LPJ Lab - Neuroimmunometabolism
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lpjlab.org
LPJ Lab - Neuroimmunometabolism
@lpjlab.org
Welcome to Luca Peruzzotti-Jametti's lab @University of Cambridge!

We're dedicated to investigating how cell #metabolism shapes #brain - #immune interactions to pioneer new therapies for #MultipleSclerosis and other CNS disorders.

https://www.LPJLab.org
Pinned
🚨ALERT: If you live in the USA, please contact Congress to prioritize Pharmacy Benefit Manager (PBM) reform, so that people with multiple sclerosis receive the medications meant for them!🚨 #MS #Healthcare
Please click and act here before the ⚠️Jan 30 deadline⚠️: nmss.quorum.us/campaign/152...
Act Now: Tell Congress to Act on PBM Reform Before January 30
Contact Congress today!
nmss.quorum.us
🚨ALERT: If you live in the USA, please contact Congress to prioritize Pharmacy Benefit Manager (PBM) reform, so that people with multiple sclerosis receive the medications meant for them!🚨 #MS #Healthcare
Please click and act here before the ⚠️Jan 30 deadline⚠️: nmss.quorum.us/campaign/152...
Act Now: Tell Congress to Act on PBM Reform Before January 30
Contact Congress today!
nmss.quorum.us
January 15, 2026 at 3:50 PM
Reposted by LPJ Lab - Neuroimmunometabolism
A new CRISPR-based approach has identified key immune signals that regulate macrophage behavior in multiple sclerosis, offering deeper insight into the mechanisms driving neuroinflammation. doi.org/hbjfrf
New insight into the immune signals driving inflammation in multiple sclerosis
Multiple sclerosis (MS) is a chronic neurological disease characterized by nerve damage and consequent impairments in vision, movement, balance and mental function.
medicalxpress.com
January 10, 2026 at 3:30 PM
Reposted by LPJ Lab - Neuroimmunometabolism
3 papers on EBV and MS

Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis

Anoctamin-2 (ANO2) is targeted by T cells in approximately 57% of persons with MS

www.cell.com/cell/fu...
1/6
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple sclerosis, with T cell responses against ANO2 occurring in over half of patients. These ANO2-specific T cells share cross-reactivity and pathogenic features with T cell responses to EBNA1 from Epstein-Barr virus, and their activation worsens MS-like disease in mice.
www.cell.com
January 13, 2026 at 9:12 PM
Reposted by LPJ Lab - Neuroimmunometabolism
REVIEW | E Asimakidou, @lpjlab.org et al. (U Cambridge)

How metabolic interactions between microglia and neurons shape brain health 🧪
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
dlvr.it
January 8, 2026 at 6:04 PM
Merry Christmas from the LPJ Lab! 🎄
It’s been a joy to see the lab grow in 2025. I’m incredibly proud of this brilliant team and our shared mission to improve the lives of those with incurable diseases.
Here’s to the challenges ahead! 💪
@camneuro.bsky.social
@camneurodept.bsky.social
@cam.ac.uk
December 24, 2025 at 2:15 PM
New research in Nature Metabolism reveals that neuronal fatty acid oxidation is crucial for fueling memory formation after intensive learning. This metabolic shift supports the high energy demands in fruit flies. 🧠🪰
#Neuroscience #Metabolism #Memory
www.nature.com/articles/s42...
Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila - Nature Metabolism
Neurons are shown to use fatty acid β-oxidation as a fuel source for memory formation upon intensive learning in Drosophila, challenging the view that neurons are unable to use fatty acids for energy…
www.nature.com
December 16, 2025 at 3:51 AM
Please share the next "Neural Circuits of behavior" school in #Pisa, organised by @biancasilvalab.bsky.social

We will be exploring how #neuroplasticity shapes the #brain and #cognition 🧠
#NeuroSky #Neuroscience

⚠️ Applications and #scholarships are open until 15/01/26 ⚠️

www.sns.it/it/evento/ne...
Neural Circuits of behavior: from synapses to action | ScuolaNormaleSuperiore
www.sns.it
December 13, 2025 at 4:55 AM
Just wrapped up the CAJAL Advanced Neuroscience Training Programme in Bordeaux! 🍷🧠
It was a privilege to introduce such a brilliant group of students to the world of #Neuroimmunometabolism.
The future of our field looks very bright!
#Neuroscience #Immunology #Cajal #Bordeaux

tinyurl.com/276b6upe
December 7, 2025 at 8:36 AM
⚠️ Just out in @natmetabolism.nature.com ⚠️

Our latest review with @pluchinolab.bsky.social & @biancasilvalab.bsky.social explores how #microglia and #neuron #metabolism shapes #brain health and cognition! 🧠

Our Evridiki Asimakidou did a wonderful job leading this! 👏

www.nature.com/articles/s42...
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease - Nature Metabolism
This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.
www.nature.com
November 21, 2025 at 5:32 PM
New Nature Metabolism review breaks down the history, role, and therapeutic promise of itaconate. Learn how this metabolite exerts potent anti-inflammatory effects—a crucial mechanism for future drug development!
#Immunometabolism #Inflammation
www.nature.com/articles/s42...
Metabolic Messengers: itaconate
McGettrick et al. provide a succinct yet broad overview of the immunometabolite itaconate as an immunomodulatory molecule.
www.nature.com
October 5, 2025 at 6:13 AM
Fascinating read on #brain 🧠 tumor #immunology! Primary brain tumors vs metastases have fundamentally different immune microenvironments.
This is why secondaries often show a better response to #immunotherapy. share.google/RJdXIc02PCyH...
share.google
October 4, 2025 at 8:22 PM
Reposted by LPJ Lab - Neuroimmunometabolism
The immunology of brain tumors | Science Immunology www.science.org/doi/10.1126/...

Happy to share this review article by @lukasbunse.bsky.social, Theresa Bunse and I @platten-lab.bsky.social, Michael Kilian, Fran Quintana @quintanalabhms.bsky.social.
The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
www.science.org
October 4, 2025 at 10:49 AM
New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪
#Neuroscience #Mitochondria #Metabolism #BioRxiv

www.biorxiv.org/content/10.1...
Metabolic and transcriptional adaptations to phagocytosis sustain microglia functionality and regenerative properties
Phagocytosis of apoptotic cells, or efferocytosis, is a tightly regulated process that ensures tissue homeostasis and prevents mounting inflammatory responses. In the brain parenchyma, it is executed ...
www.biorxiv.org
September 24, 2025 at 8:04 AM
Use the form on our website! www.LPJLab.org
LPJLab
www.lpjlab.org
September 17, 2025 at 6:25 PM
#PhD position available!

Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis.
This is a great opportunity for anyone interested in neuroimmunology! 🧠

Please SHARE and APPLY here:
www.imperial.ac.uk/brain-scienc...
Funding
Funding is often secured through Wellcome Trust or MRC DTP Fellowships. Further information about this and specific projects studying under the supervision of Departmental supervisors who have obtaine...
www.imperial.ac.uk
September 17, 2025 at 8:20 AM
Thank you, Stuart!
Glad you were able to attend. CNS inflammation is such an important and evolving area of neuroscience. I think it's a field with immense potential for new discoveries and tangible patient benefits.
September 15, 2025 at 10:01 AM
Reposted by LPJ Lab - Neuroimmunometabolism
Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY
#CNS2025
September 11, 2025 at 4:38 PM
Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine
www.science.org/doi/10.1126/...
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies
Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.
www.science.org
September 11, 2025 at 8:42 AM
Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience!

www.cell.com/cell/fulltex...
Single-cell multiregion epigenomic rewiring in Alzheimer’s disease progression and cognitive resilience
A single-cell epigenomic and transcriptomic atlas across six brain regions in Alzheimer’s disease reveals widespread epigenomic relaxation and information loss, associated with the selective depletion...
www.cell.com
September 9, 2025 at 3:40 PM
Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧

We had a great chat about the latest research in MS and how we're working to find new treatments. 💪

Listen to the full episode here 👇
ms-perspektive.com/129-luca-per...
Hope for Myelin Repair: Stem Cells & Progressive MS
Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.
ms-perspektive.com
September 4, 2025 at 2:42 PM
Reposted by LPJ Lab - Neuroimmunometabolism
PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis)

An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application

https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab
Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism
Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
bit.ly
August 27, 2025 at 4:42 PM
Absolutely! And I was happy to see that we share the same opinions! 😁
August 27, 2025 at 5:04 PM
Beyond understanding the #brain, our goal is to heal it!
www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa

Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care!

Register here: tinyurl.com/27rzs5ku
August 27, 2025 at 3:23 PM