Mass Lab
@masslab.bsky.social
Based @LIMES Institute @University of Bonn, researching developmental immunology. We ❤️ macrophages!
Pinned
Mass Lab
@masslab.bsky.social
· Jun 18
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Reposted by Mass Lab
Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper!
Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.
🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG
Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.
🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG
December 26, 2025 at 3:58 PM
Congratulations to Drs. Jose Villadangos and Hamish McWilliam's (@hay-mish.bsky.social) labs on their @science.org paper!
Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.
🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG
Their teams at the Doherty Institute showed that #macrophages are key for MR1 antigen presentation and MAIT cell immunity.
🗒️ https://bit.ly/49W1GW1
🎤 https://bit.ly/44Ay1OG
Reposted by Mass Lab
🚨 Postdoctoral Opportunity for Female Scientists🚨
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
December 19, 2025 at 12:24 AM
🚨 Postdoctoral Opportunity for Female Scientists🚨
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
The University of Vienna is awarding at least 20 fully funded 4 year postdoctoral positions to outstanding female scientists
Interested? Get in touch via direct message
careers.univie.ac.at/en/postdoc/e...
#MicroSky 🧪
#PostDoc @univie.ac.at
🧬🍽️ Your macrophages may be carrying your mother’s metabolic history!
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming
December 6, 2025 at 2:51 PM
🧬🍽️ Your macrophages may be carrying your mother’s metabolic history!
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming
In our @cp-trendsimmuno.bsky.social article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory #Macrophages #MaternalNutrition #DOHaD #EarlyLifeProgramming
Reposted by Mass Lab
Fresh from Elvira Mass Lab @masslab.bsky.social. We are happy to share our thoughts on how maternal malnutrition can shape the development of offspring tissue-resident macrophages during early development. Happy reading!
Maternal diet shapes the development and identity of tissue-resident macrophages #immunology
Maternal diet shapes the development and identity of tissue-resident macrophages
The developmental origins of health and diseases concept posits that early-life exposure to environmental adversities increases risks for diverse noncommunicable and infectious diseases. Among these adversities, maternal malnutrition is a critical determinant of offspring health trajectories. Maternal malnutrition from preconception to lactation can durably alter cellular and tissue function in the offspring. We propose that tissue-resident macrophages (TRMs) act as central mediators of this developmental programming. Seeding tissues during embryogenesis, integrating metabolic and hormonal signals, and persisting throughout life, TRMs can encode maternal nutritional states into lasting tissue adaptations. We summarize how specific maternal diets program distinct TRM subsets and how programmed TRMs link maternal nutritional statuses to disease susceptibility. TRMs may offer early intervention targets to improve offspring health.
dlvr.it
December 6, 2025 at 9:11 AM
Fresh from Elvira Mass Lab @masslab.bsky.social. We are happy to share our thoughts on how maternal malnutrition can shape the development of offspring tissue-resident macrophages during early development. Happy reading!
Reposted by Mass Lab
#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 14, 2025 at 4:15 PM
#Microglia and CD8⁺ T cell activation precede neuronal loss in a murine model of spastic paraplegia 15. From Frolov, @haohuang0086.bsky.social, Stumm, @masslab.bsky.social, Beyer et al.: rupress.org/jem/article/...
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells.
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
Characterization of the mammalian prodefinitive angio-hematopoietic lineage
The identification of mammalian prodefinitive angio-hematopoietic progenitors clarifies early hematopoiesis and macrophage development.
www.science.org
November 11, 2025 at 11:27 AM
Happy to have contributed to this beautiful story on #macrophage #development in mice and in #iPSC derived cells.
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
www.science.org/doi/10.1126/...
Big congrats to first author Tomi Lazarov for this massive work!!!!👏
Interested in #macrophages? Don't forget the check out this Seminar Series 👇
WE ARE BACK FROM SUMMER BREAK for our next #MagNet #Seminar
⏰Monday, Oct 13th, 4 pm (CET)
🧑🔬Thomas Marichal
🗣️“Decoding the lung macrophage landscape: trajectories, niches and functions in health and disease"
see poster and webpage for the #zoom link: macrophagenetwork.com/magnet-semin...
⏰Monday, Oct 13th, 4 pm (CET)
🧑🔬Thomas Marichal
🗣️“Decoding the lung macrophage landscape: trajectories, niches and functions in health and disease"
see poster and webpage for the #zoom link: macrophagenetwork.com/magnet-semin...
October 12, 2025 at 6:29 AM
Interested in #macrophages? Don't forget the check out this Seminar Series 👇
Reposted by Mass Lab
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
October 5, 2025 at 9:35 AM
The Vienna BioCenter PhD Program application deadline is approaching: October 10!
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Join one of Europe’s premier life science campuses, home to cutting-edge research across all areas of biology.
Apply and start your scientific journey in Vienna!
training.vbc.ac.at/phd-program/
#PhD #LifeSciences
Reposted by Mass Lab
🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de
Application deadline: Sept 26
Link: www.mu-ds.de
MUDS - Helmholtz Information & Data Science Academy
www.mu-ds.de
September 10, 2025 at 7:06 AM
🔔PhD position open. Interested in building competencies in computational biology in spatial transcriptomics? Malte Luecken's lab and I have an open PhD position, part of the Munich School of Data Science.
Application deadline: Sept 26
Link: www.mu-ds.de
Application deadline: Sept 26
Link: www.mu-ds.de
Reposted by Mass Lab
Had the wonderful opportunity to present our data on the effect of microplastics on macrophages at #EMDS2025 ! Such a beautiful venue 🤩 @masslab.bsky.social
Fascinating (and disturbing!) presentation about the impact of ingested microplastics on liver macrophages by @mariafviola.bsky.social #EMDS2025
September 16, 2025 at 1:07 PM
Had the wonderful opportunity to present our data on the effect of microplastics on macrophages at #EMDS2025 ! Such a beautiful venue 🤩 @masslab.bsky.social
Reposted by Mass Lab
Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!
September 8, 2025 at 12:00 PM
Application is open! Come join us and our fantastic line-up of speakers next year in March in Bonn!
Reposted by Mass Lab
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue | The EMBO Journal
imageimageDisruption of ciliogenesis in Bardet-Biedl syndrome (BBS) leads to obesity and disrupted
adipogenesis. This study reveals that ciliary dysfunction in a mouse model of BBS
induces a a cell fa...
www.embopress.org
August 21, 2025 at 3:57 AM
🚨 New in The EMBO Journal!
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Loss of BBS8 disrupts ciliary Hedgehog signaling, switching adipocyte precursors into fibrogenic cells—remodeling adipose tissue before obesity begins.
🔬 #BBS #cilia @for5547.bsky.social @sfb1454.bsky.social @batenergy.bsky.social
📄 www.embopress.org/doi/full/10....
Reposted by Mass Lab
Come be my colleague! We have three open positions at the Assistant/Associate Professor level for candidates in all areas of the biological sciences.
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
www.imperial.ac.uk
August 18, 2025 at 9:02 AM
Come be my colleague! We have three open positions at the Assistant/Associate Professor level for candidates in all areas of the biological sciences.
www.imperial.ac.uk/jobs/search-...
www.imperial.ac.uk/jobs/search-...
Reposted by Mass Lab
#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...
August 15, 2025 at 2:45 PM
#WomenInSTEM becoming independent: People should feel free to be themselves and do great science. We asked ten women researchers about their science and the process of setting up a lab as an independent researcher: rupress.org/jem/article/...
Reposted by Mass Lab
Out today! www.science.org/doi/10.1126/... From @kknoop.bsky.social & myself on early life immune development & the beautiful publication from Megan Koch & M Shenoy www.science.org/doi/10.1126/... Take home message: timing of early life exposures, milk IgG here, is critical for immune development.
Setting the table for immune tolerance
Interaction between breast milk antibodies and gut microbes shape immune responses during weaning
www.science.org
August 14, 2025 at 7:47 PM
Out today! www.science.org/doi/10.1126/... From @kknoop.bsky.social & myself on early life immune development & the beautiful publication from Megan Koch & M Shenoy www.science.org/doi/10.1126/... Take home message: timing of early life exposures, milk IgG here, is critical for immune development.
Reposted by Mass Lab
This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!
scim.ag/3UqRrA6
scim.ag/3UqRrA6
August 12, 2025 at 8:32 PM
This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!
scim.ag/3UqRrA6
scim.ag/3UqRrA6
Reposted by Mass Lab
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
July 19, 2025 at 7:52 PM
Our recent overview of human stem cell models for studying neuropsychiatric disorders (including their limitations and future directions) is now openly available @annualreviews.bsky.social of Neuroscience
With the great @rebeccalevymdphd.bsky.social
With the great @rebeccalevymdphd.bsky.social
🧠 New book chapter out!
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
July 17, 2025 at 7:43 PM
🧠 New book chapter out!
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
We review the developmental origin and functional diversity of #microglia - key players at the crossroads of #immunity and #neurodevelopment.
🔹 Ontogeny & specialization
🔹 Transcriptional & metabolic shifts
🔹 Roles in disease & repair
👉 authors.elsevier.com/a/1lKxcErwXf...
1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
Developmental programming by maternal obesity alters offspring lifespan and immune responses in a diet- and sex-specific manner
Maternal obesity is a growing health concern that predisposes offspring to metabolic dysfunction, immune system alterations, and neurodegenerative dis…
shorturl.at
July 17, 2025 at 7:19 PM
1/ 💡We are excited to share our latest paper, continuing our exploration of how maternal obesity programs offspring health via #macrophages - this time using #Drosophila as a model: shorturl.at/28tFo
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
#MaternalObesity #Drosophila #Neurodegeneration #DOHaD #FlyResearch #MacrophageBiology
Reposted by Mass Lab
1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)
June 30, 2025 at 9:09 AM
1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)
Reposted by Mass Lab
The fantastic Menon Lab (@madhvimenon.bsky.social) in the @lydiabeckeriii.bsky.social in Manchester are hiring!!
🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨
www.jobs.manchester.ac.uk/Job/JobDetai...
Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky
🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨
www.jobs.manchester.ac.uk/Job/JobDetai...
Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky
Research Associate in Mucosal Immunology :Manchester
www.jobs.manchester.ac.uk
July 1, 2025 at 8:18 AM
The fantastic Menon Lab (@madhvimenon.bsky.social) in the @lydiabeckeriii.bsky.social in Manchester are hiring!!
🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨
www.jobs.manchester.ac.uk/Job/JobDetai...
Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky
🚨DO NOT MISS YOUR CHANCE TO APPLY!🚨
www.jobs.manchester.ac.uk/Job/JobDetai...
Postdoc seeking to unravel how lung-infiltrating #Bcells contribute to chronic lung disease #immunosky
Reposted by Mass Lab
🧪 One month until the application deadline. Get in touch if you are interested ⬇️
#immunosky #cardiosky #academicsky #ecr #studyintheuk
#immunosky #cardiosky #academicsky #ecr #studyintheuk
🧪 I am offering projects to study how air pollution affects vascular inflammation as part of Royal Holloway's MSc degree in Biological Sciences research. Contact me if you are interested in applying. www.royalholloway.ac.uk/research-and... #immunosky #cardiosky #idsky #academicsky #academicchatter
Masters by Research in Biological Sciences at Royal Holloway
Explore our internationally-renowned masters with specialist staff and breakthrough research
www.royalholloway.ac.uk
June 26, 2025 at 7:35 PM
🧪 One month until the application deadline. Get in touch if you are interested ⬇️
#immunosky #cardiosky #academicsky #ecr #studyintheuk
#immunosky #cardiosky #academicsky #ecr #studyintheuk
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Kupffer cell programming by maternal obesity triggers fatty liver disease
Nature - In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
rdcu.be
June 18, 2025 at 4:41 PM
We are SO EXCITED to share our story @nature.com:
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
🧵1/
Maternal obesity reprograms fetal liver macrophages, triggering adult fatty liver disease in the offspring.
This study uncovers how Kupffer cells act as intergenerational messengers in metabolic disease.
👉 Read here: rdcu.be/erD3b
Reposted by Mass Lab
It's time for our next #MagNet #Seminar! It's all about #KupfferCells and #KetogenicDiet presented by Gerasimos Anagnostopoulos via #Zoom
⏰ Monday, June 16th, 4 pm
Visit our homepage for more infos: macrophagenetwork.com/magnet-semin...
⏰ Monday, June 16th, 4 pm
Visit our homepage for more infos: macrophagenetwork.com/magnet-semin...
June 16, 2025 at 10:11 AM
It's time for our next #MagNet #Seminar! It's all about #KupfferCells and #KetogenicDiet presented by Gerasimos Anagnostopoulos via #Zoom
⏰ Monday, June 16th, 4 pm
Visit our homepage for more infos: macrophagenetwork.com/magnet-semin...
⏰ Monday, June 16th, 4 pm
Visit our homepage for more infos: macrophagenetwork.com/magnet-semin...
The #Rosshart Lab goes wild again! Ever wondered whether using #Wildlings in our research would change the outcome of our results? 🤔💡 #immunosky @fau.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Laboratory mice engrafted with natural gut microbiota possess a wildling-like phenotype - Nature Communications
Here, the authors apply a standardized system, called TXsystem, to transplant wild mouse gut microbiota into SPF mice, developing “TXwildlings” mice that stably retain natural microbiota and human-lik...
www.nature.com
June 15, 2025 at 6:17 PM
The #Rosshart Lab goes wild again! Ever wondered whether using #Wildlings in our research would change the outcome of our results? 🤔💡 #immunosky @fau.de
www.nature.com/articles/s41...
www.nature.com/articles/s41...