci.org/articles/vie...
JCI - Novel perspectives on extracellular vesicles in autoimmune diseases: immunogenicity, inflammation, and immune surveillance
www.jci.org
February 4, 2026 at 4:09 PM
pluchinolab.bsky.social
Mitochondrial specialization and signaling shape neuronal function

www.cell.com/trends/neuro...
Mitochondrial specialization and signaling shape neuronal function
Neurons are specialized cells designed to process information and transmit it, often across long distances. In many neurons, the axonal volume far exceeds the somato-dendritic volume, creating a need ...
www.cell.com
February 4, 2026 at 4:08 PM
Reposted by Pluchino lab - Regenerative Neuroimmunology
camneurodept.bsky.social
Dr Luca Peruzzotti Jametti has been appointed as one of two new Early Career Editors for Stem Cell Reports.

✍ The journal is actively seeking applications for the next generation of Early Career Editors. Apply by 13 March 2026.

www.clinical-neuroscience.cam.ac.uk/news/luca-pe...
February 3, 2026 at 2:26 PM
Reposted by Pluchino lab - Regenerative Neuroimmunology
lpjlab.org
I am delighted to share that I have been appointed as Early Career Editor for @stemcellreports.bsky.social, the official journal of the International Society for Stem Cell Research @isscr.org! 🔬🌍
I look forward to seeing your research in the field of stem cells!
Submit here: invt.io/1bxb9kpdtfj 👍
Check out ISSCR's society journal, Stem Cell Reports!
invt.io
February 3, 2026 at 2:30 PM
pluchinolab.bsky.social
EMito-Metrix enables automated evaluation of mitochondrial morphology across species

www.nature.com/articles/s42...
EMito-Metrix enables automated evaluation of mitochondrial morphology across species - Nature Metabolism
Nature Metabolism - EMito-Metrix enables automated evaluation of mitochondrial morphology across species
www.nature.com
February 4, 2026 at 10:19 AM
pluchinolab.bsky.social
Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain

www.science.org/doi/10.1126/...
Subventricular zone radial glial cells maintain inhibitory neuron production in the human brain
The number and diversity of inhibitory neurons (INs) increased substantially during mammalian brain evolution. However, the generative mechanisms of the vast repertoire of human INs remain elusive. We...
www.science.org
February 4, 2026 at 8:50 AM
pluchinolab.bsky.social
Spatial Flux Balance Analysis reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer

www.nature.com/articles/s41...
Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer - npj Systems Biology and Applications
npj Systems Biology and Applications - Spatial FBA reveals heterogeneous Warburg niches in renal tumors and lactate consumption in colorectal cancer
www.nature.com
February 3, 2026 at 10:22 AM
pluchinolab.bsky.social
ER remodelling is a feature of ageing and depends on ER-phagy

www.nature.com/articles/s41...
ER remodelling is a feature of ageing and depends on ER-phagy - Nature Cell Biology
Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.
www.nature.com
February 3, 2026 at 10:18 AM
pluchinolab.bsky.social
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

www.science.org/doi/10.1126/...
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease...
www.science.org
February 2, 2026 at 3:23 PM
pluchinolab.bsky.social
Dissecting surveying behavior of reactive microglia under chronic neurodegeneration

elifesciences.org/articles/107...
Dissecting surveying behavior of reactive microglia under chronic neurodegeneration
In chronic neurodegeneration associated with prion disease, reactive microglia adopt a highly mobile, neuron-by-neuron surveillance strategy, replacing homeostatic process-based monitoring with dynami...
elifesciences.org
February 2, 2026 at 2:24 PM
pluchinolab.bsky.social
Mito-nuclear communication: From cellular responses to organismal health

www.cell.com/molecular-ce...
Mito-nuclear communication: From cellular responses to organismal health
Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...
www.cell.com
January 29, 2026 at 5:01 PM
pluchinolab.bsky.social
Mitochondria as sources and targets of cellular signaling

www.cell.com/molecular-ce...
Mitochondria as sources and targets of cellular signaling
Meichsner et al. review recent insights into mitochondria as dynamic signaling hubs. The authors describe how structural plasticity and interorganellar communication enable mitochondria to serve as bo...
www.cell.com
January 29, 2026 at 3:23 PM
pluchinolab.bsky.social
Lipoic Acid for Treatment of Progressive Multiple Sclerosis
A Phase 2 Randomized Clinical Trial

www.neurology.org/doi/10.1212/...
Lipoic Acid for Treatment of Progressive Multiple Sclerosis | Neurology
Background and ObjectivesA pilot trial of the antioxidant lipoic acid (LA) in secondary progressive multiple sclerosis (MS) demonstrated a reduction in the whole-brain atrophy, suggesting neuroprotect...
www.neurology.org
January 29, 2026 at 1:37 PM
pluchinolab.bsky.social
Intestinal macrophages modulate synucleinopathy along the gut–brain axis

www.nature.com/articles/s41...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
www.nature.com
January 28, 2026 at 5:52 PM
pluchinolab.bsky.social
Single-cell proteomic landscape of the developing human brain
www.nature.com/articles/s41...
Single-cell proteomic landscape of the developing human brain - Nature Biotechnology
Single-cell proteomics maps protein dynamics in the developing human brain.
www.nature.com
January 28, 2026 at 1:55 PM
pluchinolab.bsky.social
Scientists need more time to think | @nature.com
January 28, 2026 at 1:10 PM
Reposted by Pluchino lab - Regenerative Neuroimmunology
lpjlab.org
⚠️ We are hiring a Postdoctoral Research Associate ⚠️
🚨 Deadline 9th February 2026 🚨
👍 Please like and share with your network! 👍

#CambridgeUniversity #PostdoctoralResearch #JobOpportunity

For enquiries please contact me at LP429@CAM.AC.UK or use this 🔗 to apply: www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced
www.cam.ac.uk
January 19, 2026 at 9:08 AM
pluchinolab.bsky.social
If you're seeking an exciting opportunity to advance your research career, I highly recommend checking out this postdoctoral position advertised by my colleague @lpjlab.org .org at @camneurodept.bsky.social

Don't miss your chance!

Explore the details here: www.cam.ac.uk/jobs/postdoc...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced
www.cam.ac.uk
January 19, 2026 at 3:20 PM
pluchinolab.bsky.social
🚀 Exciting Opportunity Alert! 🚀

The University of Cambridge is seeking a Postdoctoral Research Associate to join
@peruzzotti-123.bsky.social team!

Apply Here cam.ac.uk/jobs/postdoc...

More details on key requirements here www.linkedin.com/feed/update/...
Postdoctoral Research Associate (Fixed Term)
Applications are invited for a highly motivated and skilled Postdoctoral Research Associate (PDRA) to lead a cutting-edge research project focused on targeting metabolic pathways in human induced
cam.ac.uk
January 16, 2026 at 2:41 PM