Dr. Rajesh Khanna of the KhannaLabUF
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khannalabuf.bsky.social
Dr. Rajesh Khanna of the KhannaLabUF
@khannalabuf.bsky.social
420 followers 380 following 160 posts
We are unraveling a QR code for chronic pain | Prof. of Pharmacology & Therapeutics, Univ. of Florida COM | Director, Center for Advanced Pain Therapeutics and Research (CAPTOR) | Mayday Pain Fellow | 🇮🇳🇴🇲🇨🇦🇺🇸

ORCID: 0000-0002-9066-2969
Posts Replies Media Videos
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
andrewplested.bsky.social
Game changer, no doubt. Commercial systems will have expensive consumables I suppose, but huge savings to be made in cell culture, and many important but sparse native targets come into play.

Crispr-tagged targets from iPSC neurons, for example.

TRPC6 blind? 🤯
janinebrunner.bsky.social Janine Brunner @janinebrunner.bsky.social · 2d
MISO: microfluidic protein isolation enables single-particle cryo-EM structure determination from a single cell colony.

Or from a single dish of HEK cell culture in the case of two membrane proteins.

Out in Nature Methods now! lnkd.in/gpyBSceg

Wonderful collaboration with the Efremov lab.
November 15, 2025 at 2:46 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
bocklab.bsky.social
Ready to talk to cells?
📖 Read the paper: doi.org/10.1038/s415...
🧬 Try the web app with public datasets: cellwhisperer.bocklab.org
🖥️ Analyze your own datasets: github.com/epigen/cellw...
(9/11)
Multimodal learning enables chat-based exploration of single-cell data - Nature Biotechnology
CellWhisperer uses multimodal learning of transcriptomes and text to answer questions about single-cell RNA-sequencing data.
doi.org
November 11, 2025 at 12:52 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
bocklab.bsky.social
🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)
November 11, 2025 at 12:52 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
jem.org
Antunes, Zamponi et al. describe a pathogenic mutation in the deubiquitinase USP5 that is linked to congenital insensitivity to #pain. rupress.org/jem/article/...

📘 In our #Neuroscience collection: rupress.org/jem/collecti...
#SfN25
November 15, 2025 at 4:15 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
mandala-lab.bsky.social
Read our work on protein-rich domains in the plasma membrane:

www.biorxiv.org/content/10.1...
Spatial deconstruction of the plasma membrane
The plasma membrane of cells is known to be heterogeneous with regards to the spatial distribution of proteins and lipids. The segregation of molecular species in the cell membrane into specific domai...
www.biorxiv.org
November 15, 2025 at 3:01 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
natureportfolio.nature.com
A Review in Nature Reviews Neuroscience synthesizes the progress in the understanding of the neural circuits that underlie itch signal processing, transmission and encoding within the central nervous system. go.nature.com/4p0V2ls 🔒
This is figure 1, which shows the local spinal circuit for itch signal processing.
November 13, 2025 at 8:11 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
psalmotoxin.bsky.social
With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch

Here's our accompanying review!
www.jneurosci.org/content/45/4...
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state. Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details. Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.
November 12, 2025 at 6:19 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
drugmonkey.bsky.social
It is an all too common feature of academics, particularly grant funded scientist ones, to assume implicitly or explicitly that our systems select on pure merit. Right up until we, or our peeps, come up on the bad side of the dice roll. Only then is the system excoriated for being unfair.
November 7, 2025 at 4:59 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
painthejournal.bsky.social
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
November 7, 2025 at 9:00 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
iasp.bsky.social
In this week’s #PAIN Featured Image, @khannalabuf.bsky.social‬ et al. depict MGO-induced GNC2 activation in metabolic stress. High levels of MGO result in ribosome stalling and collisions with trailing ribosomes. Learn more in #PAIN bit.ly/4oITZGz
PAIN Featured Image 11 November
November 7, 2025 at 2:00 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
neuroniv.bsky.social
New human DRG atlas just dropped! 🌟
November 7, 2025 at 11:26 AM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
tedpricethepainguy.bsky.social
Another excellent position at UT Dallas, this time in the Biological Science Dept: jobs.utdallas.edu/postings/30702 Our Neuroscience and Biological Sciences faculty are closely intertwined and collaborative creating a great place to launch your independent lab!
Open Rank Faculty Position Artificial Intelligence in Biological Sciences
Position DescriptionThe School of Natural Sciences and Mathematics at The University of Texas at Dallas (UT Dallas) seeks to fill multiple open-rank (Full, Associate, or Assistant Professor) tenured/t...
jobs.utdallas.edu
November 6, 2025 at 1:30 AM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
jgp.org
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
November 5, 2025 at 9:45 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
kwolbachia.bsky.social
My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site
#microscopy #ImageJ #FluorescenceFriday #microscopyMonday
imagej.net/plugins/imag...
November 4, 2025 at 10:40 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
napainschool.bsky.social
🚨 Mark your calendars for #NAPainSchool
🗣️ Please share with anyone that might be interested to join leading experts in the pain research field for an exceptional week of training, networking and more!
northamericanpainschool.com/registration/

#Pain #PainResearch #NPAW2025 #PrioritizePain
November 4, 2025 at 8:50 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
painthejournal.bsky.social
Using quantitative proteomics and cross-omic analyses of human dorsal root ganglia, @aliibarry.bsky.social et al. show evidence for sexual dimorphism in TNFα signaling spanning the epigenetic signature to proteomic differences. Learn more in #PAIN bit.ly/42cM5wC
November 3, 2025 at 9:00 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
lampertlab.bsky.social
🎙️ José Ángel Aibar, President of the Dravet Syndrome Foundation, joins #WSCC26 (Feb 4–6, 2026, Grindelwald 🇨🇭) to talk about advancing collaboration & discovery in Dravet syndrome.

🧠 Abstracts due Nov 2 – all published in a JGP special issue!
🔗 sodiumchannelconference2026.org/WELCOME/
October 29, 2025 at 10:10 AM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
lampertlab.bsky.social
🎙️ Carol Ann Remme (Amsterdam UMC) joins #WSCC26 (Feb 4–6, 2026, Grindelwald, CH) to talk about cardiac sodium channels ❤️ and their role in cardiac physiology & disease.

🧠 Abstracts due Nov 2
🔗 sodiumchannelconference2026.org/WELCOME/

#NaV #ionchannels #cardiacphysiology #scienceconference
October 30, 2025 at 8:50 AM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
goldpainlab.bsky.social
une.peopleadmin.com/postings/23648
Open Rank, Biomedical Research
The University of New England Westbrook College of Health Professions (WCHP) invites applications for a full-time, 12-month, tenure-track faculty position from individuals with a strong record of inno...
une.peopleadmin.com
November 1, 2025 at 12:09 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
tedpricethepainguy.bsky.social
The latest work from our PRECISION Human Pain Center project is now up on @biorxivpreprint.bsky.social led by Katherin Gabriel and @oliviadavis.bsky.social with a huge contribution from @allanhpool.bsky.social's lab and, of course, the Southwest Transplant Alliance: www.biorxiv.org/content/10.1...
A molecular map of the human spinal dorsal and ventral horn defines arrangement of neuronal types and glial sex differences
The spinal cord is the gateway for sensory information from the body as it ascends to the brain, as well as a major motor output center of the nervous system. It is also a key location for sensory-mot...
www.biorxiv.org
November 1, 2025 at 12:10 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
tedpricethepainguy.bsky.social
We are seeking a senior tenured professor in our Department working on affective and/or motivational neuroscience (defined in the ad, but pretty broad). The idea is that this person is going help lead our growth in this area alongside our excellent Centers. jobs.utdallas.edu/postings/30693
Associate/Full Professor - Affective Motivational Neuroscience
Position DescriptionThe Department of Neuroscience in the School of Behavioral and Brain Sciences at The University of Texas at Dallas seeks a late-stage Associate or Full Professor faculty member to ...
jobs.utdallas.edu
October 31, 2025 at 9:15 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
lampertlab.bsky.social
⏰ Abstract deadline tomorrow! Join us in Grindelwald, Feb 4–6, 2026 Worldwide Sodium Channel Conference!
Robert Stewart (Harvard) talks on Nav1.8 inhibition & new Nav blockers for pain 💥Accepted abstracts → special issue @jgp.org👉 sodiumchannelconference2026.org
#WSCC26 #SodiumChannels #PainResearch
November 1, 2025 at 8:21 AM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
rupress.org
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
October 29, 2025 at 2:15 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
jgp.org
The review process will be overseen by JGP Associate Editors Teresa Giraldez (@giraldezt.bsky.social) and Jeanne Nerbonne, with Guest Editor and subject experts Angelika Lampert (@lampertlab.bsky.social), Hugues Abriel, and Rajesh Khanna (@khannalabuf.bsky.social) 👉 rupress.org/jgp/pages/ca...
October 29, 2025 at 2:15 PM
Reposted by Dr. Rajesh Khanna of the KhannaLabUF
science.org
Three new papers in Science report that astrocytes are indispensable for neuromodulatory signaling across diverse neural circuits, behavioral contexts, and species.

Learn more in a new #SciencePerspective: scim.ag/43iprSX
Astrocytes, hidden puppet masters of the brain
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
scim.ag
May 16, 2025 at 3:10 PM