Mass Lab
@masslab.bsky.social
Based @LIMES Institute @University of Bonn, researching developmental immunology. We ❤️ macrophages!
4/Together, these studies highlight the evolutionarily #conserved and multi-organ impact of maternal diet on offspring health and disease susceptibility.
Huge thanks to Seyhmus Bayar and our collaborators for their fantastic work!
@for5775.bsky.social
Huge thanks to Seyhmus Bayar and our collaborators for their fantastic work!
@for5775.bsky.social
July 17, 2025 at 7:19 PM
4/Together, these studies highlight the evolutionarily #conserved and multi-organ impact of maternal diet on offspring health and disease susceptibility.
Huge thanks to Seyhmus Bayar and our collaborators for their fantastic work!
@for5775.bsky.social
Huge thanks to Seyhmus Bayar and our collaborators for their fantastic work!
@for5775.bsky.social
3/ This work builds on our previous findings published in @nature.com (Huang et al., 2025), where we showed that yolk sac-derived Kupffer cells mediate fetal liver programming in obese pregnancies, driving fatty liver disease in adulthood (www.nature.com/articles/s41...)
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
www.nature.com
July 17, 2025 at 7:19 PM
3/ This work builds on our previous findings published in @nature.com (Huang et al., 2025), where we showed that yolk sac-derived Kupffer cells mediate fetal liver programming in obese pregnancies, driving fatty liver disease in adulthood (www.nature.com/articles/s41...)
2/In this study, we uncover how maternal diet in flies(corresponding to maternal obesity in mammals) disrupts #neuronal integrity and #immune function in offspring. We identify axon #degeneration and shortened #lifespan, linking maternal overnutrition to long-term health consequences.
July 17, 2025 at 7:19 PM
2/In this study, we uncover how maternal diet in flies(corresponding to maternal obesity in mammals) disrupts #neuronal integrity and #immune function in offspring. We identify axon #degeneration and shortened #lifespan, linking maternal overnutrition to long-term health consequences.
Led by @haohuang0086.bsky.social and Nora R. Balzer
📍 Developmental Biology of the Immune System, LIMES Institute
#DOHaD #macrophages #FattyLiverDisease
📍 Developmental Biology of the Immune System, LIMES Institute
#DOHaD #macrophages #FattyLiverDisease
June 18, 2025 at 4:41 PM
Led by @haohuang0086.bsky.social and Nora R. Balzer
📍 Developmental Biology of the Immune System, LIMES Institute
#DOHaD #macrophages #FattyLiverDisease
📍 Developmental Biology of the Immune System, LIMES Institute
#DOHaD #macrophages #FattyLiverDisease
12/
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
June 18, 2025 at 4:41 PM
12/
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
Big thanks to all collaborators across @sfb1454.bsky.social @unibonn.bsky.social @limes-bonn.bsky.social @dzne.science
11/
🧠 This aligns with the concept of DOHaD (Developmental Origins of Health and Disease) — and adds tissue-resident macrophages to the list of intergenerational regulators.
🧠 This aligns with the concept of DOHaD (Developmental Origins of Health and Disease) — and adds tissue-resident macrophages to the list of intergenerational regulators.
June 18, 2025 at 4:41 PM
11/
🧠 This aligns with the concept of DOHaD (Developmental Origins of Health and Disease) — and adds tissue-resident macrophages to the list of intergenerational regulators.
🧠 This aligns with the concept of DOHaD (Developmental Origins of Health and Disease) — and adds tissue-resident macrophages to the list of intergenerational regulators.
10/
🚨 Implication:
We identify a therapeutic window during gestation to target fetal KC programming — potentially preventing metabolic liver disease in later life.
🚨 Implication:
We identify a therapeutic window during gestation to target fetal KC programming — potentially preventing metabolic liver disease in later life.
June 18, 2025 at 4:41 PM
10/
🚨 Implication:
We identify a therapeutic window during gestation to target fetal KC programming — potentially preventing metabolic liver disease in later life.
🚨 Implication:
We identify a therapeutic window during gestation to target fetal KC programming — potentially preventing metabolic liver disease in later life.
9/
This work shifts the paradigm:
🔁 FLD is not just a postnatal diet effect
🧬 It can originate from developmental #macrophage programming — long before birth
This work shifts the paradigm:
🔁 FLD is not just a postnatal diet effect
🧬 It can originate from developmental #macrophage programming — long before birth
June 18, 2025 at 4:41 PM
9/
This work shifts the paradigm:
🔁 FLD is not just a postnatal diet effect
🧬 It can originate from developmental #macrophage programming — long before birth
This work shifts the paradigm:
🔁 FLD is not just a postnatal diet effect
🧬 It can originate from developmental #macrophage programming — long before birth