Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
November 9, 2025 at 3:12 AM
Beating iPSC-derived heart muscle cells videoed through a microscope. Alpha-actinin-2 is shown. #CellBiology
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
November 7, 2025 at 4:55 PM
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
November 4, 2025 at 6:50 PM
An iPSC-derived heart muscle cell assembling sarcomeres videoed through a spinning disk confocal microscope by Burnette Lab graduate student, Emma Koory. Alpha-actinin-2 is shown. Colors denote Z slices (red-bottom; green-middle; blue-top). Movie length- 40 hours.
Máire Ní Bhrádaigh from IPSC introducing our demonstration at RTÉ yesterday, as part of the European Day of Action on Eurovision. We welcome RTÉ's decision not to participate in Eurovision if apartheid Israel is in it, and we urge them to hold firm on it. #BanIsrael #FreePalestine
November 2, 2025 at 2:59 PM
Máire Ní Bhrádaigh from IPSC introducing our demonstration at RTÉ yesterday, as part of the European Day of Action on Eurovision. We welcome RTÉ's decision not to participate in Eurovision if apartheid Israel is in it, and we urge them to hold firm on it. #BanIsrael #FreePalestine
Just like yesterday's fireworks displays, this network of mature motor neurons is colourfully displaying their expression of MAP2 (red), ISL1 (orange), and SMI32 (green) with their blue nuclei.
This image is courtesy of our team working on our iPSC platform.
Photo: Will Stebbeds
This image is courtesy of our team working on our iPSC platform.
Photo: Will Stebbeds
November 6, 2025 at 9:15 AM
Just like yesterday's fireworks displays, this network of mature motor neurons is colourfully displaying their expression of MAP2 (red), ISL1 (orange), and SMI32 (green) with their blue nuclei.
This image is courtesy of our team working on our iPSC platform.
Photo: Will Stebbeds
This image is courtesy of our team working on our iPSC platform.
Photo: Will Stebbeds
Dr. Rebecca Heslin, IPSC, at our demonstration at RTÉ yesterday. She commends the workers and unions for getting RTÉ to refuse to participate in Eurovision if apartheid Israel is in it. We urge them to stay firm in this decision, the EBU must expel Israel for its genocidal crimes. #BDS
November 2, 2025 at 7:52 PM
Dr. Rebecca Heslin, IPSC, at our demonstration at RTÉ yesterday. She commends the workers and unions for getting RTÉ to refuse to participate in Eurovision if apartheid Israel is in it. We urge them to stay firm in this decision, the EBU must expel Israel for its genocidal crimes. #BDS
Spooooky microscopy!
Postdoc, shining a flashlight on their face:
"the iPSC cardiomyocyte just kept making sarcomeres, growing more and more striated. And then... it suddenly cytolyzed!"
*graduate students gasp, one faints*
Postdoc, shining a flashlight on their face:
"the iPSC cardiomyocyte just kept making sarcomeres, growing more and more striated. And then... it suddenly cytolyzed!"
*graduate students gasp, one faints*
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
October 31, 2025 at 3:02 PM
Spooooky microscopy!
Postdoc, shining a flashlight on their face:
"the iPSC cardiomyocyte just kept making sarcomeres, growing more and more striated. And then... it suddenly cytolyzed!"
*graduate students gasp, one faints*
Postdoc, shining a flashlight on their face:
"the iPSC cardiomyocyte just kept making sarcomeres, growing more and more striated. And then... it suddenly cytolyzed!"
*graduate students gasp, one faints*
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
October 31, 2025 at 2:46 PM
An iPSC heart muscle cell forming sarcomeres videoed through a microscope by Emma Koory for 20 h before it dies most dramatically. This was our first try on a new microscope, and Emma now has the imaging parameters dialed in so her cells do not go POP! Alpha-actinin-2 is shown. #CellBiology
At @ttuhsc-gsbs.bsky.social, @scientistabe.bsky.social's team developed protocols for human blood-brain barrier models.
Co-culturing iPSC-derived astrocytes and neurons with endothelial cells mimics the neurovascular unit under stroke conditions.
link.springer.com/protocol/10....
Co-culturing iPSC-derived astrocytes and neurons with endothelial cells mimics the neurovascular unit under stroke conditions.
link.springer.com/protocol/10....
Human iPSC-Derived Astrocyte–Endothelial Cell and Neuron–Endothelial Cell Co-culture Models of the Blood–Brain Barrier to Study the Impact of Ischemic Stroke in Vitro
The role of the blood–brain barrier (BBB) in pathogenic mechanisms of neurodegenerative disorders, including stroke, is well recognized. In vitro BBB models offer opportunities to recapitulate a...
link.springer.com
October 29, 2025 at 7:06 PM
At @ttuhsc-gsbs.bsky.social, @scientistabe.bsky.social's team developed protocols for human blood-brain barrier models.
Co-culturing iPSC-derived astrocytes and neurons with endothelial cells mimics the neurovascular unit under stroke conditions.
link.springer.com/protocol/10....
Co-culturing iPSC-derived astrocytes and neurons with endothelial cells mimics the neurovascular unit under stroke conditions.
link.springer.com/protocol/10....
Do human iPSC derived microglia also possess similar electrophysiological properties?
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
Ion Channels and Receptors as Determinants of Microglial Function
Microglia provide immune surveillance of the CNS. They display diverse behaviors,
including nondirectional and directed motility of their processes, phagocytosis of
targets such as dying neurons or su...
www.cell.com
October 25, 2025 at 5:42 PM
Do human iPSC derived microglia also possess similar electrophysiological properties?
www.cell.com/trends/neuro...
www.cell.com/trends/neuro...
💙💛🍁
Canadian officers observe and advise Ukrainian soldiers during precision shooting exercises at the IPSC military base #OTD October 25, 2017 in Yavoriv, Ukraine.
The aim of these training courses is to create a corps of sergeants and field officers and to break with decades of Soviet heritage.
Canadian officers observe and advise Ukrainian soldiers during precision shooting exercises at the IPSC military base #OTD October 25, 2017 in Yavoriv, Ukraine.
The aim of these training courses is to create a corps of sergeants and field officers and to break with decades of Soviet heritage.
October 25, 2025 at 3:24 PM
💙💛🍁
Canadian officers observe and advise Ukrainian soldiers during precision shooting exercises at the IPSC military base #OTD October 25, 2017 in Yavoriv, Ukraine.
The aim of these training courses is to create a corps of sergeants and field officers and to break with decades of Soviet heritage.
Canadian officers observe and advise Ukrainian soldiers during precision shooting exercises at the IPSC military base #OTD October 25, 2017 in Yavoriv, Ukraine.
The aim of these training courses is to create a corps of sergeants and field officers and to break with decades of Soviet heritage.
A single sensory neuron grown from an induced pluripotent stem cell (iPSC), labeled for tubulin and actin to reveal its inner architecture.
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
October 24, 2025 at 3:47 PM
A single sensory neuron grown from an induced pluripotent stem cell (iPSC), labeled for tubulin and actin to reveal its inner architecture.
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
🧠 This living model is used to study neurodevelopment, regeneration, and disease — how sensory pathways form, fail, and might be repaired.
#FluorescenceFriday
Our CEO Nick Manusos had the opportunity to speak at the Cell & Gene Meeting on the Mesa, where he shared insights into our #iPSC platform and lead candidate for the treatment of #ParkinsonsDisease. Thank you to the Alliance for Regenerative Medicine for another wonderful meeting! #CGMesa25
October 24, 2025 at 2:58 PM
Our CEO Nick Manusos had the opportunity to speak at the Cell & Gene Meeting on the Mesa, where he shared insights into our #iPSC platform and lead candidate for the treatment of #ParkinsonsDisease. Thank you to the Alliance for Regenerative Medicine for another wonderful meeting! #CGMesa25
An iPSC-cardiac myocyte (heart muscle cell) in cell culture photographed through a microscope by former Burnette lab graduate student, Dr. James Hayes. We are preparing cover submissions for his last two first author papers from the lab! Actin filaments are shown. #CellBiology
October 22, 2025 at 3:24 PM
An iPSC-cardiac myocyte (heart muscle cell) in cell culture photographed through a microscope by former Burnette lab graduate student, Dr. James Hayes. We are preparing cover submissions for his last two first author papers from the lab! Actin filaments are shown. #CellBiology
Two Postdoctoral Researcher Positions at University of Oxford to study Alzheimer’s disease using AI and iPSC models in the Translational Neuroscience Group. Closing date: 6th November
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
Postdoc Researcher: Modelling Alzheimer’s’ with iPSCs & AI Phenotyping
Two Postdoctoral Researchers at University of Oxford to study Alzheimer’s disease using AI and iPSC models in the Translational Neuroscience Group.
www.dementiaresearcher.nihr.ac.uk
October 18, 2025 at 8:34 PM
Two Postdoctoral Researcher Positions at University of Oxford to study Alzheimer’s disease using AI and iPSC models in the Translational Neuroscience Group. Closing date: 6th November
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
www.dementiaresearcher.nihr.ac.uk/job/postdoc-...
It’s #FluorescenceFriday but I only have this brightfield of my iPSC-derived motor neurons and I’m happy with them, so that’s it, okay bye 🔬
October 17, 2025 at 9:05 PM
It’s #FluorescenceFriday but I only have this brightfield of my iPSC-derived motor neurons and I’m happy with them, so that’s it, okay bye 🔬
For #FluorescenceFriday - human iPSC-derived cerebral organoid - labeled w/ MAP2🟢, CTIP2🔴, PAX6⚪, Hoechst🔵 from our Molecular Neurogenetics team. Image credit to @tsawada1.bsky.social and JHU Human Genetics grad student Bailey Spiegelberg 🔬🧠🧪
October 17, 2025 at 5:17 PM
For #FluorescenceFriday - human iPSC-derived cerebral organoid - labeled w/ MAP2🟢, CTIP2🔴, PAX6⚪, Hoechst🔵 from our Molecular Neurogenetics team. Image credit to @tsawada1.bsky.social and JHU Human Genetics grad student Bailey Spiegelberg 🔬🧠🧪
One prevalent diagnostic symptom of #Noonansyndrome is congenital pulmonary valve stenosis. Work from the Gelb lab advances an iPSC platform for studying valve development and function. #cardiosky 🫀 🧪
#raredisease #rasopathies
#raredisease #rasopathies
A high-fidelity protocol for #hiPSC-derived Fibrosa vs Spongiosa #ValvularIntersistialCell
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
Endocardial state +FGF2/BMP4/TGFB2➡️
Fibrosa subset: PRRX2 TIMP3 ITGA2 (most discriminative marker)
Endocardial state +FGF2➡️
Spongiosa subset: LUM APOE
bioRxiv 2025
www.biorxiv.org/content/10.1...
October 16, 2025 at 11:35 PM
One prevalent diagnostic symptom of #Noonansyndrome is congenital pulmonary valve stenosis. Work from the Gelb lab advances an iPSC platform for studying valve development and function. #cardiosky 🫀 🧪
#raredisease #rasopathies
#raredisease #rasopathies
🎉Our last paper, BDNF Overexpression Enhances Neuronal Activity and Axonal Growth in Human iPSC-Derived Neural Cultures, has been featured on the @ub.edu website!
The article highlights our recent work on stem cell-based therapies for brain damage. @ubneuro.bsky.social 🔬🧠🧫
web.ub.edu/en/web/actua...
The article highlights our recent work on stem cell-based therapies for brain damage. @ubneuro.bsky.social 🔬🧠🧫
web.ub.edu/en/web/actua...
New advances to boost regeneration and plasticity of brain neurons
web.ub.edu
October 14, 2025 at 10:51 AM
🎉Our last paper, BDNF Overexpression Enhances Neuronal Activity and Axonal Growth in Human iPSC-Derived Neural Cultures, has been featured on the @ub.edu website!
The article highlights our recent work on stem cell-based therapies for brain damage. @ubneuro.bsky.social 🔬🧠🧫
web.ub.edu/en/web/actua...
The article highlights our recent work on stem cell-based therapies for brain damage. @ubneuro.bsky.social 🔬🧠🧫
web.ub.edu/en/web/actua...
Éirígí #ForANewRepublic activists attended a local IPSC march in Newry today to show solidarity with the people of Palestine after facing two years of genocide in Gaza. #GazaGenocide
October 11, 2025 at 6:02 PM
Éirígí #ForANewRepublic activists attended a local IPSC march in Newry today to show solidarity with the people of Palestine after facing two years of genocide in Gaza. #GazaGenocide
Having a complete, personalized reference genome of the sample you are analyzing allows for investigations like this in the most complex regions of the genome without having to worry about reference bias. More “matched” T2T assemblies are on the way for commonly used iPSC lines like KOLF2.1J...
October 10, 2025 at 3:27 PM
Having a complete, personalized reference genome of the sample you are analyzing allows for investigations like this in the most complex regions of the genome without having to worry about reference bias. More “matched” T2T assemblies are on the way for commonly used iPSC lines like KOLF2.1J...
"We cannot, we WILL NOT, allow apartheid Israel to slip back into the status quo when this genocide ends.
Stand with Palestine this saturday, and always.
Free Palestine Until Palestine is Free"
~ Belfast IPSC
Stand with Palestine this saturday, and always.
Free Palestine Until Palestine is Free"
~ Belfast IPSC
October 9, 2025 at 9:27 AM
"We cannot, we WILL NOT, allow apartheid Israel to slip back into the status quo when this genocide ends.
Stand with Palestine this saturday, and always.
Free Palestine Until Palestine is Free"
~ Belfast IPSC
Stand with Palestine this saturday, and always.
Free Palestine Until Palestine is Free"
~ Belfast IPSC
There's our lovely Paddy Kelly, longstanding IPSC activist, home after being kidnapped by apartheid Israel in international waters while sailing to break the illegal siege of Gaza. Welcome back, a legend indeed! #FreePalestine 🇵🇸
October 7, 2025 at 4:11 PM
There's our lovely Paddy Kelly, longstanding IPSC activist, home after being kidnapped by apartheid Israel in international waters while sailing to break the illegal siege of Gaza. Welcome back, a legend indeed! #FreePalestine 🇵🇸
Éirígí activists and members of the 1916 Societies marching together in Dublin City this afternoon as part of the Republican Bloc at the IPSC organised march marking the two year anniversary of the start of the #GazaGenocide…
October 4, 2025 at 3:50 PM
Éirígí activists and members of the 1916 Societies marching together in Dublin City this afternoon as part of the Republican Bloc at the IPSC organised march marking the two year anniversary of the start of the #GazaGenocide…