Nature Reviews Neurology, Published online: 17 November 2025; doi:10.1038/s41582-025-01160-0This article reviews the epidemiology and clinical characteristics of multiple sclerosis (MS) in Latin America and how they might be influenced by genetic, environmental and socioeconomic factors that are unique to this region. The authors also describe diagnostic criteria, differential diagnosis and current approaches to MS treatment and management in Latin American countries.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01166-8Developmental trajectories and genetic architectures differ between inidividuals with autism who are diagnosed early or later in life, new research has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01169-5Lipids derived from extracellular vesicles in adipose tissue from people with obesity can promote amyloid-β aggregation, according to new research.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01165-9The C9orf72 hexanucleotide expansion that causes amyotrophic lateral sclerosis (ALS) compromises microglial function, new research has shown.

Nature Reviews Neurology, Published online: 17 November 2025; doi:10.1038/s41582-025-01160-0This article reviews the epidemiology and clinical characteristics of multiple sclerosis (MS) in Latin America and how they might be influenced by genetic, environmental and socioeconomic factors that are unique to this region. The authors also describe diagnostic criteria, differential diagnosis and current approaches to MS treatment and management in Latin American countries.

Nature Reviews Neurology, Published online: 13 November 2025; doi:10.1038/s41582-025-01159-7Genome-wide association studies have identified genetic modifiers, mostly DNA repair genes, that significantly influence the onset and progression of Huntington disease, pointing to somatic CAG repeat expansions as a key pathological driver. Here, Tabrizi and colleagues review the evidence for this paradigm and discuss the potential for therapeutic interventions.

Nature Reviews Neurology, Published online: 13 November 2025; doi:10.1038/s41582-025-01159-7Genome-wide association studies have identified genetic modifiers, mostly DNA repair genes, that significantly influence the onset and progression of Huntington disease, pointing to somatic CAG repeat expansions as a key pathological driver. Here, Tabrizi and colleagues review the evidence for this paradigm and discuss the potential for therapeutic interventions.

To study the association of Epstein–Barr virus (EBV) and multiple sclerosis (MS) as compared to 10 different control diseases, 10,669 patients with MS and 42,222 controls were identified by ICD10 cod...

Comparative studies in AD and PiD reveal critical regulatory changes and identify risk gene associations for PiD.

An analysis of rare genetic variants identifies three genes—MAP1A, ANO8 and ANK2—that have a role in attention deficit hyperactivity disorder (ADHD) and investigates the potential underlying biologica...

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01166-8Developmental trajectories and genetic architectures differ between inidividuals with autism who are diagnosed early or later in life, new research has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01167-7PET imaging of synaptic vesicle protein 2A could enable visualization of grey matter pathology in multiple sclerosis, new work has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01165-9The C9orf72 hexanucleotide expansion that causes amyotrophic lateral sclerosis (ALS) compromises microglial function, new research has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01168-6Serial analysis of glioblastoma tissue during treatment can help to reveal and monitor treatment responses, according to a new study.

INTRODUCTION Some research suggests that blood–brain barrier (BBB) integrity is altered in Alzheimer's disease (AD). Few studies have examined markers of BBB integrity and their interactions with AD...

Multiple sclerosis (MS) is a chronic, immune-mediated disease characterized by inflammation, demyelination, and neurodegeneration (McGinley et al., 2021; Mey et al., 2023). Natalizumab, a recombinant ...

Using a mouse model enabling an inducible ‘switch’, Golden et al. show that an astrocyte-specific replacement of the Alzheimer’s risk gene APOE4 with protective APOE2 alters metabolism and gene expres...

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01166-8Developmental trajectories and genetic architectures differ between inidividuals with autism who are diagnosed early or later in life, new research has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01169-5Lipids derived from extracellular vesicles in adipose tissue from people with obesity can promote amyloid-β aggregation, according to new research.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01167-7PET imaging of synaptic vesicle protein 2A could enable visualization of grey matter pathology in multiple sclerosis, new work has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01165-9The C9orf72 hexanucleotide expansion that causes amyotrophic lateral sclerosis (ALS) compromises microglial function, new research has shown.

Nature Reviews Neurology, Published online: 11 November 2025; doi:10.1038/s41582-025-01168-6Serial analysis of glioblastoma tissue during treatment can help to reveal and monitor treatment responses, according to a new study.

Objective This study was undertaken to identify novel blood-based biomarkers associated with the early diagnosis of status epilepticus (SE) by exploring proteomic alterations in plasma extracellular...

This cohort study assesses data for US Medicare beneficiaries 65 years and older to map incident epilepsy at the smallest geography permissible by privacy constraints and identify contextual social an...

Traumatic brain injury (TBI) increases one’s risk of developing Alzheimer’s disease and tauopathy. Yet, the mechanisms linking TBI to neurodegenerativ…