Stem Cell Reports
@stemcellreports.bsky.social
For scientists. By scientists. The official journal of the @isscr.org | Editor-in-Chief: Janet Rossant, CC, PhD
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR
November 11, 2025 at 5:35 PM
Loss-of-function analysis of the #Oct4 distal (DE) and proximal enhancers (PE) shows that Oct4 PE and DE are required for primed and naive pluripotency, respectively. Powerful genetic tools to dissect Oct4’s role in #pluripotency & early development. https://ow.ly/JShz50Xo5nz
ISSCR
ISSCR
New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
November 10, 2025 at 9:10 PM
New #organoid research shows transplanted human stomach organoids can induce gastric insulin-secreting cells in vivo. Potential for future therapeutic development using this technology for insulin-dependent #diabetes. https://ow.ly/88W850Xo2nR
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 10, 2025 at 7:00 PM
Meet our Early Career Editor at #ASSCR2025! Pengyi Yang is attending the Australasian Society for Stem Cell Research (ASSCR) Conference in Gold Coast, Australia, 10-12 November 2025. Connect with Dr. Yang to discuss whether your research is a fit for publishing in Stem Cell Reports!
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
November 7, 2025 at 4:55 PM
Online now! ModulatingJAK2-STAT3 pathway promotes expansion & maturation of human iPSC-derived myogenic progenitor cells; advancing in vitro generation of skeletal muscle progenitor cells for potential cell therapy applications. https://ow.ly/6qAz50XkBvY
Sanford Burnham Prebys | ISSCR
Sanford Burnham Prebys | ISSCR
Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
November 6, 2025 at 8:00 PM
Online now! An evolutionary conserved role for EZH2-polycomb repressive complex 2 (PRC2) in safeguarding #pluripotency from primitive #endoderm cell fate. #hypoblast #transdifferentiation https://ow.ly/Q2eZ50XkBks
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
ISSCR | Cell Press | SickKids Foundation | The Gairdner Foundation
New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
November 5, 2025 at 5:10 PM
New in Stem Cell Reports: Activation of canonical #Wnt signaling increases efficiency for direct reprogramming efficiency into human hepatic progenitor cells https://ow.ly/kcFf50XkB3k
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 5, 2025 at 1:00 PM
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the CANCOR 2025: Canadian Conference for Organoid Research today in Ontario, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Meet our Early Career Editor at #CANCOR2025! Amy Wong is attending the Canadian Conference for Organoid Research in Ontario, Canada, 5-6 November 2025. Connect with Dr. Wong to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 4, 2025 at 8:30 PM
Meet our Early Career Editor at #CANCOR2025! Amy Wong is attending the Canadian Conference for Organoid Research in Ontario, Canada, 5-6 November 2025. Connect with Dr. Wong to discuss whether your research is a fit for publishing in Stem Cell Reports!
New from Mayo Clinic: Differentiation of stem cell-derived pancreatic β-cells induces #circadian clock genes, and transplanted SCβ-cells exhibit circadian rhythms in #insulin secretion & optimize insulin secretion to host’s circadian phase https://ow.ly/XMmg50XkARN
ISSCR
ISSCR
November 4, 2025 at 5:30 PM
New from Mayo Clinic: Differentiation of stem cell-derived pancreatic β-cells induces #circadian clock genes, and transplanted SCβ-cells exhibit circadian rhythms in #insulin secretion & optimize insulin secretion to host’s circadian phase https://ow.ly/XMmg50XkARN
ISSCR
ISSCR
#Hypoxia dynamically alters oligodendrocyte precursor cell (OPC)phenotypes post-stroke; “oxygen tone” as a key regulator of OPC dynamic adaptation after stroke, offering a promising strategy for stroke #celltherapy. https://ow.ly/6k0m50XkAyR
ISSCR | SickKids Foundation | The Gairdner Foundation
ISSCR | SickKids Foundation | The Gairdner Foundation
November 3, 2025 at 9:40 PM
#Hypoxia dynamically alters oligodendrocyte precursor cell (OPC)phenotypes post-stroke; “oxygen tone” as a key regulator of OPC dynamic adaptation after stroke, offering a promising strategy for stroke #celltherapy. https://ow.ly/6k0m50XkAyR
ISSCR | SickKids Foundation | The Gairdner Foundation
ISSCR | SickKids Foundation | The Gairdner Foundation
Reposted by Stem Cell Reports
Advance your research and career by joining the ISSCR member! Connect with a global stem cell network through webinars, International Symposia, the Annual Meeting, networking events, and our Society journal, Stem Cell Reports
Discover the benefits 👉 www.isscr.org/membership
Discover the benefits 👉 www.isscr.org/membership
November 3, 2025 at 7:00 PM
Advance your research and career by joining the ISSCR member! Connect with a global stem cell network through webinars, International Symposia, the Annual Meeting, networking events, and our Society journal, Stem Cell Reports
Discover the benefits 👉 www.isscr.org/membership
Discover the benefits 👉 www.isscr.org/membership
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 3, 2025 at 2:00 PM
Early Career Editor Amy Wong (Amy Wong 🇨🇦) is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Early Career Editor Nika Shakiba is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 3, 2025 at 1:00 PM
Early Career Editor Nika Shakiba is attending the Till & McCulloch Meeting today in Ottawa, Canada. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Associate Editor April Pyle (@aprilpyle.bsky.social) is attending the Gene and Cell-Based Therapies: Progress in Clinical Translation meeting today in California, USA. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
November 2, 2025 at 1:00 PM
Associate Editor April Pyle (@aprilpyle.bsky.social) is attending the Gene and Cell-Based Therapies: Progress in Clinical Translation meeting today in California, USA. Connect with her to discuss whether your research is a fit for publishing in Stem Cell Reports!
Online now! Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis #intercellularcommunication #spermatogonia https://ow.ly/J0FZ50XhMg3
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
October 31, 2025 at 3:01 PM
Online now! Extracellular-vesicle-mediated transfer of let-7b/7c promotes the proliferation of transition-state spermatogonia in neonatal mouse testis #intercellularcommunication #spermatogonia https://ow.ly/J0FZ50XhMg3
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
New mapping review of the philosophical and ethical issues associated with developing and using human #organ-on-chip models. #organoids #personalizedmedicine #digitaltwins #stemcells https://ow.ly/Eqex50XkA1m
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
October 30, 2025 at 8:01 PM
New mapping review of the philosophical and ethical issues associated with developing and using human #organ-on-chip models. #organoids #personalizedmedicine #digitaltwins #stemcells https://ow.ly/Eqex50XkA1m
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
New research from Boston Children’s Hospital! Dual reporter mESC line created to study joint lineage cell differentiation & the roles of TGF-β, Wnt, & MAPK signaling pathways in joint lineage specification in vitro & ex vivo https://ow.ly/bo4j50XhLUS ISSCR
October 30, 2025 at 1:55 PM
New research from Boston Children’s Hospital! Dual reporter mESC line created to study joint lineage cell differentiation & the roles of TGF-β, Wnt, & MAPK signaling pathways in joint lineage specification in vitro & ex vivo https://ow.ly/bo4j50XhLUS ISSCR
Scientists from Roche Innovation Center recently joined The Stem Cell Report podcast to discuss insights from their new model of the blood-brain barrier. Listen to the full episode 👉https://ow.ly/lkRi50Xh6PV ISSCR
October 29, 2025 at 6:20 PM
Scientists from Roche Innovation Center recently joined The Stem Cell Report podcast to discuss insights from their new model of the blood-brain barrier. Listen to the full episode 👉https://ow.ly/lkRi50Xh6PV ISSCR
The LINC01612-DVL2-WNT regulatory axis promotes human endoderm differentiation – a key modulator of human definitive endoderm differentiation. #longnoncodingRNA #DVL2 #WNT #endoderm https://ow.ly/zvgJ50XhLB8
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
October 29, 2025 at 1:35 PM
The LINC01612-DVL2-WNT regulatory axis promotes human endoderm differentiation – a key modulator of human definitive endoderm differentiation. #longnoncodingRNA #DVL2 #WNT #endoderm https://ow.ly/zvgJ50XhLB8
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
ISSCR | Cell Press | The Gairdner Foundation | SickKids Foundation
Online now! First comprehensive database of potential cell-cell interactions in liver cell homeostasis & regeneration. Authors identified & validated 2 previously unknown signaling interactions involved in acceleration & delaying liver regeneration https://ow.ly/8ZfM50XhLnj ISSCR
October 28, 2025 at 9:30 PM
Online now! First comprehensive database of potential cell-cell interactions in liver cell homeostasis & regeneration. Authors identified & validated 2 previously unknown signaling interactions involved in acceleration & delaying liver regeneration https://ow.ly/8ZfM50XhLnj ISSCR
Stem Cell Reports is an open-access journal communicating the latest in basic, translational, and clinical stem cell research. Explore recent papers and discover the scope of discoveries we publish.
👉 https://bit.ly/47WgkeW
👉 https://bit.ly/47WgkeW
October 28, 2025 at 4:00 PM
Stem Cell Reports is an open-access journal communicating the latest in basic, translational, and clinical stem cell research. Explore recent papers and discover the scope of discoveries we publish.
👉 https://bit.ly/47WgkeW
👉 https://bit.ly/47WgkeW
Early Career Editor Pengyi Yang is attending the upcoming Australasian Society for Stem Cell Research (ASSCR) Conference 2025 in Gold Coast, Australia. Connect with him there to discuss whether your research is a fit for publishing in Stem Cell Reports!
October 28, 2025 at 12:00 PM
Early Career Editor Pengyi Yang is attending the upcoming Australasian Society for Stem Cell Research (ASSCR) Conference 2025 in Gold Coast, Australia. Connect with him there to discuss whether your research is a fit for publishing in Stem Cell Reports!
New study maps transcriptomic differences between in vitro skeletal muscle models & in vivo muscle, highlighting targetable processes to improve the models while paving the way for similar studies on other cell types. https://ow.ly/nCXq50XhL0L
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
October 27, 2025 at 8:20 PM
New study maps transcriptomic differences between in vitro skeletal muscle models & in vivo muscle, highlighting targetable processes to improve the models while paving the way for similar studies on other cell types. https://ow.ly/nCXq50XhL0L
ISSCR | The Gairdner Foundation | SickKids Foundation
ISSCR | The Gairdner Foundation | SickKids Foundation
Early Career Editor Kai Kretzschmar is presenting at the German Society for Cell Biology Conference today in Heidelberg, Germany. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!
October 27, 2025 at 12:00 PM
Early Career Editor Kai Kretzschmar is presenting at the German Society for Cell Biology Conference today in Heidelberg, Germany. Connect with him to discuss whether your research is a fit for publishing in Stem Cell Reports!
#Organoid research from University of Michigan Kellogg Eye Center: Multi-omics establishes METTL3-dependent m6A as a critical epitranscriptomic layer in retinal development, unveiling a genomic paradigm in which chromatin accessibility diverges from transcriptional output https://ow.ly/UrHl50XhKGr
October 24, 2025 at 5:59 PM
#Organoid research from University of Michigan Kellogg Eye Center: Multi-omics establishes METTL3-dependent m6A as a critical epitranscriptomic layer in retinal development, unveiling a genomic paradigm in which chromatin accessibility diverges from transcriptional output https://ow.ly/UrHl50XhKGr