Pluchino lab - Regenerative Neuroimmunology
@pluchinolab.bsky.social
University of Cambridge Team developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇨🇦🇫🇷🇮🇩🇿🇦🇦🇺🇭🇰🇪🇸🇺🇦
X/Twitter @Pluchinolab
Web pluchinolab.org
X/Twitter @Pluchinolab
Web pluchinolab.org
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology - Nature Metabolism
Barnett et al. disentangle the differential contribution of mitochondrial complex I- and complex III-derived ROS to astrocytic function, with CIII-derived ROS being a major driver of neuroinflammatory...
www.nature.com
November 5, 2025 at 8:40 AM
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…
www.sciencedirect.com
October 29, 2025 at 8:03 AM
Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders
Liu et al. reveal that neutrophil extracellular traps (NETs) serve as markers of post-stroke
emotional disorders. The infiltration of NETs into the brain parenchyma leads to the
morphological and func...
www.cell.com
October 28, 2025 at 6:29 PM
Lcn2 from neutrophil extracellular traps induces astrogliosis and post-stroke emotional disorders
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Thrilled to welcome Chiara Garsia to the lab as a visiting PhD student.
With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells.
Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch
With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells.
Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch
October 28, 2025 at 4:34 PM
Thrilled to welcome Chiara Garsia to the lab as a visiting PhD student.
With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells.
Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch
With a background in genetics and stem cell therapies, Chiara is set to advance our research on CRISPRa-engineered neural stem cells.
Welcome aboard, Chiara! 🌟 #ResearchExcellence #StemCellResearch
A full life cycle biological clock based on routine clinical data and its impact in health and diseases | Nature Medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A full life cycle biological clock based on routine clinical data and its impact in health and diseases - Nature Medicine
The biological clock model LifeClock predicts biological age across all life stages from routine clinical data, revealing distinct pediatric and adult disease risk patterns.
www.nature.com
October 27, 2025 at 8:49 PM
A full life cycle biological clock based on routine clinical data and its impact in health and diseases | Nature Medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Alzheimer’s disease causes bone marrow myelopoiesis dysfunction | bioRxiv
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Alzheimer’s disease causes bone marrow myelopoiesis dysfunction
Accumulating evidence suggests that both innate and adaptive immunity play crucial roles in combating Alzheimer’s disease (AD). Specifically, enhancing the homing of monocyte-derived macrophages to th...
www.biorxiv.org
October 25, 2025 at 12:31 PM
Alzheimer’s disease causes bone marrow myelopoiesis dysfunction | bioRxiv
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
We previously reported that T96K is a gain-of-function mutation in TREM2 based on its ability to increase ligand-dependent activation. Here, we show t…
www.sciencedirect.com
October 23, 2025 at 3:53 PM
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Are these the happiest PhD students in the world?
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
www.nature.com/articles/d41...
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
www.nature.com/articles/d41...
Are these the happiest PhD students in the world?
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
www.nature.com
October 23, 2025 at 9:21 AM
Are these the happiest PhD students in the world?
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
www.nature.com/articles/d41...
Brazil, Australia and Italy have the highest satisfaction scores in Nature’s global 2025 PhD survey — but are these nations really the best places to do a doctorate?
www.nature.com/articles/d41...
Transcriptional regulation of disease-relevant microglial activation programs
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Transcriptional regulation of disease-relevant microglial activation programs
Microglia, the brain’s innate immune cells, can adopt a wide variety of activation states relevant to health and disease. Dysregulation of microglial activation occurs in numerous brain disorders, and...
www.biorxiv.org
October 23, 2025 at 8:48 AM
Transcriptional regulation of disease-relevant microglial activation programs
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice | PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice
How can motor function be restored after stroke? This study shows in mice that combining robotic rehabilitation with non-invasive gamma band neuromodulation improves motor recovery by restoring moveme...
journals.plos.org
October 21, 2025 at 6:31 PM
Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice | PLOS Biology
journals.plos.org/plosbiology/...
journals.plos.org/plosbiology/...
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis - Nature Medicine
Myelin damage in multiple sclerosis can be detected up to 7 years before symptoms, with early immune pathway activation and a 21-protein panel showing promise for presymptomatic diagnosis.
www.nature.com
October 21, 2025 at 8:18 AM
Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com/articles/d41...
He showed that specialized cells retain the genes to form an organism.
www.nature.com/articles/d41...
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com
October 21, 2025 at 8:13 AM
John Gurdon obituary: Biologist who made cloning possible
He showed that specialized cells retain the genes to form an organism.
www.nature.com/articles/d41...
He showed that specialized cells retain the genes to form an organism.
www.nature.com/articles/d41...
Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab - Koji Shinoda, Katsuhisa Masaki, Ayano Matsuyoshi, Yuu-ichi Kira, Kazunori Iwao, Eizo Tanaka, Mitsuru Watanabe, Daisuke ...
We describe a case of tumefactive demyelinating lesion (TDL) that occurred during B-cell depletion therapy by ofatumumab and discuss its pathogenesis through se...
journals.sagepub.com
October 21, 2025 at 8:12 AM
Tumefactive demyelinating lesion during B-cell depletion therapy by ofatumumab
journals.sagepub.com/doi/10.1177/...
journals.sagepub.com/doi/10.1177/...
WHITE MATTER IN FOCUS SYMPOSIUM: EXPLORING THE ROLE OF MYELIN AND OLIGODENDROCYTES IN NEURODEGENERATION
neuroscience.cam.ac.uk/event-posts/...
neuroscience.cam.ac.uk/event-posts/...
White matter in focus symposium: Exploring the role of myelin and oligodendrocytes in neurodegeneration
Current research is increasingly highlighting the role of oligodendrocytes in neurodegeneration and specifically in dementia. Explore this theme across disease areas in the upcoming symposium White…
neuroscience.cam.ac.uk
October 20, 2025 at 4:31 PM
WHITE MATTER IN FOCUS SYMPOSIUM: EXPLORING THE ROLE OF MYELIN AND OLIGODENDROCYTES IN NEURODEGENERATION
neuroscience.cam.ac.uk/event-posts/...
neuroscience.cam.ac.uk/event-posts/...
Reposted by Pluchino lab - Regenerative Neuroimmunology
🚨Scientists have identified a rare brain cell that may drive inflammation in progressive multiple sclerosis (MS)
🔎This important discovery could pave the way for more effective therapies
🔗 For more info: bit.ly/48xJvW1
@cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk
🔎This important discovery could pave the way for more effective therapies
🔗 For more info: bit.ly/48xJvW1
@cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk
‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell - NIHR Cambridge Biomedical Research Centre
Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the dis...
bit.ly
October 13, 2025 at 12:08 PM
🚨Scientists have identified a rare brain cell that may drive inflammation in progressive multiple sclerosis (MS)
🔎This important discovery could pave the way for more effective therapies
🔗 For more info: bit.ly/48xJvW1
@cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk
🔎This important discovery could pave the way for more effective therapies
🔗 For more info: bit.ly/48xJvW1
@cuh.nhs.uk @camneuro.bsky.social @camneurodept.bsky.social @cam.ac.uk
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
Pilat et al. show that the Alzheimer’s disease (AD)-associated gain-of-function mutation,
T96K, in the microglial receptor Trem2 reduces levels of soluble Trem2 and Aβ uptake
in microglial cells and i...
www.cell.com
October 20, 2025 at 2:44 PM
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer’s disease by impairing microglial function
www.cell.com/neuron/fullt...
www.cell.com/neuron/fullt...
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
www.nature.com
October 20, 2025 at 2:01 PM
Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics
www.nature.com/articles/s42...
www.nature.com/articles/s42...
MRI-based multi-organ clocks for healthy aging and disease assessment | Nature Medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
MRI-based multi-organ clocks for healthy aging and disease assessment - Nature Medicine
A new study combines MRI data with proteomic, metabolomic and RNA data to develop and examine seven organ-specific MRI-based aging clocks, uncovering links to overall mortality and organ-specific dise...
www.nature.com
October 16, 2025 at 8:28 PM
MRI-based multi-organ clocks for healthy aging and disease assessment | Nature Medicine
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Pluchino lab - Regenerative Neuroimmunology
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Metabolic dysregulation is a hallmark of aging, but how metabolic pathway activity
(flux) changes with age has yet to be broadly assessed. Here, Jankowski et al. measure
metabolite concentrations and ...
www.cell.com
October 16, 2025 at 4:30 PM
Aged mice exhibit widespread metabolic changes but preserved major fluxes: Cell Metabolism www.cell.com/cell-metabol...