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LPJ Lab - Neuroimmunometabolism
@lpjlab.org
460 followers 740 following 100 posts
Welcome to Luca Peruzzotti-Jametti's lab @University of Cambridge!

We're dedicated to investigating how cell #metabolism shapes #brain - #immune interactions to pioneer new therapies for #MultipleSclerosis and other CNS disorders.

https://www.LPJLab.org
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LPJ Lab - Neuroimmunometabolism @lpjlab.org · Sep 4
Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧

We had a great chat about the latest research in MS and how we're working to find new treatments. 💪

Listen to the full episode here 👇
ms-perspektive.com/129-luca-per...
Hope for Myelin Repair: Stem Cells & Progressive MS
Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.
ms-perspektive.com
lpjlab.org
New Nature Metabolism review breaks down the history, role, and therapeutic promise of itaconate. Learn how this metabolite exerts potent anti-inflammatory effects—a crucial mechanism for future drug development!
#Immunometabolism #Inflammation
www.nature.com/articles/s42...
Metabolic Messengers: itaconate
McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.
www.nature.com
October 5, 2025 at 6:13 AM
lpjlab.org
Fascinating read on #brain 🧠 tumor #immunology! Primary brain tumors vs metastases have fundamentally different immune microenvironments.
This is why secondaries often show a better response to #immunotherapy. share.google/RJdXIc02PCyH...
share.google
October 4, 2025 at 8:22 PM
Reposted by LPJ Lab - Neuroimmunometabolism
michael-platten.bsky.social
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
October 4, 2025 at 10:49 AM
lpjlab.org
New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪
#Neuroscience #Mitochondria #Metabolism #BioRxiv

www.biorxiv.org/content/10.1...
Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties
Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...
www.biorxiv.org
September 24, 2025 at 8:04 AM
lpjlab.org
#PhD position available!

Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis.
This is a great opportunity for anyone interested in neuroimmunology! 🧠

Please SHARE and APPLY here:
www.imperial.ac.uk/brain-scienc...
Funding
Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...
www.imperial.ac.uk
September 17, 2025 at 8:20 AM
Reposted by LPJ Lab - Neuroimmunometabolism
camneuro.bsky.social
Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY
#CNS2025
September 11, 2025 at 4:38 PM
lpjlab.org
Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine
www.science.org/doi/10.1126/...
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies
Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.
www.science.org
September 11, 2025 at 8:42 AM
Reposted by LPJ Lab - Neuroimmunometabolism
gregory-ms.com
An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair.

ms-perspektive.de/en/129-luca-...

#MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org
Hope for Myelin Repair: Stem Cells & Progressive MS
Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.
ms-perspektive.de
September 10, 2025 at 11:54 AM
lpjlab.org
Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!

www.cell.com/cell/fulltex...
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...
www.cell.com
September 9, 2025 at 3:40 PM
lpjlab.org
Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧

We had a great chat about the latest research in MS and how we're working to find new treatments. 💪

Listen to the full episode here 👇
ms-perspektive.com/129-luca-per...
Hope for Myelin Repair: Stem Cells & Progressive MS
Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.
ms-perspektive.com
September 4, 2025 at 2:42 PM
Reposted by LPJ Lab - Neuroimmunometabolism
cytosurge.bsky.social
www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM
MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation - Nature Cancer
Cangkrama et al. show that tumor cells from various cancer types use the mitochondrial trafficking protein MIRO2 and nanotubes to transfer mitochondria into surrounding fibroblasts, thereby inducing c...
www.nature.com
August 29, 2025 at 9:10 AM
Reposted by LPJ Lab - Neuroimmunometabolism
natmetabolism.nature.com
PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)

An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism
Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
bit.ly
August 27, 2025 at 4:42 PM
lpjlab.org
Beyond understanding the #brain, our goal is to heal it!
www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa

Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care!

Register here: tinyurl.com/27rzs5ku
August 27, 2025 at 3:23 PM
lpjlab.org
The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic.
Dive in and let us know what you think!

www.nature.com/articles/s42...
Mitochondrial transfer - Nature Metabolism
Intercellular mitochondrial transfer has recently attracted substantial attention, both from a fundamental and therapeutic point of view. At the same time, the topic continues to be met with scepticis...
www.nature.com
August 27, 2025 at 10:41 AM
lpjlab.org
Cool event alert! 🧠
The next European Microglial Webinar is happening on Tuesday, 02/09 at 5pm CEST / 3pm GMT.
Michael Dolan will be speaking on "Formation and Function of Microglial States in Remyelination."
Zoom Link: unil.zoom.us/j/93018596158
#Microglia #Neuroscience
August 26, 2025 at 12:16 PM
Reposted by LPJ Lab - Neuroimmunometabolism
ryanlab.bsky.social
The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism
Great work from @lydialynch.bsky.social lab and colleagues
www.nature.com/articles/s42...
The source of dietary fat influences anti-tumour immunity in obese mice - Nature Metabolism
This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
www.nature.com
July 25, 2025 at 4:21 PM
lpjlab.org
What a night!
Our lab traded pipettes for axes, and let's just say we honed our missing skills with expert precision! 😉
It was an absolute blast seeing everyone de-stress and have a laugh, no matter where the axes landed 🪓🎯
Huge thanks to everyone! 👏
#Neuroscience #AxeThrowing #TeamBuilding
July 22, 2025 at 8:45 PM
lpjlab.org
A super cool #single-cell spatial transcriptomic mouse #brain atlas is out! 🐭🧠🔬
Unveiling cell types, #gene expression, & TF dynamics across the whole brain!
Awesome! ✨
#neuroskyence #neuroscience #compneurosky

www.cell.com/neuron/fullt...
Single-cell spatial transcriptomic atlas of the whole mouse brain
Han et al. used snRNA-seq and Stereo-seq to generate a detailed mouse brain atlas with over 4 million spatially resolved cells and 29,655 genes. Their findings include region- enriched cell clusters a...
www.cell.com
July 9, 2025 at 7:11 PM
lpjlab.org
Thrilled to share our latest paper showing that the transplantation of directly induced neural #StemCells enhances #remyelination of chronic demyelinating lesions!
💉🧠=💪
A great team effort with @pluchinolab.bsky.social and all our collaborators! #MultipleSclerosis

academic.oup.com/brain/advanc...
Remyelination of chronic demyelinated lesions with directly induced neural stem cells
Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts. They show that i
academic.oup.com
July 9, 2025 at 8:16 AM
Reposted by LPJ Lab - Neuroimmunometabolism
camneurodept.bsky.social
An @cam.ac.uk study published in Brain shows stem cell grafts can restore myelin in #MS lesions in mice. This holds promise for chronic demyelinating disorders & progressive multiple sclerosis.

Congrats to @lpjlab.org @pluchinolab.bsky.social

The paper: academic.oup.com/brain/advanc...
July 7, 2025 at 2:29 PM
lpjlab.org
Biotechnological approaches and therapeutic potential of #mitochondria transfer and transplantation 💉
www.nature.com/articles/s41...
Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation - Nature Communications
Mitochondrial dysfunction is involved in several disease states, mitochondria transfer and transplantation have the potential to address this. Here, the authors review recent advancements and cha...
www.nature.com
July 4, 2025 at 8:12 AM
lpjlab.org
Get ready for a scientific breakthrough! 🧑‍🔬
#DeepMind AlphaGenome is here: cutting-edge #AI to decode the mysteries of the human #genome!
This isn't just about data; it's about unlocking entirely new ways to understand health & disease
#Genomics #FutureOfMedicine

deepmind.google/discover/blo...
AlphaGenome: AI for better understanding the genome
Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.
deepmind.google
June 28, 2025 at 1:07 PM
lpjlab.org
📢 Exciting Welcome to Sinéad and Ishan! 📢

We're thrilled to welcome both to the LPJ Lab for their #SummerInternship!
Under Evridiki's guidance, they'll contribute to the understanding of #Microglia in #MultipleSclerosis.
Here's to a #summer of groundbreaking neurobiology and exciting insights!
June 25, 2025 at 8:27 AM
lpjlab.org
The immunoproteasome modulates cell metabolism and actively drives neurodegeneration in #MultipleSclerosis.
This really underscores the complex interplay between #immunity, #metabolism, and #brain health! 🧠
#Neuroscience #Neuroskyence

www.cell.com/cell/fulltex...
The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis
Neuronal proteasomal dysfunction is a hallmark of neuroinflammatory and neurodegenerative diseases. This study reveals that the interferon-induced immunoproteasome drastically decreases proteasomal ac...
www.cell.com
June 21, 2025 at 7:10 AM
lpjlab.org
Ferroptosis contributes to #MultipleSclerosis and its pharmacological targeting suppresses experimental disease progression
www.nature.com/articles/s41...
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression - Cell Death & Differentiation
Cell Death & Differentiation - Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
www.nature.com
June 21, 2025 at 7:06 AM