Stem Cell Reports
@stemcellreports.bsky.social
For scientists. By scientists. The official journal of the @isscr.org | Editor-in-Chief: Janet Rossant, CC, PhD
Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh
December 23, 2025 at 9:09 PM
Explore the 10 most downloaded papers of 2025! Together, these highly read articles reflect the extraordinary scientific range of the field and underscore the journal’s role as a trusted platform for impactful stem cell science. https://www.isscr.org/isscr-news/04ry219odbnptyf0we3sikaw0311hh
New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR
December 23, 2025 at 3:20 PM
New study provides the alternative splicing landscape during muscle stem cell activation & demonstrates that a single-gene splicing change can significantly influence satellite cell activation & essential pathways such as #Notch signaling. https://ow.ly/8uJP50XMwJU ISSCR
New #organoid study published in Stem Cell Reports highlights the role of #autophagy in lacrimal glands along with potential therapeutic interventions for dry eye disease. https://ow.ly/9kxK50XMwiT
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 22, 2025 at 8:01 PM
New #organoid study published in Stem Cell Reports highlights the role of #autophagy in lacrimal glands along with potential therapeutic interventions for dry eye disease. https://ow.ly/9kxK50XMwiT
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30
ISSCR
ISSCR
December 19, 2025 at 8:10 PM
Online now! A comprehensive overview of pluripotent stem cell lines for clinical use.166 clinical hPSC lines available for licensing and distribution, including 11 used in clinical trials, with information on consent, regulation, and characterization. https://ow.ly/tQ2j50XMw30
ISSCR
ISSCR
New airway #clubcell research! Metabolic-immune crosstalk underlying #asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation. https://ow.ly/s5tS50XMvME
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
December 19, 2025 at 2:44 PM
New airway #clubcell research! Metabolic-immune crosstalk underlying #asthma pathogenesis and identify mitochondrial pyruvate metabolism as a therapeutic target to limit epithelial remodeling and type 2 inflammation. https://ow.ly/s5tS50XMvME
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from Stem Cells to Disease Modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
December 16, 2025 at 2:00 PM
Anne Grapin-Botton, Stem Cell Reports Associate Editor, is attending the Organoids from Stem Cells to Disease Modeling in Paris, France in January 2026. Connect with her there to discuss whether your research is a fit for publishing in Stem Cell Reports!
Reposted by Stem Cell Reports
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages
In this article, Gayen and colleagues demonstrate that m6A RNA methylation is dispensable
for the maintenance of X chromosome inactivation; however, it partly contributes to
the maintenance of X to au...
www.cell.com
December 13, 2025 at 4:55 AM
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
Reposted by Stem Cell Reports
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Delighted to share our publication in @stemcellreports.bsky.social on the role of #m6A_RNA methylation in #Xchromosome dosage compensation during #embryogenesis, jointly driven by Hemant and @barorunumi.bsky.social. 🔗 www.cell.com/stem-cell-re...
@isscr.org
🧵
@isscr.org
🧵
The role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages
In this article, Gayen and colleagues demonstrate that m6A RNA methylation is dispensable
for the maintenance of X chromosome inactivation; however, it partly contributes to
the maintenance of X to au...
www.cell.com
December 15, 2025 at 6:56 AM
Excited to share my first-ever publication, now out in @stemcellreports.bsky.social !! Heartiest congratulations to
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Hemant and @barorunumi.bsky.social for jointly leading the work. Grateful to my PI, Srimonta for giving me this opportunity to contribute to this study.
#m6A #X:A_dosage @isscr.org
Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org
December 11, 2025 at 9:20 PM
Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org
New research provides significant insight into the role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages. https://ow.ly/76jn50XHyLs
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 11, 2025 at 6:11 PM
New research provides significant insight into the role of m6A RNA methylation in the maintenance of X chromosome inactivation and X-to-autosome dosage compensation in early embryonic lineages. https://ow.ly/76jn50XHyLs
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
December 8, 2025 at 7:10 PM
New study uses cross-modal integration of #metabolomics and cardiac functionality to capture dynamic metabotoxic effects of #doxorubicin in engineered heart tissues. #heartonchip #cardiotoxicity https://ow.ly/HfsS50XC6NI
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
Dr. Harsha Devalla, Stem Cell Reports Early Career Editor , is attending the Assembloids and Complex Cell-Cell Interactions in New York, USA 8-11 December 2025. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
December 8, 2025 at 2:00 PM
Dr. Harsha Devalla, Stem Cell Reports Early Career Editor , is attending the Assembloids and Complex Cell-Cell Interactions in New York, USA 8-11 December 2025. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Dr. Bruno Di Stefano (Bruno Di Stefano) Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!
December 6, 2025 at 2:00 PM
Dr. Bruno Di Stefano (Bruno Di Stefano) Stem Cell Reports Early Career Editor , will be at the American Society of Hematology Annual Meeting in Florida, USA 6-9 December 2025. Connect with him to discuss whether your research is fit for publishing in Stem Cell Reports!
Hypoxic stress is an early pathogenic event in VCP-mutant #ALS astrocytes. Aberrant HIF-1ɑ activation drives astrocytic dysfunct. & compromises neuronal support, highlighting therapeutic potential in targeting HIF-1ɑ signaling https://ow.ly/QJh850XC6is
The Francis Crick Institute | ISSCR
The Francis Crick Institute | ISSCR
December 5, 2025 at 4:55 PM
Hypoxic stress is an early pathogenic event in VCP-mutant #ALS astrocytes. Aberrant HIF-1ɑ activation drives astrocytic dysfunct. & compromises neuronal support, highlighting therapeutic potential in targeting HIF-1ɑ signaling https://ow.ly/QJh850XC6is
The Francis Crick Institute | ISSCR
The Francis Crick Institute | ISSCR
New research from MRC Laboratory of Molecular Biology and Cambridge Stem Cell Institute adjusts PSC culture for neural organoid generation competency based on proteomic data & published literature. Read the full paper: https://ow.ly/bP6C50XC5U6
ISSCR
ISSCR
December 4, 2025 at 7:38 PM
New research from MRC Laboratory of Molecular Biology and Cambridge Stem Cell Institute adjusts PSC culture for neural organoid generation competency based on proteomic data & published literature. Read the full paper: https://ow.ly/bP6C50XC5U6
ISSCR
ISSCR
Variants in the SHANK2 gene, linked to neurodevelopmental disorders like autism, were modeled using human iPSC-derived neurons & multielectrode arrays. Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism https://ow.ly/LthV50Xve9r
University of Toronto | ISSCR
University of Toronto | ISSCR
November 28, 2025 at 3:45 PM
Variants in the SHANK2 gene, linked to neurodevelopmental disorders like autism, were modeled using human iPSC-derived neurons & multielectrode arrays. Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism https://ow.ly/LthV50Xve9r
University of Toronto | ISSCR
University of Toronto | ISSCR
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
November 26, 2025 at 2:54 PM
In this episode of The Stem Cell Report Podcast, guests discuss their investigation on the effect of diverse culture conditions on the cell type composition, gene expression profiles, & maturation status of human PSC-derived intestinal epithelial cells. tinyurl.com/3s4pkj34
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
November 26, 2025 at 1:35 PM
New study finds inducible Cars2 mutation in mice causes mitochondrial dysfunction and anemia and Cars2-mutant megakaryocyte-erythroid progenitors (MEPs) generate less erythroblasts, revealing mitochondria as key “navigators” for MEP lineage commitment. https://ow.ly/Xn6U50Xve7I
ISSCR
ISSCR
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 25, 2025 at 3:35 PM
New research from NYU Grossman School of Medicine: Stem cell-based approach to identify important regulatory transcription factors in various pathways during mammalian cell differentiation. #development #spinalcord https://ow.ly/i55H50Xve5V
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
November 24, 2025 at 4:01 PM
New #organoid research models RPGRIP1-inherited retinal disease; connecting cilium, stress response, and #proteostasis abnormalities to inform variant and therapy assessment. #ciliopathies #AAVtherapy #photoreceptors https://ow.ly/xTwl50Xva6s
University of Sydney (USYD) | ISSCR
University of Sydney (USYD) | ISSCR
Reposted by Stem Cell Reports
Hi All, @stemcellreports.bsky.social, is the official meeting journal of #ISSCR2026. It communicates basic discoveries in stem cell research, plus translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbk6l8kbi
Join me at the ISSCR 2026 Annual Meeting!
Register now
invt.io
November 21, 2025 at 3:06 PM
Hi All, @stemcellreports.bsky.social, is the official meeting journal of #ISSCR2026. It communicates basic discoveries in stem cell research, plus translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbk6l8kbi
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 24, 2025 at 1:00 PM
Meet Early Career Editor Harsha Devalla at the Assembloids and Complex Cell-Cell Interactions meeting in New York, USA, 8-11 December 2025. Connect with Dr. Devalla to discuss whether your research is a fit for publishing in Stem Cell Reports!
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 21, 2025 at 7:05 PM
Community and bioethicists’ perspectives on iPSC research with biobanked samples collected using broad consent; support for broad consent, commercial, more benefit sharing, ongoing community engagement, and oversight. https://ow.ly/qApR50Xv90Y
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 21, 2025 at 3:00 PM
Meet Early Career Editor Bruno Di Stefano (Bruno Di Stefano) at #ASH2025 in Orlando, USA 6-9 December 2025. Connect with Dr. Di Stefano to discuss whether your research is a fit for publishing in Stem Cell Reports!
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay
November 20, 2025 at 10:04 PM
New article explores 4,481 YouTube videos about stem cells to map how medical knowledge is shared online, revealing a complex discourse dominated by celebrity influencers in the promotion and discussion of putative stem cell treatments. https://ow.ly/iNUG50Xv8Ay